L-dehydroascorbic acid can substitute l-ascorbic acid as dietary vitamin C source in guinea pigs

Redox Biology

Volumn 7, Issue , 2016, Pages 8-13

  Frikke Schmidt, Henriette ^a   Tveden Nyborg, Pernille ^a   Lykkesfeldt, Jens ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Ascorbate recycling; Bioavailability; Guinea pig; Human; Mouse; Rat; Vitamin C

Indexed keywords

ASCORBIC ACID; DEHYDROASCORBIC ACID; VITAMIN;

ADRENAL GLAND; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG DOSE COMPARISON; DRUG ERYTHROCYTE LEVEL; DRUG LIVER LEVEL; DRUG MUSCLE LEVEL; DRUG OXIDATION; DRUG TISSUE LEVEL; FEMALE; HARTLEY GUINEA PIG; HEART; INTESTINE; KIDNEY; LUNG; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SPECIES COMPARISON; SPLEEN; VITAMIN METABOLISM; VITAMIN SUPPLEMENTATION; ANIMAL; ASCORBIC ACID DEFICIENCY; CHEMISTRY; COMPARATIVE STUDY; DIETARY SUPPLEMENT; DOSE RESPONSE; ERYTHROCYTE; GUINEA PIG; HUMAN; LIVER; RAT; TISSUE DISTRIBUTION;

ANIMALS; ASCORBIC ACID; ASCORBIC ACID DEFICIENCY; DEHYDROASCORBIC ACID; DIETARY SUPPLEMENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; GUINEA PIGS; HUMANS; INTESTINES; LIVER; MICE; RATS; TISSUE DISTRIBUTION; VITAMINS;

EID: 84947767028     PISSN: 22132317     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.redox.2015.11.003     Document Type: Article

References (35)

1. Lykkesfeldt J., Michels A.J., Frei B. Vitamin C. Adv. Nutr. 2014, 5:16-18. 10.3945/an.113.005157.
2. Frei B., Birlouez-Aragon I., Lykkesfeldt J. Authors' perspective: what is the optimum intake of vitamin C in humans?. Crit. Rev. Food Sci. Nutr. 2012, 52:815-829. 10.1080/10408398.2011.649149.
3. May J.M., Cobb C.E., Mendiratta S., Hill K.E., Burk R.F. Reduction of the ascorbyl free radical to ascorbate by thioredoxin reductase. J. Biol. Chem. 1998, 273:23039-23045.
4. Wells W.W., Xu D.P., Washburn M.P. Glutathione: dehydroascorbate oxidoreductases. Methods Enzymol. 1995, 252:30-38.
5. Menniti F.S., Knoth J., Diliberto E.J. Role of ascorbic acid in dopamine beta-hydroxylation. The endogenous enzyme cofactor and putative electron donor for cofactor regeneration. J. Biol. Chem. 1986, 261:16901-16908.
6. Tveden-Nyborg P., Lykkesfeldt J. Does vitamin C deficiency increase lifestyle-associated vascular disease progression? Evidence based on experimental and clinical studies. Antioxidants Redox Signal. 2013, 19:2084-2104. 10.1089/ars.2013.5382.
7. Kawai T., Nishikimi M., Ozawa T., Yagi K. A missense mutation of l-gulono-gamma-lactone oxidase causes the inability of scurvy-prone osteogenic disorder rats to synthesize l-ascorbic acid. J. Biol. Chem. 1992, 267:21973-21976.
8. Maeda N., Hagihara H., Nakata Y., Hiller S., Wilder J., Reddick R. Aortic wall damage in mice unable to synthesize ascorbic acid. Proc. Natl. Acad. Sci. USA 2000, 97:841-846.
9. Yang H. Conserved or lost: molecular evolution of the key gene GULO in vertebrate vitamin C biosynthesis. Biochem. Genet. 2013, 51:413-425. 10.1007/s10528-013-9574-0.
10. Ogiri Y., Sun F., Hayami S., Fujimura A., Yamamoto K., Yaita M., Kojo S. Very low vitamin C activity of orally administered l-dehydroascorbic acid. J. Agric. Food Chem. 2002, 50:227-229.
11. Lykkesfeldt J., Loft S., Poulsen H.E. Determination of ascorbic acid and dehydroascorbic acid in plasma by high-performance liquid chromatography with coulometric detection - are they reliable biomarkers of oxidative stress?. Anal. Biochem. 1995, 229:329-335. 10.1006/abio.1995.1421.
12. Birck M.M., Tveden-Nyborg P., Lindblad M.M., Lykkesfeldt J. Non-terminal blood sampling techniques in guinea pigs. J. Vis. Exp. 2014, e51982. 10.3791/51982.
13. Lykkesfeldt J. Ascorbate and dehydroascorbic acid as biomarkers of oxidative stress: validity of clinical data depends on vacutainer system used. Nutr. Res. 2012, 32:66-69. 10.1016/j.nutres.2011.11.005.
14. Lykkesfeldt J., Determination of ascorbic acid and dehydroascorbic acid in biological samples by high-performance liquid chromatography using subtraction methods: reliable reduction with Tris[2-carboxyethyl]phosphine hydrochloride [published erratum appears in Anal. Biochem. 2001; 292, 173]. Analytical Biochemistry, 2000, 282. pp. 89-93.
15. Lykkesfeldt J. Ascorbate and dehydroascorbic acid as reliable biomarkers of oxidative stress: analytical reproducibility and long-term stability of plasma samples subjected to acidic deproteinization. Cancer Epidemiol. Biomark. Prev. 2007, 16:2513-2516. 10.1158/1055-9965.EPI-07-0639.
16. Lykkesfeldt J. Determination of ascorbic acid and dehydroascorbic acid in biological samples by high-performance liquid chromatography using subtraction methods: reliable reduction with tris[2-carboxyethyl]phosphine hydrochloride. Anal. Biochem. 2000, 282:89-93. 10.1006/abio.2000.4592.
17. Lykkesfeldt J., Viscovich M., Poulsen H.E. Ascorbic acid recycling in human erythrocytes is induced by smoking in vivo. Free Radic. Biol. Med. 2003, 35:1439-1447.
18. Linkswiler H. The effect of the Ingestion of ascorbic acid and dehydroascorbic acid upon the blood levels of these two components in human subjects. J. Nutr. 1958, 64:43-54.
19. Sabry J.H., Fisher K.H., Dodds M.L. Human utilization of dehydroascorbic acid. J. Nutr. 1958, 64:457-466.
20. Todhunter E.N., Mc M.T., Ehmke D.A. Utilization of dehydroascorbic acid by human subjects. J. Nutr. 1950, 42:297-308.
21. Tsujimura M., Higasa S., Nakayama K., Yanagisawa Y., Iwamoto S., Kagawa Y. Vitamin C activity of dehydroascorbic acid in humans--association between changes in the blood vitamin C concentration or urinary excretion after oral loading. J. Nutr. Sci. Vitaminol. 2008, 54:315-320.
22. Lindblad M., Tveden-Nyborg P., Lykkesfeldt J. Regulation of vitamin C homeostasis during deficiency. Nutrients 2013, 5:2860-2879. 10.3390/nu5082860.
23. Langham M. The transfer of l-ascorbic acid and dehydro-l-ascorbic acid into the aqueous humour of the rabbit and cat. J. Physiol. 1950, 111:388-393.
24. Cui Y., Otsuka M., Fujiwara Y. Reduction of dehydroerythorbic acid in vitamin C-deficient guinea pigs. J. Nutr. Sci. Vitaminol. 2001, 47:316-320.
25. Hirst E.L. Ascorbic acid as the antiscorbutic factor. Biochem. J. 1933, 27:1271-1278.
26. Hornig D., Weber F., Wiss O. Uptake and release of [I-14C]ascorbic acid and [I-14C]dehydroascorbic acid by erythrocytes of guinea pigs. Clin. Chim. Acta 1971, 31:25-35.
27. Hornig D., Weber F., Wiss O. Tissue distribution of labelled material in vitamin C-deficient guinea pigs after intravenous injection of 1-14C) ascorbic acid or (1-14C) dehydroascorbic acid. Int. J. Vitam. Nutr. Res. 1972, 42:511-523.
28. Hornig D., Weber F., Wiss O. Studies on the distribution of (1-14C) ascorbic acid and (1-14C) dehydroascorbic acid in guinea pigs after oral application. Int. J. Vitam. Nutr. Res. 1974, 44:217-229.
29. Dayton P.G., Snell M.M., Perel J.M. Ascorbic and dehydroascorbic acids in guinea pigs and rats. J. Nutr. 1966, 88:338-344.
30. May J.M., Qu Z.C., Whitesell R.R. Ascorbic acid recycling enhances the antioxidant reserve of human erythrocytes. Biochemistry 1995, 34:12721-12728.
31. Lykkesfeldt J. Increased oxidative damage in vitamin C deficiency is accompanied by induction of ascorbic acid recycling capacity in young but not mature guinea pigs. Free. Radic. Res. 2002, 36:567-574.
32. Harrison F.E., May J.M. Vitamin C function in the brain: vital role of the ascorbate transporter SVCT2. Free Radic. Biol. Med. 2009, 46:719-730.
33. Tveden-Nyborg P., Johansen L.K., Raida Z., Villumsen C.K., Larsen J.O., Lykkesfeldt J. Vitamin C deficiency in early postnatal life impairs spatial memory and reduces the number of hippocampal neurons in guinea pigs. Am. J. Clin. Nutr. 2009, 90:540-546. 10.3945/ajcn.2009.27954.
34. Tveden-Nyborg P., Vogt L., Schjoldager J.G., Jeannet N., Hasselholt S., Paidi M.D., Christen S., Lykkesfeldt J. Maternal vitamin C deficiency during pregnancy persistently impairs hippocampal neurogenesis in offspring of guinea pigs. PLos One 2012, 7:e48488. 10.1371/journal.pone.0048488.
35. Hasselholt S., Tveden-Nyborg P., Lykkesfeldt J. Distribution of vitamin C is tissue specific with early saturation of the brain and adrenal glands following differential oral dose regimens in guinea pigs. Br. J. Nutr. 2015, 113:1539-1549. 10.1017/S0007114515000690.