The AP-3 adaptor complex mediates sorting of yeast and mammalian PQ-loop-family basic amino acid transporters to the vacuolar/lysosomal membrane

Scientific Reports

Volumn 5, Issue , 2015, Pages

  Llinares, Elisa ^a   Barry, Abdoulaye Oury ^a   André, Bruno ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; AMINO ACID TRANSPORTER; SACCHAROMYCES CEREVISIAE PROTEIN;

CELL VACUOLE; CHEMISTRY; ENDOSOME; HELA CELL LINE; HUMAN; LYSOSOME; METABOLISM; PROTEIN MOTIF; SACCHAROMYCES CEREVISIAE;

ADAPTOR PROTEIN COMPLEX 3; AMINO ACID MOTIFS; AMINO ACID TRANSPORT SYSTEMS; ENDOSOMES; HELA CELLS; HUMANS; LYSOSOMES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; VACUOLES;

EID: 84947460196     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep16665     Document Type: Article

References (40)

1. Gahl, W. A., Thoene, J. G., & Schneider, J. A. Cystinosis. N. Engl. J. Med. 347, 111-121 (2002
2. Town, M., et al. A novel gene encoding an integral membrane protein is mutated in nephropathic cystinosis. Nat. Genet. 18, 319-324 (1998
3. Kalatzis, V., Cherqui, S., Antignac, C., & Gasnier, B. Cystinosin, the protein defective in cystinosis, is a H(+ )-driven lysosomal cystine transporter. EMBO J. 20, 5940-5949 (2001
4. Thoene, J. G., Oshima, R. G., Crawhall, J. C., Olson, D. L., & Schneider, J. A. Cystinosis. Intracellular cystine depletion by aminothiols in vitro and in vivo. J. Clin. Invest. 58, 180-189 (1976
5. Pisoni, R. L., Thoene, J. G., & Christensen, H. N. Detection and characterization of carrier-mediated cationic amino acid transport in lysosomes of normal and cystinotic human fibroblasts. Role in therapeutic cystine removal?. J. Biol. Chem. 260, 4791-4798 (1985
6. Jezegou, A., et al. Heptahelical protein PQLC2 is a lysosomal cationic amino acid exporter underlying the action of cysteamine in cystinosis therapy. Proc. Natl. Acad. Sci. USA 109, E3434-43 (2012
7. Chen, L.-Q., et al. Sugar transporters for intercellular exchange and nutrition of pathogens. Nature 468, 527-532 (2010
8. Xuan, Y. H., et al. Functional role of oligomerization for bacterial and plant SWEET sugar transporter family. Proc. Natl. Acad. Sci. USA 110, E3685-94 (2013
9. Bricker, D. K., et al. A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans. Science 337, 96-100 (2012
10. Xu, Y., et al. Structures of bacterial homologues of SWEET transporters in two distinct conformations. Nature 515, 448-452 (2014
11. Brohee, S., Barriot, R., Moreau, Y., & Andre, B. YTPdb: a wiki database of yeast membrane transporters. Biochim. Biophys. Acta 1798, 1908-1912 (2010
12. Gao, X.-D., Wang, J., Keppler-Ross, S., & Dean, N. ERS1 encodes a functional homologue of the human lysosomal cystine transporter. FEBS J. 272, 2497-2511 (2005
13. Gerrard, S. R., Levi, B. P., & Stevens, T. H. Pep12p is a multifunctional yeast syntaxin that controls entry of biosynthetic, endocytic and retrograde traffic into the prevacuolar compartment. Traffic 1, 259-269 (2000
14. Dell?Angelica, E. C. AP-3-dependent trafficking and disease: the first decade. Curr. Opin. Cell Biol. 21, 552-559 (2009
15. Bonifacino, J. S., & Traub, L. M. Signals for sorting of transmembrane proteins to endosomes and lysosomes. Annu. Rev. Biochem. 72, 395-447 (2003
16. Darsow, T., Burd, C. G., & Emr, S. D. Acidic di-leucine motif essential for AP-3-dependent sorting and restriction of the functional specificity of the Vam3p vacuolar t-SNARE. J. Cell Biol. 142, 913-922 (1998
17. Li, M., Rong, Y., Chuang, Y.-S., Peng, D., & Emr, S. D. Ubiquitin-Dependent Lysosomal Membrane Protein Sorting and Degradation. Mol. Cell 57, 467-478 (2015
18. Piper, R. C., Cooper, A. A., Yang, H., & Stevens, T. H. VPS27 controls vacuolar and endocytic traffic through a prevacuolar compartment in Saccharomyces cerevisiae. J. Cell Biol. 131, 603-617 (1995
19. Janvier, K., & Bonifacino, J. S. Role of the endocytic machinery in the sorting of lysosome-Associated membrane proteins. Mol. Biol. Cell 16, 4231-4242 (2005
20. Cowles, C. R., Odorizzi, G., Payne, G. S., & Emr, S. D. The AP-3 adaptor complex is essential for cargo-selective transport to the yeast vacuole. Cell 91, 109-118 (1997
21. Stepp, J. D., Huang, K., & Lemmon, S. K. The yeast adaptor protein complex, AP-3, is essential for the efficient delivery of alkaline phosphatase by the alternate pathway to the vacuole. J. Cell Biol. 139, 1761-1774 (1997
22. Vowels, J. J., & Payne, G. S. A dileucine-like sorting signal directs transport into an AP-3-dependent, clathrin-independent pathway to the yeast vacuole. EMBO J. 17, 2482-2493 (1998
23. Sun, B., Chen, L., Cao, W., Roth, A. F., & Davis, N. G. The yeast casein kinase Yck3p is palmitoylated, then sorted to the vacuolar membrane with AP-3-dependent recognition of a YXXPhi adaptin sorting signal. Mol. Biol. Cell 15, 1397-1406 (2004
24. Pokrzywa, W., Guerriat, B., Dodzian, J., & Morsomme, P. Dual sorting of the Saccharomyces cerevisiae vacuolar protein Sna4p. Eukaryotic Cell 8, 278-286 (2009
25. Renard, H.-F., Demaegd, D., Guerriat, B., & Morsomme, P. Efficient ER exit and vacuole targeting of yeast Sna2p require two tyrosine-based sorting motifs. Traffic 11, 931-946 (2010
26. Berger, A. C., et al. The subcellular localization of the Niemann-Pick Type C proteins depends on the adaptor complex AP-3. J Cell Sci 120, 3640-3652 (2007
27. Segarra, V. A., Boettner, D. R., & Lemmon, S. K. Atg27 Tyrosine Sorting Motif is Important for Its Trafficking and Atg9 Localization. Traffic (2014), doi: 10.1111/tra.12253
28. Lauwers, E., Erpapazoglou, Z., Haguenauer-Tsapis, R., & Andre, B. The ubiquitin code of yeast permease trafficking. Trends Cell Biol. 20, 196-204 (2010
29. Odorizzi, G., Cowles, C. R., & Emr, S. D. The AP-3 complex: a coat of many colours. Trends Cell Biol. 8, 282-288 (1998
30. Pedrazzini, E., Komarova, N. Y., Rentsch, D., & Vitale, A. Traffic routes and signals for the tonoplast. Traffic 14, 622-628 (2013
31. Le Borgne, R., Alconada, A., Bauer, U., & Hoflack, B. The mammalian AP-3 adaptor-like complex mediates the intracellular transport of lysosomal membrane glycoproteins. J. Biol. Chem. 273, 29451-29461 (1998
32. Dell?Angelica, E. C., Shotelersuk, V., Aguilar, R. C., Gahl, W. A., & Bonifacino, J. S. Altered trafficking of lysosomal proteins in Hermansky-Pudlak syndrome due to mutations in the beta 3A subunit of the AP-3 adaptor. Mol. Cell 3, 11-21 (1999
33. Theos, A. C., et al. Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes. Mol. Biol. Cell 16, 5356-5372 (2005
34. Sitaram, A., et al. Differential recognition of a dileucine-based sorting signal by AP-1 and AP-3 reveals a requirement for both BLOC-1 and AP-3 in delivery of OCA2 to melanosomes. Mol. Biol. Cell 23, 3178-3192 (2012
35. Andrzejewska, Z., et al. Lysosomal targeting of cystinosin requires AP-3. Traffic 16, 712-726 (2015
36. Jacobs, P., Jauniaux, J. C., & Grenson, M. A cis-dominant regulatory mutation linked to the argB-ArgC gene cluster in Saccharomyces cerevisiae. J. Mol. Biol. 139, 691-704 (1980
37. Nikko, E., Marini, A. M., & Andre, B. Permease recycling and ubiquitination status reveal a particular role for Bro1 in the multivesicular body pathway. J. Biol. Chem. 278, 50732-50743 (2003
38. Emr, S. D., Schauer, I., Hansen, W., Esmon, P., & Schekman, R. Invertase beta-galactosidase hybrid proteins fail to be transported from the endoplasmic reticulum in Saccharomyces cerevisiae. Mol. Cell. Biol. 4, 2347-2355 (1984
39. Bonneaud, N., et al. A family of low and high copy replicative, integrative and single-stranded S. cerevisiae/E. coli shuttle vectors. Yeast 7, 609-615 (1991
40. Mumberg, D., Muller, R., & Funk, M. Regulatable promoters of Saccharomyces cerevisiae: comparison of transcriptional activity and their use for heterologous expression. Nucleic Acids Res. 22, 5767-5768 (1994