Intracranial arterial four-dimensional flow is associated with metrics of brain health and Alzheimer's disease

Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring

Volumn 1, Issue 4, 2015, Pages 420-428

  Berman, Sara E ^a,b   Rivera Rivera, Leonardo A ^a   Clark, Lindsay R ^a   Racine, Annie M ^a,b   Keevil, Jon G ^a   Bratzke, Lisa C ^a,b   Carlsson, Cynthia M ^a,c   Bendlin, Barbara B ^a,c   Rowley, Howard A ^a   Blennow, Kaj ^d   Zetterberg, Henrik ^d,e   Asthana, Sanjay ^a,c   Turski, Patrick ^a   Johnson, Sterling C ^a,c,f   Wieben, Oliver ^a  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c WILLIAM S MIDDLETON MEMORIAL VETERANS HOSPITAL   (United States)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Alzheimer's disease; Cardiovascular risk; Circle of Willis; Mean blood flow; Pulsatility index

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; BIOLOGICAL MARKER;

ADULT; ALZHEIMER DISEASE; ARTERY BLOOD FLOW; ARTICLE; ATHEROSCLEROTIC CARDIOVASCULAR DISEASE RISK SCORE; BRAIN ATROPHY; BRAIN CIRCULUS ARTERIOSUS; BRAIN SIZE; CARDIOVASCULAR PARAMETERS; CEREBROSPINAL FLUID ANALYSIS; CONTROLLED STUDY; DEMENTIA; FEMALE; FOUR DIMENSIONAL FLOW MAGNETIC RESONANCE IMAGING; HUMAN; INTERNAL CAROTID ARTERY; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; MIDDLE CEREBRAL ARTERY; MILD COGNITIVE IMPAIRMENT; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SCANNER; PULSATILE FLOW; PULSE PRESSURE; RADIOLOGICAL PARAMETERS; SCORING SYSTEM;

EID: 84947806173     PISSN: None     EISSN: 23528729     Source Type: Journal    
DOI: 10.1016/j.dadm.2015.09.005     Document Type: Article

References (37)

1. Schneider J.A., Bennett D.A. Where vascular meets neurodegenerative disease. Stroke 2010, 41:S144-S146.
2. Schneider J.A., Arvanitakis Z., Leurgans S.E., Bennett D.A. The neuropathology of probable Alzheimer disease and mild cognitive impairment. Ann Neurol 2009, 66:200-208.
3. Hughes T.M., Craft S., Lopez O.L. Review of "the potential role of arterial stiffness in the pathogenesis of Alzheimer's disease". Neurodegener Dis Manag 2015, 5:121-135.
4. Gorelick P.B., Scuteri A., Black S.E., Decarli C., Greenberg S.M., Iadecola C., et al. Vascular contributions to cognitive impairment and dementia: A statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2011, 42:2672-2713.
5. Skoog I., Lernfelt B., Landahl S., Palmertz B., Andreasson L.A., Nilsson L., et al. 15-year longitudinal study of blood pressure and dementia. Lancet 1996, 347:1141-1145.
6. Roher A.E., Tyas S.L., Maarouf C.L., Daugs I.D., Kokjohn T.A., Emmerling M.R., et al. Intracranial atherosclerosis as a contributing factor to Alzheimer's disease dementia. Alzheimers Dement 2011, 7:436-444.
7. Roher A.E., Debbins J.P., Malek-Ahmadi M., Chen K., Pipe J.G., Maze S., et al. Cerebral blood flow in Alzheimer's disease. Vasc Health Risk Manag 2012, 8:599-611.
8. Claassen J.A., Diaz-Arrastia R., Martin-Cook K., Levine B.D., Zhang R. Altered cerebral hemodynamics in early Alzheimer disease: A pilot study using transcranial Doppler. J Alzheimers Dis 2009, 17:621-629.
9. Roher A.E., Garami Z., Tyas S.L., Maarouf C.L., Kokjohn T.A., Belohlavek M., et al. Transcranial Doppler ultrasound blood flow velocity and pulsatility index as systemic indicators for Alzheimer's disease. Alzheimers Dement 2011, 7:445-455.
10. Hughes T.M., Kuller L.H., Barinas-Mitchell E.J., Mackey R.H., McDade E.M., Klunk W.E., et al. Pulse wave velocity is associated with beta-amyloid deposition in the brains of very elderly adults. Neurology 2013, 81:1711-1718.
11. Hughes T.M., Kuller L.H., Barinas-Mitchell E.J., McDade E.M., Klunk W.E., Cohen A.D., et al. Arterial stiffness and beta-amyloid progression in nondemented elderly adults. JAMA Neurol 2014, 71:562-568.
12. Markl M., Frydrychowicz A., Kozerke S., Hope M., Wieben O. 4D flow MRI. J Magn Reson Imaging 2012, 36:1015-1036.
13. Gu T., Korosec F.R., Block W.F., Fain S.B., Turk Q., Lum D., et al. PC VIPR: A high-speed 3D phase-contrast method for flow quantification and high-resolution angiography. AJNR Am J Neuroradiol 2005, 26:743-749.
14. Johnson K.M., Lum D.P., Turski P.A., Block W.F., Mistretta C.A., Wieben O. Improved 3D phase contrast MRI with off-resonance corrected dual echo VIPR. Magn Reson Med 2008, 60:1329-1336.
15. Rivera-Rivera L, Patrick T, Schrauben E, Kilgas P, Hoffman C, Johnson KM, et al. 4D flow MRI for intracranial hemodynamic assessment in Alzheimer's disease. ISMRM 23rd Scientific Meeting and Exhibition, Toronto, Canada. 2015; 4312.
16. McKhann G.M., Knopman D.S., Chertkow H., Hyman B.T., Jack C.R., Kawas C.H., et al. The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimers Dement 2011, 7:263-269.
17. Liu J., Redmond M.J., Brodsky E.K., Alexander A.L., Lu A., Thornton F.J., et al. Generation and visualization of four-dimensional MR angiography data using an undersampled 3-D projection trajectory. IEEE Trans Med Imaging 2006, 25:148-157.
18. Stalder A.F., Russe M.F., Frydrychowicz A., Bock J., Hennig J., Markl M. Quantitative 2D and 3D phase contrast MRI: Optimized analysis of blood flow and vessel wall parameters. Magn Reson Med 2008, 60:1218-1231.
19. Malone I.B., Leung K.K., Clegg S., Barnes J., Whitwell J.L., Ashburner J., et al. Accurate automatic estimation of total intracranial volume: a nuisance variable with less nuisance. Neuroimage 2015, 104:366-372.
20. Mielke M.M., Haughey N.J., Bandaru V.V., Zetterberg H., Blennow K., Andreasson U., et al. Cerebrospinal fluid sphingolipids, beta-amyloid, and tau in adults at risk for Alzheimer's disease. Neurobiol Aging 2014, 35:2486-2494.
21. Blennow K., Wallin A., Agren H., Spenger C., Siegfried J., Vanmechelen E. Tau protein in cerebrospinal fluid: A biochemical marker for axonal degeneration in Alzheimer disease?. Mol Chem Neuropathol 1995, 26:231-245.
22. Vanmechelen E., Vanderstichele H., Davidsson P., Van Kerschaver E., Van Der Perre B., Sjogren M., et al. Quantification of tau phosphorylated at threonine 181 in human cerebrospinal fluid: A sandwich ELISA with a synthetic phosphopeptide for standardization. Neurosci Lett 2000, 285:49-52.
23. Andreasen N., Hesse C., Davidsson P., Minthon L., Wallin A., Winblad B., et al. Cerebrospinal fluid beta-amyloid(1-42) in Alzheimer disease: Differences between early- and late-onset Alzheimer disease and stability during the course of disease. Arch Neurol 1999, 56:673-680.
24. Goff D.C., Lloyd-Jones D.M., Bennett G., Coady S., D'Agostino R.B., Gibbons R., et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: A report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Coll Cardiol 2014, 63:2935-2959.
25. West S.G., Aiken L.S., Cham H., Liu Y. Multiple regression: The basics and beyond for clinical scientists. The Oxford handbook of research strategies for clinical psychology 2013, Oxford University Press, New York, 272-252. J.S. Comer, P.C. Kendall (Eds.).
26. Gupta A., Preis S.R., Beiser A., Devine S., Hankee L., Seshadri S., et al. Mid-life cardiovascular risk impacts memory function: The Framingham Offspring Study. Alzheimer Dis Assoc Disord 2015, 29:117-123.
27. Hohman T.J., Samuels L.R., Liu D., Gifford K.A., Mukherjee S., Benson E.M., et al. Stroke risk interacts with Alzheimer's disease biomarkers on brain aging outcomes. Neurobiol Aging 2015, 36:2501-2508.
28. Curiati P.K., Magaldi R.M., Suemoto C.K., Bottino C.M., Nitrini R., Farfel J.M., et al. Vascular risk as a predictor of cognitive decline in a cohort of elderly patients with mild to moderate dementia. Dement Geriatr Cogn Dis Extra 2014, 4:402-409.
29. Nation D.A., Edmonds E.C., Bangen K.J., Delano-Wood L., Scanlon B.K., Han S.D., et al. Pulse pressure in relation to tau-mediated neurodegeneration, cerebral amyloidosis, and progression to dementia in very old adults. JAMA Neurol 2015, 72:546-553.
30. Crystal H.A., Schneider J.A., Bennett D.A., Leurgans S., Levine S.R. Associations of cerebrovascular and Alzheimer's disease pathology with brain atrophy. Curr Alzheimer Res 2014, 11:309-316.
31. Kooistra M., Geerlings M.I., van der Graaf Y., Mali W.P., Vincken K.L., Kappelle L.J., et al. Vascular brain lesions, brain atrophy, and cognitive decline. The Second Manifestations of ARTerial disease-Magnetic Resonance (SMART-MR) study. Neurobiol Aging 2014, 35:35-41.
32. Muller M., Appelman A.P., van der Graaf Y., Vincken K.L., Mali W.P., Geerlings M.I. Brain atrophy and cognition: Interaction with cerebrovascular pathology?. Neurobiol Aging 2011, 32:885-893.
33. Mawuenyega K.G., Sigurdson W., Ovod V., Munsell L., Kasten T., Morris J.C., et al. Decreased clearance of CNS beta-amyloid in Alzheimer's disease. Science 2010, 330:1774.
34. Iliff J.J., Wang M., Liao Y., Plogg B.A., Peng W., Gundersen G.A., et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta. Sci Transl Med 2012, 4:147ra11.
35. Armstrong R.A. Classic beta-amyloid deposits cluster around large diameter blood vessels rather than capillaries in sporadic Alzheimer's disease. Curr Neurovasc Res 2006, 3:289-294.
36. Li H., Guo Q., Inoue T., Polito V.A., Tabuchi K., Hammer R.E., et al. Vascular and parenchymal amyloid pathology in an Alzheimer disease knock-in mouse model: Interplay with cerebral blood flow. Mol Neurodegener 2014, 9:28.
37. Smith E.E., Vijayappa M., Lima F., Delgado P., Wendell L., Rosand J., et al. Impaired visual evoked flow velocity response in cerebral amyloid angiopathy. Neurology 2008, 71:1424-1430.