Rational design of thermostable vaccines by engineered peptide-induced virus selfbiomineralization under physiological conditions

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 19, 2013, Pages 7619-7624

  Wang, Guangchuan ^a,b   Cao, Rui Yuan ^b   Chen, Rong ^c   Mo, Lijuan ^d   Han, Jian Feng ^b   Wang, Xiaoyu ^b,e   Xu, Xurong ^e   Jiang, Tao ^b   Deng, Yong Qiang ^b   Lyu, Ke ^c   Zhu, Shun Ya ^b   Qin, E De ^b   Tang, Ruikang ^a,e   Qin, Cheng Feng ^b  

^a ZHEJIANG UNIVERSITY   (China)

^b BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

^c INSTITUTE PASTEUR OF SHANGHAI   (China)

^d ZHEJIANG UNIVERSITY   (China)

^e ZHEJIANG UNIVERSITY   (China)

Author keywords

Genetic engineering; Shell; Vaccine design

Indexed keywords

CALCIUM PHOSPHATE; LIVE VACCINE; UNCLASSIFIED DRUG; VIRUS NUCLEATING PEPTIDE; VIRUS PROTEIN;

ARTICLE; BIOMIMETICS; BIOMINERALIZATION; DRUG DESIGN; DRUG STABILITY; DRUG STORAGE; ENTEROVIRUS 71; ENVIRONMENTAL TEMPERATURE; GENETIC ENGINEERING; HEAT TREATMENT; IMMUNOGENICITY; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVERSE GENETICS; STORAGE TEMPERATURE; THERMOSTABILITY; VIRUS CAPSID; VIRUS CHARACTERIZATION; VIRUS MORPHOLOGY; VIRUS STRAIN;

GENETIC ENGINEERING; SHELL; VACCINE DESIGN;

ANIMALS; CERCOPITHECUS AETHIOPS; ENTEROVIRUS A, HUMAN; GENETIC ENGINEERING; HUMANS; IMMUNIZATION; MICE; MICE, INBRED BALB C; PEPTIDES; PROTEIN ENGINEERING; TEMPERATURE; VERO CELLS; VIRAL VACCINES;

EID: 84877316692     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1300233110     Document Type: Article

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