A novel locus in the oxidative stress-related gene ALOX12 moderates the association between PTSD and thickness of the prefrontal cortex

Psychoneuroendocrinology

Volumn 62, Issue , 2015, Pages 359-365

  Miller, Mark W ^a,b   Wolf, Erika J ^a,b   Sadeh, Naomi ^a,b   Logue, Mark ^a,b,c   Spielberg, Jeffrey M ^a,b   Hayes, Jasmeet P ^a,b   Sperbeck, Emily ^b   Schichman, Steven A ^d   Stone, Angie ^d   Carter, Weleetka C ^d   Humphries, Donald E ^a   Milberg, William ^a,e   McGlinchey, Regina ^a,e  

^a VA BOSTON HEALTHCARE SYSTEM   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^d CENTRAL ARKANSAS VETERANS HEALTHCARE SYSTEM   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

ALOX12; Cortical thickness; Factor analysis; Genetic association analysis; Oxidative stress; Posttraumatic stress disorder

Indexed keywords

ADULT; ALOX 12 GENE; ALOX 15 GENE; ANTERIOR CINGULATE; ARTICLE; CONTROLLED STUDY; CORTICAL THICKNESS (BRAIN); DISEASE SEVERITY; FEMALE; GENE; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC VARIABILITY; HUMAN; LEFT HEMISPHERE; MAJOR CLINICAL STUDY; MALE; MEDIAL ORBITOFRONTAL CORTEX; MIDDLE FRONTAL GYRUS; NEUROIMAGING; OXIDATIVE STRESS; POSTTRAUMATIC STRESS DISORDER; PREFRONTAL CORTEX; PRIORITY JOURNAL; RIGHT HEMISPHERE; SINGLE NUCLEOTIDE POLYMORPHISM; SUPERIOR FRONTAL GYRUS; GENETIC ASSOCIATION STUDY; GENETICS; MIDDLE AGED; PATHOLOGY; VETERAN; YOUNG ADULT;

ALOX12 PROTEIN, HUMAN; ALOX15 PROTEIN, HUMAN; ARACHIDONATE 12 LIPOXYGENASE; ARACHIDONATE 15 LIPOXYGENASE;

ADULT; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; FEMALE; GENETIC ASSOCIATION STUDIES; HUMANS; MALE; MIDDLE AGED; OXIDATIVE STRESS; POLYMORPHISM, SINGLE NUCLEOTIDE; PREFRONTAL CORTEX; STRESS DISORDERS, POST-TRAUMATIC; VETERANS; YOUNG ADULT;

EID: 84947442936     PISSN: 03064530     EISSN: 18733360     Source Type: Journal    
DOI: 10.1016/j.psyneuen.2015.09.003     Document Type: Article

References (38)

1. Bendani M.K., Palluy O., Cook-Moreau J., Beneytout J.L., Rigaud M., Vallat J.M. Localization of 12-lipoxygenase mRNA in cultured oligodendrocytes and astrocytes by in situ reverse transcriptase and polymerase chain reaction. Neurosci. Lett. 1995, 189:159-162.
2. Blake D.D., Weathers F.W., Nagy L.M. A clinician rating scale for assessing current and lifetime PTSD: the CAPS-I. Behav. Ther. 1993, 18:187-188.
3. Bush G., Luu P., Posner M.I. Cognitive and emotional influences in anterior cingulate cortex. Trends Cogn. Sci. 2000, 4:215-222.
4. Chen C.-H., Fiecas M., Gutiérrez E.D., Panizzon M.S., Eyler L.T., Vuoksimaa E., Thompson W.K., Fennema-Notestine C., Haglar D.J., Jernigan T.L., Neale M.C., Franz C.E., Lyons M.J., Fischl B., Tsuang M.T., Dale A.M., Kremen W.S. Genetic topography of brain morphology. Proc. Natl. Acad. Sci. U. S. A. 2013, 110:17089-17094.
5. Chen C.-H., Gutierrez E.D., Thompson W., Panizzon M.S., Jernigan T.L., Eyler L.T., Fennema-Notestine C., Jak A.J., Neale M.C., Franz C.E., Lyons M.J., Grant M.D., Fischl B., Seidman L.J., Tsuang M.T., Kremen W.S., Dale A.M. Hierarchical genetic organization of human cortical surface area. Science 2012, 335:1634-1636.
6. Chen Z.J., He Y., Rosa-Neto P., Germann J., Evans A.C. Revealing modular architecture of human brain structural networks by using cortical thickness from MRI. Cereb. Cortex 2008, 18:2374-2381.
7. Corbo V., Salat D.H., Amick M.M., Leritz E.C., Milberg W.P., McGlinchey R.E. Reduced cortical thickness in veterans exposed to early life trauma. Psychiatry Res.: Neuroimaging 2014, 223:53-60.
8. Delgado M.R., Nearing K.I., LeDoux J.E., Phelps E.A. Neural circuitry underlying the regulation of conditioned fear and its relation to extinction. Neuron 2008, 59:829-838.
9. Etkin A., Egner T., Peraza D.M., Kandel E.R., Hirsch J. Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activity in the amygdala. Neuron 2006, 51:871-882.
10. First M.B., Spitzer R.L., Gibbon M., Williams J. Structured Clinical Interview for Axis I DSM-IV Disorders 1994, New York Psychiatric Institute, Department of Biometrics Research, New York.
11. Fischl B., Dale A.M. Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proc. Natl. Acad. Sci. U. S. A 2000, 97:11050-11055.
12. Giannopoulos P.F., Joshi Y.B., Chu J., Pratico D. The 12-15-lipoxygenase is a modulator of Alzheimer's related tau pathology in vivo. Aging Cell 2013, 12:1082-1090.
13. Grafton S.T., Mazziotta J.C., Woods R.P., Phelps M.E. Human functional anatomy of visually guided finger movements. Brain 1992, 115:565-587.
14. Hovatta I., Juhila J., Donner J. Oxidative stress in anxiety and comorbid disorders. Neurosci. Res. 2010, 68:261-275.
15. Huret J.-L., Ahmad M., Arsaban M., Bernheim A., Cigna J., Desangles F., Guignard J.-C., Jacquemot-Perbal M.-C., Labarussias M., Leberre V., Malo A., Morel-Pair C., Mossafa H., Potier J.-C., Texier G., Viguié F., Yau Chun Wan-Senon S., Zasadzinski A., Dessen P. Atlas of genetics and cytogenetics in oncology and haematology in 2013. Nucleic Acids Res. 2013, 41:D920-D924. (Database issue).
16. Kim T., Kim H.J., Park J.K., Kim J.W., Chung J.H. Association between polymorphisms of arachidonate 12-lipoxygenase (ALOX12) and schizophrenia in a Korean population. Behav. Brain Funct. 2010, 6(1). 4.
17. Kühn S., Gallinat J. Gray matter correlates of posttraumatic stress disorder: a quantitative meta-analysis. Biol. Psychiatry 2013, 73:70-74.
18. Lerch J.P., Worsley K., Shaw W.P., Greenstein D.K., Lenroot R.K., Giedd J., Evans A.C. Mapping anatomical correlations across cerebral cortex (MACACC) using cortical thickness from MRI. Neuroimage 2006, 31:993-1003.
19. Li J., O W., Li W., Jiang Z.G., Ghanbari H.A. Oxidative stress and neurodegenerative disorders. Int. J. Mol. Sci. 2013, 14:24438-24475.
20. Li Y., Maher P., Schubert D. A role for 12-lipoxygenase in nerve cell death caused by glutathione depletion. Neuron 1997, 19:453-463.
21. Li J., Wang H., Rosenberg P.A. Vitamin K prevents oxidative cell death by inhibiting activation of 12-lipoxygenase in developing oligodendrocytes. J. Neurosci. Res. 2009, 87:1997-2005.
22. Lindemer E.R., Salat D.H., Leritz E.C., McGlinchey R.E., Milberg W.P. Reduced cortical thickness with increased lifetime burden of PTSD in OEF-OIF veterans and the impact of comorbid TBI. Neuroimage Clin. 2013, 2:601-611.
23. Mesulam M. Principles of Behavioral and Cognitive Neurology 2000, Oxford University Press, New York.
24. Miller M.W., Sadeh N. Traumatic stress, oxidative stress and posttraumatic stress disorder: neurodegeneration and the accelerated-aging hypothesis. Mol. Psychiatry 2014, 19:1156-1162.
25. Narr K.L., Bilder R.M., Toga A.W., Woods R.P., Rex D.E., Szeszko P.R., Robinson D., Sevy S., Gunduz-Bruce H., Wang Y.-P., DeLuca H., Thompson P.M. Mapping cortical thickness and gray matter concentration in first episode schizophrenia. Cereb. Cortex 2005, 15:708-719.
26. O'Leary D.D., Chou S.J., Sahara S. Area patterning of the mammalian cortex. Neuron 2007, 56:252-269.
27. Pallast S., Arai K., Ziaoying W., Lo E.H., Leyen K. 12/15-Lipoxygenase targets neuronal mitochondria under oxidative stress. J. Neurochem. 2009, 111:882-889.
28. Palta P., Samuel L.J., Miller E.R., Szanton S.L. Depression and oxidative stress results from a meta-analysis of observational studies. Psychosom. Med. 2014, 76:12.
29. Patel R., Spreng R.N., Shin L.M., Girard T.A. Neurocircuitry models of posttraumatic stress disorder and beyond: a meta-analysis of functional neuroimaging studies. Neurosci. Biobehav. Rev. 2012, 36:2130-2142.
30. Practicò D., Zhukareva V., Yao Y., Uryu K., Funk C.D., Lawson J.A., Trojanowski J.Q., Lee V.M.-Y. 12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress. Am. J. Pathol. 2004, 164:1655-1662.
31. Price A.L., Patterson N.J., Plenge R.M., Weinblatt M.E., Shadick N.A., Reich D. Principal components analysis corrects for stratification in genome-wide association studies. Nat. Genet. 2006, 38:904-909.
32. Purcell S., Neale B., Todd-Brown K., Thomas L., Ferreira M.A.R., Bender D., Maller J., Sklar P., de Bakker P.I.W., Daly M.J., Sham P.C. PLINK: A tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 2007, 81:559-575.
33. Rimol L.M., Panizzon M.S., Fennema-Notestine C., Eyler L.T., Fischl B., Franz C.E., Hagler D.J., Lyons M.J., Neale M.C., Pacheco J., Perry M.E., Schmitt J.E., Grant M.D., Seidman L.J., Thermenos H.W., Tsuang M.T., Eisen S.A., Kremen W.S., Dale A.M. Cortical thickness is influenced by regionally-specific genetic factors. Biol. Psychiatry 2010, 67:493-499.
34. Schiavone S., Jaquet V., Trabace L., Krause K. Severe life stress and oxidative stress in the brain: from animal models to human pathology. Antioxid. Redox Signal. 2013, 18:1475-1490.
35. Seiler A., Schneider M., Förster H., Roth S., Wirth E.K., Culmsee C., Plesnila N., Kremmer E., Rådmark O., Wurst W., Bornkamm G.W., Schweizer U., Conrad M. Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent-and AIF-mediated cell death. Cell Metab. 2008, 8:237-248.
36. Wilson C.B., McLaughlin L.D., Nair A., Ebenezer P.J., Dange R., Francis J. Inflammation and oxidative stress are elevated in the brain, blood, and adrenal glands during the progression of post-traumatic stress disorder in a predator exposure animal model. PLoS One 2013, 8:e76146.
37. Yao Y., Clark C.M., Trojanowski J.Q., Lee V.M., Practico D. Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment. Ann. Neurol. 2005, 58:623-626.
38. Yigitkanli K., Pekcec A., Karatas H., Pallast S., Mandeville E., Joshi N., Smirnova N., Gazaryan I., Ratan R.R., Witztum J.L., Montaner J., Holman T.R., Lo E.H., van Leyen K. Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke. Ann. Neurol. 2013, 73:129-135.