Polymer/metal nanocomposites for biomedical applications

Materials Science and Engineering C

Volumn 60, Issue , 2016, Pages 195-203

  Zare, Yasser ^a   Shabani, Iman ^a  

^a AMIRKABIR UNIVERSITY OF TECHNOLOGY   (Iran)

Author keywords

Antimicrobial effect; Biomedical application; Conductive device; Polymer metal nanocomposite; Sensor

Indexed keywords

CONDUCTIVE MATERIALS; FUNCTIONAL POLYMERS; MEDICAL APPLICATIONS; METAL NANOPARTICLES; METALLIC MATRIX COMPOSITES; NANOCOMPOSITES; SENSORS;

ANTI-MICROBIAL EFFECTS; BIOMEDICAL APPLICATIONS; BIOMEDICAL PRODUCTS; CONDUCTIVE DEVICE; INDUSTRIAL COMMUNITIES; NANOFILLER; OPTICAL CHARACTERISTICS;

POLYMER MATRIX COMPOSITES;

ANTIINFECTIVE AGENT; METAL NANOPARTICLE; NANOCOMPOSITE; POLYMER;

ANTI-INFECTIVE AGENTS; METAL NANOPARTICLES; NANOCOMPOSITES; POLYMERS;

EID: 84947295905     PISSN: 09284931     EISSN: 18730191     Source Type: Journal    
DOI: 10.1016/j.msec.2015.11.023     Document Type: Review

References (105)

1. S.P. Victor, and J. Muthu Bioactive, mechanically favorable, and biodegradable copolymer nanocomposites for orthopedic applications Mater. Sci. Eng. C 39 2014 150 160
2. E. Ritzhaupt-Kleissl, J. Boehm, J. Hausselt, and T. Hanemann Thermoplastic polymer nanocomposites for applications in optical devices Mater. Sci. Eng. C 26 2006 1067 1071
3. K. Fukushima, D. Tabuani, and G. Camino Nanocomposites of PLA and PCL based on montmorillonite and sepiolite Mater. Sci. Eng. C 29 2009 1433 1441
4. F. Vitale, L. Mirenghi, E. Piscopiello, G. Pellegrini, E. Trave, G. Mattei, I. Fratoddi, M. Russo, L. Tapfer, and P. Mazzoldi Gold nanoclusters-organometallic polymer nanocomposites: synthesis and characterization Mater. Sci. Eng. C 27 2007 1300 1304
5. M. Norouzi, Y. Zare, and P. Kiany Nanoparticles as effective flame retardants for natural and synthetic textile polymers: application, mechanism, and optimization Polym. Rev. 2015 1 30
6. Y. Zare Determination of polymer-nanoparticles interfacial adhesion and its role in shape memory behavior of shape memory polymer nanocomposites Int. J. Adhes. Adhes. 54 2014 67 71
7. Y. Zare New models for yield strength of polymer/clay nanocomposites Compos. Part B 73 2015 111 117
8. Y. Zare 3Recycled Polymers: Properties and Applications 2015 (Chapter 3)
9. 3 ternary nanocomposite using composite theories J. Appl. Polym. Sci. 123 2012 2309 2319
10. 3 ternary nanocomposite J. Appl. Polym. Sci. 124 2012 1225 1233
11. M.K. Shukla, R.P. Singh, C. Reddy, and B. Jha Synthesis and characterization of agar-based silver nanoparticles and nanocomposite film with antibacterial applications Bioresour. Technol. 107 2012 295 300
12. D.H. Williams, and B. Bardsley The vancomycin group of antibiotics and the fight against resistant bacteria Angew. Chem. Int. Ed. 38 1999 1172 1193
13. N.G. Patel, A. Kumar, V.N. Jayawardana, C.D. Woodworth, and P.A. Yuya Fabrication, nanomechanical characterization, and cytocompatibility of gold-reinforced chitosan bio-nanocomposites Mater. Sci. Eng. C 44 2014 336 344
14. L. Tamayo, P. Zapata, N. Vejar, M. Azócar, M. Gulppi, X. Zhou, G. Thompson, F. Rabagliati, and M. Páez Release of silver and copper nanoparticles from polyethylene nanocomposites and their penetration into Listeria monocytogenes Mater. Sci. Eng. C 40 2014 24 31
15. M. Knite, V. Teteris, B. Polyakov, and D. Erts Electric and elastic properties of conductive polymeric nanocomposites on macro-and nanoscales Mater. Sci. Eng. C 19 2002 15 19
16. U. Chatterjee, S.K. Jewrajka, and S. Guha Dispersion of functionalized silver nanoparticles in polymer matrices: stability, characterization, and physical properties Polym. Compos. 30 2009 827 834
17. H.-Y. Mi, Z. Li, L.-S. Turng, Y. Sun, and S. Gong Silver nanowire/thermoplastic polyurethane elastomer nanocomposites: thermal, mechanical, and dielectric properties Mater. Des. 56 2014 398 404
18. W.K. Son, J.H. Youk, and W.H. Park Antimicrobial cellulose acetate nanofibers containing silver nanoparticles Carbohydr. Polym. 65 2006 430 434
19. F. Carrasco, J. Gámez-Pérez, O. Santana, and M.L. Maspoch Processing of poly (lactic acid)/organomontmorillonite nanocomposites: microstructure, thermal stability and kinetics of the thermal decomposition Chem. Eng. J. 178 2011 451 460
20. 2 nanocomposite sorbent for arsenate removal Chem. Eng. J. 268 2015 362 370
21. Y. Zare A simple technique for determination of interphase properties in polymer nanocomposites reinforced with spherical nanoparticles Polymer 72 2015 93 97
22. Y. Zare Estimation of material and interfacial/interphase properties in clay/polymer nanocomposites by yield strength data Appl. Clay Sci. 115 2015 61 66
23. Y. Zare Effects of interphase on tensile strength of polymer/CNT nanocomposites by Kelly-Tyson theory Mech. Mater. 85 2015 1 6
24. Y. Zare, A. Daraei, M. Vatani, and P. Aghasafari An analysis of interfacial adhesion in nanocomposites from recycled polymers Comput. Mater. Sci. 81 2014 612 616
25. Y. Zare Study on interfacial properties in polymer blend ternary nanocomposites: role of nanofiller content Comput. Mater. Sci. 2015
26. Y. Zare, and H. Garmabi Thickness, modulus and strength of interphase in clay/polymer nanocomposites Appl. Clay Sci. 105 2015 66 70
27. 3) and a polymer matrix (PP) in a ternary polymer nanocomposite Appl. Surf. Sci. 321 2014 219 225
28. Y. Zare, and H. Garmabi Attempts to simulate the modulus of polymer/carbon nanotube nanocomposites and future trends Polym. Rev. 54 2014 377 400
29. Y. Zare Modeling of tensile modulus in polymer/carbon nanotubes (CNT) nanocomposites Synth. Met. 202 2015 68 72
30. Y. Zare, and H. Garmabi A developed model to assume the interphase properties in a ternary polymer nanocomposite reinforced with two nanofillers Compos. Part B 75 2015 29 35
31. Y. Zare Recent progress on preparation and properties of nanocomposites from recycled polymers: a review Waste Manag. 33 2013 598 604
32. Y. Zare Modeling the strength and thickness of the interphase of polymer nanocomposite reinforced with spherical nanoparticles J. Colloid Interface Sci. 2015
33. 3 ternary nanocomposite using response surface methodology J. Appl. Polym. Sci. 122 2011 3188 3200
34. E. Seyedjafari, M. Soleimani, N. Ghaemi, and I. Shabani Nanohydroxyapatite-coated electrospun poly (l-lactide) nanofibers enhance osteogenic differentiation of stem cells and induce ectopic bone formation Biomacromolecules 11 2010 3118 3125
35. I. Shabani, V. Haddadi-Asl, E. Seyedjafari, and M. Soleimani Cellular infiltration on nanofibrous scaffolds using a modified electrospinning technique Biochem. Biophys. Res. Commun. 423 2012 50 54
36. I. Shabani, V. Haddadi-Asl, M. Soleimani, E. Seyedjafari, and S.M. Hashemi Ion-exchange polymer nanofibers for enhanced osteogenic differentiation of stem cells and ectopic bone formation ACS Appl. Mater. Interfaces 6 2013 72 82
37. I. Shabani, M.M. Hasani-Sadrabadi, V. Haddadi-Asl, and M. Soleimani Nanofiber-based polyelectrolytes as novel membranes for fuel cell applications J. Membr. Sci. 368 2011 233 240
38. I. Shabani, V. Haddadi-Asl, M. Soleimani, E. Seyedjafari, F. Babaeijandaghi, and N. Ahmadbeigi Enhanced infiltration and biomineralization of stem cells on collagen-grafted three-dimensional nanofibers Tissue Eng. A 17 2011 1209 1218
39. A. Gautam, and S. Ram Preparation and thermomechanical properties of Ag-PVA nanocomposite films Mater. Chem. Phys. 119 2010 266 271
40. S. Mahendia, A. Tomar, and S. Kumar Electrical conductivity and dielectric spectroscopic studies of PVA-Ag nanocomposite films J. Alloys Compd. 508 2010 406 411
41. B.L. España-Sánchez, C.A. Ávila-Orta, F. Padilla-Vaca, M.G. Neira-Velázquez, P. González-Morones, J.A. Rodríguez-González, E. Hernández-Hernández, Á. Rangel-Serrano, L. Yate, and R.F. Ziolo Enhanced antibacterial activity of melt processed poly (propylene) Ag and Cu nanocomposites by argon plasma treatment Plasma Process. Polym. 11 2014 353 365
42. P.A. Zapata, L. Tamayo, M. Páez, E. Cerda, I. Azócar, and F.M. Rabagliati Nanocomposites based on polyethylene and nanosilver particles produced by metallocenic "in situ" polymerization: synthesis, characterization, and antimicrobial behavior Eur. Polym. J. 47 2011 1541 1549
43. B. Domènech, M. Muñoz, D. Muraviev, and J. Macanás Polymer-Silver Nanocomposites as Antibacterial Materials 2013
44. H. Deka, N. Karak, R.D. Kalita, and A.K. Buragohain Bio-based thermostable, biodegradable and biocompatible hyperbranched polyurethane/Ag nanocomposites with antimicrobial activity Polym. Degrad. Stab. 95 2010 1509 1517
45. G. Papageorgiou, D. Achilias, N. Nianias, P. Trikalitis, and D. Bikiaris Effect of the type of nano-filler on the crystallization and mechanical properties of syndiotactic polystyrene based nanocomposites Thermochim. Acta 565 2013 82 94
46. K. Vimala, Y.M. Mohan, K.S. Sivudu, K. Varaprasad, S. Ravindra, N.N. Reddy, Y. Padma, B. Sreedhar, and K. MohanaRaju Fabrication of porous chitosan films impregnated with silver nanoparticles: a facile approach for superior antibacterial application Colloids Surf. B: Biointerfaces 76 2010 248 258
47. O. Valmikanathan, O. Ostroverkhova, I. Mulla, K. Vijayamohanan, and S. Atre The effect of synthesis procedure on the structure and properties of palladium/polycarbonate nanocomposites Polymer 49 2008 3413 3418
48. V. Chaudhary, A. Thakur, and A. Bhowmick Improved optical and electrical response in metal-polymer nanocomposites for photovoltaic applications J. Mater. Sci. 46 2011 6096 6105
49. J.-Y. Lee, Y. Liao, R. Nagahata, and S. Horiuchi Effect of metal nanoparticles on thermal stabilization of polymer/metal nanocomposites prepared by a one-step dry process Polymer 47 2006 7970 7979
50. A.B. Afzal, M. Akhtar, M. Nadeem, M. Ahmad, M. Hassan, T. Yasin, and M. Mehmood Structural and electrical properties of polyaniline/silver nanocomposites J. Phys. D. Appl. Phys. 42 2009 015411
51. K. Gupta, P. Jana, and A. Meikap Optical and electrical transport properties of polyaniline-silver nanocomposite Synth. Met. 160 2010 1566 1573
52. J. An, X. Yuan, Q. Luo, and D. Wang Preparation of chitosan-graft-(methyl methacrylate)/Ag nanocomposite with antimicrobial activity Polym. Int. 59 2010 62 70
53. C.-W. Chou, S.-h. Hsu, H. Chang, S.-M. Tseng, and H.-R. Lin Enhanced thermal and mechanical properties and biostability of polyurethane containing silver nanoparticles Polym. Degrad. Stab. 91 2006 1017 1024
54. X. Huang, P. Jiang, and C. Kim Electrical properties of polyethylene/aluminum nanocomposites J. Appl. Phys. 102 2007 124103
55. M. Salvadori, F. Teixeira, L. Sgubin, M. Cattani, and I. Brown Surface modification by metal ion implantation forming metallic nanoparticles in an insulating matrix Appl. Surf. Sci. 2014
56. J. Kim, and B.A. Grzybowski Controlling reversible dielectric breakdown in metal/polymer nanocomposites Adv. Mater. 24 2012 1850 1855
57. A. Choudhury Polyaniline/silver nanocomposites: dielectric properties and ethanol vapour sensitivity Sensors Actuators B Chem. 138 2009 318 325
58. W.F. Lee, and K.T. Tsao Preparation and properties of nanocomposite hydrogels containing silver nanoparticles by ex situ polymerization J. Appl. Polym. Sci. 100 2006 3653 3661
59. X. Huang, P. Jiang, and L. Xie Ferroelectric polymer/silver nanocomposites with high dielectric constant and high thermal conductivity Appl. Phys. Lett. 95 2009 242901
60. N.A. Nikonorova, E.B. Barmatov, D.A. Pebalk, M.V. Barmatova, G. Domínguez-Espinosa, R. Diaz-Calleja, and P. Pissis Electrical properties of nanocomposites based on comb-shaped nematic polymer and silver nanoparticles J. Phys. Chem. C 111 2007 8451 8458
61. S. Pothukuchi, Y. Li, and C. Wong Development of a novel polymer-metal nanocomposite obtained through the route of in situ reduction for integral capacitor application J. Appl. Polym. Sci. 93 2004 1531 1538
62. G.W. Kreutzberg Microglia: a sensor for pathological events in the CNS Trends Neurosci. 19 1996 312 318
63. D.N. Muraviev, P. Ruiz, M. Muñoz, and J. Macanás Novel strategies for preparation and characterization of functional polymer-metal nanocomposites for electrochemical applications Pure Appl. Chem. 80 2008 2425 2437
64. S.S. Barkade, J.B. Naik, and S.H. Sonawane Ultrasound assisted miniemulsion synthesis of polyaniline/Ag nanocomposite and its application for ethanol vapor sensing Colloids Surf. A Physicochem. Eng. Asp. 378 2011 94 98
65. A.A. Athawale, S. Bhagwat, and P.P. Katre Nanocomposite of Pd-polyaniline as a selective methanol sensor Sensors Actuators B Chem. 114 2006 263 267
66. C. de Julián Fernández, M. Manera, J. Spadavecchia, G. Maggioni, A. Quaranta, G. Mattei, M. Bazzan, E. Cattaruzza, M. Bonafini, and E. Negro Study of the gas optical sensing properties of Au-polyimide nanocomposite films prepared by ion implantation Sensors Actuators B Chem. 111 2005 225 229
67. Y. Xiang, and D. Chen Preparation of a novel pH-responsive silver nanoparticle/poly (HEMA-PEGMA-MAA) composite hydrogel Eur. Polym. J. 43 2007 4178 4187
68. S. Pandey, G.K. Goswami, and K.K. Nanda Green synthesis of biopolymer-silver nanoparticle nanocomposite: an optical sensor for ammonia detection Int. J. Biol. Macromol. 51 2012 583 589
69. R. Gradess, R. Abargues, A. Habbou, J. Canet-Ferrer, E. Pedrueza, A. Russell, J.L. Valdés, and J.P. Martínez-Pastor Localized surface plasmon resonance sensor based on Ag-PVA nanocomposite thin films J. Mater. Chem. 19 2009 9233 9240
70. S. Sharma, C. Nirkhe, S. Pethkar, and A.A. Athawale Chloroform vapour sensor based on copper/polyaniline nanocomposite Sensors Actuators B Chem. 85 2002 131 136
71. J. Zhang, X. Liu, S. Wu, H. Xu, and B. Cao One-pot fabrication of uniform polypyrrole/Au nanocomposites and investigation for gas sensing Sensors Actuators B Chem. 186 2013 695 700
72. V. Mazeiko, A. Kausaite-Minkstimiene, A. Ramanaviciene, Z. Balevicius, and A. Ramanavicius Gold nanoparticle and conducting polymer-polyaniline-based nanocomposites for glucose biosensor design Sensors Actuators B Chem. 189 2013 187 193
73. J. Njagi, and S. Andreescu Stable enzyme biosensors based on chemically synthesized Au-polypyrrole nanocomposites Biosens. Bioelectron. 23 2007 168 175
74. F.N. Crespilho, R.M. Iost, S.A. Travain, O.N. Oliveira Jr., and V. Zucolotto Enzyme immobilization on Ag nanoparticles/polyaniline nanocomposites Biosens. Bioelectron. 24 2009 3073 3077
75. J. Mathiyarasu, S. Senthilkumar, K. Phani, and V. Yegnaraman PEDOT-Au nanocomposite film for electrochemical sensing Mater. Lett. 62 2008 571 573
76. X. Qin, H. Wang, Z. Miao, J. Li, and Q. Chen A novel non-enzyme hydrogen peroxide sensor based on catalytic reduction property of silver nanowires Talanta 139 2015 56 61
77. B. Derkus, E. Emregul, and K.C. Emregul Copper-zinc alloy nanoparticle based enzyme-free superoxide radical sensing on a screen-printed electrode Talanta 134 2015 206 214
78. G. Sun, L. Zhang, Y. Zhang, H. Yang, C. Ma, S. Ge, M. Yan, J. Yu, and X. Song Multiplexed enzyme-free electrochemical immunosensor based on ZnO nanorods modified reduced graphene oxide-paper electrode and silver deposition-induced signal amplification strategy Biosens. Bioelectron. 71 2015 30 36
79. K. Vimala, K. Samba Sivudu, Y. Murali Mohan, B. Sreedhar, and K. Mohana Raju Controlled silver nanoparticles synthesis in semi-hydrogel networks of poly (acrylamide) and carbohydrates: a rational methodology for antibacterial application Carbohydr. Polym. 75 2009 463 471
80. H.-L. Liu, S.A. Dai, K.-Y. Fu, and S.-h. Hsu Antibacterial properties of silver nanoparticles in three different sizes and their nanocomposites with a new waterborne polyurethane Int. J. Nanomedicine 5 2010 1017
81. B.S. Liu, and T.B. Huang Nanocomposites of genipin-crosslinked chitosan/silver nanoparticles-structural reinforcement and antimicrobial properties Macromol. Biosci. 8 2008 932 941
82. P.K. Prabhakar, S. Raj, P. Anuradha, S.N. Sawant, and M. Doble Biocompatibility studies on polyaniline and polyaniline-silver nanoparticle coated polyurethane composite Colloids Surf. B: Biointerfaces 86 2011 146 153
83. E. Fortunati, L. Latterini, S. Rinaldi, J. Kenny, and I. Armentano PLGA/Ag nanocomposites: in vitro degradation study and silver ion release J. Mater. Sci. Mater. Med. 22 2011 2735 2744
84. N. Cioffi, L. Torsi, N. Ditaranto, G. Tantillo, L. Ghibelli, L. Sabbatini, T. Bleve-Zacheo, M. D'Alessio, P.G. Zambonin, and E. Traversa Copper nanoparticle/polymer composites with antifungal and bacteriostatic properties Chem. Mater. 17 2005 5255 5262
85. M. Potara, E. Jakab, A. Damert, O. Popescu, V. Canpean, and S. Astilean Synergistic antibacterial activity of chitosan-silver nanocomposites on Staphylococcus aureus Nanotechnology 22 2011 135101
86. V.R. Babu, C. Kim, S. Kim, C. Ahn, and Y.-I. Lee Development of semi-interpenetrating carbohydrate polymeric hydrogels embedded silver nanoparticles and its facile studies on E. coli Carbohydr. Polym. 81 2010 196 202
87. N. Cioffi, N. Ditaranto, L. Torsi, R. Picca, E. De Giglio, L. Sabbatini, L. Novello, G. Tantillo, T. Bleve-Zacheo, and P. Zambonin Synthesis, analytical characterization and bioactivity of Ag and Cu nanoparticles embedded in poly-vinyl-methyl-ketone films Anal. Bioanal. Chem. 382 2005 1912 1918
88. N.-l. Zhou, Y. Liu, L. Li, N. Meng, Y.-x. Huang, J. Zhang, S.-h. Wei, and J. Shen A new nanocomposite biomedical material of polymer/Clay-Cts-Ag nanocomposites Curr. Appl. Phys. 7 2007 e58 e62
89. S.Y. Lee, H.J. Kim, R. Patel, S.J. Im, J.H. Kim, and B.R. Min Silver nanoparticles immobilized on thin film composite polyamide membrane: characterization, nanofiltration, antifouling properties Polym. Adv. Technol. 18 2007 562 568
90. X. Xu, Q. Yang, Y. Wang, H. Yu, X. Chen, and X. Jing Biodegradable electrospun poly (l-lactide) fibers containing antibacterial silver nanoparticles Eur. Polym. J. 42 2006 2081 2087
91. K. Morley, P. Webb, N. Tokareva, A. Krasnov, V. Popov, J. Zhang, C. Roberts, and S. Howdle Synthesis and characterisation of advanced UHMWPE/silver nanocomposites for biomedical applications Eur. Polym. J. 43 2007 307 314
92. W. Zhang, Y.-H. Zhang, J.-H. Ji, J. Zhao, Q. Yan, and P.K. Chu Antimicrobial properties of copper plasma-modified polyethylene Polymer 47 2006 7441 7445
93. H.-f. Liu, Z.-l. Liu, C.-s. Xie, J. Yu, and C.-h. Zhu The antifertility effectiveness of copper/low-density polyethylene nanocomposite and its influence on the endometrial environment in rats Contraception 75 2007 157 161
94. A. Hebeish, M. El-Naggar, M.M. Fouda, M. Ramadan, S.S. Al-Deyab, and M. El-Rafie Highly effective antibacterial textiles containing green synthesized silver nanoparticles Carbohydr. Polym. 86 2011 936 940
95. C.-Y. Chen, and C.-L. Chiang Preparation of cotton fibers with antibacterial silver nanoparticles Mater. Lett. 62 2008 3607 3609
96. K. Firoz Babu, P. Dhandapani, S. Maruthamuthu, and M. Anbu Kulandainathan One pot synthesis of polypyrrole silver nanocomposite on cotton fabrics for multifunctional property Carbohydr. Polym. 90 2012 1557 1563
97. M.R. De Moura, L.H. Mattoso, and V. Zucolotto Development of cellulose-based bactericidal nanocomposites containing silver nanoparticles and their use as active food packaging J. Food Eng. 109 2012 520 524
98. T.B. Mostafa, and A.S. Darwish An approach toward construction of tuned chitosan/polyaniline/metal hybrid nanocomposites for treatment of meat industry wastewater Chem. Eng. J. 243 2014 326 339
99. M.A. Busolo, and J.M. Lagaron Antimicrobial biocomposites of melt-compounded polylactide films containing silver-based engineered clays J. Plast. Film Sheeting 2013 (8756087913478601)
100. A. Incoronato, G. Buonocore, A. Conte, M. Lavorgna, and M. Del Nobile J. Food Prot. 73 2010 2256 2262
101. J.H. Park, M.R. Karim, I.K. Kim, I.W. Cheong, J.W. Kim, D.G. Bae, J.W. Cho, and J.H. Yeum Electrospinning fabrication and characterization of poly (vinyl alcohol)/montmorillonite/silver hybrid nanofibers for antibacterial applications Colloid Polym. Sci. 288 2010 115 121
102. H. Song, B. Li, Q.-B. Lin, H.-J. Wu, and Y. Chen Migration of silver from nanosilver-polyethylene composite packaging into food simulants Food Addit. Contam. A 28 2011 1758 1762
103. M. Ibarra-Alonso, S. Sánchez-Valdes, E. Ramírez-Vargas, S. Fernandez-Tavizón, J. Romero-Garcia, A. Ledezma-Perez, L. Ramos de Valle, O. Rodriguez-Fernandez, A. Espinoza-Martinez, and J. Martinez-Colunga Preparation and characterization of Polyethylene/Clay/Silver nanocomposites using functionalized polyethylenes as an adhesion promoter J. Adhes. Sci. Technol. 2015 1 13
104. P. Dallas, V.K. Sharma, and R. Zboril Silver polymeric nanocomposites as advanced antimicrobial agents: classification, synthetic paths, applications, and perspectives Adv. Colloid Interf. Sci. 166 2011 119 135
105. J. Choi, and N.S. Wang Nanoparticles in Biomedical Applications and Their Safety Concerns 2011 INTECH Open Access Publisher