Omeprazole attenuates pulmonary aryl hydrocarbon receptor activation and potentiates hyperoxia-induced developmental lung injury in newborn mice

Toxicological Sciences

Volumn 148, Issue 1, 2015, Pages 276-287

  Shivanna, Binoy ^a   Zhang, Shaojie ^a   Patel, Ananddeep ^a   Jiang, Weiwu ^a   Wang, Lihua ^a   Welty, Stephen E ^a   Moorthy, Bhagavatula ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

aryl hydrocarbon receptor; hyperoxia; inflammation; lung development; Omeprazole; oxidative stress

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; OMEPRAZOLE; VASCULOTROPIN RECEPTOR 2; AHR PROTEIN, MOUSE; ANTIULCER AGENT; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BIOLOGICAL MARKER; PROTON PUMP INHIBITOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL INJURY; HYPEROXIA; HYPEROXIA INDUCED DEVELOPMENTAL LUNG INJURY; LUNG; LUNG INJURY; MOUSE; NEWBORN; NONHUMAN; OXIDATIVE STRESS; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CHEMICALLY INDUCED; DISEASE MODEL; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; HUMAN; INTRAPERITONEAL DRUG ADMINISTRATION; LUNG ALVEOLUS; LUNG DYSPLASIA; METABOLISM; PATHOLOGY; RANDOMIZATION; RESPIRATORY MUCOSA; VASCULARIZATION;

ANIMALS; ANIMALS, NEWBORN; ANTI-ULCER AGENTS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BIOMARKERS; BRONCHOPULMONARY DYSPLASIA; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; INFANT, NEWBORN; INJECTIONS, INTRAPERITONEAL; LUNG; MICE, INBRED C57BL; OMEPRAZOLE; OXIDATIVE STRESS; PROTON PUMP INHIBITORS; PULMONARY ALVEOLI; RANDOM ALLOCATION; RECEPTORS, ARYL HYDROCARBON; RESPIRATORY MUCOSA;

EID: 84947780251     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfv183     Document Type: Article

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