The effects of levetiracetam on cognition: A non-interventional surveillance study

Epilepsy and Behavior

Volumn 13, Issue 4, 2008, Pages 642-649

  Helmstaedter, Christoph ^a   Witt, Juri Alexander ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

Author keywords

Antiepileptic drug; Cognition; Cognitive side effects; Epilepsy; EpiScope; EpiTrack; Levetiracetam; Non interventional surveillance study; Seizure control

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; ETIRACETAM; GABAPENTIN; LAMOTRIGINE; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PREGABALIN; PRIMIDONE; TOPIRAMATE; VALPROIC ACID; ZONISAMIDE;

ADOLESCENT; ADULT; AGED; ARTICLE; AUTONOMIC DYSFUNCTION; COGNITIVE DEFECT; CONTROLLED STUDY; DETERIORATION; DISEASE CONTROL; DISEASE SURVEILLANCE; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; DRUG WITHDRAWAL; EPILEPSY; FATIGUE; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MONOTHERAPY; PREDICTION; RELAPSE; SEIZURE; TREATMENT OUTCOME; UNSPECIFIED SIDE EFFECT;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ANTICONVULSANTS; COGNITION DISORDERS; EPILEPSY; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PIRACETAM; PROSPECTIVE STUDIES; REGRESSION ANALYSIS; YOUNG ADULT;

EID: 54049084489     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2008.07.012     Document Type: Article

References (24)

1. Bergey G.K. Evidence-based treatment of idiopathic generalized epilepsies with new antiepileptic drugs. Epilepsia 46 Suppl. 9 (2005) 161-168
2. Rocamora R., Wagner K., and Schulze-Bonhage A. Levetiracetam reduces frequency and duration of epileptic activity in patients with refractory primary generalized epilepsy. Seizure 15 (2006) 428-433
3. Kumar S.P., and Smith P.E. Levetiracetam as add-on therapy in generalised epilepsies. Seizure 13 (2004) 475-477
4. Berkovic S.F., Knowlton R.C., Leroy R.F., Schiemann J., and Falter U. Placebo-controlled study of levetiracetam in idiopathic generalized epilepsy. Neurology 69 (2007) 1751-1760
5. Shorvon S.D., Lowenthal A., Janz D., Bielen E., and Loiseau P. For the European Levetiracetam Study Group. Multicenter double-blind, randomized, placebo-controlled trial of levetiracetam as add-on therapy in patients with refractory partial seizures. Epilepsia 41 (2000) 1179-1186
6. Beran R.G., Berkovic S.F., Black A.B., et al. Efficacy and safety of levetiracetam 1000-3000 mg/day in patients with refractory partial-onset seizures: a multicenter, open-label single-arm study. Epilepsy Res 63 (2005) 1-9
7. Aldenkamp A.P., De Krom M., and Reijs R. Newer antiepileptic drugs and cognitive issues. Epilepsia 44 Suppl. 4 (2003) 21-29
8. Meador K.J. Cognitive and memory effects of the new antiepileptic drugs. Epilepsy Res 68 1 (2006) 63-67
9. Ortinski P., and Meador K.J. Cognitive side effects of antiepileptic drugs. Epilepsy Behav 5 Suppl. 1 (2004) S60-S65
10. Park S.P., Hwang Y.H., Lee H.W., Suh C.K., Kwon S.H., and Lee B.I. Long-term cognitive and mood effects of zonisamide monotherapy in epilepsy patients. Epilepsy Behav 12 (2008) 102-108
11. Meador K.J., Gevins A., Loring D.W., et al. Neuropsychological and neurophysiologic effects of carbamazepine and levetiracetam. Neurology 69 (2007) 2076-2084
12. Mecarelli O., Vicenzini E., Pulitano P., et al. Clinical, cognitive, and neurophysiologic correlates of short-term treatment with carbamazepine, oxcarbazepine, and levetiracetam in healthy volunteers. Ann Pharmacother 38 (2004) 1816-1822
13. Zhou B., Zhang Q., Tian L., Xiao J., Stefan H., and Zhou D. Effects of levetiracetam as an add-on therapy on cognitive function and quality of life in patients with refractory partial seizures. Epilepsy Behav 12 (2008) 305-310
14. Piazzini A., Chifari R., Canevini M.P., Turner K., Fontana S.P., and Canger R. Levetiracetam: an improvement of attention and of oral fluency in patients with partial epilepsy. Epilepsy Res 68 (2006) 181-188
15. Ciesielski A.S., Samson S., and Steinhoff B.J. Neuropsychological and psychiatric impact of add-on titration of pregabalin versus levetiracetam: a comparative short-term study. Epilepsy Behav 9 (2006) 424-431
16. Gomer B., Wagner K., Frings L., et al. The influence of antiepileptic drugs on cognition: a comparison of levetiracetam with topiramate. Epilepsy Behav 10 (2007) 486-494
17. Neyens L.G., Alpherts W.C., and Aldenkamp A.P. Cognitive effects of a new pyrrolidine derivative (levetiracetam) in patients with epilepsy. Prog Neuropsychopharmacol Biol Psychiatry 19 (1995) 411-419
18. Cramer J.A., and Van Hammee G. Maintenance of improvement in health-related quality of life during long-term treatment with levetiracetam. Epilepsy Behav 4 (2003) 118-123
19. French J., Edrich P., and Cramer J.A. A systematic review of the safety profile of levetiracetam: a new antiepileptic drug. Epilepsy Res 47 (2001) 77-90
20. Lutz M.T., and Helmstaedter C. EpiTrack: tracking cognitive side effects of medication on attention and executive functions in patients with epilepsy. Epilepsy Behav 7 (2005) 708-714
21. Kalbe E., Kessler J., Schwarze C., and Calabrese P. Episcope(R): ein Screening zur Erfassung kognitiver Störungen bei Patienten mit Epilepsie. Akt Neurol 31 S1 (2004)
22. Elixhauser A., Leidy N.K., Meador K., Means E., and Willian M.K. The relationship between memory performance, perceived cognitive function, and mood in patients with epilepsy. Epilepsy Res 37 (1999) 13-24
23. Hoppe C., Elger C.E., and Helmstaedter C. Long-term memory impairment in patients with focal epilepsy. Epilepsia 48 Suppl. 9 (2007) 26-29
24. Sawrie S.M., Martin R.C., Kuzniecky R., et al. Subjective versus objective memory change after temporal lobe epilepsy surgery. Neurology 53 (1999) 1511-1517