Interleukin-27 ameliorates coxsackievirus-B3-induced viral myocarditis by inhibiting Th17 cells Positive-strand RNA viruses

Virology Journal

Volumn 12, Issue 1, 2015, Pages

  Zhu, Hengshan ^a   Lou, Chuang ^b   Liu, Ping ^a  

^a YAN'AN UNIVERSITY   (China)

^b Department of Respiratory Medicine   (China)

Author keywords

CVB3; Interleukin 27; Th17 cells; Viral myocarditis

Indexed keywords

CYTOKINE; GLYCOPROTEIN GP 130; IMMUNOGLOBULIN G; INTERLEUKIN 17; INTERLEUKIN 27; RECOMBINANT INTERLEUKIN 27; IMMUNOLOGIC FACTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; COXSACKIEVIRUS B3; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HEART; HISTOPATHOLOGY; KINETICS; MALE; MOUSE; NONHUMAN; PATHOGENESIS; REAL TIME POLYMERASE CHAIN REACTION; SCORING SYSTEM; SURVIVAL RATE; TH17 CELL; VIRUS MYOCARDITIS; VIRUS NEUTRALIZATION; WEIGHT REDUCTION; ANIMAL; BAGG ALBINO MOUSE; COXSACKIEVIRUS INFECTIONS; DISEASE MODEL; DRUG EFFECTS; ENTEROVIRUS B; IMMUNOLOGY; MYOCARDITIS; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

ANIMALS; COXSACKIEVIRUS INFECTIONS; DISEASE MODELS, ANIMAL; ENTEROVIRUS B, HUMAN; IMMUNOLOGIC FACTORS; INTERLEUKIN-27; MALE; MICE, INBRED BALB C; MYOCARDITIS; SURVIVAL ANALYSIS; TH17 CELLS; TREATMENT OUTCOME;

EID: 84947486382     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/s12985-015-0418-x     Document Type: Article

References (24)

1. Kuhl U, Schultheiss HP. Viral myocarditis: diagnosis, aetiology and management. Drugs. 2009;69(10):1287-302. doi: 10.2165/00003495-200969100-00001.
2. Andreoletti L, Leveque N, Boulagnon C, Brasselet C, Fornes P. Viral causes of human myocarditis. Arch Cardiovasc Dis. 2009;102(6-7):559-68. doi: 10.1016/j.acvd.2009.04.010.
3. Yajima T, Knowlton KU. Viral myocarditis: from the perspective of the virus. Circulation. 2009;119(19):2615-24. doi: 10.1161/CIRCULATIONAHA.108.766022.
4. Reddy J, Massilamany C, Buskiewicz I, Huber SA. Autoimmunity in viral myocarditis. Curr Opin Rheumatol. 2013;25(4):502-8. doi: 10.1097/BOR.0b013e3283620036.
5. Fairweather D, Stafford KA, Sung YK. Update on coxsackievirus B3 myocarditis. Curr Opin Rheumatol. 2012;24(4):401-7. doi: 10.1097/BOR.0b013e328353372d.
6. Pflanz S, Timans JC, Cheung J, Rosales R, Kanzler H, Gilbert J, et al. IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells. Immunity. 2002;16(6):779-90.
7. Pflanz S, Hibbert L, Mattson J, Rosales R, Vaisberg E, Bazan JF, et al. WSX-1 and glycoprotein 130 constitute a signal-transducing receptor for IL-27. J Immunol. 2004;172(4):2225-31.
8. Hall AO, Silver JS, Hunter CA. The immunobiology of IL-27. Adv Immunol. 2012;115:1-44. doi: 10.1016/B978-0-12-394299-9.00001-1.
9. Owaki T, Asakawa M, Morishima N, Hata K, Fukai F, Matsui M, et al. A role for IL-27 in early regulation of Th1 differentiation. J Immunol. 2005;175(4):2191-200.
10. Owaki T, Asakawa M, Fukai F, Mizuguchi J, Yoshimoto T. IL-27 induces Th1 differentiation via p38 MAPK/T-bet- and intercellular adhesion molecule-1/LFA-1/ERK1/2-dependent pathways. J Immunol. 2006;177(11):7579-87.
11. Larousserie F, Charlot P, Bardel E, Froger J, Kastelein RA, Devergne O. Differential effects of IL-27 on human B cell subsets. J Immunol. 2006;176(10):5890-7.
12. Batten M, Li J, Yi S, Kljavin NM, Danilenko DM, Lucas S, et al. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol. 2006;7(9):929-36. doi: 10.1038/ni1375.
13. Stumhofer JS, Laurence A, Wilson EH, Huang E, Tato CM, Johnson LM, et al. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol. 2006;7(9):937-45. doi: 10.1038/ni1376.
14. Awasthi A, Carrier Y, Peron JP, Bettelli E, Kamanaka M, Flavell RA, et al. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat Immunol. 2007;8(12):1380-9. doi: 10.1038/ni1541.
15. Imamichi T, Yang J, Huang DW, Brann TW, Fullmer BA, Adelsberger JW, et al. IL-27, a novel anti-HIV cytokine, activates multiple interferon-inducible genes in macrophages. Aids. 2008;22(1):39-45. doi: 10.1097/QAD.0b013e3282f3356c.
16. Fakruddin JM, Lempicki RA, Gorelick RJ, Yang J, Adelsberger JW, Garcia-Pineres AJ, et al. Noninfectious papilloma virus-like particles inhibit HIV-1 replication: implications for immune control of HIV-1 infection by IL-27. Blood. 2007;109(5):1841-9. doi: 10.1182/blood-2006-02-001578.
17. Kong Q, Xue Y, Wu W, Yang F, Liu Y, Gao M, et al. IL-22 exacerbates the severity of CVB3-induced acute viral myocarditis in IL-17A-deficient mice. Mol Med Rep. 2013;7(4):1329-35. doi: 10.3892/mmr.2013.1323.
18. Li Z, Yue Y, Xiong S. Distinct Th17 inductions contribute to the gender bias in CVB3-induced myocarditis. Cardiovasc Pathol. 2013;22(5):373-82. doi: 10.1016/j.carpath.2013.02.004.
19. Yuan J, Yu M, Lin QW, Cao AL, Yu X, Dong JH, et al. Th17 cells contribute to viral replication in coxsackievirus B3-induced acute viral myocarditis. J Immunol. 2010;185(7):4004-10. doi: 10.4049/jimmunol.1001718.
20. Fan Y, Weifeng W, Yuluan Y, Qing K, Yu P, Yanlan H. Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of coxsackievirus b3-induced viral myocarditis reduces myocardium inflammation. Virol J. 2011;8:17. doi: 10.1186/1743-422X-8-17.
21. Takeda A, Hamano S, Yamanaka A, Hanada T, Ishibashi T, Mak TW, et al. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J Immunol. 2003;170(10):4886-90.
22. Xie Y, Chen R, Zhang X, Chen P, Liu X, Xie Y, et al. The role of Th17 cells and regulatory T cells in Coxsackievirus B3-induced myocarditis. Virology. 2011;421(1):78-84. doi: 10.1016/j.virol.2011.09.006.
23. Diveu C, McGeachy MJ, Boniface K, Stumhofer JS, Sathe M, Joyce-Shaikh B, et al. IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells. J Immunol. 2009;182(9):5748-56. doi: 10.4049/jimmunol.0801162.
24. El-behi M, Ciric B, Yu S, Zhang GX, Fitzgerald DC, Rostami A. Differential effect of IL-27 on developing versus committed Th17 cells. J Immunol. 2009;183(8):4957-67. doi: 10.4049/jimmunol.0900735.