Protective effects of alginate–chitosan microspheres loaded with alkaloids from Coptis chinensis Franch. and Evodia rutaecarpa (Juss.) Benth. (Zuojin Pill) against ethanol-induced acute gastric mucosal injury in rats

Drug Design, Development and Therapy

Volumn 9, Issue , 2015, Pages 6151-6165

  Wang, Qiang Song ^a,b   Zhu, Xiao Ning ^a   Jiang, Heng Li ^a   Wang, Gui Fang ^a   Cui, Yuan Lu ^a  

^a TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b INSTITUTE OF BIOMEDICAL ENGINEERING   (China)

Author keywords

Alginate; Alkaloids; Anti inflammatory; Chitosan; Gastric mucosal injury; Mucoadhesive microspheres

Indexed keywords

ALGINIC ACID; ALKALOID; BERBERINE; CHITOSAN; COPTISINE; EPIBERBERINE; EVODIAMINE; GASTROINTESTINAL MUCOSA PROTECTIVE AGENT; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; JATRORRHIZINE; MESSENGER RNA; MICROSPHERE; OMEPRAZOLE; PALMATINE; RUTAECARPINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ALCOHOL; ANTIULCER AGENT; AUTACOID; DRUG CARRIER; GLUCURONIC ACID; HERBACEOUS AGENT; HEXURONIC ACID; IL1B PROTEIN, RAT; NOS2 PROTEIN, RAT; TUMOR NECROSIS FACTOR;

ACUTE GASTRIC MUCOSAL INJURY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COPTIS CHINENSIS; DOWN REGULATION; DRUG DELIVERY SYSTEM; DRUG EFFECT; GENE EXPRESSION; MALE; MICROENCAPSULATION; MUCOADHESION; NONHUMAN; PARTICLE SIZE; RAT; STOMACH MUCOSA INJURY; STOMACH MUCUS; STOMACH PROTECTION; SURFACE PROPERTY; SUSTAINED DRUG RELEASE; TETRADIUM RUTICARPUM; ADHESION; ANALOGS AND DERIVATIVES; ANIMAL; CELL PROTECTION; CHEMICALLY INDUCED; CHEMISTRY; COPTIS; DISEASE MODEL; DRUG EFFECTS; EVODIA; GENETICS; INSTITUTE FOR CANCER RESEARCH MOUSE; ISOLATION AND PURIFICATION; MEDICINAL CHEMISTRY; MEDICINAL PLANT; METABOLISM; PATHOLOGY; PHYTOTHERAPY; SOLUBILITY; SPRAGUE DAWLEY RAT; STOMACH MUCOSA; STOMACH ULCER; TIME FACTOR;

ADHESIVENESS; ALGINATES; ALKALOIDS; ANIMALS; ANTI-ULCER AGENTS; CHEMISTRY, PHARMACEUTICAL; CHITOSAN; COPTIS; CYTOPROTECTION; DISEASE MODELS, ANIMAL; DRUG CARRIERS; DRUGS, CHINESE HERBAL; ETHANOL; EVODIA; GASTRIC MUCOSA; GLUCURONIC ACID; HEXURONIC ACIDS; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; MALE; MICE, INBRED ICR; MICROSPHERES; NITRIC OXIDE SYNTHASE TYPE II; PHYTOTHERAPY; PLANTS, MEDICINAL; RATS, SPRAGUE-DAWLEY; SOLUBILITY; STOMACH ULCER; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84948126128     PISSN: None     EISSN: 11778881     Source Type: Journal    
DOI: 10.2147/DDDT.S96056     Document Type: Article

References (51)

1. Mota KS, Dias GE, Pinto ME, et al. Flavonoids with gastroprotective activity. Molecules. 2009;14(3):979-1012.
2. Rao ChV, Ojha SK, Radhakrishnan K, et al. Antiulcer activity of Utleria salicifolia rhizome extract. J Ethnopharmacol. 2004;91(2-3):243-249.
3. Hejazi R, Amiji M. Stomach-specific anti-H. pylori therapy. I: preparation and characterization of tetracyline-loaded chitosan microspheres. Int J Pharm. 2002;235(1-2):87-94.
4. Ji C, Khademhosseini A, Dehghani F. Enhancing cell penetration and proliferation in chitosan hydrogels for tissue engineering applications. Biomaterials. 2011;32(36):9719-9729.
5. Ong SY, Wu J, Moochhala SM, et al. Development of a chitosan-based wound dressing with improved hemostatic and antimicrobial properties. Biomaterials. 2008;29(32):4323-4332.
6. Tronci G, Ajiro H, Russell SJ, et al. Tunable drug-loading capability of chitosan hydrogels with varied network architectures. Acta Biomater. 2014;10(2):821-830.
7. Narayanan RP, Melman G, Letourneau NJ, et al. Photodegradable iron(iii) cross-linked alginate gels. Biomacromolecules. 2012;13(8):2465-2471.
8. Wu J, Kong T, Yeung KW, et al. Fabrication and characterization of monodisperse PLGA-alginate core-shell microspheres with monodisperse size and homogeneous shells for controlled drug release. Acta Biomater. 2013;9(7):7410-7419.
9. Anal AK, Stevens WF. Chitosan-alginate multilayer beads for controlled release of ampicillin. Int J Pharm. 2005;290(1-2):45-54.
10. Tarnawski A, Szabo IL, Husain SS, Soreghan B. Regeneration of gastric mucosa during ulcer healing is triggered by growth factors and signal transduction pathways. J Physiol Paris. 2001;95(1-6):337-344.
11. Hibbs JB Jr, Taintor RR, Vavrin Z. Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite. Science. 1987;235(4787):473-476.
12. Palmer RM, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature. 1988;333(6174):664-666.
13. Marletta MA. Nitric oxide synthase structure and mechanism. J Biol Chem. 1993;268(17):12231-12234.
14. Kleinert H, Pautz A, Linker K, Schwarz PM. Regulation of the expression of inducible nitric oxide synthase. Eur J Pharmacol. 2004;500(1-3):255-266.
15. Chatterjee M, Saluja R, Kanneganti S, et al. Biochemical and molecular evaluation of neutrophil NOS in spontaneously hypertensive rats. Cell Mol Biol (Noisy-le-grand). 2007;53(1):84-93.
16. Salvemini D, de Nucci G, Gryglewski RJ, Vane JR. Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor. Proc Natl Acad Sci U S A. 1989;86(16):6328-6332.
17. Souza MH, Lemos HP, Oliveira RB, Cunha FQ. Gastric damage and granulocyte infiltration induced by indomethacin in tumour necrosis factor receptor 1 (TNF-R1) or inducible nitric oxide synthase (iNOS) deficient mice. Gut. 2004;53(6):791-796.
18. Harris SG, Padilla J, Koumas L, et al. Prostaglandins as modulators of immunity. Trends Immunol. 2002;23(3):144-150.
19. Ma L, del Soldato P, Wallace JL. Divergent effects of new cyclooxygenase inhibitors on gastric ulcer healing: shifting the angiogenic balance. Proc Natl Acad Sci U S A. 2002;99(20):13243-13247.
20. Konturek SJ, Konturek PC, Brzozowski T. Prostaglandins and ulcer healing. J Physiol Pharmacol. 2005;56(Suppl 5):5-31.
21. Pharmacopoeia CoN. Pharmacopoeia of the People's Republic of China. Beijing, China: Press of Chemical Industry; 2010.
22. Wang QS, Cui YL, Dong TJ, et al. Ethanol extract from a Chinese herbal formula, "Zuojin Pill", inhibit the expression of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 mouse macrophages. J Ethnopharmacol. 2012;141(1):377-385.
23. Wang QS, Ding SL, Mao HP, et al. Antidepressant-like effect of ethanol extract from Zuojin Pill, containing two herbal drugs of Rhizoma Coptidis and Fructus Evodiae, is explained by modulating the monoaminergic neurotransmitter system in mice. J Ethnopharmacol. 2013;148(2):603-609.
24. Akiyama Y, Nagahara N, Kashihara T, et al. In vitro and in vivo evaluation of mucoadhesive microspheres prepared for the gastrointestinal tract using polyglycerol esters of fatty acids and a poly(acrylic acid) derivative. Pharm Res. 1995;12(3):397-405.
25. Liu Y, Li XR, Fan JY, et al. Experimental research on effects of Xue Dan Wei Chang Pill on gastric ulcer. LiShiZhen Med Mater Med Res. 2010;21:301-302.
26. Salga MS, Ali HM, Abdulla MA, Abdelwahab SI. Gastroprotective activity and mechanism of novel dichlorido-zinc(ii)-4-(2-(5-methoxybenzylideneamino)ethyl)piperazin-1-iumphenolate complex on ethanol-induced gastric ulceration. Chem Biol Interact. 2012;195(2):144-153.
27. Sidahmed HM, Hashim NM, Amir J, et al. Pyranocycloartobiloxanthone A, a novel gastroprotective compound from Artocarpus obtusus Jarret, against ethanol-induced acute gastric ulcer in vivo. Phytomedicine. 2013;20(10):834-843.
28. Wang QS, Xiang Y, Cui YL, et al. Dietary blue pigments derived from genipin, attenuate inflammation by inhibiting LPS-induced iNOS and COX-2 expression via the NF-kappaB inactivation. PLoS One. 2012;7(3):e34122.
29. Wang QS, Cui YL, Wang YF, Chi W. Effects of compounds from bi-qi capsule on the expression of inflammatory mediators in lipopolysaccharide-stimulated RAW 264.7 macrophages. J Ethnopharmacol. 2011;136(3):480-487.
30. Sowndhararajan K, Kang SC. Protective effect of ethyl acetate fraction of Acacia ferruginea DC. against ethanol-induced gastric ulcer in rats. J Ethnopharmacol. 2013;148(1):175-181.
31. Franke A, Teyssen S, Singer MV. Alcohol-related diseases of the esophagus and stomach. Dig Dis. 2005;23(3-4):204-213.
32. Choi EY, Hwang HJ, Kim IH, Nam TJ. Protective effects of a polysaccharide from Hizikia fusiformis against ethanol toxicity in rats. Food Chem Toxicol. 2009;47(1):134-139.
33. Ineu RP, Pereira ME, Aschner M, et al. Diphenyl diselenide reverses gastric lesions in rats: involvement of oxidative stress. Food Chem Toxicol. 2008;46(9):3023-3029.
34. Hasgul R, Uysal S, Haltas H, et al. Protective effects of Ankaferd blood stopper on aspirin-induced oxidative mucosal damage in a rat model of gastric injury. Toxicol Ind Health. 2014;30(10):888-895.
35. Burger D, Dayer JM, Palmer G, Gabay C. Is IL-1 a good therapeutic target in the treatment of arthritis? Best Pract Res Clin Rheumatol. 2006;20(5):879-896.
36. Kwiecien S, Brzozowski T, Konturek SJ. Effects of reactive oxygen species action on gastric mucosa in various models of mucosal injury. J Physiol Pharmacol. 2002;53(1):39-50.
37. Liu Y, Tian X, Gou L, et al. Protective effect of l-citrulline against ethanol-induced gastric ulcer in rats. Environ Toxicol Pharmacol. 2012;34(2):280-287.
38. Axon AT. The role of acid inhibition in the treatment of Helicobacter pylori infection. Scand J Gastroenterol Suppl. 1994;201:16-23.
39. Fontana G, Licciardi M, Mansueto S, et al. Amoxicillin-loaded polyethylcyanoacrylate nanoparticles: influence of PEG coating on the particle size, drug release rate and phagocytic uptake. Biomaterials. 2001;22(21):2857-2865.
40. Dhaliwal S, Jain S, Singh HP, Tiwary AK. Mucoadhesive microspheres for gastroretentive delivery of acyclovir: in vitro and in vivo evaluation. AAPS J. 2008;10(2):322-330.
41. Amiji MM. Tetracycline-containing chitosan microspheres for local treatment of Helicobacter pylori infection. Cellulose. 2007;14:3-14.
42. Ko JK, Cho CH, Lam SK. Adaptive cytoprotection through modulation of nitric oxide in ethanol-evoked gastritis. World J Gastroenterol. 2004;10(17):2503-2538.
43. McGuckin MA, Linden SK, Sutton P, Florin TH. Mucin dynamics and enteric pathogens. Nat Rev Microbiol. 2011;9(4):265-278.
44. Kristal B, Shurtz-Swirski R, Chezar J, et al. Participation of peripheral polymorphonuclear leukocytes in the oxidative stress and inflammation in patients with essential hypertension. Am J Hypertens. 1998;11(8):921-928.
45. Luiz-Ferreira A, Cola M, Barbastefano V, et al. Healing, antioxidant and cytoprotective properties of Indigofera truxillensis in different models of gastric ulcer in rats. Int J Mol Sci. 2012;13(11):14973-14991.
46. Esplugues JV, Whittle BJ, Moncada S. Modulation by opioids and by afferent sensory neurones of prostanoid protection of the rat gastric mucosa. Br J Pharmacol. 1992;106(4):846-852.
47. Abdelwahab SI. Protective mechanism of gallic acid and its novel derivative against ethanol-induced gastric ulcerogenesis: involvement of immunomodulation markers, Hsp70 and Bcl-2-associated X protein. Int Immunopharmacol. 2013;16(2):296-305.
48. Shimoyama AT, Santin JR, Machado ID, et al. Antiulcerogenic activity of chlorogenic acid in different models of gastric ulcer. Naunyn Schmiedebergs Arch Pharmacol. 2013;386(1):5-14.
49. Najar IA, Sachin BS, Sharma SC, et al. Modulation of P-glycoprotein ATPase activity by some phytoconstituents. Phytother Res. 2010;24(3):454-458.
50. Zhang X, Qiu F, Jiang J, Gao C, Tan Y. Intestinal absorption mechanisms of berberine, palmatine, jateorhizine, and coptisine: involvement of P-glycoprotein. Xenobiotica. 2011;41(4):290-296.
51. Shi R, Zhou H, Ma B, et al. Pharmacokinetics and metabolism of jatrorrhizine, a gastric prokinetic drug candidate. Biopharm Drug Dispos. 2012;33(3):135-145.