Nervous System Lyme Disease

Clinics in Laboratory Medicine

Volumn 35, Issue 4, 2015, Pages 779-795

  Halperin, John J ^a,b  

^a Overlook Medical Center   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

Diagnosis; Garin Bujadoux Bannwarth syndrome; Lyme disease; Nervous system; Neuroborreliosis; Spinal fluid; Treatment

Indexed keywords

DOXYCYCLINE; BACTERIUM ANTIBODY;

ANTIBODY PRODUCTION; BORRELIA INFECTION; BRAIN INFECTION; CENTRAL NERVOUS SYSTEM; CHRONIC LYME DISEASE; CLINICAL FEATURE; CRANIAL NEUROPATHY; CROSS REACTION; CYTOKINE PRODUCTION; HUMAN; LABORATORY DIAGNOSIS; LYME DISEASE; MONONEUROPATHY; MONONEUROPATHY MULTIPLEX; NERVOUS SYSTEM; NONHUMAN; PATHOPHYSIOLOGY; PATIENT CARE; PERIPHERAL NERVOUS SYSTEM; POSTTREATMENT LYME DISEASE SYNDROME; PRIORITY JOURNAL; RADICULITIS; REVIEW; SENSITIVITY AND SPECIFICITY; SYMPTOM ASSESSMENT; ANIMAL; CEREBROSPINAL FLUID; COMPLICATION; LYME NEUROBORRELIOSIS;

ANIMALS; ANTIBODIES, BACTERIAL; DOXYCYCLINE; HUMANS; LYME NEUROBORRELIOSIS;

EID: 84947488157     PISSN: 02722712     EISSN: 15579832     Source Type: Journal    
DOI: 10.1016/j.cll.2015.07.002     Document Type: Review

References (74)

1. Marist.Poll. Alzheimer's most feared disease. 2012. Available at:. Accessed August 31, 2013. http://maristpoll.marist.edu/1114-alzheimers-most-feared-disease/.
2. Halperin J.J. Lyme disease - neurology, neurobiology and behavior. Clin Infect Dis 2014, 58(9):1267-1272.
3. Pachner A.R. Neurologic manifestations of Lyme disease, the new "great imitator". Rev Infect Dis 1989, 6:S1482-S1486.
4. Logigian E.L., Kaplan R.F., Steere A.C. Successful treatment of Lyme encephalopathy with intravenous ceftriaxone. J Infect Dis 1999, 180(2):377-383.
5. Washington, DC: U.S. Department of Defense, Office of the Assistant Secretary of Defense (Public Affairs); 2002.
6. Margos G., Wilske B., Sing A., et al. Borrelia bavariensis sp. nov. is widely distributed in Europe and Asia. Int J Syst Evol Microbiol 2013, 63(Pt 11):4284-4288.
7. Halperin J.J., Krupp L.B., Golightly M.G., et al. Lyme borreliosis-associated encephalopathy. Neurology 1990, 40:1340-1343.
8. Krupp L.B., Masur D., Schwartz J., et al. Cognitive functioning in late Lyme borreliosis. Arch Neurol 1991, 48:1125-1129.
9. Nadelman R.B., Herman E., Wormser G.P. Screening for Lyme disease in hospitalized psychiatric patients: prospective serosurvey in an endemic area. Mt Sinai J Med 1997, 64(6):409-412.
10. Hassett A.L., Radvanski D.C., Buyske S., et al. Psychiatric comorbidity and other psychological factors in patients with "chronic Lyme disease". Am J Med 2009, 122:843-850.
11. Lantos P.M. Chronic Lyme disease: the controversies and the science. Expert Rev Anti Infect Ther 2011, 9(7):787-797.
12. Wormser G.P., Dattwyler R.J., Shapiro E.D., et al. The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis 2006, 43:1089-1134.
13. Garin C., Bujadoux A. Paralysie par les tiques. J Med Lyon 1922, 71:765-767.
14. Bannwarth A. Chronische lymphocytare meningitis, entzundliche polyneuritis und "rheumatismus". Arch Psychiatr Nervenkr 1941, 113:284-376.
15. Karlsson M., Hovind H.K., Svenungsson B., et al. Cultivation and characterization of spirochetes from cerebrospinal fluid of patients with Lyme borreliosis. J Clin Microbiol 1990, 28(3):473-479.
16. Avery R.A., Frank G., Eppes S.C. Diagnostic utility of Borrelia burgdorferi cerebrospinal fluid polymerase chain reaction in children with Lyme meningitis. Pediatr Infect Dis J 2005, 24(8):705-708.
17. Roberts E.D., Bohm R.P., Lowrie R.C., et al. Pathogenesis of Lyme neuroborreliosis in the rhesus monkey: the early disseminated and chronic phases of disease in the peripheral nervous system. J Infect Dis 1998, 178(3):722-732.
18. Ogrinc K., Lotric-Furlan S., Maraspin V., et al. Suspected early Lyme neuroborreliosis in patients with erythema migrans. Clin Infect Dis 2013, 57(4):501-509.
19. Cerar T., Ogrinc K., Cimperman J., et al. Validation of cultivation and PCR methods for diagnosis of Lyme neuroborreliosis. J Clin Microbiol 2008, 46(10):3375-3379.
20. Meier C., Grahmann F., Engelhardt A., et al. Peripheral nerve disorders in Lyme-Borreliosis. Nerve biopsy studies from eight cases. Acta Neuropathol (Berl) 1989, 79(3):271-278.
21. Vallat J.M., Hugon J., Lubeau M., et al. Tick-bite meningoradiculoneuritis: clinical, electrophysiologic, and histologic findings in 10 cases. Neurology 1987, 37(5):749-753.
22. Halperin J.J., Little B.W., Coyle P.K., et al. Lyme disease - a treatable cause of peripheral neuropathy. Neurology 1987, 37:1700-1706.
23. Aberer E., Brunner C., Suchanek G., et al. Molecular mimicry and Lyme borreliosis: a shared antigenic determinant between Borrelia burgdorferi and human tissue. Ann Neurol 1989, 26(6):732-737.
24. Sigal L.H. Molecular mimicry and Lyme borreliosis. Ann Neurol 1990, 28(2):195-196. [letter].
25. Martin R., Gran B., Zhao Y., et al. Molecular mimicry and antigen-specific T cell responses in multiple sclerosis and chronic CNS Lyme disease. J Autoimmun 2001, 16(3):187-192.
26. Garcia-Monco J.C., Seidman R.J., Benach J.L. Experimental immunization with Borrelia burgdorferi induces development of antibodies to gangliosides. Infect Immun 1995, 63(10):4130-4137.
27. Garcia Monco J.C., Wheeler C.M., Benach J.L., et al. Reactivity of neuroborreliosis patients (Lyme disease) to cardiolipin and gangliosides. J Neurol Sci 1993, 117(1-2):206-214.
28. Luft B.J., Steinman C.R., Neimark H.C., et al. Invasion of the central nervous system by Borrelia burgdorferi in acute disseminated infection. JAMA 1992, 267(10):1364-1367.
29. Ljostad U., Mygland A. CSF B-lymphocyte chemoattractant (CXCL13) in the early diagnosis of acute Lyme neuroborreliosis. J Neurol 2008, 255(5):732-737.
30. Rupprecht T.A., Plate A., Adam M., et al. The chemokine CXCL13 is a key regulator of B cell recruitment to the cerebrospinal fluid in acute Lyme neuroborreliosis. J Neuroinflammation 2009, 6:42.
31. Halperin J.J., Pacheco-Quinto J., Herdt A., et al. [S37.007] serum and CSF cytokines in patients with active CNS Lyme disease, other inflammatory CNS diseases, encephalopathy following treated Lyme disease, other encephalopathies, and normal controls. Am Acad Neurol 2015, Washington, DC.
32. Hammers Berggren S., Hansen K., Lebech A.M., et al. Borrelia burgdorferi-specific intrathecal antibody production in neuroborreliosis: a follow-up study. Neurology 1993, 43(1):169-175.
33. Halperin J.J., Heyes M.P. Neuroactive kynurenines in Lyme borreliosis. Neurology 1992, 42(1):43-50.
34. Strle K., Stupica D., Drouin E.E., et al. Elevated levels of IL-23 in a subset of patients with post-Lyme disease symptoms following erythema migrans. Clin Infect Dis 2014, 58(3):372-380.
35. Soloski M.J., Crowder L.A., Lahey L.J., et al. Serum inflammatory mediators as markers of human Lyme disease activity. PLoS One 2014, 9(4):e93243.
36. Schriefer M.E. Lyme Disease Diagnosis: Serology. Clin Lab Med 2015, in press.
37. Alby K., Capraro G.A. Alternatives to Serologic Testing for Diagnosis of Lyme Disease. Clin Lab Med 2015, in press.
38. Halperin J.J., Luft B.J., Volkman D.J., et al. Lyme neuroborreliosis - peripheral nervous system manifestations. Brain 1990, 113:1207-1221.
39. Henriksson A., Link H., Cruz M., et al. Immunoglobulin abnormalities in cerebrospinal fluid and blood over the course of lymphocytic meningoradiculitis (Bannwarth's syndrome). Ann Neurol 1986, 20:337-345.
40. Stiernstedt G.T., Granstrom M., Hederstedt B., et al. Diagnosis of spirochetal meningitis by enzyme linked immunosorbent assay and indirect immunofluorescence assay in serum and cerebrospinal fluid. J Clin Microbiol 1985, 21:819-825.
41. Hansen K, Lebech A-M. Intrathecal synthesis of Borrelia burgdorferi specific immunoglobulin G, A and M in neuroborreliosis - an antibody capture assay. Paper presented at: IV International Conference on Lyme Borreliosis 1990. Stockholm, Sweden, June 18-21, 1990.
42. Halperin J.J., Luft B.J., Anand A.K., et al. Lyme neuroborreliosis: central nervous system manifestations. Neurology 1989, 39(6):753-759.
43. Steere A.C., Berardi V.P., Weeks K.E., et al. Evaluation of the intrathecal antibody response to Borrelia burgdorferi as a diagnostic test for Lyme neuroborreliosis. J Infect Dis 1990, 161(6):1203-1209.
44. Mygland A., Ljostad U., Fingerle V., et al. EFNS guidelines on the diagnosis and management of European Lyme neuroborreliosis. Eur J Neurol 2010, 17(1):8-16. e11-14.
45. Halperin J.J., Volkman D.J., Wu P. Central nervous system abnormalities in Lyme neuroborreliosis. Neurology 1991, 41:1571-1582.
46. Logigian E.L., Kaplan R.F., Steere A.C. Chronic neurologic manifestations of Lyme disease. N Engl J Med 1990, 323(21):1438-1444.
47. Sanders L. Think like a doctor: mirror, mirror solved. New York Times 2014, 2014.
48. Bacon R.M., Kugeler K.J., Mead P.S. Surveillance for Lyme disease - United States, 1992-2006. MMWR Morb Mortal Wkly Rep 2008, 57(SS10):1-9.
49. England J.D., Bohm R.P., Roberts E.D., et al. Mononeuropathy multiplex in rhesus monkeys with chronic Lyme disease. Ann Neurol 1997, 41(3):375-384.
50. Hopf H.C. Peripheral neuropathy in acrodermatitis chronica atrophicans (Herxheimer). J Neurol Neurosurg Psychiatry 1975, 38(5):452-458.
51. Logigian E.L., Steere A.C. Clinical and electrophysiologic findings in chronic neuropathy of Lyme disease. Neurology 1992, 42(2):303-311.
52. Krishnamurthy K.B., Liu G.T., Logigian E.L. Acute Lyme neuropathy presenting with polyradicular pain, abdominal protrusion, and cranial neuropathy. Muscle Nerve 1993, 16(11):1261-1264.
53. Sibony P., Halperin J., Coyle P., et al. Reactive Lyme serology in patients with optic neuritis and papilledema. J Neuro Ophthal 2005, 25(2):71-82.
54. Blanc F., Ballonzoli L., Marcel C., et al. Lyme optic neuritis. J Neurol Sci 2010, 295:117-119.
55. Djukic M., Larsen J., Lingor P., et al. Unilateral phrenic nerve lesion in Lyme neuroborreliosis. BMC Pulm Med 2013, 13:4.
56. Nord J.A., Karter D. Lyme disease complicated with pseudotumor cerebri. Clin Infect Dis 2003, 37(2):e25-e26.
57. Zemel L. Lyme disease and pseudotumor. Mayo Clin Proc 2000, 75(3):315.
58. Jacobson D.M., Frens D.B. Pseudotumor cerebri syndrome associated with Lyme disease. Am J Ophthalmol 1989, 107(1):81-82.
59. Ackermann R., Rehse K.B., Gollmer E., et al. Chronic neurologic manifestations of erythema migrans borreliosis. Ann N Y Acad Sci 1988, 539:16-23.
60. Ackermann R., Gollmer E., Rehse K.B. Progressive Borrelia encephalomyelitis. Chronic manifestation of erythema chronicum migrans disease of the nervous system. Dtsch Med Wochenschr 1985, 110(26):1039-1042.
61. Halperin J.J., Pass H.L., Anand A.K., et al. Nervous system abnormalities in Lyme disease. Ann N Y Acad Sci 1988, 539:24-34.
62. Cameron D.J., Johnson L.B., Maloney E.L. Evidence assessments and guideline recommendations in Lyme disease: the clinical management of known tick bites, erythema migrans rashes and persistent disease. Expert Rev Anti Infect Ther 2014, 12(9):1103-1135.
63. Seltzer E.G., Gerber M.A., Cartter M.L., et al. Long-term outcomes of persons with Lyme disease. JAMA 2000, 283(5):609-616.
64. Skogman B.H., Croner S., Odkvist L. Acute facial palsy in children-a 2-year follow-up study with focus on Lyme neuroborreliosis. Int J Pediatr Otorhinolaryngol 2003, 67(6):597-602.
65. Shadick N.A., Phillips C.B., Sangha O., et al. Musculoskeletal and neurologic outcomes in patients with previously treated Lyme disease. Ann Intern Med 1999, 131(12):919-926.
66. Wormser G.P., Weitzner E., McKenna D., et al. Long-term assessment of fatigue in patients with culture-confirmed Lyme Disease. Am J Med 2015, 128(2):181-184.
67. Klempner M.S., Hu L.T., Evans J., et al. Two controlled trials of antibiotic treatment in patients with persistent symptoms and a history of Lyme disease. N Engl J Med 2001, 345(2):85-92.
68. Krupp L.B., Hyman L.G., Grimson R., et al. Study and treatment of post Lyme disease (STOP-LD): a randomized double masked clinical trial. Neurology 2003, 60(12):1923-1930.
69. Fallon B.A., Keilp J.G., Corbera K.M., et al. A randomized, placebo-controlled trial of repeated IV antibiotic therapy for Lyme encephalopathy. Neurology 2008, 70:992-1003.
70. Committee on the Diagnostic Criteria for Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Beyond myalgic encephalomyelitis/chronic fatigue syndrome: redefining an illness 2015, The National Academies Press, Washington, DC.
71. Luo N., Johnson J., Shaw J., et al. Self-reported health status of the general adult U.S. population as assessed by the EQ-5D and Health Utilities Index. Med Care 2005, 43(11):1078-1086.
72. Telford S.R., Wormser G.P. Bartonella spp. transmission by ticks not established. Emerg Infect Dis 2010, 16(3):379-384.
73. Dattwyler R.J., Halperin J.J., Volkman D.J., et al. Treatment of late Lyme disease. Lancet 1988, 1:1191-1193.
74. Halperin J.J., Shapiro E.D., Logigian E.L., et al. Practice parameter: treatment of nervous system Lyme disease. Neurology 2007, 69(1):91-102.