The Role of the Endothelin System in the Vascular Dysregulation Involved in Retinitis Pigmentosa

Journal of Ophthalmology

Volumn 2015, Issue , 2015, Pages

  Sorrentino, Francesco Saverio ^a   Bonifazzi, Claudio ^b   Perri, Paolo ^b  

^a MAGGIORE HOSPITAL   (Italy)

^b UNIVERSITY OF FERRARA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84947465900     PISSN: 2090004X     EISSN: 20900058     Source Type: Journal    
DOI: 10.1155/2015/405234     Document Type: Review

References (73)

1. K. Konieczka, A. J. Flammer, M. Todorova, P. Meyer, and J. Flammer, "Retinitis pigmentosa and ocular blood flow," EPMA Journal, vol. 3, no. 1, article 17, 2012.
2. J. E. Grunwald, A. M. Maguire, and J. Dupont, "Retinal hemodynamics in retinitis pigmentosa," American Journal of Ophthalmology, vol. 122, no. 4, pp. 502-508, 1996.
3. M. Cellini, E. Strobbe, C. Gizzi, and E.C. Campos, "ET-1plasma levels and ocular blood flow in retinitis pigmentosa," Canadian Journal of Physiology and Pharmacology, vol. 88, no. 6, pp. 630-635, 2010.
4. B. Falsini, G. M. Anselmi, D. Marangoni et al., "Subfoveal choroidal blood flow and central retinal function in retinitis pigmentosa," Investigative Ophthalmology & Visual Science, vol. 52, no. 2, pp. 1064-1069, 2011.
5. S. Wolf, H. Pöstgens, B. Bertram, K. Schulte, C. Teping, and M. Reim, "Hemodynamic findings of patients with retinitis pigmentosa," Klinische Monatsblätter für Augenheilkunde, vol. 199, no. 5, pp. 325-329, 1991.
6. M. Cellini, L. Santiago, P. Versura, and R. Caramazza, "Plasma levels of endothelin-1 in retinitis pigmentosa," Ophthalmologica, vol. 216, no. 4, pp. 265-268, 2002.
7. E. M. Vingolo, S. Lupo, P. L. Grenga et al., "Endothelin-1 plasma concentrations in patients with retinitis pigmentosa," Regulatory Peptides, vol. 160, no. 1-3, pp. 64-67, 2010.
8. H. Ohguro, Y. Mashima, and M. Nakazawa, "Low levels of plasma endothelin-1 in patients with retinitis pigmentosa," Clinical Ophthalmology, vol. 4, no. 1, pp. 569-573, 2010.
9. H. Saner, H. Würbel, F. Mahler, J. Flammer, and P. Gasser, "Microvasculatory evaluation of vasospastic syndromes," in Continuous Transcutaneous Monitoring, vol. 7 of Advances in Experimental Medicine and Biology, pp. 215-218, Springer, New York, NY, USA, 1987.
10. U. Guthauser, J. Flammer, and F. Mahler, "The relationship between digital and ocular vasospasm," Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 226, no. 3, pp. 224-226, 1988.
11. F. Mahler, H. Saner, H. Würbel, and J. Flammer, "Local cooling test for clinical capillaroscopy in Raynaud's phenomenon, unstable angina, and vasospastic visual disorders," Vasa, vol. 18, no. 3, pp. 201-204, 1989.
12. J. Flammer and M. Mozaffarieh, "Autoregulation, a balancing act between supply and demand," Canadian Journal of Ophthalmology, vol. 43, no. 3, pp. 317-321, 2008.
13. D. Kavroulaki, K. Gugleta, A. Kochkorov, R. Katamay, J. Flammer, and S. Orgül, "Relation of body mass index and blood pressure to subjective and objective acral temperature," Klinische Monatsblatter fur Augenheilkunde, vol. 226, no. 4, pp. 328-331, 2009.
14. M. Emre, S. Orgül, K. Gugleta, and J. Flammer, "Ocular blood flow alteration in glaucoma is related to systemic vascular dysregulation," British Journal of Ophthalmology, vol. 88, no. 5, pp. 662-666, 2004.
15. K. Gugleta, C. Zawinka, I. Rickenbacher et al., "Analysis of retinal vasodilation after flicker light stimulation in relation to vasospastic propensity," Investigative Ophthalmology and Visual Science, vol. 47, no. 9, pp. 4034-4041, 2006.
16. C. P. Hamel, "Retinitis pigmentosa," Orphanet Journal of Rare Diseases, vol. 1, article 40, 2006.
17. A. T. Fahim, S. P. Daiger, and R. G. Weleber, "Retinitis pigmentosa overview," in Gene Reviews, R. A. Pagon, M. P. Adam, H.H. Ardinger et al., Eds., University of Washington, Seattle, Wash, USA, 1993-2015.
18. S. Ferrari, E. Di Iorio, V. Barbaro, D. Ponzin, F. S. Sorrentino, and F. Parmeggiani, "Retinitis pigmentosa: genes and disease mechanisms," Current Genomics, vol. 12, no. 4, pp. 238-249, 2011.
19. F. Parmeggiani, "Clinics, epidemiology and genetics of retinitis pigmentosa," Current Genomics, vol. 12, no. 4, pp. 236-237, 2011.
20. S. P. Daiger, L. S. Sullivan, and S. J. Bowne, "Genes and mutations causing retinitis pigmentosa," Clinical Genetics, vol. 84, no. 2, pp. 132-141, 2013.
21. J. Flammer, M. Pache, and T. Resink, "Vasospasm, its role in the pathogenesis of diseases with particular reference to the eye," Progress in Retinal and Eye Research, vol. 20, no. 3, pp. 319-349, 2001.
22. J. Flammer, K. Konieczka, and A. J. Flammer, "The primary vascular dysregulation syndrome: implications for eye diseases," EPMA Journal, vol. 4, no. 1, article 14, 2013.
23. V. A. Convertino, "Neurohumoral mechanisms associated with orthostasis: reaffirmation of the significant contribution of the heart rate response," Frontiers in Physiology, vol. 5, article 236, 2014.
24. I. O. Haefliger, P. Meyer, J. Flammer, and T. F. Lüscher, "The vascular endothelium as a regulator of the ocular circulation: a new concept in ophthalmology?" Survey of Ophthalmology, vol. 39, no. 2, pp. 123-132, 1994.
25. I. O. Haefliger, J. Flammer, J.-L. Bény, and T. F. Lüscher, "Endothelium-dependent vasoactive modulation in the ophthalmic circulation," Progress in Retinal and Eye Research, vol. 20, no. 2, pp. 209-225, 2001.
26. J. Flammer and M. Mozaffarieh, "Autoregulation, a balancing act between supply and demand," Canadian Journal of Ophthalmology, vol. 43, no. 3, pp. 317-321, 2008.
27. W. Neuhuber and F. Schrödl, "Autonomic control of the eye and the iris," Autonomic Neuroscience: Basic and Clinical, vol. 165, no. 1, pp. 67-79, 2011.
28. R. M. Kedzierski and M. Yanagisawa, "Endothelin system: the double-edged sword in health and disease," Annual Review of Pharmacology and Toxicology, vol. 41, pp. 851-876, 2001.
29. D. E. Clouthier, K. Hosoda, J. A. Richardson et al., "Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice," Development, vol. 125, no. 5, pp. 813-824, 1998.
30. A. G. Baynash, K. Hosoda, A. Giaid et al., "Interaction of endothelin-3 with endothelin-B receptor is essential for development of epidermal melanocytes and enteric neurons," Cell, vol. 79, no. 7, pp. 1277-1285, 1994.
31. K. Hosoda, R. E. Hammer, J. A. Richardson et al., "Targeted and natural (piebald-lethal)mutations of endothelin-B receptor gene produce megacolon associated with spotted coat color in mice," Cell, vol. 79, no. 7, pp. 1267-1276, 1994.
32. M. Bianchi, J. Adur, S. Takizawa, K. Saida, and V. H. Casco, "Endothelin system in intestinal villi: a possible role of endothelin-2/vasoactive intestinal contractor in the maintenance of intestinal architecture," Biochemical and Biophysical Research Communications, vol. 417, no. 4, pp. 1113-1118, 2012.
33. A. N. Bramall, M. J. Szego, L. R. Pacione et al., "Endothelin- 2-mediated protection of mutant photoreceptors in inherited photoreceptor degeneration," PLoS ONE, vol. 8, no. 2, Article ID e58023, 2013.
34. M. Yanagisawa, H. Kurihara, S. Kimura et al., "A novel potent vasoconstrictor peptide produced by vascular endothelial cells," Nature, vol. 332, no. 6163, pp. 411-415, 1988.
35. T. Masaki, S. Kimura, M. Yanagisawa, and K. Goto, "Molecular and cellular mechanism of endothelin regulation: implications for vascular function," Circulation, vol. 84, no. 4, pp. 1457-1468, 1991.
36. J. R. Vane, R. Botting, and T. Masaki, "Endothelin," Journal of Cardiovascular Pharmacology, vol. 13, supplement 5, pp. S1-S23, 1989.
37. M. S. Simonson and M. J. Dunn, "Cellular signaling by peptides of the endothelin gene family," The FASEB Journal, vol. 4, no. 12, pp. 2989-3000, 1990.
38. T. Miyauchi, M. Yanagisawa, T. Tomizawa et al., "Increased plasma concentrations of endothelin-1 and big endothelin-1 in acute myocardial infarction," The Lancet, vol. 334, no. 8653, pp. 53-54, 1989.
39. K. Takahashi, M. A. Ghatei, H.-C. Lam, D. J. O'Halloran, and S. R. Bloom, "Elevatedplasma endothelin in patients with diabetes mellitus," Diabetologia, vol. 33, no. 5, pp. 306-310, 1990.
40. M. Kohno, K. Yasunari, K.-I. Murakawa et al., "Plasma immunoreactive endothelin in essential hypertension," The American Journal of Medicine, vol. 88, no. 6, pp. 614-618, 1990.
41. A. Lerman, B. S. Edwards, J. W. Hallett, D. M. Heublein, S. M. Sandberg, and J. C. Burnett Jr., "Circulating and tissue endothelin immunore activity in advanced atherosclerosis," The New England Journal of Medicine, vol. 325, no. 14, pp. 997-1001, 1991.
42. M. W. MacCumber, H. D. Jampel, and S. H. Snyder, "Ocular effects of the endothelins: abundant peptides in the eye," Archives of Ophthalmology, vol. 109, no. 5, pp. 705-709, 1991.
43. E. Granstam, L. Wang, and A. Bill, "Ocular effects of endothelin- 1 in the cat," Current Eye Research, vol. 11, no. 4, pp. 325-332, 1992.
44. P. Chollet, F. Malecaze, L. Gouzi, J. L. Arne, and J. Plouet, "Endothelin 1 is a growth factor for corneal endothelium," Experimental Eye Research, vol. 57, no. 5, pp. 595-600, 1993.
45. A. Ripodas, J. A. de Juan, M. Roldán-Pallarés et al., "Localisation of endothelin-1mRNA expression and immunore activity in the retina and optic nerve from human and porcine eye. Evidence for endothelin-1 expression in astrocytes," Brain Research, vol. 912, no. 2, pp. 137-143, 2001.
46. S. Narayan, A. M. Brun, and T. Yorio, "Endothelin-1 distribution and basolateral secretion in the retinal pigment epithelium," Experimental Eye Research, vol. 79, no. 1, pp. 11-19, 2004.
47. H. J. Kaiser, J. Flammer, M. Wenk, and T. Luscher, "Endothelin-1 plasma levels in normal-tension glaucoma. Abnormal response to postural changes," Graefe's Archive for Clinical and Experimental Ophthalmology, vol. 233, no. 8, pp. 484-488, 1995.
48. H. Oku, T. Kida, T. Sugiyama, J. Hamada, B. Sato, and T. Ikeda, "Possible involvement of endothelin-1 and nitric oxide in the pathogenesis of proliferative diabetic retinopathy," Retina, vol. 21, no. 6, pp. 647-651, 2001.
49. M. Roldán-Pallarés, R. Rollín, A. Mediero et al., "Immunoreactive ET-1 in the vitreous humor and epiretinal membranes of patients with proliferative vitreoretinopathy," Molecular Vision, vol. 11, pp. 461-471, 2005.
50. I. Ohguro, H. Ohguro, H. Ohkuro, and M. Nakazawa, "Study of contribution of low level of plasma endothelin-1 concentration to pathogenesis of glaucomatous optic neuropathy," Hirosaki Medical Journal, vol. 57, no. 2-4, pp. 59-64, 2006.
51. A. Finzi, M. Cellini, E. Strobbe, and E. C. Campos, "ET-1 plasma levels, choroidal thickness and multifocal electroretinogram in retinitis pigmentosa," Life Sciences, vol. 118, no. 2, pp. 386-390, 2014.
52. M. J. Grimshaw, J. L. Wilson, and F. R. Balkwill, "Endothelin-2 is a macrophage chemoattractant: implications for macrophage distribution in tumors," European Journal of Immunology, vol. 32, no. 9, pp. 2393-2400, 2002.
53. A. Rattner and J. Nathans, "The genomic response to retinal disease and injury: evidence for endothelin signaling from photoreceptors to glia," Journal of Neuroscience, vol. 25, no. 18, pp. 4540-4549, 2005.
54. L. R. Pacione, M. J. Szego, S. Ikeda, P. M. Nishina, and R. R. McInnes, "Progress toward understanding the genetic and biochemical mechanisms of inherited photoreceptor degenerations," Annual Review of Neuroscience, vol. 26, pp. 657-700, 2003.
55. A. Bringmann and A. Reichenbach, "Role of Muller cells in retinal degenerations," Frontiers in Bioscience, vol. 6, pp. e72-92, 2001.
56. M. García and E. Vecino, "Role of Müller glia in neuroprotection and regeneration in the retina," Histology and Histopathology, vol. 18, no. 4, pp. 1205-1218, 2003.
57. G. P. Lewis and S. K. Fisher, "Up-regulation of glial fibrillary acidic protein in response to retinal injury: its potential role in glial remodeling and a comparison to vimentin expression," International Review of Cytology, vol. 230, pp. 263-290, 2003.
58. C. Ulrich, W.-D. Ulrich, K. Vehlow, and S. Vehlow, "Hemodynamic aspects of retinitis pigmentosa," Fortschritte der Ophthalmologie, vol. 88, no. 6, pp. 642-647, 1991.
59. M. Cellini, R. Lodi, G. L. Possati, M. Sbrocca, D. Pelle, and N. Giubilei, "Color Doppler ultrasonography in retinitis pigmentosa: preliminary study," Journal Français d'Ophtalmologie, vol. 20, no. 9, pp. 659-663, 1997.
60. E. Strobbe, M. Cellini, M. Fresina, and E. C. Campos, "ET-1 plasma levels, aqueous flare, and choroidal thickness in patients with retinitis pigmentosa," Journal of Ophthalmology, vol. 2015, Article ID 292615, 6 pages, 2015.
61. K. Polak, V. Petternel, A. Luksch et al., "Effect of endothelin and BQ123 on ocular blood flow parameters in healthy subjects," Investigative Ophthalmology & Visual Science, vol. 42, no. 12, pp. 2949-2956, 2001.
62. K. Polak, A. Luksch, B. Frank, K. Jandrasits, E. Polska, and L. Schmetterer, "Regulation of human retinal blood flow by endothelin-1," Experimental Eye Research, vol. 76, no. 5, pp. 633-640, 2003.
63. D. T. Hartong, E. L. Berson, and T. P. Dryja, "Retinitis pigmentosa," The Lancet, vol. 368, no. 9549, pp. 1795-1809, 2006.
64. J. L. Stone, W. E. Barlow, M. S. Humayun, E. De Juan Jr., and A. H. Milam, "Morphometric analysis of macular photoreceptors and ganglion cells in retinas with retinitis pigmentosa," Archives of Ophthalmology, vol. 110, no. 11, pp. 1634-1639, 1992.
65. 2 in the retina of anesthetized miniature pigs in normoxia and hyperoxia," Experimental Eye Research, vol. 49, no. 3, pp. 347-360, 1989.
66. S. Dallinger, G. T. Dorner, R. Wenzel et al., "Endothelin- 1 contributes to hyperoxia-induced vasoconstriction in the human retina," Investigative Ophthalmology and Visual Science, vol. 41, no. 3, pp. 864-869, 2000.
67. M. Shihara, Y. Hirooka, N. Hori et al., "Endothelin-1 increases the neuronal activity and augments the responses to glutamate in the NTS," The American Journal of Physiology-Regulatory Integrative and Comparative Physiology, vol. 275, no. 2, pp. R658-R665, 1998.
68. T. Kobayashi, H. Oku, M. Fukuhara et al., "Endothelin- 1 enhances glutamate-induced retinal cell death, possibly through ETA receptors," Investigative Ophthalmology & Visual Science, vol. 46, no. 12, pp. 4684-4690, 2005.
69. B receptor in retinal ganglion cell death in glaucoma," Canadian Journal of Physiology and Pharmacology, vol. 86, no. 6, pp. 380-393, 2008.
70. V. Marigo, "Programmed cell death in retinal degeneration: targeting apoptosis in photoreceptors as potential therapy for retinal degeneration," Cell Cycle, vol. 6, no. 6, pp. 652-655, 2007.
71. Z.-Y. Li, D. E. Possin, and A.H. Milam, "Histopathology of bone spicule pigmentation in retinitis pigmentosa," Ophthalmology, vol. 102, no. 5, pp. 805-816, 1995.
72. K. Komeima, B. S. Rogers, and P. A. Campochiaro, "Antioxidants slow photoreceptor cell death in mousemodels of retinitis pigmentosa," Journal of Cellular Physiology, vol. 213, no. 3, pp. 809-815, 2007.
73. C. Martínez-Fernández de la Cámara, D. Salom, M. D. Sequedo et al., "Altered antioxidant-oxidant status in the aqueous humor and peripheral blood of patients with retinitis pigmentosa," PLoS ONE, vol. 8, no. 9, Article ID e74223, 2013.