Targeted screening of at-risk adults for acute HIV-1 infection in sub-Saharan Africa

AIDS

Volumn 29, Issue , 2015, Pages S221-S230

  Sanders, Eduard J ^a,b,c   Wahome, Elizabeth ^a   Powers, Kimberly A ^c   Werner, Lisa ^d   Fegan, Greg ^a,b   Lavreys, Ludo ^f   Mapanje, Clement ^g   McClelland, Scott ^h   Garrett, Nigel ^e   Miller, William C ^d,i   Graham, Susan M ^a,h  

^a KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c UNIVERSITY OF AMSTERDAM   (Netherlands)

^d IL   (United States)

^e UNIVERSITY OF KWAZULU NATAL   (South Africa)

^f Maisha Consulting Bvba   (Belgium)

^g UNIVERSITY OF NORTH CAROLINA PROJECT   (Malawi)

^h UNIVERSITY OF WASHINGTON   (United States)

ⁱ UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN P24; VIRUS RNA; GAG PROTEIN;

ADULT; AFRICA SOUTH OF THE SAHARA; ARTHRALGIA; ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DIARRHEA; FATIGUE; FEMALE; FEVER; GENITAL ULCER; HEADACHE; HIGH RISK PATIENT; HIGH RISK POPULATION; HIV TEST; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; LOSS OF APPETITE; LYMPHADENOPATHY; MAJOR CLINICAL STUDY; MALE; MASS SCREENING; MYALGIA; PRIORITY JOURNAL; RASH; RNA VIRUS; SEROCONVERSION; SEXUALLY TRANSMITTED DISEASE; SORE THROAT; VAGINA CANDIDIASIS; VAGINA DISCHARGE; VIRUS LOAD; VOMITING; WEIGHT REDUCTION; YOUNG ADULT; ACUTE DISEASE; ADOLESCENT; ALGORITHM; BLOOD; EVALUATION STUDY; HIV INFECTIONS; ISOLATION AND PURIFICATION; PROCEDURES; RETROSPECTIVE STUDY; RISK FACTOR;

ACUTE DISEASE; ADOLESCENT; ADULT; AFRICA SOUTH OF THE SAHARA; ALGORITHMS; FEMALE; HIV CORE PROTEIN P24; HIV INFECTIONS; HIV-1; HUMANS; MALE; MASS SCREENING; RETROSPECTIVE STUDIES; RISK FACTORS; VIRAL LOAD; YOUNG ADULT;

EID: 84947713528     PISSN: 02699370     EISSN: 14735571     Source Type: Journal    
DOI: 10.1097/QAD.0000000000000924     Document Type: Article

References (25)

1. Sudarshi D, Pao D, Murphy G, Parry J, Dean G, Fisher M. Missed opportunities for diagnosing primary HIV infection. Sex Transm Infect 2008; 84:14-16.
2. Sanders EJ, Wahome E, Mwangome M, Thiong'o AN, Okuku HS, Price MA, et al. Most adults seek urgent healthcare when acquiring HIV-1 and are frequently treated for malaria in coastal Kenya. AIDS 2011; 25:1219-1224.
3. Wood E, Kerr T, Rowell G, Montaner JS, Phillips P, Korthuis PT, et al. Does this adult patient have early HIV infection? The rational clinical examination systematic review. JAMA 2014; 312:278-285.
4. Mlisana K, Sobieszczyk M, Werner L, Feinstein A, van Logger-enberg F, Naicker N, et al. Challenges of diagnosing acute HIV-1 subtype C infection in African women: performance of a clinical algorithm and the need for point-of-care nucleic-acid based testing. PLoS One 2013; 8:e62928.
5. Powers KA, Miller WC, Pilcher CD, Mapanje C, Martinson FE, Fiscus SA, et al. Improved detection of acute HIV-1 infection in sub-Saharan Africa: development of a risk score algorithm. AIDS 2007; 21:2237-2242.
6. Lavreys L, Thompson ML, Martin HL Jr, Mandaliya K, Ndinya-Achola JO, Bwayo JJ, et al. Primary human immunodeficiency virus type 1 infection: clinical manifestations among women in Mombasa, Kenya. Clin Infect Dis 2000; 30:486-490.
7. Wahome E, Fegan G, Okuku HS, Mugo P, Price MA, Mwashi-gadi G, et al. Evaluation of an empiric risk screening score to identify acute and early HIV-1 infection among MSM in Coastal Kenya. AIDS 2013; 27:2163-2166.
8. Cohen MS, Shaw GM, McMichael AJ, Haynes BF. Acute HIV-1 Infection. N Engl J Med 2011; 364:1943-1954.
9. Miller WC, Rosenberg NE, Rutstein SE, Powers KA. Role of acute and early HIV infection in the sexual transmission of HIV. Curr Opin HIV AIDS 2010; 5:277-282.
10. Cohen MS, Chen YQ, McCauley M, Gamble T, Hosseinipour MC, Kumarasamy N, et al. Prevention of HIV-1 infection with early antiretroviral therapy. N Engl J Med 2011; 365:493-505.
11. Group ISS, Lundgren JD, Babiker AG, Gordin F, Emery S, Grund B, et al. Initiation of antiretroviral therapy in early asymptomatic HIV infection. N Engl J Med 2015; 373:795-807.
12. Group TAS, Danel C, Moh R, Gabillard D, Badje A, Le Carrou J, et al. A trial of early antiretrovirals and isoniazid preventive therapy in Africa. N Engl J Med 2015; 373:808-822.
13. Powers KA, Cohen MS. Acute HIV-1 infection in sub-Saharan Africa: a common occurrence overlooked. AIDS 2014; 28:1365-1367.
14. Sanders EJ, Mugo P, Prins HA, Wahome E, Thiong'o AN, Mwashigadi G, et al. Acute HIV-1 infection is as common as malaria in young febrile adults seeking care in coastal Kenya. AIDS 2014; 28:1357-1363.
15. Rosenberg NE, Pilcher CD, Busch MP, Cohen MS. How can we better identify early HIV infections? Curr Opin HIV AIDS 2015; 10:61-68.
16. WHO. Delivering HIV test results and messages for re-testing and counselling in adults. Switzerland: World Health Organization; 2010. pp. 1-32.
17. Bebell LM, Pilcher CD, Dorsey G, Havlir D, Kamya MR, Busch MP, et al. Acute HIV-1 infection is highly prevalent in Ugandan adults with suspected malaria. AIDS 2010; 24:1945-1952.
18. Serna-Bolea C, Munoz J, Almeida JM, Nhacolo A, Letang E, Nhampossa T, et al. High prevalence of symptomatic acute HIV infection in an outpatient ward in southern Mozambique: identification and follow-up. AIDS 2010; 24:603-608.
19. DHHS. Panel on Antiretroviral Guidelines for Adults and Adolescents. Department of Health and Human Services; pp. 133-139. http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdoles centGL.pdf. 2015. [Accessed 29 September 2001]
20. Fiebig EW, Wright DJ, Rawal BD, Garrett PE, Schumacher RT, Peddada L, et al. Dynamics of HIV viremia and antibody seroconversion in plasma donors: implications for diagnosis and staging of primary HIV infection. AIDS 2003; 17:1871-1879.
21. Sanders EJ, Powers KA, Karita E, Kamali A, Kilemba W, Allen S, et al. Recall of acute retroviral symptoms in a multicentre cohort study in Africa. AIDS Res Hum Retroviruses 2014; 30 (Suppl 1):A93.
22. Sullivan PS, Fideli U, Wall KM, Chomba E, Vwalika C, Kilembe W, et al. Prevalence of seroconversion symptoms and relationship to set-point viral load: findings from a subtype C epidemic, 1995-2009. AIDS 2012; 26:175-184.
23. Sanders EJ, Powers KA, Karita E, Kamali A, Kilemba W, Allen S, et al. Differences in acute retroviral syndrome by HIV-1 subtype in a multicentre cohort study in Africa [abstract 1044]. Conference on Retroviruses and Opportunistic Infections; 2015; Seattle, Washington.
24. Claiborne DT, Prince JL, Scully E, Macharia G, Micci L, Lawson B, et al. Replicative fitness of transmitted HIV-1 drives acute immune activation, proviral load in memory CD4R T cells, and disease progression. Proc Natl Acad Sci USA 2015; 112:E1480-1489.
25. Meditz AL, MaWhinney S, Allshouse A, Feser W, Markowitz M, Little S, et al. Sex, race, and geographic region influence clinical outcomes following primary HIV-1 infection. J Infect Dis 2011; 203:442-451.