Placental-Specific sFLT-1 e15a Protein Is Increased in Preeclampsia, Antagonizes Vascular Endothelial Growth Factor Signaling, and Has Antiangiogenic Activity

Hypertension

Volumn 66, Issue 6, 2015, Pages 1251-1259

  Palmer, Kirsten R ^a   Kaitu'u Lino, Tu'uhevaha J ^a   Hastie, Roxanne ^a   Hannan, Natalie J ^a   Ye, Louie ^a   Binder, Natalie ^a   Cannon, Ping ^a   Tuohey, Laura ^a   Johns, Terrance G ^b   Shub, Alexis ^a   Tong, Stephen ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

angiogenesis inhibitors; endothelial cells; preeclampsia; pregnancy; vascular endothelial growth factor A

Indexed keywords

PLACENTA PROTEIN; PROTEIN KINASE B; SOLUBLE FMS LIKE TYROSINE KINASE 1 PROTEIN; UNCLASSIFIED DRUG; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; ANGIOGENESIS INHIBITOR; FLT1 PROTEIN, HUMAN; ISOPROTEIN; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL INVASION; CELL MIGRATION; CELL VIABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; GESTATIONAL AGE; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PATHOPHYSIOLOGY; PLACENTA TISSUE; PREECLAMPSIA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PURIFICATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SYNCYTIOTROPHOBLAST; TROPHOBLAST; UMBILICAL VEIN ENDOTHELIAL CELL; ADULT; ANIMAL; BLOOD; C57BL MOUSE; CELL CULTURE; CELL MOTION; DRUG EFFECTS; FLUORESCENCE MICROSCOPY; GENETICS; METABOLISM; NEWBORN; PLACENTA; PREGNANCY; RNA INTERFERENCE; WESTERN BLOTTING;

ADULT; ANGIOGENESIS INHIBITORS; ANIMALS; BLOTTING, WESTERN; CELL MOVEMENT; CELLS, CULTURED; FEMALE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INFANT, NEWBORN; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; PLACENTA; PRE-ECLAMPSIA; PREGNANCY; PROTEIN ISOFORMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TROPHOBLASTS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 84947490530     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.115.05883     Document Type: Article

References (17)

1. Duley L. The global impact of pre-eclampsia and eclampsia. Semin Perinatol. 2009;33:130-137. doi: 10.1053/j.semperi.2009.02.010.
2. Agarwal I, Karumanchi SA. Preeclampsia and the Anti-Angiogenic State. Pregnancy Hypertens. 2011;1:17-21. doi: 10.1016/j.preghy. 2010.10.007.
3. Powe CE, Levine RJ, Karumanchi SA. Preeclampsia, a disease of the maternal endothelium: the role of antiangiogenic factors and implications for later cardiovascular disease. Circulation. 2011;123:2856-2869. doi: 10.1161/CIRCULATIONAHA.109.853127.
4. Maynard SE, Min JY, Merchan J, Lim KH, Li J, Mondal S, Libermann TA, Morgan JP, Sellke FW, Stillman IE, Epstein FH, Sukhatme VP, Karumanchi SA. Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia. J Clin Invest. 2003;111:649-658. doi: 10.1172/JCI17189.
5. Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, Thadhani R, Sachs BP, Epstein FH, Sibai BM, Sukhatme VP, Karumanchi SA. Circulating angiogenic factors and the risk of preeclampsia. N Engl J Med. 2004;350:672-683. doi: 10.1056/NEJMoa031884.
6. Jebbink J, Keijser R, Veenboer G, van der Post J, Ris-Stalpers C, Afink G. Expression of placental FLT1 transcript variants relates to both gestational hypertensive disease and fetal growth. Hypertension. 2011;58:70-76. doi: 10.1161/HYPERTENSIONAHA.110.164079.
7. Sela S, Itin A, Natanson-Yaron S, Greenfield C, Goldman-Wohl D, Yagel S, Keshet E. A novel human-specific soluble vascular endothelial growth factor receptor 1: cell-type-specific splicing and implications to vascular endothelial growth factor homeostasis and preeclampsia. Circ Res. 2008;102:1566-1574. doi: 10.1161/CIRCRESAHA.108.171504.
8. Thomas CP, Andrews JI, Raikwar NS, Kelley EA, Herse F, Dechend R, Golos TG, Liu KZ. A recently evolved novel trophoblast-enriched secreted form of fms-like tyrosine kinase-1 variant is up-regulated in hypoxia and preeclampsia. J Clin Endocrinol Metab. 2009;94:2524-2530. doi: 10.1210/jc.2009-0017.
9. Krugner-Higby L, Luck M, Hartley D, Crispen HM, Lubach GR, Coe CL. High-risk pregnancy in rhesus monkeys (Macaca mulatta): a case of ectopic, abdominal pregnancy with birth of a live, term infant, and a case of gestational diabetes complicated by pre-eclampsia. J Med Primatol. 2009;38:252-256. doi: 10.1111/j.1600-0684.2009.00349.x.
10. Thornton JG, Onwude JL. Convulsions in pregnancy in related gorillas. Am J Obstet Gynecol. 1992;167:240-241.
11. Whitehead CL, Palmer KR, Nilsson U, Gao Y, Saglam B, Lappas M, Tong S. Placental expression of a novel primate-specific splice variant of sFlt-1 is upregulated in pregnancies complicated by severe early onset pre-eclampsia. BJOG. 2011;118:1268-1271. doi: 10.1111/j.1471-0528.2011.02962.x.
12. Kaitu'u-Lino TJ, Tong S, Beard S, Hastie R, Tuohey L, Brownfoot F, Onda K, Hannan NJ. Characterization of protocols for primary trophoblast purification, optimized for functional investigation of sFlt-1 and soluble endoglin. Pregnancy Hypertens. 2014;4:287-295. doi: 10.1016/j. preghy.2014.09.003.
13. Onda K, Tong S, Nakahara A, Kondo M, Monchusho H, Hirano T, Kaitu'u-Lino T, Beard S, Binder N, Tuohey L, Brownfoot F, Hannan NJ. Sofalcone upregulates the nuclear factor (erythroid-derived 2)-like 2/heme oxygenase-1 pathway, reduces soluble fms-like tyrosine kinase-1, and quenches endothelial dysfunction: potential therapeutic for preeclampsia. Hypertension. 2015;65:855-862. doi: 10.1161/HYPERTENSIONAHA.114.04781.
14. Stacker SA, Vitali A, Caesar C, Domagala T, Groenen LC, Nice E, Achen MG, Wilks AF. A mutant form of vascular endothelial growth factor (VEGF) that lacks VEGF receptor-2 activation retains the ability to induce vascular permeability. J Biol Chem. 1999;274:34884-34892.
15. Baker M, Robinson SD, Lechertier T, Barber PR, Tavora B, D'Amico G, Jones DT, Vojnovic B, Hodivala-Dilke K. Use of the mouse aortic ring assay to study angiogenesis. Nat Protoc. 2012;7:89-104. doi: 10.1038/nprot.2011.435.
16. Cindrova-Davies T, Sanders DA, Burton GJ, Charnock-Jones DS. Soluble FLT1 sensitizes endothelial cells to inflammatory cytokines by antagonizing VEGF receptor-mediated signalling. Cardiovasc Res. 2011;89:671-679. doi: 10.1093/cvr/cvq346.
17. Kumasawa K, Ikawa M, Kidoya H, Hasuwa H, Saito-Fujita T, Morioka Y, Takakura N, Kimura T, Okabe M. Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model. Proc Natl Acad Sci U S A. 2011;108:1451-1455. doi: 10.1073/pnas.1011293108.