-
1
-
-
84869223443
-
Personalized medicine in a phase i clinical trials program: The MD Anderson Cancer Center initiative
-
Tsimberidou AM, Iskander NG, Hong DS, Wheler JJ, Falchook GS, Fu S, Piha-Paul S, Naing A, Janku F, Luthra R, Ye Y, Wen S, Berry D, Kurzrock R (2012) Personalized medicine in a phase I clinical trials program: the MD Anderson Cancer Center initiative. Clin Cancer Res Off J Am Assoc Cancer Res 18(22):6373-6383. doi: 10.1158/1078-0432.CCR-12-1627
-
(2012)
Clin Cancer Res off J Am Assoc Cancer Res
, vol.18
, Issue.22
, pp. 6373-6383
-
-
Tsimberidou, A.M.1
Iskander, N.G.2
Hong, D.S.3
Wheler, J.J.4
Falchook, G.S.5
Fu, S.6
Piha-Paul, S.7
Naing, A.8
Janku, F.9
Luthra, R.10
Ye, Y.11
Wen, S.12
Berry, D.13
Kurzrock, R.14
-
2
-
-
79951906119
-
Pilot study using molecular profiling of patients' tumors to find potential targets and select treatments for their refractory cancers
-
Von Hoff DD, Stephenson JJ Jr, Rosen P, Loesch DM, Borad MJ, Anthony S, Jameson G, Brown S, Cantafio N, Richards DA, Fitch TR, Wasserman E, Fernandez C, Green S, Sutherland W, Bittner M, Alarcon A, Mallery D, Penny R (2010) Pilot study using molecular profiling of patients' tumors to find potential targets and select treatments for their refractory cancers. J Clin Oncol Off J Am Soc Clin Oncol 28(33):4877-4883. doi: 10.1200/JCO.2009.26.5983
-
(2010)
J Clin Oncol off J Am Soc Clin Oncol
, vol.28
, Issue.33
, pp. 4877-4883
-
-
Von Hoff, D.D.1
Stephenson, J.J.2
Rosen, P.3
Loesch, D.M.4
Borad, M.J.5
Anthony, S.6
Jameson, G.7
Brown, S.8
Cantafio, N.9
Richards, D.A.10
Fitch, T.R.11
Wasserman, E.12
Fernandez, C.13
Green, S.14
Sutherland, W.15
Bittner, M.16
Alarcon, A.17
Mallery, D.18
Penny, R.19
-
4
-
-
68649121646
-
The RASopathies: Developmental syndromes of Ras/MAPK pathway dysregulation
-
Tidyman WE, Rauen KA (2009) The RASopathies: developmental syndromes of Ras/MAPK pathway dysregulation. Curr Opin Genet Dev 19(3):230-236. doi: 10.1016/j.gde.2009.04.001
-
(2009)
Curr Opin Genet Dev
, vol.19
, Issue.3
, pp. 230-236
-
-
Tidyman, W.E.1
Rauen, K.A.2
-
5
-
-
34248591612
-
Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer
-
Roberts PJ, Der CJ (2007) Targeting the Raf-MEK-ERK mitogen-activated protein kinase cascade for the treatment of cancer. Oncogene 26(22):3291-3310. doi: 10.1038/sj.onc.1210422
-
(2007)
Oncogene
, vol.26
, Issue.22
, pp. 3291-3310
-
-
Roberts, P.J.1
Der, C.J.2
-
6
-
-
0042743826
-
BRAF oncogenic mutations correlate with progression rather than initiation of human melanoma
-
1:CAS:528:DC%2BD3sXlsFOjtLk%3D 12873977
-
Dong J, Phelps RG, Qiao R, Yao S, Benard O, Ronai Z, Aaronson SA (2003) BRAF oncogenic mutations correlate with progression rather than initiation of human melanoma. Cancer Res 63(14):3883-3885
-
(2003)
Cancer Res
, vol.63
, Issue.14
, pp. 3883-3885
-
-
Dong, J.1
Phelps, R.G.2
Qiao, R.3
Yao, S.4
Benard, O.5
Ronai, Z.6
Aaronson, S.A.7
-
7
-
-
33746263912
-
BRAF and NRAS mutations in melanoma and melanocytic nevi
-
Poynter JN, Elder JT, Fullen DR, Nair RP, Soengas MS, Johnson TM, Redman B, Thomas NE, Gruber SB (2006) BRAF and NRAS mutations in melanoma and melanocytic nevi. Melanoma Res 16(4):267-273. doi: 10.1097/01.cmr.0000222600.73179.f3
-
(2006)
Melanoma Res
, vol.16
, Issue.4
, pp. 267-273
-
-
Poynter, J.N.1
Elder, J.T.2
Fullen, D.R.3
Nair, R.P.4
Soengas, M.S.5
Johnson, T.M.6
Redman, B.7
Thomas, N.E.8
Gruber, S.B.9
-
8
-
-
84879466800
-
Conjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas
-
Griewank KG, Westekemper H, Murali R, Mach M, Schilling B, Wiesner T, Schimming T, Livingstone E, Sucker A, Grabellus F, Metz C, Susskind D, Hillen U, Speicher MR, Woodman SE, Steuhl KP, Schadendorf D (2013) Conjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas. Clin Cancer Res Off J Am Assoc Cancer Res 19(12):3143-3152. doi: 10.1158/1078-0432.CCR-13-0163
-
(2013)
Clin Cancer Res off J Am Assoc Cancer Res
, vol.19
, Issue.12
, pp. 3143-3152
-
-
Griewank, K.G.1
Westekemper, H.2
Murali, R.3
Mach, M.4
Schilling, B.5
Wiesner, T.6
Schimming, T.7
Livingstone, E.8
Sucker, A.9
Grabellus, F.10
Metz, C.11
Susskind, D.12
Hillen, U.13
Speicher, M.R.14
Woodman, S.E.15
Steuhl, K.P.16
Schadendorf, D.17
-
9
-
-
33749021085
-
Somatic activation of KIT in distinct subtypes of melanoma
-
Curtin JA, Busam K, Pinkel D, Bastian BC (2006) Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol Off J Am Soc Clin Oncol 24(26):4340-4346. doi: 10.1200/JCO.2006.06.2984
-
(2006)
J Clin Oncol off J Am Soc Clin Oncol
, vol.24
, Issue.26
, pp. 4340-4346
-
-
Curtin, J.A.1
Busam, K.2
Pinkel, D.3
Bastian, B.C.4
-
10
-
-
78651446131
-
Mutations in GNA11 in uveal melanoma
-
Van Raamsdonk CD, Griewank KG, Crosby MB, Garrido MC, Vemula S, Wiesner T, Obenauf AC, Wackernagel W, Green G, Bouvier N, Sozen MM, Baimukanova G, Roy R, Heguy A, Dolgalev I, Khanin R, Busam K, Speicher MR, O'Brien J, Bastian BC (2010) Mutations in GNA11 in uveal melanoma. N Engl J Med 363(23):2191-2199. doi: 10.1056/NEJMoa1000584
-
(2010)
N Engl J Med
, vol.363
, Issue.23
, pp. 2191-2199
-
-
Van Raamsdonk, C.D.1
Griewank, K.G.2
Crosby, M.B.3
Garrido, M.C.4
Vemula, S.5
Wiesner, T.6
Obenauf, A.C.7
Wackernagel, W.8
Green, G.9
Bouvier, N.10
Sozen, M.M.11
Baimukanova, G.12
Roy, R.13
Heguy, A.14
Dolgalev, I.15
Khanin, R.16
Busam, K.17
Speicher, M.R.18
O'Brien, J.19
Bastian, B.C.20
more..
-
11
-
-
79959795786
-
Improved survival with vemurafenib in melanoma with BRAF V600E mutation
-
Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, Larkin J, Dummer R, Garbe C, Testori A, Maio M, Hogg D, Lorigan P, Lebbe C, Jouary T, Schadendorf D, Ribas A, O'Day SJ, Sosman JA, Kirkwood JM, Eggermont AM, Dreno B, Nolop K, Li J, Nelson B, Hou J, Lee RJ, Flaherty KT, McArthur GA (2011) Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364(26):2507-2516. doi: 10.1056/NEJMoa1103782
-
(2011)
N Engl J Med
, vol.364
, Issue.26
, pp. 2507-2516
-
-
Chapman, P.B.1
Hauschild, A.2
Robert, C.3
Haanen, J.B.4
Ascierto, P.5
Larkin, J.6
Dummer, R.7
Garbe, C.8
Testori, A.9
Maio, M.10
Hogg, D.11
Lorigan, P.12
Lebbe, C.13
Jouary, T.14
Schadendorf, D.15
Ribas, A.16
O'Day, S.J.17
Sosman, J.A.18
Kirkwood, J.M.19
Eggermont, A.M.20
Dreno, B.21
Nolop, K.22
Li, J.23
Nelson, B.24
Hou, J.25
Lee, R.J.26
Flaherty, K.T.27
McArthur, G.A.28
more..
-
12
-
-
84864285704
-
Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
-
Hauschild A, Grob JJ, Demidov LV, Jouary T, Gutzmer R, Millward M, Rutkowski P, Blank CU, Miller WH Jr, Kaempgen E, Martin-Algarra S, Karaszewska B, Mauch C, Chiarion-Sileni V, Martin AM, Swann S, Haney P, Mirakhur B, Guckert ME, Goodman V, Chapman PB (2012) Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 380(9839):358-365. doi: 10.1016/S0140-6736(12)60868-X
-
(2012)
Lancet
, vol.380
, Issue.9839
, pp. 358-365
-
-
Hauschild, A.1
Grob, J.J.2
Demidov, L.V.3
Jouary, T.4
Gutzmer, R.5
Millward, M.6
Rutkowski, P.7
Blank, C.U.8
Miller, W.H.9
Kaempgen, E.10
Martin-Algarra, S.11
Karaszewska, B.12
Mauch, C.13
Chiarion-Sileni, V.14
Martin, A.M.15
Swann, S.16
Haney, P.17
Mirakhur, B.18
Guckert, M.E.19
Goodman, V.20
Chapman, P.B.21
more..
-
13
-
-
84855179546
-
Vemurafenib for melanoma metastases to the brain
-
Rochet NM, Kottschade LA, Markovic SN (2011) Vemurafenib for melanoma metastases to the brain. N Engl J Med 365(25):2439-2441. doi: 10.1056/NEJMc1111672
-
(2011)
N Engl J Med
, vol.365
, Issue.25
, pp. 2439-2441
-
-
Rochet, N.M.1
Kottschade, L.A.2
Markovic, S.N.3
-
14
-
-
84868120907
-
Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): A multicentre, open-label, phase 2 trial
-
Long GV, Trefzer U, Davies MA, Kefford RF, Ascierto PA, Chapman PB, Puzanov I, Hauschild A, Robert C, Algazi A, Mortier L, Tawbi H, Wilhelm T, Zimmer L, Switzky J, Swann S, Martin AM, Guckert M, Goodman V, Streit M, Kirkwood JM, Schadendorf D (2012) Dabrafenib in patients with Val600Glu or Val600Lys BRAF-mutant melanoma metastatic to the brain (BREAK-MB): a multicentre, open-label, phase 2 trial. Lancet Oncol 13(11):1087-1095. doi: 10.1016/S1470-2045(12)70431-X
-
(2012)
Lancet Oncol
, vol.13
, Issue.11
, pp. 1087-1095
-
-
Long, G.V.1
Trefzer, U.2
Davies, M.A.3
Kefford, R.F.4
Ascierto, P.A.5
Chapman, P.B.6
Puzanov, I.7
Hauschild, A.8
Robert, C.9
Algazi, A.10
Mortier, L.11
Tawbi, H.12
Wilhelm, T.13
Zimmer, L.14
Switzky, J.15
Swann, S.16
Martin, A.M.17
Guckert, M.18
Goodman, V.19
Streit, M.20
Kirkwood, J.M.21
Schadendorf, D.22
more..
-
15
-
-
84863673204
-
Improved survival with MEK inhibition in BRAF-mutated melanoma
-
Group MS 10.1056/NEJMoa1203421 1:CAS:528:DC%2BC38XhtFKjs7zN 22663011
-
Flaherty KT, Robert C, Hersey P, Nathan P, Garbe C, Milhem M, Demidov LV, Hassel JC, Rutkowski P, Mohr P, Dummer R, Trefzer U, Larkin JM, Utikal J, Dreno B, Nyakas M, Middleton MR, Becker JC, Casey M, Sherman LJ, Wu FS, Ouellet D, Martin AM, Patel K, Schadendorf D, Group MS (2012) Improved survival with MEK inhibition in BRAF-mutated melanoma. N Engl J Med 367(2):107-114. doi: 10.1056/NEJMoa1203421
-
(2012)
N Engl J Med
, vol.367
, Issue.2
, pp. 107-114
-
-
Flaherty, K.T.1
Robert, C.2
Hersey, P.3
Nathan, P.4
Garbe, C.5
Milhem, M.6
Demidov, L.V.7
Hassel, J.C.8
Rutkowski, P.9
Mohr, P.10
Dummer, R.11
Trefzer, U.12
Larkin, J.M.13
Utikal, J.14
Dreno, B.15
Nyakas, M.16
Middleton, M.R.17
Becker, J.C.18
Casey, M.19
Sherman, L.J.20
Wu, F.S.21
Ouellet, D.22
Martin, A.M.23
Patel, K.24
Schadendorf, D.25
more..
-
16
-
-
84868224906
-
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
-
Flaherty KT, Infante JR, Daud A, Gonzalez R, Kefford RF, Sosman J, Hamid O, Schuchter L, Cebon J, Ibrahim N, Kudchadkar R, Burris HA 3rd, Falchook G, Algazi A, Lewis K, Long GV, Puzanov I, Lebowitz P, Singh A, Little S, Sun P, Allred A, Ouellet D, Kim KB, Patel K, Weber J (2012) Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med 367(18):1694-1703. doi: 10.1056/NEJMoa1210093
-
(2012)
N Engl J Med
, vol.367
, Issue.18
, pp. 1694-1703
-
-
Flaherty, K.T.1
Infante, J.R.2
Daud, A.3
Gonzalez, R.4
Kefford, R.F.5
Sosman, J.6
Hamid, O.7
Schuchter, L.8
Cebon, J.9
Ibrahim, N.10
Kudchadkar, R.11
Burris, H.A.12
Falchook, G.13
Algazi, A.14
Lewis, K.15
Long, G.V.16
Puzanov, I.17
Lebowitz, P.18
Singh, A.19
Little, S.20
Sun, P.21
Allred, A.22
Ouellet, D.23
Kim, K.B.24
Patel, K.25
Weber, J.26
more..
-
17
-
-
84879717023
-
Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: A phase 2 double-blind randomised study
-
Robert C, Dummer R, Gutzmer R, Lorigan P, Kim KB, Nyakas M, Arance A, Liszkay G, Schadendorf D, Cantarini M, Spencer S, Middleton MR (2013) Selumetinib plus dacarbazine versus placebo plus dacarbazine as first-line treatment for BRAF-mutant metastatic melanoma: a phase 2 double-blind randomised study. Lancet Oncol 14(8):733-740. doi: 10.1016/S1470-2045(13)70237-7
-
(2013)
Lancet Oncol
, vol.14
, Issue.8
, pp. 733-740
-
-
Robert, C.1
Dummer, R.2
Gutzmer, R.3
Lorigan, P.4
Kim, K.B.5
Nyakas, M.6
Arance, A.7
Liszkay, G.8
Schadendorf, D.9
Cantarini, M.10
Spencer, S.11
Middleton, M.R.12
-
18
-
-
80755181069
-
Prospective molecular marker analyses of EGFR and KRAS from a randomized, placebo-controlled study of erlotinib maintenance therapy in advanced non-small-cell lung cancer
-
Brugger W, Triller N, Blasinska-Morawiec M, Curescu S, Sakalauskas R, Manikhas GM, Mazieres J, Whittom R, Ward C, Mayne K, Trunzer K, Cappuzzo F (2011) Prospective molecular marker analyses of EGFR and KRAS from a randomized, placebo-controlled study of erlotinib maintenance therapy in advanced non-small-cell lung cancer. J Clin Oncol Off J Am Soc Clin Oncol 29(31):4113-4120. doi: 10.1200/JCO.2010.31.8162
-
(2011)
J Clin Oncol off J Am Soc Clin Oncol
, vol.29
, Issue.31
, pp. 4113-4120
-
-
Brugger, W.1
Triller, N.2
Blasinska-Morawiec, M.3
Curescu, S.4
Sakalauskas, R.5
Manikhas, G.M.6
Mazieres, J.7
Whittom, R.8
Ward, C.9
Mayne, K.10
Trunzer, K.11
Cappuzzo, F.12
-
19
-
-
84871720411
-
Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: A randomised, multicentre, placebo-controlled, phase 2 study
-
Janne PA, Shaw AT, Pereira JR, Jeannin G, Vansteenkiste J, Barrios C, Franke FA, Grinsted L, Zazulina V, Smith P, Smith I, Crino L (2013) Selumetinib plus docetaxel for KRAS-mutant advanced non-small-cell lung cancer: a randomised, multicentre, placebo-controlled, phase 2 study. Lancet Oncol 14(1):38-47. doi: 10.1016/S1470-2045(12)70489-8
-
(2013)
Lancet Oncol
, vol.14
, Issue.1
, pp. 38-47
-
-
Janne, P.A.1
Shaw, A.T.2
Pereira, J.R.3
Jeannin, G.4
Vansteenkiste, J.5
Barrios, C.6
Franke, F.A.7
Grinsted, L.8
Zazulina, V.9
Smith, P.10
Smith, I.11
Crino, L.12
-
20
-
-
84929071676
-
A randomized phase 2 study of the MEK1/MEK2 inhibitor trametinib (GSK1120212) compared with docetaxel in KRAS-mutant advanced non-small cell lung cancer (NSCLC)
-
Blumenschein G Jr, Smit EF, Planchard D, Kim DW, Cadranel J, De Pas T, Dunphy F, Udud K, Ahn MJ, Hanna NH, Kim JH, Mazieres J, Kim SW, Baas P, Rappold E, Redhu S, Puski A, Wu FS, Janne PA (2015) A randomized phase 2 study of the MEK1/MEK2 inhibitor trametinib (GSK1120212) compared with docetaxel in KRAS-mutant advanced non-small cell lung cancer (NSCLC). Ann Oncol. doi: 10.1093/annonc/mdv072
-
(2015)
Ann Oncol
-
-
Blumenschein, G.1
Smit, E.F.2
Planchard, D.3
Kim, D.W.4
Cadranel, J.5
De Pas, T.6
Dunphy, F.7
Udud, K.8
Ahn, M.J.9
Hanna, N.H.10
Kim, J.H.11
Mazieres, J.12
Kim, S.W.13
Baas, P.14
Rappold, E.15
Redhu, S.16
Puski, A.17
Wu, F.S.18
Janne, P.A.19
-
21
-
-
0037205048
-
The phosphoinositide 3-kinase pathway
-
Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296(5573):1655-1657. doi: 10.1126/science.296.5573.1655
-
(2002)
Science
, vol.296
, Issue.5573
, pp. 1655-1657
-
-
Cantley, L.C.1
-
22
-
-
40649096375
-
Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms
-
Zhao L, Vogt PK (2008) Helical domain and kinase domain mutations in p110alpha of phosphatidylinositol 3-kinase induce gain of function by different mechanisms. Proc Natl Acad Sci USA 105(7):2652-2657. doi: 10.1073/pnas.0712169105
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, Issue.7
, pp. 2652-2657
-
-
Zhao, L.1
Vogt, P.K.2
-
23
-
-
0032578999
-
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
-
1:CAS:528:DyaK1cXovValug%3D%3D 9445477
-
Stephens L, Anderson K, Stokoe D, Erdjument-Bromage H, Painter GF, Holmes AB, Gaffney PR, Reese CB, McCormick F, Tempst P, Coadwell J, Hawkins PT (1998) Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B. Science 279(5351):710-714
-
(1998)
Science
, vol.279
, Issue.5351
, pp. 710-714
-
-
Stephens, L.1
Anderson, K.2
Stokoe, D.3
Erdjument-Bromage, H.4
Painter, G.F.5
Holmes, A.B.6
Gaffney, P.R.7
Reese, C.B.8
McCormick, F.9
Tempst, P.10
Coadwell, J.11
Hawkins, P.T.12
-
24
-
-
84868356696
-
Identification of inositol polyphosphate 4-phosphatase type II as a novel tumor resistance biomarker in human laryngeal cancer HEp-2 cells
-
Kim JS, Yun HS, Um HD, Park JK, Lee KH, Kang CM, Lee SJ, Hwang SG (2012) Identification of inositol polyphosphate 4-phosphatase type II as a novel tumor resistance biomarker in human laryngeal cancer HEp-2 cells. Cancer Biol Ther 13(13):1307-1318. doi: 10.4161/cbt.21788
-
(2012)
Cancer Biol Ther
, vol.13
, Issue.13
, pp. 1307-1318
-
-
Kim, J.S.1
Yun, H.S.2
Um, H.D.3
Park, J.K.4
Lee, K.H.5
Kang, C.M.6
Lee, S.J.7
Hwang, S.G.8
-
25
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
1:CAS:528:DC%2BD38XlvV2htr8%3D 12150926
-
Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, Tokunaga C, Avruch J, Yonezawa K (2002) Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 110(2):177-189
-
(2002)
Cell
, vol.110
, Issue.2
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
Yoshino, K.4
Oshiro, N.5
Hidayat, S.6
Tokunaga, C.7
Avruch, J.8
Yonezawa, K.9
-
26
-
-
0034614637
-
The hallmarks of cancer
-
1:CAS:528:DC%2BD3cXks1CktA%3D%3D 10647931
-
Hanahan D, Weinberg RA (2000) The hallmarks of cancer. Cell 100(1):57-70
-
(2000)
Cell
, vol.100
, Issue.1
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
27
-
-
84863078767
-
Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer
-
Baselga J, Campone M, Piccart M, Burris HA 3rd, Rugo HS, Sahmoud T, Noguchi S, Gnant M, Pritchard KI, Lebrun F, Beck JT, Ito Y, Yardley D, Deleu I, Perez A, Bachelot T, Vittori L, Xu Z, Mukhopadhyay P, Lebwohl D, Hortobagyi GN (2012) Everolimus in postmenopausal hormone-receptor-positive advanced breast cancer. N Engl J Med 366(6):520-529. doi: 10.1056/NEJMoa1109653
-
(2012)
N Engl J Med
, vol.366
, Issue.6
, pp. 520-529
-
-
Baselga, J.1
Campone, M.2
Piccart, M.3
Burris, H.A.4
Rugo, H.S.5
Sahmoud, T.6
Noguchi, S.7
Gnant, M.8
Pritchard, K.I.9
Lebrun, F.10
Beck, J.T.11
Ito, Y.12
Yardley, D.13
Deleu, I.14
Perez, A.15
Bachelot, T.16
Vittori, L.17
Xu, Z.18
Mukhopadhyay, P.19
Lebwohl, D.20
Hortobagyi, G.N.21
more..
-
28
-
-
62449179465
-
A first-in-human phase i study to evaluate the pan-PI3K inhibitor GDC-0941 administered QD or BID in patients with advanced solid tumors
-
doi: 10.1200/JCO.2008.18.5918
-
Wagner AJ, Von Hoff DH, Lorusso PM, Tibes R, Mazina KE, Ware JA et al (2009) A first-in-human phase I study to evaluate the pan-PI3K inhibitor GDC-0941 administered QD or BID in patients with advanced solid tumors. In: ASCO annual meeting proceedings. doi: 10.1200/JCO.2008.18.5918
-
(2009)
ASCO Annual Meeting Proceedings
-
-
Wagner, A.J.1
Von Hoff, D.H.2
Lorusso, P.M.3
Tibes, R.4
Mazina, K.E.5
Ware, J.A.6
-
29
-
-
84861992072
-
A phase i study evaluating GDC-0941, an oral phosphoinositide-3 kinase (PI3K) inhibitor, in patients with advanced solid tumors or multiple myeloma
-
Moreno Garcia V, Baird RD, Shah KJ, Basu B, Tunariu N, Blanco M et al (2011) A phase I study evaluating GDC-0941, an oral phosphoinositide-3 kinase (PI3K) inhibitor, in patients with advanced solid tumors or multiple myeloma. In: ASCO annual meeting proceedings, vol 29, p 3021
-
(2011)
ASCO Annual Meeting Proceedings
, vol.29
, pp. 3021
-
-
Moreno Garcia, V.1
Baird, R.D.2
Shah, K.J.3
Basu, B.4
Tunariu, N.5
Et, Al. B.M.6
-
30
-
-
83355169753
-
A phase i dose-escalation study to evaluate GDC-0941, a pan-PI3K inhibitor, administered QD or BID in patients with advanced or metastatic solid tumors
-
doi: 10.1200/JCO.2011.36.5742
-
Von Hoff DD, LoRusso P, Demetri GD, Weiss GJ, Shapiro G, Ramanathan RK et al (2011) A phase I dose-escalation study to evaluate GDC-0941, a pan-PI3K inhibitor, administered QD or BID in patients with advanced or metastatic solid tumors. In: ASCO annual meeting proceedings, vol 29, p 3052. doi: 10.1200/JCO.2011.36.5742
-
(2011)
ASCO Annual Meeting Proceedings
, vol.29
, pp. 3052
-
-
Von Hoff, D.D.1
LoRusso, P.2
Demetri, G.D.3
Weiss, G.J.4
Shapiro, G.5
Ramanathan, R.K.6
-
31
-
-
84856071447
-
Phase I, dose-escalation study of BKM120, an oral pan-Class i PI3K inhibitor, in patients with advanced solid tumors
-
Bendell JC, Rodon J, Burris HA, de Jonge M, Verweij J, Birle D, Demanse D, De Buck SS, Ru QC, Peters M, Goldbrunner M, Baselga J (2012) Phase I, dose-escalation study of BKM120, an oral pan-Class I PI3K inhibitor, in patients with advanced solid tumors. J Clin Oncol Off J Am Soc Clin Oncol 30(3):282-290. doi: 10.1200/JCO.2011.36.1360
-
(2012)
J Clin Oncol off J Am Soc Clin Oncol
, vol.30
, Issue.3
, pp. 282-290
-
-
Bendell, J.C.1
Rodon, J.2
Burris, H.A.3
De Jonge, M.4
Verweij, J.5
Birle, D.6
Demanse, D.7
De Buck, S.S.8
Ru, Q.C.9
Peters, M.10
Goldbrunner, M.11
Baselga, J.12
-
32
-
-
84876221586
-
The PI3K/mTOR inhibitor BEZ235 given twice daily for the treatment of patients (pts) with advanced solid tumors
-
abstr. 3097
-
Arkenau H-T, Jones SF, Kurkjian C, Infante JR, Pant S, Burris HA et al (2012) The PI3K/mTOR inhibitor BEZ235 given twice daily for the treatment of patients (pts) with advanced solid tumors. In: ASCO annual meeting proceedings, vol 30, abstr. 3097
-
(2012)
ASCO Annual Meeting Proceedings
, vol.30
-
-
Arkenau, H.-T.1
Jones, S.F.2
Kurkjian, C.3
Infante, J.R.4
Pant, S.5
Burris, H.A.6
-
33
-
-
84863688392
-
A phase I/IB dose-escalation study of BEZ235 in combination with trastuzumab in patients with PI3-kinase or PTEN altered HER2+ metastatic breast cancer
-
abstr. 508. doi: 10.1200/JCO.2011.40.5902
-
Krop IE, Saura C, Ahnert JR, Becerra C, Britten CD, Isakoff SJ et al (2012) A phase I/IB dose-escalation study of BEZ235 in combination with trastuzumab in patients with PI3-kinase or PTEN altered HER2+ metastatic breast cancer. In: ASCO annual meeting proceedings, vol 30, abstr. 508. doi: 10.1200/JCO.2011.40.5902
-
(2012)
ASCO Annual Meeting Proceedings
, vol.30
-
-
Krop, I.E.1
Saura, C.2
Ahnert, J.R.3
Becerra, C.4
Britten, C.D.5
Isakoff, S.J.6
-
34
-
-
79955975429
-
Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer
-
Carver BS, Chapinski C, Wongvipat J, Hieronymus H, Chen Y, Chandarlapaty S, Arora VK, Le C, Koutcher J, Scher H, Scardino PT, Rosen N, Sawyers CL (2011) Reciprocal feedback regulation of PI3K and androgen receptor signaling in PTEN-deficient prostate cancer. Cancer Cell 19(5):575-586. doi: 10.1016/j.ccr.2011.04.008
-
(2011)
Cancer Cell
, vol.19
, Issue.5
, pp. 575-586
-
-
Carver, B.S.1
Chapinski, C.2
Wongvipat, J.3
Hieronymus, H.4
Chen, Y.5
Chandarlapaty, S.6
Arora, V.K.7
Le, C.8
Koutcher, J.9
Scher, H.10
Scardino, P.T.11
Rosen, N.12
Sawyers, C.L.13
-
35
-
-
76949106361
-
Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer
-
Reid AH, Attard G, Ambroisine L, Fisher G, Kovacs G, Brewer D, Clark J, Flohr P, Edwards S, Berney DM, Foster CS, Fletcher A, Gerald WL, Moller H, Reuter VE, Scardino PT, Cuzick J, de Bono JS, Cooper CS, Transatlantic Prostate G (2010) Molecular characterisation of ERG, ETV1 and PTEN gene loci identifies patients at low and high risk of death from prostate cancer. Br J Cancer 102(4):678-684. doi: 10.1038/sj.bjc.6605554
-
(2010)
Br J Cancer
, vol.102
, Issue.4
, pp. 678-684
-
-
Reid, A.H.1
Attard, G.2
Ambroisine, L.3
Fisher, G.4
Kovacs, G.5
Brewer, D.6
Clark, J.7
Flohr, P.8
Edwards, S.9
Berney, D.M.10
Foster, C.S.11
Fletcher, A.12
Gerald, W.L.13
Moller, H.14
Reuter, V.E.15
Scardino, P.T.16
Cuzick, J.17
De Bono, J.S.18
Cooper, C.S.19
-
36
-
-
84899785427
-
Characterization of the novel and specific PI3Kalpha inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials
-
Fritsch C, Huang A, Chatenay-Rivauday C, Schnell C, Reddy A, Liu M, Kauffmann A, Guthy D, Erdmann D, De Pover A, Furet P, Gao H, Ferretti S, Wang Y, Trappe J, Brachmann SM, Maira SM, Wilson C, Boehm M, Garcia-Echeverria C, Chene P, Wiesmann M, Cozens R, Lehar J, Schlegel R, Caravatti G, Hofmann F, Sellers WR (2014) Characterization of the novel and specific PI3Kalpha inhibitor NVP-BYL719 and development of the patient stratification strategy for clinical trials. Mol Cancer Ther 13(5):1117-1129. doi: 10.1158/1535-7163.MCT-13-0865
-
(2014)
Mol Cancer Ther
, vol.13
, Issue.5
, pp. 1117-1129
-
-
Fritsch, C.1
Huang, A.2
Chatenay-Rivauday, C.3
Schnell, C.4
Reddy, A.5
Liu, M.6
Kauffmann, A.7
Guthy, D.8
Erdmann, D.9
De Pover, A.10
Furet, P.11
Gao, H.12
Ferretti, S.13
Wang, Y.14
Trappe, J.15
Brachmann, S.M.16
Maira, S.M.17
Wilson, C.18
Boehm, M.19
Garcia-Echeverria, C.20
Chene, P.21
Wiesmann, M.22
Cozens, R.23
Lehar, J.24
Schlegel, R.25
Caravatti, G.26
Hofmann, F.27
Sellers, W.R.28
more..
-
37
-
-
84883559711
-
Phase i study of BYL719, an alpha-specific PI3K inhibitor, in patients with PIK3CA mutant advanced solid tumors: Preliminary efficacy and safety in patients with PIK3CA mutant ER-positive (ER+) metastatic breast cancer (MBC)
-
Juric AAG, Burris HA, Juric D et al (2012) Phase I study of BYL719, an alpha-specific PI3K inhibitor, in patients with PIK3CA mutant advanced solid tumors: preliminary efficacy and safety in patients with PIK3CA mutant ER-positive (ER+) metastatic breast cancer (MBC). Cancer Res. 72(24 supplement):P6-10-07
-
(2012)
Cancer Res.
, vol.72
, Issue.24
, pp. P61007
-
-
Juric, A.A.G.1
Burris, H.A.2
Juric, D.3
-
38
-
-
84855415767
-
Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition
-
Hoeflich KP, Merchant M, Orr C, Chan J, Den Otter D, Berry L, Kasman I, Koeppen H, Rice K, Yang NY, Engst S, Johnston S, Friedman LS, Belvin M (2012) Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res 72(1):210-219. doi: 10.1158/0008-5472.CAN-11-1515
-
(2012)
Cancer Res
, vol.72
, Issue.1
, pp. 210-219
-
-
Hoeflich, K.P.1
Merchant, M.2
Orr, C.3
Chan, J.4
Den Otter, D.5
Berry, L.6
Kasman, I.7
Koeppen, H.8
Rice, K.9
Yang, N.Y.10
Engst, S.11
Johnston, S.12
Friedman, L.S.13
Belvin, M.14
-
39
-
-
84923182481
-
A phase Ib dose-escalation study of the oral pan-PI3K inhibitor buparlisib (BKM120) in combination with the oral MEK1/2 inhibitor trametinib (GSK1120212) in patients with selected advanced solid tumors
-
Bedard PL, Tabernero J, Janku F, Wainberg ZA, Paz-Ares L, Vansteenkiste J, Van Cutsem E, Perez-Garcia J, Stathis A, Britten CD, Le N, Carter K, Demanse D, Csonka D, Peters M, Zubel A, Nauwelaerts H, Sessa C (2015) A phase Ib dose-escalation study of the oral pan-PI3K inhibitor buparlisib (BKM120) in combination with the oral MEK1/2 inhibitor trametinib (GSK1120212) in patients with selected advanced solid tumors. Clin Cancer Res Off J Am Assoc Cancer Res 21(4):730-738. doi: 10.1158/1078-0432.CCR-14-1814
-
(2015)
Clin Cancer Res off J Am Assoc Cancer Res
, vol.21
, Issue.4
, pp. 730-738
-
-
Bedard, P.L.1
Tabernero, J.2
Janku, F.3
Wainberg, Z.A.4
Paz-Ares, L.5
Vansteenkiste, J.6
Van Cutsem, E.7
Perez-Garcia, J.8
Stathis, A.9
Britten, C.D.10
Le, N.11
Carter, K.12
Demanse, D.13
Csonka, D.14
Peters, M.15
Zubel, A.16
Nauwelaerts, H.17
Sessa, C.18
-
40
-
-
40849147041
-
EGFR antagonists in cancer treatment
-
Ciardiello F, Tortora G (2008) EGFR antagonists in cancer treatment. N Engl J Med 358(11):1160-1174. doi: 10.1056/NEJMra0707704
-
(2008)
N Engl J Med
, vol.358
, Issue.11
, pp. 1160-1174
-
-
Ciardiello, F.1
Tortora, G.2
-
41
-
-
27544503230
-
Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
-
Thatcher N, Chang A, Parikh P, Rodrigues Pereira J, Ciuleanu T, von Pawel J, Thongprasert S, Tan EH, Pemberton K, Archer V, Carroll K (2005) Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 366(9496):1527-1537. doi: 10.1016/S0140-6736(05)67625-8
-
(2005)
Lancet
, vol.366
, Issue.9496
, pp. 1527-1537
-
-
Thatcher, N.1
Chang, A.2
Parikh, P.3
Rodrigues Pereira, J.4
Ciuleanu, T.5
Von Pawel, J.6
Thongprasert, S.7
Tan, E.H.8
Pemberton, K.9
Archer, V.10
Carroll, K.11
-
42
-
-
22044445517
-
Erlotinib in previously treated non-small-cell lung cancer
-
National Cancer Instituteof Canada Clinical Trials G 10.1056/NEJMoa050753 1:CAS:528:DC%2BD2MXmtFaksbo%3D 16014882
-
Shepherd FA, Rodrigues Pereira J, Ciuleanu T, Tan EH, Hirsh V, Thongprasert S, Campos D, Maoleekoonpiroj S, Smylie M, Martins R, van Kooten M, Dediu M, Findlay B, Tu D, Johnston D, Bezjak A, Clark G, Santabarbara P, Seymour L, National Cancer Instituteof Canada Clinical Trials G (2005) Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 353(2):123-132. doi: 10.1056/NEJMoa050753
-
(2005)
N Engl J Med
, vol.353
, Issue.2
, pp. 123-132
-
-
Shepherd, F.A.1
Rodrigues Pereira, J.2
Ciuleanu, T.3
Tan, E.H.4
Hirsh, V.5
Thongprasert, S.6
Campos, D.7
Maoleekoonpiroj, S.8
Smylie, M.9
Martins, R.10
Van Kooten, M.11
Dediu, M.12
Findlay, B.13
Tu, D.14
Johnston, D.15
Bezjak, A.16
Clark, G.17
Santabarbara, P.18
Seymour, L.19
-
43
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, Harris PL, Haserlat SM, Supko JG, Haluska FG, Louis DN, Christiani DC, Settleman J, Haber DA (2004) Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350(21):2129-2139. doi: 10.1056/NEJMoa040938NEJMoa040938
-
(2004)
N Engl J Med
, vol.350
, Issue.21
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
Harris, P.L.7
Haserlat, S.M.8
Supko, J.G.9
Haluska, F.G.10
Louis, D.N.11
Christiani, D.C.12
Settleman, J.13
Haber, D.A.14
-
44
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, Herman P, Kaye FJ, Lindeman N, Boggon TJ, Naoki K, Sasaki H, Fujii Y, Eck MJ, Sellers WR, Johnson BE, Meyerson M (2004) EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 304(5676):1497-1500. doi: 10.1126/science.1099314
-
(2004)
Science
, vol.304
, Issue.5676
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
Herman, P.7
Kaye, F.J.8
Lindeman, N.9
Boggon, T.J.10
Naoki, K.11
Sasaki, H.12
Fujii, Y.13
Eck, M.J.14
Sellers, W.R.15
Johnson, B.E.16
Meyerson, M.17
-
45
-
-
45149084723
-
First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations
-
Sequist LV, Martins RG, Spigel D, Grunberg SM, Spira A, Janne PA, Joshi VA, McCollum D, Evans TL, Muzikansky A, Kuhlmann GL, Han M, Goldberg JS, Settleman J, Iafrate AJ, Engelman JA, Haber DA, Johnson BE, Lynch TJ (2008) First-line gefitinib in patients with advanced non-small-cell lung cancer harboring somatic EGFR mutations. J Clin Oncol 26(15):2442-2449. doi: 10.1200/JCO.2007.14.8494
-
(2008)
J Clin Oncol
, vol.26
, Issue.15
, pp. 2442-2449
-
-
Sequist, L.V.1
Martins, R.G.2
Spigel, D.3
Grunberg, S.M.4
Spira, A.5
Janne, P.A.6
Joshi, V.A.7
McCollum, D.8
Evans, T.L.9
Muzikansky, A.10
Kuhlmann, G.L.11
Han, M.12
Goldberg, J.S.13
Settleman, J.14
Iafrate, A.J.15
Engelman, J.A.16
Haber, D.A.17
Johnson, B.E.18
Lynch, T.J.19
-
46
-
-
34250161814
-
Prospective study of gefitinib in epidermal growth factor receptor fluorescence in situ hybridization-positive/phospho-Akt-positive or never smoker patients with advanced non-small-cell lung cancer: The ONCOBELL trial
-
Cappuzzo F, Ligorio C, Janne PA, Toschi L, Rossi E, Trisolini R, Paioli D, Holmes AJ, Magrini E, Finocchiaro G, Bartolini S, Cancellieri A, Ciardiello F, Patelli M, Crino L, Varella-Garcia M (2007) Prospective study of gefitinib in epidermal growth factor receptor fluorescence in situ hybridization-positive/phospho-Akt-positive or never smoker patients with advanced non-small-cell lung cancer: the ONCOBELL trial. J Clin Oncol 25(16):2248-2255. doi: 10.1200/JCO.2006.09.4300
-
(2007)
J Clin Oncol
, vol.25
, Issue.16
, pp. 2248-2255
-
-
Cappuzzo, F.1
Ligorio, C.2
Janne, P.A.3
Toschi, L.4
Rossi, E.5
Trisolini, R.6
Paioli, D.7
Holmes, A.J.8
Magrini, E.9
Finocchiaro, G.10
Bartolini, S.11
Cancellieri, A.12
Ciardiello, F.13
Patelli, M.14
Crino, L.15
Varella-Garcia, M.16
-
47
-
-
69949162760
-
Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma
-
Mok TS, Wu YL, Thongprasert S, Yang CH, Chu DT, Saijo N, Sunpaweravong P, Han B, Margono B, Ichinose Y, Nishiwaki Y, Ohe Y, Yang JJ, Chewaskulyong B, Jiang H, Duffield EL, Watkins CL, Armour AA, Fukuoka M (2009) Gefitinib or carboplatin-paclitaxel in pulmonary adenocarcinoma. N Engl J Med 361(10):947-957. doi: 10.1056/NEJMoa0810699
-
(2009)
N Engl J Med
, vol.361
, Issue.10
, pp. 947-957
-
-
Mok, T.S.1
Wu, Y.L.2
Thongprasert, S.3
Yang, C.H.4
Chu, D.T.5
Saijo, N.6
Sunpaweravong, P.7
Han, B.8
Margono, B.9
Ichinose, Y.10
Nishiwaki, Y.11
Ohe, Y.12
Yang, J.J.13
Chewaskulyong, B.14
Jiang, H.15
Duffield, E.L.16
Watkins, C.L.17
Armour, A.A.18
Fukuoka, M.19
-
48
-
-
75249087060
-
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): An open label, randomised phase 3 trial
-
Mitsudomi T, Morita S, Yatabe Y, Negoro S, Okamoto I, Tsurutani J, Seto T, Satouchi M, Tada H, Hirashima T, Asami K, Katakami N, Takada M, Yoshioka H, Shibata K, Kudoh S, Shimizu E, Saito H, Toyooka S, Nakagawa K, Fukuoka M, West Japan Oncology G (2010) Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol 11(2):121-128. doi: 10.1016/S1470-2045(09)70364-X
-
(2010)
Lancet Oncol
, vol.11
, Issue.2
, pp. 121-128
-
-
Mitsudomi, T.1
Morita, S.2
Yatabe, Y.3
Negoro, S.4
Okamoto, I.5
Tsurutani, J.6
Seto, T.7
Satouchi, M.8
Tada, H.9
Hirashima, T.10
Asami, K.11
Katakami, N.12
Takada, M.13
Yoshioka, H.14
Shibata, K.15
Kudoh, S.16
Shimizu, E.17
Saito, H.18
Toyooka, S.19
Nakagawa, K.20
Fukuoka, M.21
more..
-
49
-
-
77953930730
-
Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR
-
North-East Japan Study G 10.1056/NEJMoa0909530 1:CAS:528:DC%2BC3cXot1Gjt7Y%3D 20573926
-
Maemondo M, Inoue A, Kobayashi K, Sugawara S, Oizumi S, Isobe H, Gemma A, Harada M, Yoshizawa H, Kinoshita I, Fujita Y, Okinaga S, Hirano H, Yoshimori K, Harada T, Ogura T, Ando M, Miyazawa H, Tanaka T, Saijo Y, Hagiwara K, Morita S, Nukiwa T, North-East Japan Study G (2010) Gefitinib or chemotherapy for non-small-cell lung cancer with mutated EGFR. N Engl J Med 362(25):2380-2388. doi: 10.1056/NEJMoa0909530
-
(2010)
N Engl J Med
, vol.362
, Issue.25
, pp. 2380-2388
-
-
Maemondo, M.1
Inoue, A.2
Kobayashi, K.3
Sugawara, S.4
Oizumi, S.5
Isobe, H.6
Gemma, A.7
Harada, M.8
Yoshizawa, H.9
Kinoshita, I.10
Fujita, Y.11
Okinaga, S.12
Hirano, H.13
Yoshimori, K.14
Harada, T.15
Ogura, T.16
Ando, M.17
Miyazawa, H.18
Tanaka, T.19
Saijo, Y.20
Hagiwara, K.21
Morita, S.22
Nukiwa, T.23
more..
-
50
-
-
79960889662
-
Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): A multicentre, open-label, randomised, phase 3 study
-
Zhou C, Wu YL, Chen G, Feng J, Liu XQ, Wang C, Zhang S, Wang J, Zhou S, Ren S, Lu S, Zhang L, Hu C, Hu C, Luo Y, Chen L, Ye M, Huang J, Zhi X, Zhang Y, Xiu Q, Ma J, Zhang L, You C (2011) Erlotinib versus chemotherapy as first-line treatment for patients with advanced EGFR mutation-positive non-small-cell lung cancer (OPTIMAL, CTONG-0802): a multicentre, open-label, randomised, phase 3 study. Lancet Oncol 12(8):735-742. doi: 10.1016/S1470-2045(11)70184-X
-
(2011)
Lancet Oncol
, vol.12
, Issue.8
, pp. 735-742
-
-
Zhou, C.1
Wu, Y.L.2
Chen, G.3
Feng, J.4
Liu, X.Q.5
Wang, C.6
Zhang, S.7
Wang, J.8
Zhou, S.9
Ren, S.10
Lu, S.11
Zhang, L.12
Hu, C.13
Hu, C.14
Luo, Y.15
Chen, L.16
Ye, M.17
Huang, J.18
Zhi, X.19
Zhang, Y.20
Xiu, Q.21
Ma, J.22
Zhang, L.23
You, C.24
more..
-
51
-
-
84857502654
-
Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): A multicentre, open-label, randomised phase 3 trial
-
Spanish Lung Cancer Group in collaboration with Groupe Francais de P-C, Associazione Italiana Oncologia T 10.1016/S1470-2045(11)70393-X 1:CAS:528:DC%2BC38XjsVCgsbk%3D 22285168
-
Rosell R, Carcereny E, Gervais R, Vergnenegre A, Massuti B, Felip E, Palmero R, Garcia-Gomez R, Pallares C, Sanchez JM, Porta R, Cobo M, Garrido P, Longo F, Moran T, Insa A, De Marinis F, Corre R, Bover I, Illiano A, Dansin E, de Castro J, Milella M, Reguart N, Altavilla G, Jimenez U, Provencio M, Moreno MA, Terrasa J, Munoz-Langa J, Valdivia J, Isla D, Domine M, Molinier O, Mazieres J, Baize N, Garcia-Campelo R, Robinet G, Rodriguez-Abreu D, Lopez-Vivanco G, Gebbia V, Ferrera-Delgado L, Bombaron P, Bernabe R, Bearz A, Artal A, Cortesi E, Rolfo C, Sanchez-Ronco M, Drozdowskyj A, Queralt C, de Aguirre I, Ramirez JL, Sanchez JJ, Molina MA, Taron M, Paz-Ares L, Spanish Lung Cancer Group in collaboration with Groupe Francais de P-C, Associazione Italiana Oncologia T (2012) Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised phase 3 trial. Lancet Oncol 13(3):239-246. doi: 10.1016/S1470-2045(11)70393-X
-
(2012)
Lancet Oncol
, vol.13
, Issue.3
, pp. 239-246
-
-
Rosell, R.1
Carcereny, E.2
Gervais, R.3
Vergnenegre, A.4
Massuti, B.5
Felip, E.6
Palmero, R.7
Garcia-Gomez, R.8
Pallares, C.9
Sanchez, J.M.10
Porta, R.11
Cobo, M.12
Garrido, P.13
Longo, F.14
Moran, T.15
Insa, A.16
De Marinis, F.17
Corre, R.18
Bover, I.19
Illiano, A.20
Dansin, E.21
De Castro, J.22
Milella, M.23
Reguart, N.24
Altavilla, G.25
Jimenez, U.26
Provencio, M.27
Moreno, M.A.28
Terrasa, J.29
Munoz-Langa, J.30
Valdivia, J.31
Isla, D.32
Domine, M.33
Molinier, O.34
Mazieres, J.35
Baize, N.36
Garcia-Campelo, R.37
Robinet, G.38
Rodriguez-Abreu, D.39
Lopez-Vivanco, G.40
Gebbia, V.41
Ferrera-Delgado, L.42
Bombaron, P.43
Bernabe, R.44
Bearz, A.45
Artal, A.46
Cortesi, E.47
Rolfo, C.48
Sanchez-Ronco, M.49
Drozdowskyj, A.50
Queralt, C.51
De Aguirre, I.52
Ramirez, J.L.53
Sanchez, J.J.54
Molina, M.A.55
Taron, M.56
Paz-Ares, L.57
more..
-
52
-
-
77953541527
-
Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: A multicentre, randomised, placebo-controlled phase 3 study
-
Investigators S 10.1016/S1470-2045(10)70112-1 1:CAS:528:DC%2BC3cXntVCksb0%3D 20493771
-
Cappuzzo F, Ciuleanu T, Stelmakh L, Cicenas S, Szczesna A, Juhasz E, Esteban E, Molinier O, Brugger W, Melezinek I, Klingelschmitt G, Klughammer B, Giaccone G, Investigators S (2010) Erlotinib as maintenance treatment in advanced non-small-cell lung cancer: a multicentre, randomised, placebo-controlled phase 3 study. Lancet Oncol 11(6):521-529. doi: 10.1016/S1470-2045(10)70112-1
-
(2010)
Lancet Oncol
, vol.11
, Issue.6
, pp. 521-529
-
-
Cappuzzo, F.1
Ciuleanu, T.2
Stelmakh, L.3
Cicenas, S.4
Szczesna, A.5
Juhasz, E.6
Esteban, E.7
Molinier, O.8
Brugger, W.9
Melezinek, I.10
Klingelschmitt, G.11
Klughammer, B.12
Giaccone, G.13
-
53
-
-
84883055532
-
Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer and wild-type EGFR tumours (TAILOR): A randomised controlled trial
-
Garassino MC, Martelli O, Broggini M, Farina G, Veronese S, Rulli E, Bianchi F, Bettini A, Longo F, Moscetti L, Tomirotti M, Marabese M, Ganzinelli M, Lauricella C, Labianca R, Floriani I, Giaccone G, Torri V, Scanni A, Marsoni S, Trialists T (2013) Erlotinib versus docetaxel as second-line treatment of patients with advanced non-small-cell lung cancer and wild-type EGFR tumours (TAILOR): a randomised controlled trial. Lancet Oncol 14(10):981-988. doi: 10.1016/S1470-2045(13)70310-3
-
(2013)
Lancet Oncol
, vol.14
, Issue.10
, pp. 981-988
-
-
Garassino, M.C.1
Martelli, O.2
Broggini, M.3
Farina, G.4
Veronese, S.5
Rulli, E.6
Bianchi, F.7
Bettini, A.8
Longo, F.9
Moscetti, L.10
Tomirotti, M.11
Marabese, M.12
Ganzinelli, M.13
Lauricella, C.14
Labianca, R.15
Floriani, I.16
Giaccone, G.17
Torri, V.18
Scanni, A.19
Marsoni, S.20
Trialists, T.21
more..
-
54
-
-
84947553080
-
Adjuvant erlotinib (E) versus placebo (P) for completely resected stage IB-IIIA EGFR-positive (IHC/FISH) non-small cell lung cancer (NSCLC): RADIANT results
-
Altorki NK, O'brien MER, Eberhardt WEE, Richardson FC, Wang J, Foley MA, Horan JD, Shepherd FA, Kelly K (2014) Adjuvant erlotinib (E) versus placebo (P) for completely resected stage IB-IIIA EGFR-positive (IHC/FISH) non-small cell lung cancer (NSCLC): RADIANT results. Int J Radiat Oncol 90:S2-S3
-
(2014)
Int J Radiat Oncol
, vol.90
, pp. S2-S3
-
-
Altorki, N.K.1
O'Brien, M.E.R.2
Eberhardt, W.E.E.3
Richardson, F.C.4
Wang, J.5
Foley, M.A.6
Horan, J.D.7
Shepherd, F.A.8
Kelly, K.9
-
55
-
-
71649096662
-
Biomarker analysis from completely resected NSCLC patients enrolled in an adjuvant erlotinib clinical trial (RADIANT)
-
Richardson F, Richardson K, Sennello G, Young D, Orlov S, Papai-Szekely Z, Keshavjee S, Kim J, Cerfolio R, Shepherd FA (2009) Biomarker analysis from completely resected NSCLC patients enrolled in an adjuvant erlotinib clinical trial (RADIANT). ASCO Meet Abstr 27(15S):7520
-
(2009)
ASCO Meet Abstr
, vol.27
, Issue.15
, pp. 7520
-
-
Richardson, F.1
Richardson, K.2
Sennello, G.3
Young, D.4
Orlov, S.5
Papai-Szekely, Z.6
Keshavjee, S.7
Kim, J.8
Cerfolio, R.9
Shepherd, F.A.10
-
56
-
-
84873714629
-
The SELECT study: A multicenter phase II trial of adjuvant erlotinib in resected epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC)
-
Neal JW, Pennell NA, Govindan R, Lanuti M, Rosovsky RPG, Heist RS, Shaw AT, Temel JS, Muzikansky A, Janne PA, Lynch TJ, Azzoli CG, Sequist LV (2012) The SELECT study: a multicenter phase II trial of adjuvant erlotinib in resected epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC). In: ASCO meeting abstracts, vol 30 (15-suppl), p 7010
-
(2012)
ASCO Meeting Abstracts
, vol.30
, Issue.15
, pp. 7010
-
-
Neal, J.W.1
Pennell, N.A.2
Govindan, R.3
Lanuti, M.4
Rpg, R.5
Heist, R.S.6
Shaw, A.T.7
Temel, J.S.8
Muzikansky, A.9
Janne, P.A.10
Lynch, T.J.11
Azzoli, C.G.12
Sequist, L.V.13
-
57
-
-
84884736973
-
Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations
-
Sequist LV, Yang JC, Yamamoto N, O'Byrne K, Hirsh V, Mok T, Geater SL, Orlov S, Tsai CM, Boyer M, Su WC, Bennouna J, Kato T, Gorbunova V, Lee KH, Shah R, Massey D, Zazulina V, Shahidi M, Schuler M (2013) Phase III study of afatinib or cisplatin plus pemetrexed in patients with metastatic lung adenocarcinoma with EGFR mutations. J Clin Oncol 31(27):3327-3334. doi: 10.1200/JCO.2012.44.2806
-
(2013)
J Clin Oncol
, vol.31
, Issue.27
, pp. 3327-3334
-
-
Sequist, L.V.1
Yang, J.C.2
Yamamoto, N.3
O'Byrne, K.4
Hirsh, V.5
Mok, T.6
Geater, S.L.7
Orlov, S.8
Tsai, C.M.9
Boyer, M.10
Su, W.C.11
Bennouna, J.12
Kato, T.13
Gorbunova, V.14
Lee, K.H.15
Shah, R.16
Massey, D.17
Zazulina, V.18
Shahidi, M.19
Schuler, M.20
more..
-
58
-
-
79953118839
-
Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors
-
Sequist LV, Waltman BA, Dias-Santagata D, Digumarthy S, Turke AB, Fidias P, Bergethon K, Shaw AT, Gettinger S, Cosper AK, Akhavanfard S, Heist RS, Temel J, Christensen JG, Wain JC, Lynch TJ, Vernovsky K, Mark EJ, Lanuti M, Iafrate AJ, Mino-Kenudson M, Engelman JA (2011) Genotypic and histological evolution of lung cancers acquiring resistance to EGFR inhibitors. Sci Transl Med 3(75):75ra26. doi: 10.1126/scitranslmed.3002003
-
(2011)
Sci Transl Med
, vol.3
, Issue.75
, pp. 75ra26
-
-
Sequist, L.V.1
Waltman, B.A.2
Dias-Santagata, D.3
Digumarthy, S.4
Turke, A.B.5
Fidias, P.6
Bergethon, K.7
Shaw, A.T.8
Gettinger, S.9
Cosper, A.K.10
Akhavanfard, S.11
Heist, R.S.12
Temel, J.13
Christensen, J.G.14
Wain, J.C.15
Lynch, T.J.16
Vernovsky, K.17
Mark, E.J.18
Lanuti, M.19
Iafrate, A.J.20
Mino-Kenudson, M.21
Engelman, J.A.22
more..
-
59
-
-
77949891126
-
Cetuximab and first-line taxane/carboplatin chemotherapy in advanced non-small-cell lung cancer: Results of the randomized multicenter phase III trial BMS099
-
Lynch TJ, Patel T, Dreisbach L, McCleod M, Heim WJ, Hermann RC, Paschold E, Iannotti NO, Dakhil S, Gorton S, Pautret V, Weber MR, Woytowitz D (2010) Cetuximab and first-line taxane/carboplatin chemotherapy in advanced non-small-cell lung cancer: results of the randomized multicenter phase III trial BMS099. J Clin Oncol 28(6):911-917. doi: 10.1200/JCO.2009.21.9618
-
(2010)
J Clin Oncol
, vol.28
, Issue.6
, pp. 911-917
-
-
Lynch, T.J.1
Patel, T.2
Dreisbach, L.3
McCleod, M.4
Heim, W.J.5
Hermann, R.C.6
Paschold, E.7
Iannotti, N.O.8
Dakhil, S.9
Gorton, S.10
Pautret, V.11
Weber, M.R.12
Woytowitz, D.13
-
60
-
-
65349116059
-
Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): An open-label randomised phase III trial
-
Pirker R, Pereira JR, Szczesna A, von Pawel J, Krzakowski M, Ramlau R, Vynnychenko I, Park K, Yu CT, Ganul V, Roh JK, Bajetta E, O'Byrne K, de Marinis F, Eberhardt W, Goddemeier T, Emig M, Gatzemeier U, Team FS (2009) Cetuximab plus chemotherapy in patients with advanced non-small-cell lung cancer (FLEX): an open-label randomised phase III trial. Lancet 373(9674):1525-1531. doi: 10.1016/S0140-6736(09)60569-9
-
(2009)
Lancet
, vol.373
, Issue.9674
, pp. 1525-1531
-
-
Pirker, R.1
Pereira, J.R.2
Szczesna, A.3
Von Pawel, J.4
Krzakowski, M.5
Ramlau, R.6
Vynnychenko, I.7
Park, K.8
Yu, C.T.9
Ganul, V.10
Roh, J.K.11
Bajetta, E.12
O'Byrne, K.13
De Marinis, F.14
Eberhardt, W.15
Goddemeier, T.16
Emig, M.17
Gatzemeier, U.18
-
61
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A, Bets D, Mueser M, Harstrick A, Verslype C, Chau I, Van Cutsem E (2004) Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer. N Engl J Med 351(4):337-345. doi: 10.1056/NEJMoa033025
-
(2004)
N Engl J Med
, vol.351
, Issue.4
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
Khayat, D.4
Bleiberg, H.5
Santoro, A.6
Bets, D.7
Mueser, M.8
Harstrick, A.9
Verslype, C.10
Chau, I.11
Van Cutsem, E.12
-
62
-
-
36148941301
-
Cetuximab for the treatment of colorectal cancer
-
Jonker DJ, O'Callaghan CJ, Karapetis CS, Zalcberg JR, Tu D, Au HJ, Berry SR, Krahn M, Price T, Simes RJ, Tebbutt NC, van Hazel G, Wierzbicki R, Langer C, Moore MJ (2007) Cetuximab for the treatment of colorectal cancer. N Engl J Med 357(20):2040-2048. doi: 10.1056/NEJMoa071834
-
(2007)
N Engl J Med
, vol.357
, Issue.20
, pp. 2040-2048
-
-
Jonker, D.J.1
O'Callaghan, C.J.2
Karapetis, C.S.3
Zalcberg, J.R.4
Tu, D.5
Au, H.J.6
Berry, S.R.7
Krahn, M.8
Price, T.9
Simes, R.J.10
Tebbutt, N.C.11
Van Hazel, G.12
Wierzbicki, R.13
Langer, C.14
Moore, M.J.15
-
63
-
-
84875734469
-
Predictive value of epidermal growth factor receptor expression for first-line chemotherapy plus cetuximab in patients with head and neck and colorectal cancer: Analysis of data from the EXTREME and CRYSTAL studies
-
Licitra L, Storkel S, Kerr KM, Van Cutsem E, Pirker R, Hirsch FR, Vermorken JB, von Heydebreck A, Esser R, Celik I, Ciardiello F (2013) Predictive value of epidermal growth factor receptor expression for first-line chemotherapy plus cetuximab in patients with head and neck and colorectal cancer: analysis of data from the EXTREME and CRYSTAL studies. Eur J Cancer 49(6):1161-1168. doi: 10.1016/j.ejca.2012.11.018
-
(2013)
Eur J Cancer
, vol.49
, Issue.6
, pp. 1161-1168
-
-
Licitra, L.1
Storkel, S.2
Kerr, K.M.3
Van Cutsem, E.4
Pirker, R.5
Hirsch, F.R.6
Vermorken, J.B.7
Von Heydebreck, A.8
Esser, R.9
Celik, I.10
Ciardiello, F.11
-
64
-
-
59949091448
-
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
-
Bokemeyer C, Bondarenko I, Makhson A, Hartmann JT, Aparicio J, de Braud F, Donea S, Ludwig H, Schuch G, Stroh C, Loos AH, Zubel A, Koralewski P (2009) Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 27(5):663-671. doi: 10.1200/JCO.2008.20.8397
-
(2009)
J Clin Oncol
, vol.27
, Issue.5
, pp. 663-671
-
-
Bokemeyer, C.1
Bondarenko, I.2
Makhson, A.3
Hartmann, J.T.4
Aparicio, J.5
De Braud, F.6
Donea, S.7
Ludwig, H.8
Schuch, G.9
Stroh, C.10
Loos, A.H.11
Zubel, A.12
Koralewski, P.13
-
65
-
-
84903694472
-
Final results from PRIME: Randomized phase III study of panitumumab with FOLFOX4 for first-line treatment of metastatic colorectal cancer
-
Douillard JY, Siena S, Cassidy J, Tabernero J, Burkes R, Barugel M, Humblet Y, Bodoky G, Cunningham D, Jassem J, Rivera F, Kocakova I, Ruff P, Blasinska-Morawiec M, Smakal M, Canon JL, Rother M, Oliner KS, Tian Y, Xu F, Sidhu R (2014) Final results from PRIME: randomized phase III study of panitumumab with FOLFOX4 for first-line treatment of metastatic colorectal cancer. Ann Oncol 25(7):1346-1355. doi: 10.1093/annonc/mdu141
-
(2014)
Ann Oncol
, vol.25
, Issue.7
, pp. 1346-1355
-
-
Douillard, J.Y.1
Siena, S.2
Cassidy, J.3
Tabernero, J.4
Burkes, R.5
Barugel, M.6
Humblet, Y.7
Bodoky, G.8
Cunningham, D.9
Jassem, J.10
Rivera, F.11
Kocakova, I.12
Ruff, P.13
Blasinska-Morawiec, M.14
Smakal, M.15
Canon, J.L.16
Rother, M.17
Oliner, K.S.18
Tian, Y.19
Xu, F.20
Sidhu, R.21
more..
-
66
-
-
84899981129
-
Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (ASPECCT): A randomised, multicentre, open-label, non-inferiority phase 3 study
-
Price TJ, Peeters M, Kim TW, Li J, Cascinu S, Ruff P, Suresh AS, Thomas A, Tjulandin S, Zhang K, Murugappan S, Sidhu R (2014) Panitumumab versus cetuximab in patients with chemotherapy-refractory wild-type KRAS exon 2 metastatic colorectal cancer (ASPECCT): a randomised, multicentre, open-label, non-inferiority phase 3 study. Lancet Oncol 15(6):569-579. doi: 10.1016/S1470-2045(14)70118-4
-
(2014)
Lancet Oncol
, vol.15
, Issue.6
, pp. 569-579
-
-
Price, T.J.1
Peeters, M.2
Kim, T.W.3
Li, J.4
Cascinu, S.5
Ruff, P.6
Suresh, A.S.7
Thomas, A.8
Tjulandin, S.9
Zhang, K.10
Murugappan, S.11
Sidhu, R.12
-
67
-
-
33646381326
-
Gastrointestinal stromal tumors with KIT exon 11 deletions are associated with poor prognosis
-
Andersson J, Bumming P, Meis-Kindblom JM, Sihto H, Nupponen N, Joensuu H, Oden A, Gustavsson B, Kindblom LG, Nilsson B (2006) Gastrointestinal stromal tumors with KIT exon 11 deletions are associated with poor prognosis. Gastroenterology 130(6):1573-1581. doi: 10.1053/j.gastro.2006.01.043
-
(2006)
Gastroenterology
, vol.130
, Issue.6
, pp. 1573-1581
-
-
Andersson, J.1
Bumming, P.2
Meis-Kindblom, J.M.3
Sihto, H.4
Nupponen, N.5
Joensuu, H.6
Oden, A.7
Gustavsson, B.8
Kindblom, L.G.9
Nilsson, B.10
-
68
-
-
41749118496
-
Molecular pathobiology of gastrointestinal stromal sarcomas
-
Corless CL, Heinrich MC (2008) Molecular pathobiology of gastrointestinal stromal sarcomas. Annu Rev Pathol 3:557-586. doi: 10.1146/annurev.pathmechdis.3.121806.151538
-
(2008)
Annu Rev Pathol
, vol.3
, pp. 557-586
-
-
Corless, C.L.1
Heinrich, M.C.2
-
69
-
-
84880916984
-
Long-term efficacy of imatinib for treatment of metastatic GIST
-
Patel S (2013) Long-term efficacy of imatinib for treatment of metastatic GIST. Cancer Chemother Pharmacol 72(2):277-286. doi: 10.1007/s00280-013-2135-8
-
(2013)
Cancer Chemother Pharmacol
, vol.72
, Issue.2
, pp. 277-286
-
-
Patel, S.1
-
70
-
-
0642368571
-
Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
-
Heinrich MC, Corless CL, Demetri GD, Blanke CD, von Mehren M, Joensuu H, McGreevey LS, Chen CJ, Van den Abbeele AD, Druker BJ, Kiese B, Eisenberg B, Roberts PJ, Singer S, Fletcher CD, Silberman S, Dimitrijevic S, Fletcher JA (2003) Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol 21(23):4342-4349. doi: 10.1200/JCO.2003.04.190
-
(2003)
J Clin Oncol
, vol.21
, Issue.23
, pp. 4342-4349
-
-
Heinrich, M.C.1
Corless, C.L.2
Demetri, G.D.3
Blanke, C.D.4
Von Mehren, M.5
Joensuu, H.6
McGreevey, L.S.7
Chen, C.J.8
Van Den Abbeele, A.D.9
Druker, B.J.10
Kiese, B.11
Eisenberg, B.12
Roberts, P.J.13
Singer, S.14
Fletcher, C.D.15
Silberman, S.16
Dimitrijevic, S.17
Fletcher, J.A.18
-
71
-
-
81855226071
-
Gastrointestinal stromal tumours: Origin and molecular oncology
-
Corless CL, Barnett CM, Heinrich MC (2011) Gastrointestinal stromal tumours: origin and molecular oncology. Nat Rev Cancer 11(12):865-878. doi: 10.1038/nrc3143
-
(2011)
Nat Rev Cancer
, vol.11
, Issue.12
, pp. 865-878
-
-
Corless, C.L.1
Barnett, C.M.2
Heinrich, M.C.3
-
72
-
-
33749505836
-
Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: A randomised controlled trial
-
Demetri GD, van Oosterom AT, Garrett CR, Blackstein ME, Shah MH, Verweij J, McArthur G, Judson IR, Heinrich MC, Morgan JA, Desai J, Fletcher CD, George S, Bello CL, Huang X, Baum CM, Casali PG (2006) Efficacy and safety of sunitinib in patients with advanced gastrointestinal stromal tumour after failure of imatinib: a randomised controlled trial. Lancet 368(9544):1329-1338. doi: 10.1016/S0140-6736(06)69446-4
-
(2006)
Lancet
, vol.368
, Issue.9544
, pp. 1329-1338
-
-
Demetri, G.D.1
Van Oosterom, A.T.2
Garrett, C.R.3
Blackstein, M.E.4
Shah, M.H.5
Verweij, J.6
McArthur, G.7
Judson, I.R.8
Heinrich, M.C.9
Morgan, J.A.10
Desai, J.11
Fletcher, C.D.12
George, S.13
Bello, C.L.14
Huang, X.15
Baum, C.M.16
Casali, P.G.17
-
73
-
-
84872892692
-
Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): An international, multicentre, randomised, placebo-controlled, phase 3 trial
-
Investigators Gs 10.1016/S0140-6736(12)61857-1 1:CAS:528:DC%2BC38XhslarsLvL 23177515
-
Demetri GD, Reichardt P, Kang YK, Blay JY, Rutkowski P, Gelderblom H, Hohenberger P, Leahy M, von Mehren M, Joensuu H, Badalamenti G, Blackstein M, Le Cesne A, Schoffski P, Maki RG, Bauer S, Nguyen BB, Xu J, Nishida T, Chung J, Kappeler C, Kuss I, Laurent D, Casali PG, Investigators Gs (2013) Efficacy and safety of regorafenib for advanced gastrointestinal stromal tumours after failure of imatinib and sunitinib (GRID): an international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 381(9863):295-302. doi: 10.1016/S0140-6736(12)61857-1
-
(2013)
Lancet
, vol.381
, Issue.9863
, pp. 295-302
-
-
Demetri, G.D.1
Reichardt, P.2
Kang, Y.K.3
Blay, J.Y.4
Rutkowski, P.5
Gelderblom, H.6
Hohenberger, P.7
Leahy, M.8
Von Mehren, M.9
Joensuu, H.10
Badalamenti, G.11
Blackstein, M.12
Le Cesne, A.13
Schoffski, P.14
Maki, R.G.15
Bauer, S.16
Nguyen, B.B.17
Xu, J.18
Nishida, T.19
Chung, J.20
Kappeler, C.21
Kuss, I.22
Laurent, D.23
Casali, P.G.24
more..
-
74
-
-
84864293774
-
Phase III study of nilotinib versus best supportive care with or without a TKI in patients with gastrointestinal stromal tumors resistant to or intolerant of imatinib and sunitinib
-
Reichardt P, Blay JY, Gelderblom H, Schlemmer M, Demetri GD, Bui-Nguyen B, McArthur GA, Yazji S, Hsu Y, Galetic I, Rutkowski P (2012) Phase III study of nilotinib versus best supportive care with or without a TKI in patients with gastrointestinal stromal tumors resistant to or intolerant of imatinib and sunitinib. Ann Oncol 23(7):1680-1687. doi: 10.1093/annonc/mdr598
-
(2012)
Ann Oncol
, vol.23
, Issue.7
, pp. 1680-1687
-
-
Reichardt, P.1
Blay, J.Y.2
Gelderblom, H.3
Schlemmer, M.4
Demetri, G.D.5
Bui-Nguyen, B.6
McArthur, G.A.7
Yazji, S.8
Hsu, Y.9
Galetic, I.10
Rutkowski, P.11
-
75
-
-
79960708519
-
Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification
-
Guo J, Si L, Kong Y, Flaherty KT, Xu X, Zhu Y, Corless CL, Li L, Li H, Sheng X, Cui C, Chi Z, Li S, Han M, Mao L, Lin X, Du N, Zhang X, Li J, Wang B, Qin S (2011) Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification. J Clin Oncol 29(21):2904-2909. doi: 10.1200/JCO.2010.33.9275
-
(2011)
J Clin Oncol
, vol.29
, Issue.21
, pp. 2904-2909
-
-
Guo, J.1
Si, L.2
Kong, Y.3
Flaherty, K.T.4
Xu, X.5
Zhu, Y.6
Corless, C.L.7
Li, L.8
Li, H.9
Sheng, X.10
Cui, C.11
Chi, Z.12
Li, S.13
Han, M.14
Mao, L.15
Lin, X.16
Du, N.17
Zhang, X.18
Li, J.19
Wang, B.20
Qin, S.21
more..
-
76
-
-
84857760658
-
Sunitinib therapy for melanoma patients with KIT mutations
-
Minor DR, Kashani-Sabet M, Garrido M, O'Day SJ, Hamid O, Bastian BC (2012) Sunitinib therapy for melanoma patients with KIT mutations. Clin Cancer Res 18(5):1457-1463. doi: 10.1158/1078-0432.CCR-11-1987
-
(2012)
Clin Cancer Res
, vol.18
, Issue.5
, pp. 1457-1463
-
-
Minor, D.R.1
Kashani-Sabet, M.2
Garrido, M.3
O'Day, S.J.4
Hamid, O.5
Bastian, B.C.6
-
77
-
-
84867867288
-
Nilotinib in patients with metastatic melanoma harboring KIT gene aberration
-
Cho JH, Kim KM, Kwon M, Kim JH, Lee J (2012) Nilotinib in patients with metastatic melanoma harboring KIT gene aberration. Invest New Drugs 30(5):2008-2014. doi: 10.1007/s10637-011-9763-9
-
(2012)
Invest New Drugs
, vol.30
, Issue.5
, pp. 2008-2014
-
-
Cho, J.H.1
Kim, K.M.2
Kwon, M.3
Kim, J.H.4
Lee, J.5
-
78
-
-
52449085884
-
Phase II study of dasatinib in Philadelphia chromosome-negative acute and chronic myeloid diseases, including systemic mastocytosis
-
Verstovsek S, Tefferi A, Cortes J, O'Brien S, Garcia-Manero G, Pardanani A, Akin C, Faderl S, Manshouri T, Thomas D, Kantarjian H (2008) Phase II study of dasatinib in Philadelphia chromosome-negative acute and chronic myeloid diseases, including systemic mastocytosis. Clin Cancer Res 14(12):3906-3915. doi: 10.1158/1078-0432.CCR-08-0366
-
(2008)
Clin Cancer Res
, vol.14
, Issue.12
, pp. 3906-3915
-
-
Verstovsek, S.1
Tefferi, A.2
Cortes, J.3
O'Brien, S.4
Garcia-Manero, G.5
Pardanani, A.6
Akin, C.7
Faderl, S.8
Manshouri, T.9
Thomas, D.10
Kantarjian, H.11
-
79
-
-
84898717745
-
Emergence of constitutively active estrogen receptor-alpha mutations in pretreated advanced estrogen receptor-positive breast cancer
-
Jeselsohn R, Yelensky R, Buchwalter G, Frampton G, Meric-Bernstam F, Gonzalez-Angulo AM, Ferrer-Lozano J, Perez-Fidalgo JA, Cristofanilli M, Gomez H, Arteaga CL, Giltnane J, Balko JM, Cronin MT, Jarosz M, Sun J, Hawryluk M, Lipson D, Otto G, Ross JS, Dvir A, Soussan-Gutman L, Wolf I, Rubinek T, Gilmore L, Schnitt S, Come SE, Pusztai L, Stephens P, Brown M, Miller VA (2014) Emergence of constitutively active estrogen receptor-alpha mutations in pretreated advanced estrogen receptor-positive breast cancer. Clin Cancer Res 20(7):1757-1767. doi: 10.1158/1078-0432.CCR-13-2332
-
(2014)
Clin Cancer Res
, vol.20
, Issue.7
, pp. 1757-1767
-
-
Jeselsohn, R.1
Yelensky, R.2
Buchwalter, G.3
Frampton, G.4
Meric-Bernstam, F.5
Gonzalez-Angulo, A.M.6
Ferrer-Lozano, J.7
Perez-Fidalgo, J.A.8
Cristofanilli, M.9
Gomez, H.10
Arteaga, C.L.11
Giltnane, J.12
Balko, J.M.13
Cronin, M.T.14
Jarosz, M.15
Sun, J.16
Hawryluk, M.17
Lipson, D.18
Otto, G.19
Ross, J.S.20
Dvir, A.21
Soussan-Gutman, L.22
Wolf, I.23
Rubinek, T.24
Gilmore, L.25
Schnitt, S.26
Come, S.E.27
Pusztai, L.28
Stephens, P.29
Brown, M.30
Miller, V.A.31
more..
-
80
-
-
37049183697
-
Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene
-
1:CAS:528:DyaL2sXhtVSht7s%3D 3798106
-
Slamon DJ, Clark GM, Wong SG, Levin WJ, Ullrich A, McGuire WL (1987) Human breast cancer: correlation of relapse and survival with amplification of the HER-2/neu oncogene. Science 235(4785):177-182
-
(1987)
Science
, vol.235
, Issue.4785
, pp. 177-182
-
-
Slamon, D.J.1
Clark, G.M.2
Wong, S.G.3
Levin, W.J.4
Ullrich, A.5
McGuire, W.L.6
-
81
-
-
84930822761
-
HER2-positive metastatic breast cancer: A changing scenario
-
Mustacchi G, Biganzoli L, Pronzato P, Montemurro F, Dambrosio M, Minelli M, Molteni L, Scaltriti L (2015) HER2-positive metastatic breast cancer: a changing scenario. Crit Rev Oncol/Hematol. doi: 10.1016/j.critrevonc.2015.02.002
-
(2015)
Crit Rev Oncol/Hematol
-
-
Mustacchi, G.1
Biganzoli, L.2
Pronzato, P.3
Montemurro, F.4
Dambrosio, M.5
Minelli, M.6
Molteni, L.7
Scaltriti, L.8
-
82
-
-
77955019276
-
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: A proof-of-concept trial
-
Tutt A, Robson M, Garber JE, Domchek SM, Audeh MW, Weitzel JN, Friedlander M, Arun B, Loman N, Schmutzler RK, Wardley A, Mitchell G, Earl H, Wickens M, Carmichael J (2010) Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer: a proof-of-concept trial. Lancet 376(9737):235-244. doi: 10.1016/S0140-6736(10)60892-6
-
(2010)
Lancet
, vol.376
, Issue.9737
, pp. 235-244
-
-
Tutt, A.1
Robson, M.2
Garber, J.E.3
Domchek, S.M.4
Audeh, M.W.5
Weitzel, J.N.6
Friedlander, M.7
Arun, B.8
Loman, N.9
Schmutzler, R.K.10
Wardley, A.11
Mitchell, G.12
Earl, H.13
Wickens, M.14
Carmichael, J.15
-
83
-
-
0028946604
-
Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer
-
9815967
-
Di Renzo MF, Olivero M, Giacomini A, Porte H, Chastre E, Mirossay L, Nordlinger B, Bretti S, Bottardi S, Giordano S et al (1995) Overexpression and amplification of the met/HGF receptor gene during the progression of colorectal cancer. Clin Cancer Res 1(2):147-154
-
(1995)
Clin Cancer Res
, vol.1
, Issue.2
, pp. 147-154
-
-
Di Renzo, M.F.1
Olivero, M.2
Giacomini, A.3
Porte, H.4
Chastre, E.5
Mirossay, L.6
Nordlinger, B.7
Bretti, S.8
Bottardi, S.9
Giordano, S.10
-
84
-
-
0034673699
-
Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas
-
Di Renzo MF, Olivero M, Martone T, Maffe A, Maggiora P, Stefani AD, Valente G, Giordano S, Cortesina G, Comoglio PM (2000) Somatic mutations of the MET oncogene are selected during metastatic spread of human HNSC carcinomas. Oncogene 19(12):1547-1555. doi: 10.1038/sj.onc.1203455
-
(2000)
Oncogene
, vol.19
, Issue.12
, pp. 1547-1555
-
-
Di Renzo, M.F.1
Olivero, M.2
Martone, T.3
Maffe, A.4
Maggiora, P.5
Stefani, A.D.6
Valente, G.7
Giordano, S.8
Cortesina, G.9
Comoglio, P.M.10
-
85
-
-
0037105707
-
Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer
-
1:CAS:528:DC%2BD38Xnt1ynsrg%3D 12234972
-
Boon EM, van der Neut R, van de Wetering M, Clevers H, Pals ST (2002) Wnt signaling regulates expression of the receptor tyrosine kinase met in colorectal cancer. Cancer Res 62(18):5126-5128
-
(2002)
Cancer Res
, vol.62
, Issue.18
, pp. 5126-5128
-
-
Boon, E.M.1
Van Der Neut, R.2
Van De Wetering, M.3
Clevers, H.4
Pals, S.T.5
-
86
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman JA, Zejnullahu K, Mitsudomi T, Song Y, Hyland C, Park JO, Lindeman N, Gale CM, Zhao X, Christensen J, Kosaka T, Holmes AJ, Rogers AM, Cappuzzo F, Mok T, Lee C, Johnson BE, Cantley LC, Janne PA (2007) MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 316(5827):1039-1043. doi: 10.1126/science.1141478
-
(2007)
Science
, vol.316
, Issue.5827
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
Song, Y.4
Hyland, C.5
Park, J.O.6
Lindeman, N.7
Gale, C.M.8
Zhao, X.9
Christensen, J.10
Kosaka, T.11
Holmes, A.J.12
Rogers, A.M.13
Cappuzzo, F.14
Mok, T.15
Lee, C.16
Johnson, B.E.17
Cantley, L.C.18
Janne, P.A.19
-
87
-
-
38049150665
-
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
-
Bean J, Brennan C, Shih JY, Riely G, Viale A, Wang L, Chitale D, Motoi N, Szoke J, Broderick S, Balak M, Chang WC, Yu CJ, Gazdar A, Pass H, Rusch V, Gerald W, Huang SF, Yang PC, Miller V, Ladanyi M, Yang CH, Pao W (2007) MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci USA 104(52):20932-20937. doi: 10.1073/pnas.0710370104
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, Issue.52
, pp. 20932-20937
-
-
Bean, J.1
Brennan, C.2
Shih, J.Y.3
Riely, G.4
Viale, A.5
Wang, L.6
Chitale, D.7
Motoi, N.8
Szoke, J.9
Broderick, S.10
Balak, M.11
Chang, W.C.12
Yu, C.J.13
Gazdar, A.14
Pass, H.15
Rusch, V.16
Gerald, W.17
Huang, S.F.18
Yang, P.C.19
Miller, V.20
Ladanyi, M.21
Yang, C.H.22
Pao, W.23
more..
-
88
-
-
78650339354
-
HGF/c-Met acts as an alternative angiogenic pathway in sunitinib-resistant tumors
-
Shojaei F, Lee JH, Simmons BH, Wong A, Esparza CO, Plumlee PA, Feng J, Stewart AE, Hu-Lowe DD, Christensen JG (2010) HGF/c-Met acts as an alternative angiogenic pathway in sunitinib-resistant tumors. Cancer Res 70(24):10090-10100. doi: 10.1158/0008-5472.CAN-10-0489
-
(2010)
Cancer Res
, vol.70
, Issue.24
, pp. 10090-10100
-
-
Shojaei, F.1
Lee, J.H.2
Simmons, B.H.3
Wong, A.4
Esparza, C.O.5
Plumlee, P.A.6
Feng, J.7
Stewart, A.E.8
Hu-Lowe, D.D.9
Christensen, J.G.10
-
89
-
-
84879071011
-
Crizotinib versus chemotherapy in advanced ALK-positive lung cancer
-
Shaw AT, Kim DW, Nakagawa K, Seto T, Crino L, Ahn MJ, De Pas T, Besse B, Solomon BJ, Blackhall F, Wu YL, Thomas M, O'Byrne KJ, Moro-Sibilot D, Camidge DR, Mok T, Hirsh V, Riely GJ, Iyer S, Tassell V, Polli A, Wilner KD, Janne PA (2013) Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. N Engl J Med 368(25):2385-2394. doi: 10.1056/NEJMoa1214886
-
(2013)
N Engl J Med
, vol.368
, Issue.25
, pp. 2385-2394
-
-
Shaw, A.T.1
Kim, D.W.2
Nakagawa, K.3
Seto, T.4
Crino, L.5
Ahn, M.J.6
De Pas, T.7
Besse, B.8
Solomon, B.J.9
Blackhall, F.10
Wu, Y.L.11
Thomas, M.12
O'Byrne, K.J.13
Moro-Sibilot, D.14
Camidge, D.R.15
Mok, T.16
Hirsh, V.17
Riely, G.J.18
Iyer, S.19
Tassell, V.20
Polli, A.21
Wilner, K.D.22
Janne, P.A.23
more..
-
90
-
-
80053386829
-
Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: A retrospective analysis
-
Shaw AT, Yeap BY, Solomon BJ, Riely GJ, Gainor J, Engelman JA, Shapiro GI, Costa DB, Ou SH, Butaney M, Salgia R, Maki RG, Varella-Garcia M, Doebele RC, Bang YJ, Kulig K, Selaru P, Tang Y, Wilner KD, Kwak EL, Clark JW, Iafrate AJ, Camidge DR (2011) Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis. Lancet Oncol 12(11):1004-1012. doi: 10.1016/S1470-2045(11)70232-7
-
(2011)
Lancet Oncol
, vol.12
, Issue.11
, pp. 1004-1012
-
-
Shaw, A.T.1
Yeap, B.Y.2
Solomon, B.J.3
Riely, G.J.4
Gainor, J.5
Engelman, J.A.6
Shapiro, G.I.7
Costa, D.B.8
Ou, S.H.9
Butaney, M.10
Salgia, R.11
Maki, R.G.12
Varella-Garcia, M.13
Doebele, R.C.14
Bang, Y.J.15
Kulig, K.16
Selaru, P.17
Tang, Y.18
Wilner, K.D.19
Kwak, E.L.20
Clark, J.W.21
Iafrate, A.J.22
Camidge, D.R.23
more..
-
91
-
-
84884993118
-
Clinical activity of the ALK inhibitor LDK378 in advanced, ALK-positive NSCLC
-
Shaw AT, Mehra R, Kim D-W et al (2013) Clinical activity of the ALK inhibitor LDK378 in advanced, ALK-positive NSCLC. In: ASCO meeting abstracts, vol 31, p 8010
-
(2013)
ASCO Meeting Abstracts
, vol.31
, pp. 8010
-
-
Shaw, A.T.1
Mehra, R.2
Kim, D.-W.3
-
92
-
-
84878971581
-
A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer
-
Socinski MA, Goldman J, El-Hariry I, Koczywas M, Vukovic V, Horn L, Paschold E, Salgia R, West H, Sequist LV, Bonomi P, Brahmer J, Chen LC, Sandler A, Belani CP, Webb T, Harper H, Huberman M, Ramalingam S, Wong KK, Teofilovici F, Guo W, Shapiro GI (2013) A multicenter phase II study of ganetespib monotherapy in patients with genotypically defined advanced non-small cell lung cancer. Clin Cancer Res 19(11):3068-3077. doi: 10.1158/1078-0432.CCR-12-3381
-
(2013)
Clin Cancer Res
, vol.19
, Issue.11
, pp. 3068-3077
-
-
Socinski, M.A.1
Goldman, J.2
El-Hariry, I.3
Koczywas, M.4
Vukovic, V.5
Horn, L.6
Paschold, E.7
Salgia, R.8
West, H.9
Sequist, L.V.10
Bonomi, P.11
Brahmer, J.12
Chen, L.C.13
Sandler, A.14
Belani, C.P.15
Webb, T.16
Harper, H.17
Huberman, M.18
Ramalingam, S.19
Wong, K.K.20
Teofilovici, F.21
Guo, W.22
Shapiro, G.I.23
more..
-
93
-
-
0028071653
-
Structure/function studies of lin-12/Notch proteins
-
1:CAS:528:DyaK2cXlsFelsb8%3D 7950324
-
Greenwald I (1994) Structure/function studies of lin-12/Notch proteins. Curr Opin Genet Dev 4(4):556-562
-
(1994)
Curr Opin Genet Dev
, vol.4
, Issue.4
, pp. 556-562
-
-
Greenwald, I.1
-
94
-
-
84906937713
-
Veliparib/carboplatin plus standard neoadjuvant therapy for high-risk breast cancer: First efficacy results from the I-SPY 2 TRIAL
-
Abstract S5-02
-
Rugo HS, Olopade O, DeMichele A, van 't Veer L, Buxton MB, Hylton N, Yee D, Chien AJ, Wallace A, PI's I-SS, Lyandres J, Davis S, Sanil A, Berry D, Esserman L (2013) Veliparib/carboplatin plus standard neoadjuvant therapy for high-risk breast cancer: first efficacy results from the I-SPY 2 TRIAL. In: 36th Annual San Antonio breast cancer symposium, Abstract S5-02
-
(2013)
36th Annual San Antonio Breast Cancer Symposium
-
-
Rugo, H.S.1
Olopade, O.2
DeMichele, A.3
Van 'T Veer, L.4
Buxton, M.B.5
Hylton, N.6
Yee, D.7
Chien, A.J.8
Wallace, A.9
I-Ss, P.10
Lyandres, J.11
Davis, S.12
Sanil, A.13
Berry, D.14
Esserman, L.15
-
95
-
-
84925440138
-
Prognostic value of FGFR gene amplification in patients with different types of cancer: A systematic review and meta-analysis
-
Chang J, Liu X, Wang S, Zhang Z, Wu Z, Zhang X, Li J (2014) Prognostic value of FGFR gene amplification in patients with different types of cancer: a systematic review and meta-analysis. PLoS One 9(8):e105524. doi: 10.1371/journal.pone.0105524
-
(2014)
PLoS One
, vol.9
, Issue.8
, pp. e105524
-
-
Chang, J.1
Liu, X.2
Wang, S.3
Zhang, Z.4
Wu, Z.5
Zhang, X.6
Li, J.7
-
96
-
-
84908030997
-
A phase II trial of brivanib in recurrent or persistent endometrial cancer: An NRG Oncology/Gynecologic Oncology Group Study
-
Powell MA, Sill MW, Goodfellow PJ, Benbrook DM, Lankes HA, Leslie KK, Jeske Y, Mannel RS, Spillman MA, Lee PS, Hoffman JS, McMeekin DS, Pollock PM (2014) A phase II trial of brivanib in recurrent or persistent endometrial cancer: an NRG Oncology/Gynecologic Oncology Group Study. Gynecol Oncol 135(1):38-43. doi: 10.1016/j.ygyno.2014.07.083
-
(2014)
Gynecol Oncol
, vol.135
, Issue.1
, pp. 38-43
-
-
Powell, M.A.1
Sill, M.W.2
Goodfellow, P.J.3
Benbrook, D.M.4
Lankes, H.A.5
Leslie, K.K.6
Jeske, Y.7
Mannel, R.S.8
Spillman, M.A.9
Lee, P.S.10
Hoffman, J.S.11
McMeekin, D.S.12
Pollock, P.M.13
-
97
-
-
84901804554
-
Phase II results of Dovitinib (TKI258) in patients with metastatic renal cell cancer
-
Escudier B, Grunwald V, Ravaud A, Ou YC, Castellano D, Lin CC, Gschwend JE, Harzstark A, Beall S, Pirotta N, Squires M, Shi M, Angevin E (2014) Phase II results of Dovitinib (TKI258) in patients with metastatic renal cell cancer. Clin Cancer Res 20(11):3012-3022. doi: 10.1158/1078-0432.CCR-13-3006
-
(2014)
Clin Cancer Res
, vol.20
, Issue.11
, pp. 3012-3022
-
-
Escudier, B.1
Grunwald, V.2
Ravaud, A.3
Ou, Y.C.4
Castellano, D.5
Lin, C.C.6
Gschwend, J.E.7
Harzstark, A.8
Beall, S.9
Pirotta, N.10
Squires, M.11
Shi, M.12
Angevin, E.13
-
98
-
-
84863900275
-
Insulin-like growth factor receptor inhibitors: Baby or the bathwater?
-
Yee D (2012) Insulin-like growth factor receptor inhibitors: baby or the bathwater? J Natl Cancer Inst 104(13):975-981. doi: 10.1093/jnci/djs258
-
(2012)
J Natl Cancer Inst
, vol.104
, Issue.13
, pp. 975-981
-
-
Yee, D.1
-
99
-
-
84885476862
-
Strategies to overcome clinical, regulatory, and financial challenges in the implementation of personalized medicine
-
Tsimberidou AM, Ringborg U, Schilsky RL (2013) Strategies to overcome clinical, regulatory, and financial challenges in the implementation of personalized medicine. Am Soc Clin Oncol Educ Book. doi: 10.1200/EdBook-AM.2013.33.118
-
(2013)
Am Soc Clin Oncol Educ Book
-
-
Tsimberidou, A.M.1
Ringborg, U.2
Schilsky, R.L.3
-
100
-
-
84907912530
-
Personalized medicine for patients with advanced cancer in the phase i program at MD Anderson: Validation and landmark analyses
-
Tsimberidou AM, Wen S, Hong DS, Wheler JJ, Falchook GS, Fu S, Piha-Paul S, Naing A, Janku F, Aldape K, Ye Y, Kurzrock R, Berry D (2014) Personalized medicine for patients with advanced cancer in the phase I program at MD Anderson: validation and landmark analyses. Clin Cancer Res 20(18):4827-4836. doi: 10.1158/1078-0432.CCR-14-0603
-
(2014)
Clin Cancer Res
, vol.20
, Issue.18
, pp. 4827-4836
-
-
Tsimberidou, A.M.1
Wen, S.2
Hong, D.S.3
Wheler, J.J.4
Falchook, G.S.5
Fu, S.6
Piha-Paul, S.7
Naing, A.8
Janku, F.9
Aldape, K.10
Ye, Y.11
Kurzrock, R.12
Berry, D.13
|