The reality of aging viewed from the arterial wall

Blood Pressure and Arterial Wall Mechanics in Cardiovascular Diseases

Volumn 9781447151982, Issue , 2014, Pages 137-153

  Alghatrif, Majd ^a,b   Lakatta, Edward G ^a,c  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Biomedical Research Center   (United States)

Author keywords

Angiotensin; Arterial aging; Inflammation; Pulse pressure; Pulse wave velocity

Indexed keywords

EID: 84947288696     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-1-4471-5198-2_12     Document Type: Chapter

References (78)

1. Lakatta EG. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: part I: aging arteries: a 'set up' for vascular disease. Circulation. 2003;107(1):139-46.
2. Faury G. Function-structure relationship of elastic arteries in evolution: from microfi brils to elastin and elastic fi bres. Pathol Biol (Paris). 2001;49(4): 310-25.
3. Lakatta EG, Wang M, Najjar SS. Arterial aging and subclinical arterial disease are fundamentally intertwined at macroscopic and molecular levels. Med Clin North Am. Elsevier Ltd; 2009 ;93(3):583-604.
4. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, et al. Heart disease and stroke statistics-2010 update: a report from the American Heart Association. Circulation. 2010;121(7):e46-215.
5. Najjar SS, Scuteri A, Shetty V, Wright JG, Muller DC, Fleg JL, et al. Pulse wave velocity is an independent predictor of the longitudinal increase in systolic blood pressure and of incident hypertension in the Baltimore Longitudinal Study of Aging. J Am Coll Cardiol. 2008;51:1377-83.
6. Wang M, et al. Proinfl ammation: the key to arterial aging. TEM. 2014;25(2):72.
7. Lakatta EG. The reality of aging viewed from the arterial wall. Artery Research. 2013;7(2):73.
8. Najjar SS, Scuteri A, Lakatta EG. Arterial aging: is it an immutable cardiovascular risk factor? Hypertension. 2005;46(3):454-62.
9. Wang M, Lakatta EG. Altered regulation of matrix metalloproteinase-2 in aortic remodeling during aging. Hypertension. 2002;39(4):865-73.
10. Spinetti G, Wang M, Monticone R, Zhang J, Zhao D, Lakatta EG. Rat aortic MCP-1 and its receptor CCR2 increase with age and alter vascular smooth muscle cell function. Arterioscler Thromb Vasc Biol. 2004;24(8):1397-402.
11. Wang M, Zhang J, Jiang L-Q, Spinetti G, Pintus G, Monticone R, et al. Proinfl ammatory profi le within the grossly normal aged human aortic wall. Hypertension. 2007;50(1):219-27.
12. Ong K-T, Delerme S, Pannier B, Safar ME, Benetos A, Laurent S, et al. Aortic stiffness is reduced beyond blood pressure lowering by short-Term and long-Term antihypertensive treatment: a meta-Analysis of individual data in 294 patients. J Hypertens. 2011;29(6): 1034-42.
13. Lakatta EG. Central arterial aging and the epidemic of systolic hypertension and atherosclerosis. J Am Soc Hypertens. 2007;1:302-40.
14. Celermajer DS, Sorensen KE, Spiegelhalter DJ, Georgakopoulos D, Robinson J, Deanfield JE. Aging is associated with endothelial dysfunction in healthy men years before the age-related decline in women. J Am Coll Cardiol. 1994;24(2):471-6.
15. Paneni F, Osto E, Costantino S, Mateescu B, Briand S, Coppolino G, et al. Deletion of the AP-1 transcription factor JunD induces oxidative stress and accelerates Age-related endothelial dysfunction. Circulation. 2013;127(11):1229-40.
16. Higashi Y, Kihara Y, Noma K. Endothelial dysfunction and hypertension in aging. Hypertens Res. 2012;35(11):1039-47. The Japanese Society of Hypertension.
17. Bode-Böger SM, Muke J, Surdacki A, Brabant G, Böger RH, Frölich JC. Oral L-Arginine improves endothelial function in healthy individuals older than 70 years. Vasc Med. 2003;8(2):77-81.
18. Williamson KA, Hamilton A, Reynolds JA, Sipos P, Crocker I, Stringer SE, et al. Age-related impairment of endothelial progenitor cell migration correlates with structural alterations of heparan sulfate proteoglycans. Aging Cell. 2013;12(1):139-47.
19. Stein JH, Korcarz CE, Hurst RT, Lonn E, Kendall CB, Mohler ER, et al. Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascula. J Am Soc Echocardiogr. 2008;21(2):93-111.
20. Nagai Y, Metter EJ, Earley CJ, Kemper MK, Becker LC, Lakatta EG, et al. Increased carotid artery intimalmedial thickness in asymptomatic older subjects with exercise-induced myocardial ischemia. Circulation. 1998;98(15):1504-9.
21. Yan SF, Ramasamy R, Naka Y, Schmidt AM. Glycation, infl ammation, and RAGE: a scaffold for the macrovascular complications of diabetes and beyond. Circ Res. 2003;93(12):1159-69.
22. Wang M, Takagi G, Asai K, Resuello RG, Natividad FF, Vatner DE, et al. Aging increases aortic MMP-2 activity and angiotensin II in nonhuman primates. Hypertension. 2003;41(6):1308-16.
23. Adams MR, Nakagomi A, Keech A, Robinson J, McCredie R, Bailey BP, et al. Carotid intima-media thickness is only weakly correlated with the extent and severity of coronary artery disease. Circulation. 1995;92(8):2127-34.
24. Kass DA, Shapiro EP, Kawaguchi M, Capriotti AR, Scuteri A, deGroof RC, et al. Improved arterial compliance by a novel advanced glycation end-product crosslink breaker. Circulation. 2001;104(13):1464-70.
25. Jiang L, Zhang J, Monticone RE, Telljohann R, Wu J, Wang M, et al. Calpain-1 regulation of matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age-Associated aortic wall calcification and fi brosis. Hypertension. 2012;60(5):1192-9.
26. Johnson KA, Polewski M, Terkeltaub RA. Transglutaminase 2 is central to induction of the arterial calcification program by smooth muscle cells. Circ Res. 2008;102(5):529-37.
27. Jandu SK, Webb AK, Pak A, Sevinc B, Nyhan D, Belkin AM, et al. Nitric oxide regulates tissue transglutaminase localization and function in the vasculature. Amino Acids. 2013;44(1):261-9.
28. Hinz B. Tissue stiffness, latent TGF-beta1 activation, and mechanical signal transduction: implications for the pathogenesis and treatment of fi brosis. Curr Rheumatol Rep. 2009;11(2):120-6.
29. Iwata T, Kamei T, Uchino F, Mimaya H, Yanagaki T, Etoh H. Pathological study on amyloidosis-relationship of amyloid deposits in the aorta to aging. Acta Pathol Jpn. 1978;28(2):193-203.
30. Merlini G, Bellotti V. Molecular mechanisms of amyloidosis. N Engl J Med. 2003;349(6):583-96.
31. Westermark P. Aspects on human amyloid forms and their fi bril polypeptides. FEBS J. 2005;272(23): 5942-9.
32. Sciarretta KL, Gordon DJ, Meredith SC. Peptidebased inhibitors of amyloid assembly. Methods Enzymol. 2006;413:273-312.
33. Thundimadathil J, Roeske RW, Jiang H-Y, Guo L. Aggregation and porin-like channel activity of a beta sheet peptide. Biochemistry. 2005;44(30): 10259-70.
34. Larsson A, Peng S, Persson H, Rosenbloom J, Abrams WR, Wassberg E, et al. Lactadherin binds to elasti-starting point for medin amyloid formation? Amyloid. Informa UK Ltd UK; 2006;13(2):78-85.
35. Peng S, Glennert J, Westermark P. Medin-Amyloid: a recently characterized age-Associated arterial amyloid form affects mainly arteries in the upper part of the body. Amyloid. 2005;12(2):96-102.
36. Mucchiano G, Cornwell GG, Westermark P. Senile aortic amyloid. Evidence for two distinct forms of localized deposits. Am J Pathol. 1992;140(4):871-7.
37. Morrell CH, Brant LJ, Ferrucci L. Model choice can obscure results in longitudinal studies. J Gerontol A Biol Sci Med Sci. 2009;64(2):215-22.
38. Häggqvist B, Näslund J, Sletten K, Westermark GT, Mucchiano G, Tjernberg LO, et al. Medin: an integral fragment of aortic smooth muscle cell-produced lactadherin forms the most common human amyloid. Proc Natl Acad Sci U S A. 1999;96(15):8669-74.
39. Cheng M, Li B, Li X, Wang Q, Zhang J, Jing X, et al. Correlation between serum lactadherin and pulse wave velocity and cardiovascular risk factors in elderly patients with type 2 diabetes mellitus. Diabetes Res Clin Pract. 2012;95(1):125-31.
40. Lam CSP, Xanthakis V, Sullivan LM, Lieb W, Aragam J, Redfield MM, et al. Aortic root remodeling over the adult life course: longitudinal data from the Framingham Heart Study. Circulation. 2010;122(9): 884-90.
41. AlGhatrif M, Strait JB, Morrell CH, Canepa M, Wright J, Elango P, et al. Longitudinal trajectories of arterial stiffness and the role of blood pressure: the Baltimore longitudinal study of aging. Hypertension. 2013;62(5):934-51.
42. Kaess BM, Rong J, Larson MG, Hamburg NM, Vita JA, Levy D, et al. Aortic stiffness, blood pressure progression, and incident hypertension. JAMA. 2012;308(9):875-81.
43. AlGhatrif M, Strait JB, Morrell CH, Canepa M, Wright J, Elango P, et al. Attenuated aortic dilatation, not increased wall stiffness best explains the rise in pulse pressure in women with aging: results from the Baltimore longitudinal study of aging. Circulation. 2013;128:A18061.
44. O'Rourke MF, Hashimoto J. Mechanical factors in arterial aging: a clinical perspective. J Am Coll Cardiol. 2007;50(1):1-13.
45. Nichols W, O'Rourke MF, Vlachopoulos C. McDonald's blood flow in arteries: theoretical, experimental and clinical principles. Boca Raton: CRC Press; 2011.
46. Mitchell GF, Lacourciere Y, Ouellet JP, Izzo Jr. JL, Neutel J, Kerwin LJ, et al. Determinants of elevated pulse pressure in middle-Aged and older subjects with uncomplicated systolic hypertension: the role of proximal aortic diameter and the aortic pressure-fl ow relationship. Circulation. 2003;108:1592-8.
47. Vaitkevicius PV, Fleg JL, Engel JH, O'Connor FC, Wright JG, Lakatta LE, et al. Effects of age and aerobic capacity on arterial stiffness in healthy-Adults. Circulation. 1993;88:1456-62.
48. Redheuil A, Yu W-C, Mousseaux E, Harouni AA, Kachenoura N, Wu CO, et al. Age-related changes in aortic arch geometry: relationship with proximal aortic function and left ventricular mass and remodeling. J Am Coll Cardiol. 2011;58(12):1262-70.
49. Mitchell GF, Parise H, Benjamin EJ, Larson MG, Keyes MJ, Vita JA, et al. Changes in arterial stiffness and wave refl ection with advancing age in healthy men and women: the Framingham Heart Study. Hypertension. 2004;43(6):1239-45.
50. Cecelja M, Jiang B, Spector TD, Chowienczyk P. Progression of central pulse pressure over 1 decade of aging and its reversal by nitroglycerin a twin study. J Am Coll Cardiol. 2012;59(5):475-83.
51. Mitchell GF. Impedance progress: aortic diameter rears its head again? Hypertension. 2007;49(6): 1207-9.
52. Van de Laar RJJ, Stehouwer CDA, van Bussel BCT, Prins MH, Twisk JWR, Ferreira I. Adherence to a Mediterranean dietary pattern in early life is associated with lower arterial stiffness in adulthood: the Amsterdam Growth and Health Longitudinal Study. J Intern Med. 2013;273(1):79-93.
53. Cooper JN, Buchanich JM, Youk A, Brooks MM, Barinas-Mitchell E, Conroy MB, et al. Reductions in arterial stiffness with weight loss in overweight and obese young adults: potential mechanisms. Atherosclerosis. 2012;223(2):485-90.
54. Hummel SL, Seymour EM, Brook RD, Kolias TJ, Sheth SS, Rosenblum HR, et al. Low-sodium dietary approaches to stop hypertension diet reduces blood pressure, arterial stiffness, and oxidative stress in hypertensive heart failure with preserved ejection fraction. Hypertension. 2012;60(5):1200-6.
55. DeSouza CA, Shapiro LF, Clevenger CM, Dinenno FA, Monahan KD, Tanaka H, et al. Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation. 2000;102(12):1351-7.
56. Austin BA, Popovic ZB, Kwon DH, Thamilarasan M, Boonyasirinant T, Flamm SD, et al. Aortic stiffness independently predicts exercise capacity in hypertrophic cardiomyopathy: a multimodality imaging study. Heart. 2010;96(16):1303-10.
57. Tanaka H, Dinenno FA, Monahan KD, Clevenger CM, DeSouza CA, Seals DR. Aging, habitual exercise, and dynamic arterial compliance. Circulation. 2000;102(11):1270-5.
58. Seals DR, Desouza CA, Donato AJ, Tanaka H. Habitual exercise and arterial aging. J Appl Physiol Soc. 2008;105(4):1323-32.
59. Kearney TM, Murphy MH, Davison GW, O'Kane MJ, Gallagher AM. Accumulated brisk walking reduces arterial stiffness in overweight adults: evidence from a randomised control trial. J Am Soc Hypertens. 2014;8(2):117-26.
60. Heckman GA, McKelvie RS. Cardiovascular aging and exercise in healthy older adults. Clin J Sport Med. 2008;18(6):479-85.
61. d'Alessio P. Aging and the endothelium. Exp Gerontol. 2004;39(2):165-71.
62. Mackenzie IS, McEniery CM, Dhakam Z, Brown MJ, Cockcroft JR, Wilkinson IB. Comparison of the effects of antihypertensive agents on central blood pressure and arterial stiffness in isolated systolic hypertension. Hypertension. 2009;54(2):409-13.
63. Morgan T, Lauri J, Bertram D, Anderson A. Effect of different antihypertensive drug classes on central aortic pressure. Am J Hypertens. 2004;17(2):118-23.
64. Asmar RG, London GM, O'Rourke ME, Safar ME. Improvement in blood pressure, arterial stiffness and wave refl ections with a very-low-dose perindopril/ indapamide combination in hypertensive patient: a comparison with atenolol. Hypertension. 2001; 38(4):922-6.
65. Williams B, Lacy PS, Thom SM, Cruickshank K, Stanton A, Collier D, et al. Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation. 2006;113(9):1213-25.
66. Dahlöf B, Devereux RB, Kjeldsen SE, Julius S, Beevers G, de Faire U, et al. Cardiovascular morbidity and mortality in the losartan intervention for endpoint reduction in hypertension study (LIFE): a randomised trial against atenolol. Lancet. 2002;359(9311):995-1003.
67. Benetos A, Vasmant D, Thiery P, Safar M. Effects of ramipril on arterial hemodynamics. J Cardiovasc Pharmacol. 1991;18 Suppl 2:S153-6.
68. Safar ME, Jankowski P. Antihypertensive therapy and de-stiffening of the arteries. Expert Opin Pharmacother. Informa UK, Ltd. London; 2010; 11(16):2625-34.
69. Mitchell GF, Dunlap ME, Warnica W, Ducharme A, Arnold JMO, Tardif J-C, et al. Long-Term trandolapril treatment is associated with reduced aortic stiffness: the prevention of events with angiotensin-converting enzyme inhibition hemodynamic substudy. Hypertension. 2007;49(6):1271-7.
70. Raison J, Rudnichi A, Safar ME. Effects of atorvastatin on aortic pulse wave velocity in patients with hypertension and hypercholesterolaemia: a preliminary study. J Hum Hypertens. 2002;16(10):705-10.
71. Ott C, Schneider MP, Schlaich MP, Schmieder RE. Rosuvastatin improves pulse wave refl ection by restoring endothelial function. Microvasc Res. 2012;84(1):60-4.
72. Tousoulis D, Oikonomou E, Siasos G, Chrysohoou C, Zaromitidou M, Kioufi s S, et al. Dose-dependent effects of short term atorvastatin treatment on arterial wall properties and on indices of left ventricular remodeling in ischemic heart failure. Atherosclerosis. 2013;227(2):367-72.
73. Farrar DJ, Bond MG, Riley WA, Sawyer JK. Anatomic correlates of aortic pulse wave velocity and carotid artery elasticity during atherosclerosis progression and regression in monkeys. Circulation. 1991;83(5):1754-63.
74. Cecelja M, Chowienczyk P. Dissociation of aortic pulse wave velocity with risk factors for cardiovascular disease other than hypertension: a systematic review. Hypertension. 2009;54(6):1328-36.
75. Bakris GL, Bank AJ, Kass DA, Neutel JM, Preston RA, Oparil S. Advanced glycation end-product crosslink breakers. A novel approach to cardiovascular pathologies related to the aging process. Am J Hypertens. 2004;17(12 Pt 2):23S-30.
76. Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006;444(7117):337-42.
77. Wang M, Zhang J, Telljohann R, Jiang L, Wu J, Monticone RE, et al. Chronic matrix metalloproteinase inhibition retards age-Associated arterial proinfl ammation and increase in blood pressure. Hypertension. 2012;60(2):459-66.
78. Wang M, Zhang J, Spinetti G, Jiang L-Q, Monticone R, Zhao D, et al. Angiotensin II activates matrix metalloproteinase type II and mimics age-Associated carotid arterial remodeling in young rats. Am J Pathol. 2005;167(5):1429-42.