Detection of putative stem cell markers, CD44/CD133, in primary and lymph node metastases in head and neck squamous cell carcinomas. A preliminary immunohistochemical and in vitro study

Clinical Otolaryngology

Volumn 40, Issue 4, 2015, Pages 312-320

  Mannelli, G ^a   Magnelli, L ^a   Deganello, A ^a   Busoni, M ^a   Meccariello, G ^a   Parrinello, G ^a   Gallo, O ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CD133 ANTIGEN; HERMES ANTIGEN; HYALURONIC ACID; GLYCOPROTEIN; LEUKOCYTE ANTIGEN; PEPTIDE; TUMOR MARKER;

ADULT; AGED; ARTICLE; CANCER CLASSIFICATION; CANCER PROGNOSIS; CANCER STEM CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL RENEWAL; CLINICAL ARTICLE; CLONOGENESIS; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GENETIC VARIABILITY; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; LYMPH NODE METASTASIS; MALE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; FLOW CYTOMETRY; HEAD AND NECK TUMOR; METABOLISM; MIDDLE AGED; PATHOLOGY; SQUAMOUS CELL CARCINOMA; TUMOR CELL CULTURE;

AGED; ANTIGENS, CD; ANTIGENS, CD44; BIOMARKERS, TUMOR; CARCINOMA, SQUAMOUS CELL; FEMALE; FLOW CYTOMETRY; GLYCOPROTEINS; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; IN VITRO TECHNIQUES; LYMPHATIC METASTASIS; MALE; MIDDLE AGED; NEOPLASTIC STEM CELLS; PEPTIDES; TUMOR CELLS, CULTURED;

EID: 84947931720     PISSN: 17494478     EISSN: 17494486     Source Type: Journal    
DOI: 10.1111/coa.12368     Document Type: Article

References (47)

1. Parkin D.M., Bray F., Ferlay J. et al. (2005) Global cancer statistics, 2002. CA Cancer J. Clin. 55, 74-108
2. Ginos M.A., Page G.P., Michalavicz B.S. et al. (2004) Identification of a gene expression signature associated with recurrent disease in squamous cell carcinoma of the head and neck. Cancer Res. 64, 55-63
3. Gallo O., Chiarelli I., Bianchi S. et al. (1996) Loss of p53 gene mutation after irradiation is associated with increate aggressiveness in recurring head and neck cancer. Clin. Cancer Res. 2, 1577-1582
4. Gallo O., Boddi V., Calzolari A. et al. (1996) bcl-2 protein expression correlates with recurrence and survival in early stage head and neck cancer treated by radiotherapy. Clin. Cancer Res. 2, 261-267
5. Hamburger A.W. & Salmon S.E. (1997) Primary bioassay of human tumor stem cells. Science 197, 461
6. Lapidot T., Sirard C., Vormoor J. et al. (1994) A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 6464, 645-648
7. Morris R.J., Fisher S.M. & Slaga T.J. (1986) Evidence that a slowly cycling subpopulation of adult murine epidermal cells retains carcinogen. Cancer Res. 46, 3061-3066
8. Clarke M.F. & Fuller M. (2006) Stem cells and cancer: two faces of eve. Cell 124, 1111-1115
9. Prince M.E., Sivanandan R., Kaczorowski A. et al. (2007) Ailles LE Identification a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. PNAS 3, 973-978
10. Okamoto A., Chikamatsu K., Sakakura K. et al. (2009) Expansion and characterization of cancer stem-like cells in squamous cell carcinoma of the head and neck. Oral Oncol. 45, 633-639
11. Pries R., Wittkopf N., Trenkle T. et al. (2008) Potential stem cell marker CD44 is constitutively expressed in permanent cell lines of head and neck cancer. In Vivo 22, 89-92
12. Wei X.D., Zhou L., Cheng L. et al. (2009) In vivo investigation of CD133 as a putative marker of cancer stem cells in Hep-2 cell line. Head Neck 31, 94-101
13. Cotsarelis G., Kaur P., Dhouailly D. et al. (1999) Epithelial stem cells in the skin: definition, markers, localization and functions. Exp. Dermatol. 8, 80-88
14. Singh S.K., Hawkins C., Clarke I.D. et al. (2004) Identification of human brain tumour initiating cells. Nature 432, 396-401
15. Miki J., Furusato B., Li H. et al. (2007) Identification of putative stem cell markers, CD133 and CXCR4, in hTERT-immortalized primary non-malignant and malignant tumor-derived human prostate epithelial cell lines and in prostate cancer specimens. Cancer Res. 67, 3153-3156
16. O'Brien C.A., Pollett A., Gallinger S. et al. (2007) A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 445, 106-110
17. Yin S., Li J., Hu C. et al. (2007) CD133 positive hepatocellular carcinoma cells possess high capacity for tumorigenicity. Int. J. Cancer 120, 1444-1450
18. Zhou L., Wei X., Cheng L. et al. (2007) CD133, one of the markers of cancer stem cells in Hep-2 cell line. Laryngoscope 117, 455-460
19. Shipitsin M., Campbell L.L., Argani P. et al. (2007) Molecular definition of breast tumor heterogeneity. Cancer Cell 11, 259-273
20. Pirinen R., Hirvikoski P., Böhm J. et al. (2000) Reduced expression of CD44v3 variant isoform is associated with unfavorable outcome in non-small cell lung carcinoma. Hum. Pathol. 31, 1088-1095
21. Kuhn S., Koch M., Nübel T. et al. (2007) A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression. Mol. Cancer Res. 5, 553-567
22. Kalish E.D., Iida N., Moffat F.L. et al. (1999) A new CD44v3-containing isoform is involved in tumor cell growth and migration during human breast carcinoma progression. Front Biosci. 4, A1-A8
23. Lucinei R.O., Jeffrey S.S. & Ribeiro-Silva A. (2010) Review, Stem cells in human breast cancer. Histol. Histopathol. 25, 371-385
24. Prince M.E., Sivanandan R., Kaczorowski A. et al. (2007) Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc. Natl Acad. Sci. USA 104, 973-978
25. Hill A., McFarlane S., Johnston P.G. et al. (2006) The emerging role of CD44 in regulating skeletal micrometastasis. Cancer Lett. 237, 1-9
26. Shmelkov S.V., Butler J.M., Hooper A.T. et al. (2008) CD133 expression is not restricted to stem cells, and both CD133+ and CD133- metastatic colon cancer cells initiate tumors. J. Clin. Invest. 118, 2111-2120
27. Abraham B.K., Fritz P., McClellan M. et al. (2005) Prevalence of CD44+/CD24-/low cells in breast cancer may not be associated with clinical outcome but may favor distant metastasis. Clin. Cancer Res. 11, 1154-1159
28. Pardal R., Clarke M.F. & Morrison S.J. (2003) Applying the principles of stem-cell biology to cancer. Nat. Rev. Cancer 3, 895-902
29. Locke M., Heywood M., Fawell S. et al. (2005) Retention of intrinsic stem cells hierarchies in carcinoma-derived cell line. Cancer Res. 65, 8944-8950
30. Wang S.J., Wong G., de Heer A.M. et al. (2009) CD44 variant isoforms in head and neck squamous cell carcinoma progression. Laryngoscope 119, 1518-1530
31. Statistical Science, Inc. (1991) S-Plus Reference Manual. Statistical Science, Inc., Seattle, WA
32. Sterz C.M., Kulle C., Dakic B. et al. (2010) A basal-cell-like compartment in head and neck squamous cell carcinomas represents the invasive front of the tumor and is expressing MMP-9. Oral Oncol. 46, 116-122
33. Harper L.J., Piper K., Common J. et al. (2007) Stem cell patterns in cell lines derived from head and neck squamous cell carcinoma. J. Oral Pathol. Med. 36, 594-603
34. Young C.L., Se-Yeong O., Yun Y.C. et al. (2011) Cancer stem cells traits in squamouspheres derived from primary head and neck squamous cell carcinomas. Oral Oncol. 47, 83-91
35. Zhang S., Balch C., Chan M.W. et al. (2008) Identification and characterization of ovarian cancer-initiating cells from primary human tumors. Cancer Res. 68, 4311-4320
36. Davis S.J., Divi V., Owen H.H. et al. (2010) Metastatic potential of cancer stem cells in head and neck squamous cell carcinoma. Arch. Otolalryngol. Head Neck Surg. 136, 1260-1266
37. Brown R.L., Reinke L.M., Damerow M.S. et al. (2011) CD44 splice isoform switching in human and mouse epithelium is essential for epithelial-mesenchymal transition and breast cancer progression. J. Clin. Invest. 3, 1064-1074
38. Thiery J.P. & Sleeman J.P. (2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nat. Rev. Mol. Cell Biol. 7, 131-142
39. Zito G., Richiusa P., Bommarito A. et al. (2008) In vitro identification and characterization of CD133pos cancer stem-like cells in anaplastic thyroid carcinoma cell lines. PLoS ONE 3, 3455-3544
40. Fillmore C.M. & Kuperwasser C. (2008) Human breast cancer cell lines contain stem-like cells that self-renew, give rise to phenotypically diverse progeny and survive chemotherapy. Breast Cancer Res. 10, 1-13
41. Ponnusamy M.P. & Batra S.K. (2008) Ovarian cancer: emerging concept on cancer stem cells. J. Ovarian Res. 1, 1-9
42. Lee C.J., Dosch J. & Simeone D.M. (2008) Pancreatic Cancer Stem Cells. J. Clin. Oncol. 26, 2806-2812
43. Chan K.S., Espinosa I., Chao M. et al. (2009) Identification, molecular characterization, clinical prognosis, and therapeutic targeting of human bladder tumor-initiating cells. PNAS 106, 14016-14021
44. Prince R., Wittkopf N., Hasselbacher K. et al. (2008) Constitutive expression of the potential stem cell marker CD44 in permanent HNSCC cell lines. HNO 56, 461-466
45. Yu D., Jin C.S., Chen O. et al. (2009) Biological characteristics of highly tumorigenic CD44+CD133+ subpopulation of laryngeal carcinoma cells. Zhonghua Zhong Liu Za Zhi 31, 99-103
46. Zhang Q., Shi S., Yen Y. et al. (2010) A subpopulation of CD133(+) cancer stem-like cells characterized in human oral squamous cell carcinoma confer resistance to chemotherapy. Cancer Lett. 289, 151-160
47. Chikamatsu K., Ishii H., Takahashi G. et al. (2012) Resistance to apoptosis-inducing stimuli in CD44+ head and neck squamous cell carcinoma cells. Head Neck 34, 336-343