Δ6-Desaturase (FADS2) deficiency unveils the role of ω3- and ω6-polyunsaturated fatty acids

EMBO Journal

Volumn 27, Issue 17, 2008, Pages 2281-2292

  Stoffel, Wilhelm ^a   Holz, Barbara ^a   Jenke, Britta ^a   Binczek, Erika ^a   Günter, Robert Heinz ^a   Kiss, Christine ^a   Karakesisoglou, Iakowos ^a   Thevis, Mario ^b   Weber, Artur Aron ^c   Arnhold, Stephan ^a   Addicks, Klaus ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b Institute of Biochemistry   (Germany)

^c UNIVERSITY HOSPITAL ESSEN   (Germany)

Author keywords

6 fatty acid desaturase deficiency; Eicosanoid deficiency; Essential fatty acids; Lack of PUFA synthesis; Male and female sterility

Indexed keywords

ICOSANOID; LEUKOTRIENE; LINOLEOYL COENZYME A DESATURASE; OMEGA 3 FATTY ACID; OMEGA 6 FATTY ACID;

ANIMAL TISSUE; ARTICLE; AUXOTROPHIC MUTANT; BLOOD TESTIS BARRIER; CARBOHYDRATE METABOLISM; CELL MEMBRANE; CELL POLARITY; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; ESSENTIAL FATTY ACID DEFICIENCY; FEMALE; GAP JUNCTION; GENE EXPRESSION; HISTOPATHOLOGY; IMMUNE RESPONSE; LIPID METABOLISM; MACROPHAGE; MALE; MOUSE; NONHUMAN; OVARY FOLLICLE; OVARY FOLLICLE DEVELOPMENT; POLLEN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SERTOLI CELL; THROMBOEMBOLISM; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; ENZYMOLOGY; GENETICS; IMMUNOLOGY; INFERTILITY; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY;

MAMMALIA; MUS;

ANIMALS; BLOOD-TESTIS BARRIER; CARBOHYDRATE METABOLISM; CELL POLARITY; CELL SURVIVAL; EICOSANOIDS; FATTY ACIDS, OMEGA-3; FATTY ACIDS, OMEGA-6; FEMALE; INFERTILITY; LINOLEOYL-COA DESATURASE; LIPID METABOLISM; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OVARIAN FOLLICLE; SERTOLI CELLS; THROMBOEMBOLISM;

EID: 51049093175     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2008.156     Document Type: Article

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