Adverse cognitive effects of antiepileptic pharmacotherapy: Each additional drug matters

European Neuropsychopharmacology

Volumn 25, Issue 11, 2015, Pages 1954-1959

  Witt, Juri Alexander ^a   Elger, Christian E ^a   Helmstaedter, Christoph ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Antiepileptic drugs; Cognition; Epilepsy; Neuropsychology; Side effects

Indexed keywords

ANTICONVULSIVE AGENT; BARBEXACLONE; CARBAMAZEPINE; CLOBAZAM; CLONAZEPAM; ESLICARBAZEPINE; ETHOSUXIMIDE; ETIRACETAM; FELBAMATE; GABAPENTIN; HARKOSERIDE; LAMOTRIGINE; OXCARBAZEPINE; PERAMPANEL; PHENOBARBITAL; PHENYTOIN; PREGABALIN; PRIMIDONE; RETIGABINE; RUFINAMIDE; SULTIAME; TIAGABINE; TOPIRAMATE; VALPROIC ACID; ZONISAMIDE;

ADULT; ARTICLE; CLINICAL EVALUATION; COGNITION; COGNITIVE DEFECT; CORRELATION ANALYSIS; CROSS-SECTIONAL STUDY; DEFINED DAILY DOSE; DISEASE SEVERITY; DRUG EFFECT; EPILEPSY; EPISODIC MEMORY; EXECUTIVE FUNCTION; FEMALE; HUMAN; LOADING DRUG DOSE; MAJOR CLINICAL STUDY; MALE; MEMORY; PARAMETERS; POLYPHARMACY; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RETROSPECTIVE STUDY; STATISTICAL ANALYSIS; VERBAL MEMORY; WORLD HEALTH ORGANIZATION; ADVERSE EFFECTS; COMBINATION DRUG THERAPY; DRUG EFFECTS; PSYCHOLOGIC TEST; PSYCHOLOGY; SEIZURES; TERTIARY CARE CENTER;

ADULT; ANTICONVULSANTS; COGNITION; DRUG THERAPY, COMBINATION; EPILEPSY; EXECUTIVE FUNCTION; FEMALE; HUMANS; MALE; MEMORY; PSYCHOLOGICAL TESTS; RETROSPECTIVE STUDIES; SEIZURES; TERTIARY CARE CENTERS;

EID: 84947491790     PISSN: 0924977X     EISSN: 18737862     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2015.07.027     Document Type: Article

References (21)

1. Aldenkamp A.P. Effects of antiepileptic drugs on cognition. Epilepsia 2001, 42(Suppl 1):S46-S51.
2. Helmstaedter C. EpiTrack. Veränderungssensitives kognitives Screening zur Qualitäts- und Outcomekontrolle der medikamentösen Epilepsiebehandlung 2012, UCB-Pharma, Monheim. 2nd ed.
3. Helmstaedter C., Lendt M., Lux S. VLMT Verbaler Lern- und Merkfähigkeitstest 2001, Beltz Test GmbH, Göttingen.
4. Helmstaedter C., Witt J.A. The effects of levetiracetam on cognition: a non-interventional surveillance study. Epilepsy Behav. 2008, 13:642-649.
5. Helmstaedter C., Witt J.A. Cognitive outcome of antiepileptic treatment with levetiracetam versus carbamazepine monotherapy: a non-interventional surveillance trial. Epilepsy Behav. 2010, 18:74-80.
6. Helmstaedter C., Witt J.A. The longer-term cognitive effects of adjunctive antiepileptic treatment with lacosamide in comparison with lamotrigine and topiramate in a naturalistic outpatient setting. Epilepsy Behav. 2013, 26:182-187.
7. Kwan P., Brodie M.J. Neuropsychological effects of epilepsy and antiepileptic drugs. Lancet 2001, 357:216-222.
8. Loring D.W., Marino S., Meador K.J. Neuropsychological and behavioral effects of antiepilepsy drugs. Neuropsychol. Rev. 2007, 17:413-425.
9. Martin R.C., Griffith H.R., Faught E., Gilliam F., Mackey M., Vogtle L. Cognitive functioning in community dwelling older adults with chronic partial epilepsy. Epilepsia 2005, 46:298-303.
10. Mula M., Trimble M.R. Antiepileptic drug-induced cognitive adverse effects: potential mechanisms and contributing factors. CNS Drugs 2009, 23:121-137.
11. Ortinski P., Meador K.J. Cognitive side effects of antiepileptic drugs. Epilepsy Behav. 2004, 5(Suppl 1):S60-S65.
12. Park S.P., Kwon S.H. Cognitive effects of antiepileptic drugs. J. Clin. Neurol. 2008, 4:99-106.
13. Phabphal K., Kanjanasatien J. Montreal cognitive assessment in cryptogenic epilepsy patients with normal mini-mental state examination scores. Epileptic Disord. 2011, 13:375-381.
14. Rösche J., Kundt G., Weber R., Fröscher W., Uhlmann C. The impact of antiepileptic polytherapy on mood and cognitive function. Acta Neurol. Belg. 2011, 111:29-32.
15. Thompson P.J., Trimble M.R. Anticonvulsant drugs and cognitive functions. Epilepsia 1982, 23:531-544.
16. Witt J.-A., Elger C.E., Helmstaedter C. Impaired verbal fluency under topiramate-evidence for synergistic negative effects of epilepsy, topiramate, and polytherapy. Eur. J. Neurol. 2013, 20:130-137.
17. Witt J.-A., Elger C.E., Helmstaedter C. Which drug-induced side effects would be tolerated in the prospect of seizure control?. Epilepsy Behav. 2013, 29:141-143.
18. Witt J.-A., Helmstaedter C. Should cognition be screened in new-onset epilepsies? A study in 247 untreated patients. J. Neurol. 2012, 259:1727-1731.
19. Witt J.-A., Helmstaedter C. Monitoring the cognitive effects of antiepileptic pharmacotherapy--approaching the individual patient. Epilepsy Behav. 2013, 26:450-456.
20. Witt J.A., Helmstaedter C. Neuropsychologie bei Epilepsie. Teil II: Gibt es eine gemeinsame Basis zur Etablierung diagnostischer Leitlinien?. Fortschr. Neurol. Psychiatr. 2009, 77:691-698.
21. Witt J.A., Helmstaedter C. The impact of antiepileptic drug treatment on attention and executive functions. Epilepsia 2010, 51(Suppl 4):S20.