Loss of Gata4 in Sertoli cells impairs the spermatogonial stem cell niche and causes germ cell exhaustion by attenuating chemokine signaling

Oncotarget

Volumn 6, Issue 35, 2015, Pages 37012-37027

  Chen, Su Ren ^a   Tang, Ji Xin ^a,b   Cheng, Jin Mei ^a,b   Li, Jian ^a,b   Jin, Cheng ^a,b   Li, Xiao Yu ^a,b   Deng, Shou Long ^a   Zhang, Yan ^a   Wang, Xiu Xia ^a   Liu, Yi Xun ^a  

^a INSTITUTE OF ZOOLOGY   (China)

^b UNIVERSITY OF CHINESE ACADEMY OF SCIENCES   (China)

Author keywords

Chemokines; Gata4; Niche; Pathology Section; Sertoli cells; Spermatogonial stem cell

Indexed keywords

CCL9 CHEMOKINE; CCRL2 CHEMOKINE; CHEMOKINE; CHEMOKINE RECEPTOR CCR1; CHEMOKINE RECEPTOR CXCR4; CXCL1 CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; STROMAL CELL DERIVED FACTOR 1; TRANSCRIPTION FACTOR GATA 4; UNCLASSIFIED DRUG; BETA CHEMOKINE; CCL9 PROTEIN, MOUSE; CXCL12 PROTEIN, MOUSE; GATA4 PROTEIN, MOUSE; LUCIFERASE; MACROPHAGE INFLAMMATORY PROTEIN; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL TRANSPLANTATION; CHEMOTAXIS; CONTROLLED STUDY; GENE DISRUPTION; GERM CELL; IN VITRO STUDY; KNOCKOUT MOUSE; MALE; MICROARRAY ANALYSIS; MOUSE; NEWBORN; NONHUMAN; PROTEIN DEPLETION; SERTOLI CELL; SPERMATOCYTE; SPERMATOGENESIS; SPERMATOGONIAL STEM CELL NICHE; SPERMATOGONIUM; STEM CELL NICHE; TISSUE CULTURE; TRANSCRIPTION REGULATION; ANIMAL; C57BL MOUSE; CELL CULTURE; CELL DIFFERENTIATION; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; PATHOLOGY; PHYSIOLOGY; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STEM CELL; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELLS, CULTURED; CHEMOKINE CXCL12; CHEMOKINES, CC; CHEMOTAXIS; FEMALE; GATA4 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; LUCIFERASES; MACROPHAGE INFLAMMATORY PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SERTOLI CELLS; SIGNAL TRANSDUCTION; SPERMATOGENESIS; SPERMATOGONIA; STEM CELL NICHE; STEM CELLS;

EID: 84947787000     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.6115     Document Type: Article

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