Overexpression of microRNA-133a inhibits ischemia-reperfusion-induced cardiomyocyte apoptosis by targeting DAPK2

Journal of Human Genetics

Volumn 60, Issue 11, 2015, Pages 709-716

  Li, Sheng ^a   Xiao, Fang Yi ^a   Shan, Pei Ren ^a   Su, Lan ^a   Chen, De Liang ^b   Ding, Jin Ye ^b   Wang, Zhi Quan ^b  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b SHANXI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

DEATH ASSOCIATED PROTEIN KINASE; DEATH ASSOCIATED PROTEIN KINASE 2; MESSENGER RNA; MICRORNA; MICRORNA 133A; UNCLASSIFIED DRUG; MIRN133 MICRORNA, RAT;

ALGORITHM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; FEMALE; GENE OVEREXPRESSION; GENETIC TRANSFECTION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LUCIFERASE ASSAY; NONHUMAN; PROTEIN EXPRESSION; RAT; RAT MODEL; REPERFUSION INJURY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUNEL ASSAY; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOLOGICAL MODEL; CARDIAC MUSCLE CELL; CELL LINE; DISEASE MODEL; GENE TARGETING; GENETICS; METABOLISM; MYOCARDIAL REPERFUSION INJURY; PATHOLOGY; UPREGULATION; WISTAR RAT;

ANIMALS; APOPTOSIS; CELL LINE; DEATH-ASSOCIATED PROTEIN KINASES; DISEASE MODELS, ANIMAL; FEMALE; GENE TARGETING; MICRORNAS; MODELS, CARDIOVASCULAR; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; RATS; RATS, WISTAR; RNA, MESSENGER; UP-REGULATION;

EID: 84948124966     PISSN: 14345161     EISSN: 1435232X     Source Type: Journal    
DOI: 10.1038/jhg.2015.96     Document Type: Article

References (38)

1. Mathers, C. D. & Loncar, D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med. 3, e442(2006).
2. Hausenloy, D. J. & Yellon, D. M. Myocardial ischemia-reperfusion injury: a neglected therapeutic target. J. Clin. Invest. 123, 92-100 (2013).
3. Frank, A., Bonney, M., Bonney, S., Weitzel, L., Koeppen, M. & Eckle, T. Myocardial ischemia reperfusion injury: from basic science to clinical bedside. Semin. Cardiothorac. Vasc. Anesth. 16, 123-132 (2012).
4. Canty, J. M. Jr & Suzuki, G. Myocardial perfusion and contraction in acute ischemia and chronic ischemic heart disease. J. Mol. Cell. Cardiol. 52, 822-831 (2012).
5. Frohlich, G. M., Meier, P., White, S. K., Yellon, D. M. & Hausenloy, D. J. Myocardial reperfusion injury: looking beyond primary PCI. Eur. Heart J. 34, 1714-1722 (2013).
6. Diez, E. R., Altamirano, L. B., Garcia, I. M., Mazzei, L., Prado, N. J., Fornes, M. W. et al. Heart remodeling and ischemia-reperfusion arrhythmias linked to myocardial vitamin d receptors deficiency in obstructive nephropathy are reversed by paricalcitol. J. Cardiovasc. Pharmacol. Ther. 20, 211-220 (2014).
7. Hausenloy, D. J. & Yellon, D. M. The therapeutic potential of ischemic conditioning: an update. Nat. Rev. Cardiol. 8, 619-629 (2011).
8. Dongworth, R. K., Mukherjee, U. A., Hall, A. R., Astin, R., Ong, S. B., Yao, Z. et al. DJ-1 protects against cell death following acute cardiac ischemia-reperfusion injury. Cell Death Dis. 5, e1082 (2014).
9. Siddall, H. K., Yellon, D. M., Ong, S. B., Mukherjee, U. A., Burke, N., Hall, A. R. et al. Loss of PINK1 increases the heart's vulnerability to ischemia-reperfusion injury. PLoS One 8, e62400 (2013).
10. Ren, X. P., Wu, J., Wang, X., Sartor, M. A., Qian, J., Jones, K. et al. MicroRNA-320 is involved in the regulation of cardiac ischemia/reperfusion injury by targeting heat-shock protein 20. Circulation 119, 2357-2366 (2009).
11. Cheng, Y., Zhu, P., Yang, J., Liu, X., Dong, S., Wang, X. et al. Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4. Cardiovasc. Res. 87, 431-439 (2010).
12. Di, Y., Lei, Y., Yu, F., Changfeng, F., Song, W. & Xuming, M. MicroRNAs expression and function in cerebral ischemia reperfusion injury. J. Mol. Neurosci. 53, 242-250 (2014).
13. Tutar, L., Tutar, E. & Tutar, Y. MicroRNAs and cancer; an overview. Curr. Pharm. Biotechnol. 15, 430-437 (2014).
14. Olson, E. N. MicroRNAs as therapeutic targets and biomarkers of cardiovascular disease. Sci. Transl. Med. 6, 239ps3 (2014).
15. Ye, Y., Perez-Polo, J. R., Qian, J. & Birnbaum, Y. The role of microRNA in modulating myocardial ischemia-reperfusion injury. Physiol. Genomics 43, 534-542 (2011).
16. Dong, D. L., Chen, C., Huo, R., Wang, N., Li, Z., Tu, Y. J. et al. Reciprocal repression between microRNA-133 and calcineurin regulates cardiac hypertrophy: a novel mechanism for progressive cardiac hypertrophy. Hypertension 55, 946-952 (2010).
17. Care, A., Catalucci, D., Felicetti, F., Bonci, D., Addario, A., Gallo, P. et al. MicroRNA-133 controls cardiac hypertrophy. Nat. Med. 13, 613-618 (2007).
18. Fichtlscherer, S., De Rosa, S., Fox, H., Schwietz, T., Fischer, A., Liebetrau, C. et al. Circulating microRNAs in patients with coronary artery disease. Circ. Res. 107, 677-684 (2010).
19. Kuwabara, Y., Ono, K., Horie, T., Nishi, H., Nagao, K., Kinoshita, M. et al. Increased microRNA-1 and microRNA-133a levels in serum of patients with cardiovascular disease indicate myocardial damage. Circ. Cardiovasc. Genet. 4, 446-454 (2011).
20. Duisters, R. F., Tijsen, A. J., Schroen, B., Leenders, J. J., Lentink, V., van der Made, I. et al. miR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling. Circ. Res. 104, 170-178 (2009)
21. Griffiths-Jones, S. miRBase: microRNA sequences and annotation. Curr. Protoc. Bioinform. Chapter 12, Unit 12.9.1-10 (2010).
22. Liu, N., Bezprozvannaya, S., Williams, A. H., Qi, X., Richardson, J. A., Bassel-Duby, R. et al. microRNA-133a regulates cardiomyocyte proliferation and suppresses smooth muscle gene expression in the heart. Genes Dev. 22, 3242-3254 (2008).
23. Xiao, J., Luo, X., Lin, H., Zhang, Y., Lu, Y., Wang, N. et al. MicroRNA miR-133 represses HERG K+ channel expression contributing to QT prolongation in diabetic hearts. J. Biol. Chem. 282, 12363-12367 (2007).
24. Luo, X., Lin, H., Pan, Z., Xiao, J., Zhang, Y., Lu, Y. et al. Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart. J. Biol. Chem. 283, 20045-20052 (2008).
25. Vandenberg, J. I., Perry, M. D., Perrin, M. J., Mann, S. A., Ke, Y. & Hill, A. P. hERG K(+) channels: structure, function, and clinical significance. Physiol. Rev. 92, 1393-1478 (2012).
26. Luo, X., Lin, H., Pan, Z., Xiao, J., Zhang, Y., Lu, Y. et al. Down-regulation of miR-1/miR-133 contributes to re-expression of pacemaker channel genes HCN2 and HCN4 in hypertrophic heart. J. Biol. Chem. 286, 28656 (2011).
27. Livak, K. J. & Schmittgen, T. D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25, 402-408 (2001).
28. Townley-Tilson, W. H., Callis, T. E. & Wang, D. MicroRNAs 1, 133, and 206: critical factors of skeletal and cardiac muscle development, function, and disease. Int. J. Biochem. Cell. Biol. 42, 1252-1255 (2010).
29. Izarra, A., Moscoso, I., Levent, E., Canon, S., Cerrada, I., Diez-Juan, A. et al. miR-133a enhances the protective capacity of cardiac progenitors cells after myocardial infarction. Stem Cell Rep. 3, 1029-1042 (2014).
30. Sayed, D., Hong, C., Chen, I. Y., Lypowy, J. & Abdellatif, M. MicroRNAs play an essential role in the development of cardiac hypertrophy. Circ. Res. 100, 416-424 (2007).
31. Tatsuguchi, M., Seok, H. Y., Callis, T. E., Thomson, J. M., Chen, J. F., Newman, M. et al. Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy. J. Mol. Cell. Cardiol. 42, 1137-1141 (2007).
32. He, B., Xiao, J., Ren, A. J., Zhang, Y. F., Zhang, H., Chen, M. et al. Role of miR-1 and miR-133a in myocardial ischemic postconditioning. J. Biomed. Sci 18, 22(2011).
33. Ivey, K. N., Muth, A., Arnold, J., King, F. W., Yeh, R. F., Fish, J. E. et al. MicroRNA regulation of cell lineages in mouse and human embryonic stem cells. Cell Stem Cell 2, 219-229 (2008).
34. Xu, C., Lu, Y., Pan, Z., Chu, W., Luo, X., Lin, H. et al. The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes. J. Cell Sci. 124, 3187 (2011).
35. Xu, C., Lu, Y., Pan, Z., Chu, W., Luo, X., Lin, H. et al. The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytes. J. Cell Sci. 120, 3045-3052 (2007).
36. Zhu, H. & Fan, G. C. Role of microRNAs in the reperfused myocardium towards post-infarct remodelling. Cardiovasc. Res. 94, 284-292 (2012).
37. Lin, Y., Hupp, T. R. & Stevens, C. Death-associated protein kinase (DAPK) and signal transduction: additional roles beyond cell death. FEBS J. 277, 48-57 (2010).
38. Britschgi, A., Trinh, E., Rizzi, M., Jenal, M., Ress, A., Tobler, A. et al. DAPK2 is a novel E2F1/KLF6 target gene involved in their proapoptotic function. Oncogene 27, 5706-5716 (2008).