Structures of the CDK12/CycK complex with AMP-PNP reveal a flexible C-terminal kinase extension important for ATP binding

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Dixon Clarke, Sarah E ^a   Elkins, Jonathan M ^a   Cheng, S W Grace ^b   Morin, Gregg B ^b,c   Bullock, Alex N ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b BRITISH COLUMBIA CANCER AGENCY   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADENYLYLIMIDODIPHOSPHATE; CCNK PROTEIN, HUMAN; CDK12 PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE; CYCLINE; PROTEIN BINDING;

ANIMAL; CHEMISTRY; ENZYME ACTIVE SITE; HUMAN; HYDROGEN BOND; MOLECULAR MODEL; PROTEIN DOMAIN; PROTEIN QUATERNARY STRUCTURE; SF9 CELL LINE; SOLUBILITY; SPODOPTERA; X RAY CRYSTALLOGRAPHY;

ADENYLYL IMIDODIPHOSPHATE; ANIMALS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYCLIN-DEPENDENT KINASES; CYCLINS; HUMANS; HYDROGEN BONDING; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, QUATERNARY; SF9 CELLS; SOLUBILITY; SPODOPTERA;

EID: 84948164846     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep17122     Document Type: Article

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