Suspected early Lyme neuroborreliosis in patients with erythema migrans

Clinical Infectious Diseases

Volumn 57, Issue 4, 2013, Pages 501-509

  Ogrinc, Katarina ^a   Lotrič Furlan, Stanka ^a   Maraspin, Vera ^a   Lusa, Lara ^b   Cerar, Tjaša ^c   Ružič Sabljič, Eva ^c   Strle, Franc ^a  

^a UNIVERSITY MEDICAL CENTRE LJUBLJANA   (Slovenia)

^b Medical Faculty   (Slovenia)

^c UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Borrelia burgdorferi sensu lato; Cerebrospinal fluid examination; Erythema migrans; Lyme borreliosis; Lyme neuroborreliosis

Indexed keywords

ALBUMIN; ANTIBIOTIC AGENT; GLUCOSE; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; PROTEIN;

ADULT; AGED; ANTIBIOTIC THERAPY; ANTIBODY PRODUCTION; ARTHRALGIA; ARTICLE; BLOOD SAMPLING; BORRELIA AFZELII; BORRELIA BURGDORFERI; CELL COUNT; CENTRAL NERVOUS SYSTEM INFECTION; CEREBROSPINAL FLUID CYTOLOGY; CLINICAL EVALUATION; CLINICAL STUDY; DISEASE DURATION; ERYTHEMA CHRONICUM MIGRANS; FACIAL NERVE PARALYSIS; FEMALE; HEADACHE; HUMAN; LOW BACK PAIN; LUMBAR PUNCTURE; LYME DISEASE; MAJOR CLINICAL STUDY; MALAISE; MALE; NAUSEA; NECK PAIN; PARESTHESIA; PLEOCYTOSIS; PREDICTIVE VALUE; PRIORITY JOURNAL; PROSPECTIVE STUDY; RADICULAR PAIN; SKIN BIOPSY; SKIN DEFECT; SLEEP DISORDER; SYMPTOM; TICK BORNE ENCEPHALITIS FLAVIVIRUS; VERTIGO; VOMITING;

BORRELIA BURGDORFERI SENSU LATO; CEREBROSPINAL FLUID EXAMINATION; ERYTHEMA MIGRANS; LYME BORRELIOSIS; LYME NEUROBORRELIOSIS;

ADULT; AGED; BORRELIA; CEREBROSPINAL FLUID; EARLY DIAGNOSIS; FEMALE; GLOSSITIS, BENIGN MIGRATORY; HUMANS; LYME NEUROBORRELIOSIS; MALE; MIDDLE AGED;

EID: 84880929569     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cit317     Document Type: Article

References (29)

1. Institute of Public Health of the Republic of Slovenia. Health Statistics Yearbook 2010 [in Slovenian]. Available at: http://url.sio.si/ba7. Accessed 20 November 2012.
2. Steere AC. Lyme disease. N Engl J Med 2001; 345:115-25.
3. Strle F, Videčnik J, Zorman P, Cimperman J, Lotrič-Furlan S, Maraspin V. Clinical and epidemiological findings for patients with erythema migrans: comparison of cohorts from the years 1993 and 2000. Wien Klin Wochenschr 2002; 114:493-7.
4. Stanek G, Fingerle V, Hunfeld KP, et al. Lyme borreliosis: clinical case definitions for diagnosis and management in Europe. Clin Microbiol Infect 2011; 17:69-79.
5. Wormser GP, Dattwyler RJ, Shapiro ED, et al. The clinical assessment, treatment, and prevention of Lyme disease, human granulocytic anaplasmosis, and babesiosis: clinical practice guidelines by the Infectious Diseases Society of America. Clin Infect Dis 2006; 43:1089-134.
6. Brouqui P, Bacellar F, Baranton G, et al. Guidelines for the diagnosis of tick-borne bacterial diseases in Europe. Clin Microbiol Infect 2004; 10:1108-32.
7. Mygland A, Ljøstad U, Fingerle V, Rupprecht T, Schmutzhard E, Steiner I. European Federation of Neurological Societies. EFNS guidelines on the diagnosis and management of European Lyme neuroborreliosis. Eur J Neurol 2010; 17:8-16.
8. Reiber H, Peter JB. Cerebrospinal fluid analysis: disease-related data patterns and evaluation programs. J Neurol Sci 2001; 184:101-22.
9. Ružić-Sabljić E, Strle F, Cimperman J, Maraspin V, Lotrič-Furlan S, Pleterski-Rigler D. Characterisation of Borrelia burgdorferi sensu lato strains isolated from patients with skin manifestations of Lyme borreliosis residing in Slovenia. J Med Microbiol 2000; 49:47-53.
10. Preac-Mursic V, Wilske B, Schierz G. European Borrelia burgdorferi isolated from humans and ticks. Culture conditions and antibiotic susceptibility. Zentralb Bakteriol Mikrobiol Hyg A 1986; 263: 112-8.
11. Ružić-Sabljić E, Maraspin V, Lotrič-Furlan S, et al. Characterization of Borrelia burgdorferi sensu lato strains isolated from human material in Slovenia. Wien Klin Wochenschr 2002; 114:544-50.
12. Ružić-Sabljić E, Arnež M, Lotrič-Furlan S, Maraspin V, Cimperman J, Strle F. Genotypic and phenotypic characterisation of Borrelia burgdorferi sensu lato strains isolated from human blood. J Med Microbiol 2001; 50:896-901.
13. Ružić-Sabljić E, Zore A, Strle F. Characterization of Borrelia burgdorferi sensu lato isolates by pulsed-field gel electrophoresis after MluI restriction of genomic DNA. Res Microbiol 2008; 159:441-8.
14. Postic D, Assous MV, Grimont PAV, Baranton G. Diversity of Borrelia burgdorferi sensu lato evidenced by restriction fragment length polymorphism of rrf (5S)-rrl (23S) intergenic spacer amplicons. Int J Syst Bacteriol 1994; 44:743-52.
15. Harrell FE Jr, Lee KL, Pollock BG. Regression models in clinical studies: determining relationships between predictors and response. J Natl Cancer Inst 1988; 80:1199-202.
16. Steyerberg EW. Clinical prediction models. New York: Springer, 2009.
17. Westfall PH, Young SS. Resampling-based multiple testing. New York: Wiley, 1993.
18. Development Core Team (2009). R: a language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing. ISBN 3-900051-07-0, Available at: http://www.R-project. org. Accessed 24 November 2012.
19. Stanek G, Strle F. Lyme borreliosis. Lancet 2003; 362:1639-47.
20. Halperin JJ. Nervous system involvement. In: Halperin JJ, ed. Lyme disease-an evidence-based approach. CAB International, 2011:208-20.
21. Pachner AR, Steiner I. Lyme neuroborreliosis: infection, immunity, and inflammation. Lancet Neurol 2007; 6:544-52.
22. Strle F, Ruzić-Sabljić E, Cimperman J, Lotrič-Furlan S, Maraspin V. Comparison of findings for patients with Borrelia garinii and Borrelia afzelii isolated from cerebrospinal fluid. Clin Infect Dis 2006; 43:704-10.
23. Stiernstedt G, Gustafsson R, Karlsson M, Svenungsson B, Sköldenberg B. Clinical manifestations and diagnosis of neuroborreliosis. Ann N Y Acad Sci 1988; 539:46-55.
24. Pfister HW, Kristoferitsch W, Meier C. Early neurological involvement (Bannwarth's syndrome). In: Weber K, Burgdorfer W, eds. Aspects of Lyme borreliosis. Berlin, Germany: Springer-Verlag, 1993: 152-67.
25. Borg R, Dotevall L, Hagberg L, et al. Intravenous ceftriaxone compared with oral doxycycline for the treatment of Lyme neuroborreliosis. Scand J Infect Dis 2005; 37:449-54.
26. Ljøstad U, Skogvoll E, Eikeland R, et al. Oral doxycycline versus intravenous ceftriaxone for European Lyme neuroborreliosis: a multicentre, noninferiority, double-blind, randomised trial. Lancet Neurol 2008; 7:690-5.
27. Cerar T, Ogrinc K, Strle F, Ružić-Sabljić E. Humoral immune responses in patients with Lyme neuroborreliosis. Clin Vaccine Immunol 2010; 17:645-50.
28. Karlsson M, Hovind-Hougen K, Svenungsson B, Stiernstedt G. Cultivation and characterization of spirochetes from cerebrospinal fluid of patients with Lyme borreliosis. J Clin Microbiol 1990; 28:473-9.
29. Logar M, Ružić-Sabljić E, Maraspin V, et al. Comparison of erythema migrans caused by Borrelia afzelii and Borrelia garinii. Infection 2004; 32:15-9.