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Volumn 55, Issue , 2015, Pages 295-301

The protein Kinase C inhibitor: Ruboxistaurin

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME INHIBITOR; INDOLE DERIVATIVE; MALEIMIDE DERIVATIVE; PROTEIN KINASE C; RUBOXISTAURIN;

EID: 84947227107     PISSN: 02503751     EISSN: 16622790     Source Type: Book Series    
DOI: 10.1159/000431204     Document Type: Article
Times cited : (21)

References (46)
  • 1
    • 0027942607 scopus 로고
    • Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders
    • Aiello LP, Avery RL, Arrigg PG, et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N Engl J Med 1994; 331:1480-1487.
    • (1994) N Engl J Med , vol.331 , pp. 1480-1487
    • Aiello, L.P.1    Avery, R.L.2    Arrigg, P.G.3
  • 2
    • 0346777254 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and diabetic retinopathy: Pathophysiological mechanisms and treatment perspectives
    • Caldwell RB, Bartoli M, Behzadian MA, et al. Vascular endothelial growth factor and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives. Diabetes Metab Res Rev 2003; 19:442-455.
    • (2003) Diabetes Metab Res Rev , vol.19 , pp. 442-455
    • Caldwell, R.B.1    Bartoli, M.2    Behzadian, M.A.3
  • 3
    • 33845191304 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is a critical stimulus for diabetic macular edema
    • Nguyen QD, Tatlipinar S, Shah SM, et al. Vascular endothelial growth factor is a critical stimulus for diabetic macular edema. Am J Ophthalmol 2006; 142:961-969.
    • (2006) Am J Ophthalmol , vol.142 , pp. 961-969
    • Nguyen, Q.D.1    Tatlipinar, S.2    Shah, S.M.3
  • 4
    • 0035669720 scopus 로고    scopus 로고
    • Protein kinase C and the development of diabetic vascular complications
    • Way KJ, Katai N, King GL: Protein kinase C and the development of diabetic vascular complications. Diabet Med 2001; 18:945-959.
    • (2001) Diabet Med , vol.18 , pp. 945-959
    • Way, K.J.1    Katai, N.2    King, G.L.3
  • 5
    • 0036939182 scopus 로고    scopus 로고
    • The potential role of PKC β in diabetic retinopathy and macular edema
    • Aiello LP: The potential role of PKC β in diabetic retinopathy and macular edema. Surv Ophthalmol 2002; 47(suppl 2):S263-S269.
    • (2002) Surv Ophthalmol , vol.47 , pp. S263-S269
    • Aiello, L.P.1
  • 7
    • 34250702110 scopus 로고    scopus 로고
    • The role of protein kinase C activation and the vascular complications of diabetes
    • Evicmen ND, King GL: The role of protein kinase C activation and the vascular complications of diabetes. Pharmacol Res 2007; 55:498-510.
    • (2007) Pharmacol Res , vol.55 , pp. 498-510
    • Evicmen, N.D.1    King, G.L.2
  • 8
    • 0036872243 scopus 로고    scopus 로고
    • Die Bedeutung der Proteinkinase C in der Pathophysiologie der diabetischen Retinopathie
    • Lang GE, Kampmeier J: Die Bedeutung der Proteinkinase C in der Pathophysiologie der diabetischen Retinopathie. Klin Monatsbl Augenheilkd 2002; 219:769-776.
    • (2002) Klin Monatsbl Augenheilkd , vol.219 , pp. 769-776
    • Lang, G.E.1    Kampmeier, J.2
  • 9
    • 0037154156 scopus 로고    scopus 로고
    • Characterization of protein kinase C β isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced cell proliferation, and retinal neovascularization
    • Suzuma K, Takahara N, Suzuma I, et al. Characterization of protein kinase C β isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced cell proliferation, and retinal neovascularization. Proc Natl Acad Sci U S A 2002; 99:721-726.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 721-726
    • Suzuma, K.1    Takahara, N.2    Suzuma, I.3
  • 10
    • 33845455480 scopus 로고    scopus 로고
    • Protein kinase Cβ inhibition: A novel therapeutic strategy for diabetic microangiopathy
    • Idris I, Donelly R: Protein kinase Cβ inhibition: a novel therapeutic strategy for diabetic microangiopathy. Diab Vasc Dis Res 2006; 3:172-178.
    • (2006) Diab Vasc Dis Res , vol.3 , pp. 172-178
    • Idris, I.1    Donelly, R.2
  • 11
    • 0033781544 scopus 로고    scopus 로고
    • Protein kinase C activation and its pharmacological inhibition in vascular disease
    • Meier M, King GL: Protein kinase C activation and its pharmacological inhibition in vascular disease. Vasc Med 2000; 5:173-185.
    • (2000) Vasc Med , vol.5 , pp. 173-185
    • Meier, M.1    King, G.L.2
  • 13
    • 42149116966 scopus 로고    scopus 로고
    • Differential regulation of VEGF signaling by PKCα and PKCε in endothelial cells
    • Rask-Madsen C, King GL: Differential regulation of VEGF signaling by PKCα and PKCε in endothelial cells. Arterioscler Thromb Vasc Biol 2008; 28:919-924.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 919-924
    • Rask-Madsen, C.1    King, G.L.2
  • 14
    • 2642709170 scopus 로고    scopus 로고
    • Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth
    • Xia P, Aiello LP, Ishii H, et al. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. J Clin Invest 1996; 98:2018-2026.
    • (1996) J Clin Invest , vol.98 , pp. 2018-2026
    • Xia, P.1    Aiello, L.P.2    Ishii, H.3
  • 15
    • 0025313272 scopus 로고
    • Increase in diacylglycerol mass in isolated glomeruli by glucose from de novo synthesis of glycerolipids
    • Craven PA, Davidson CM, DeRubertis FR: Increase in diacylglycerol mass in isolated glomeruli by glucose from de novo synthesis of glycerolipids. Diabetes 1990; 39:667-674.
    • (1990) Diabetes , vol.39 , pp. 667-674
    • Craven, P.A.1    Davidson, C.M.2    DeRubertis, F.R.3
  • 16
    • 0019332349 scopus 로고
    • Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover
    • Kishimoto A, Takai Y, Mori T, et al. Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover. J Biol Chem 1980; 255:2273-2276.
    • (1980) J Biol Chem , vol.255 , pp. 2273-2276
    • Kishimoto, A.1    Takai, Y.2    Mori, T.3
  • 17
    • 0027981889 scopus 로고
    • Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia
    • Xia P, Inoguchi T, Kern TS, et al. Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemia. Diabetes 1994; 43:1122-1129.
    • (1994) Diabetes , vol.43 , pp. 1122-1129
    • Xia, P.1    Inoguchi, T.2    Kern, T.S.3
  • 18
    • 0030754260 scopus 로고    scopus 로고
    • +-ATPase of cultured bovine retinal pigment epithelial cells measured by a new nonradioactive rubidium uptake assay
    • Crider JY, Yorio T, Sharif NA, et al. The effects of elevated glucose on Na+/K+-ATPase of cultured bovine retinal pigment epithelial cells measured by a new nonradioactive rubidium uptake assay. J Ocul Pharmacol Ther 1997; 13:337-352.
    • (1997) J Ocul Pharmacol Ther , vol.13 , pp. 337-352
    • Crider, J.Y.1    Yorio, T.2    Sharif, N.A.3
  • 19
    • 0030743466 scopus 로고    scopus 로고
    • High glucose concentrations increase endothelial cell permeability via activation of protein kinase Cα
    • Hempel A, Maasch C, Heintze U, et al. High glucose concentrations increase endothelial cell permeability via activation of protein kinase Cα . Circ Res 1997; 81:363-371.
    • (1997) Circ Res , vol.81 , pp. 363-371
    • Hempel, A.1    Maasch, C.2    Heintze, U.3
  • 20
    • 84865807287 scopus 로고    scopus 로고
    • Protein kinase C activation affects, via the mRNA-binding Hu-Antigen R/ELAV protein, vascular endothelial growth factor expression in a pericytic/endothelial coculture model
    • Amadio M, Osera C, Lupo G, et al. Protein kinase C activation affects, via the mRNA-binding Hu-Antigen R/ELAV protein, vascular endothelial growth factor expression in a pericytic/endothelial coculture model. Mol Vis 2012; 18:2153-2164.
    • (2012) Mol Vis , vol.18 , pp. 2153-2164
    • Amadio, M.1    Osera, C.2    Lupo, G.3
  • 21
    • 39149083402 scopus 로고    scopus 로고
    • PKCβ II/HuR/VEGF: A new molecular cascade in retinal pericytes for the regulation of VEGF gene expression
    • Amadio M, Scapagnini G, Lupo G, et al. PKCβ II/HuR/VEGF: a new molecular cascade in retinal pericytes for the regulation of VEGF gene expression. Pharmacol Res 2008; 57:60-66.
    • (2008) Pharmacol Res , vol.57 , pp. 60-66
    • Amadio, M.1    Scapagnini, G.2    Lupo, G.3
  • 22
    • 33947313405 scopus 로고    scopus 로고
    • VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability
    • Harhaj NS, Felinski EA, Wolpert EB, et al. VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability. Invest Ophthalmol Vis Sci 2006; 47:5106-5115.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 5106-5115
    • Harhaj, N.S.1    Felinski, E.A.2    Wolpert, E.B.3
  • 23
    • 75749119801 scopus 로고    scopus 로고
    • Inhibition of protein kinase C is not sufficient to prevent or reverse effects of VEGF165 on claudin-1 and permeability in microvascular endothelial cells
    • Deissler H, Deissler H, Lang GE: Inhibition of protein kinase C is not sufficient to prevent or reverse effects of VEGF165 on claudin-1 and permeability in microvascular endothelial cells. Invest Ophthalmol Vis Sci 2010; 51:535-542.
    • (2010) Invest Ophthalmol Vis Sci , vol.51 , pp. 535-542
    • Deissler, H.1    Deissler, H.2    Lang, G.E.3
  • 24
    • 33645553318 scopus 로고    scopus 로고
    • Endothelial tight junctions: Permeable barriers of the vessel wall
    • Bazzoni G: Endothelial tight junctions: permeable barriers of the vessel wall. Thromb Haemost 2006; 95:36-42.
    • (2006) Thromb Haemost , vol.95 , pp. 36-42
    • Bazzoni, G.1
  • 25
    • 45249116797 scopus 로고    scopus 로고
    • VEGF-induced effects on proliferation, migration and tight junctions are restored by ranibizumab (Lucentis® ) in microvascular retinal endothelial cells
    • Deissler H, Deissler H, Lang S, Lang GE: VEGF-induced effects on proliferation, migration and tight junctions are restored by ranibizumab (Lucentis® ) in microvascular retinal endothelial cells. Br J Ophthalmol 2008; 92:839-843.
    • (2008) Br J Ophthalmol , vol.92 , pp. 839-843
    • Deissler, H.1    Deissler, H.2    Lang, S.3    Lang, G.E.4
  • 26
    • 79953291729 scopus 로고    scopus 로고
    • A three-pore model describes transport properties of bovine retinal endothelial cells in normal and elevated glucose
    • Lopez-Quintero SV, Ji XY, Antonetti DA, et al. A three-pore model describes transport properties of bovine retinal endothelial cells in normal and elevated glucose. Invest Ophthalmol Vis Sci 2011; 52:1171-1180.
    • (2011) Invest Ophthalmol Vis Sci , vol.52 , pp. 1171-1180
    • Lopez-Quintero, S.V.1    Ji, X.Y.2    Antonetti, D.A.3
  • 27
    • 0033949316 scopus 로고    scopus 로고
    • Induction of endothelin-1 expression by glucose
    • Park JY, Takahara N, Gabariele A, et al. Induction of endothelin-1 expression by glucose. Diabetes 2000; 49:1239-1248.
    • (2000) Diabetes , vol.49 , pp. 1239-1248
    • Park, J.Y.1    Takahara, N.2    Gabariele, A.3
  • 28
    • 0037343260 scopus 로고    scopus 로고
    • Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes
    • Yokota T, Ma RC, Park JY, et al. Role of protein kinase C on the expression of platelet-derived growth factor and endothelin-1 in the retina of diabetic rats and cultured retinal capillary pericytes. Diabetes 2003; 52:838-845.
    • (2003) Diabetes , vol.52 , pp. 838-845
    • Yokota, T.1    Ma, R.C.2    Park, J.Y.3
  • 29
    • 1542742166 scopus 로고    scopus 로고
    • C99-PKC412-003 Study Group: Reduction of diabetic macular edema by oral administration of the kinase inhibitor PKC412
    • Campochiaro PA; C99-PKC412-003 Study Group: Reduction of diabetic macular edema by oral administration of the kinase inhibitor PKC412. Invest Ophthalmol Vis Sci 2004; 45:922-931.
    • (2004) Invest Ophthalmol Vis Sci , vol.45 , pp. 922-931
    • Campochiaro, P.A.1
  • 30
    • 13344293711 scopus 로고    scopus 로고
    • Amelioration of vascular dysfunctions in diabetic rats by an oral PKC-β inhibitor
    • Ishii H, Jirousek MR, Koya D, et al. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC-β inhibitor. Science 1996; 272:728-731.
    • (1996) Science , vol.272 , pp. 728-731
    • Ishii, H.1    Jirousek, M.R.2    Koya, D.3
  • 31
    • 8944246315 scopus 로고    scopus 로고
    • S)-13-[(dimethylamino)methyl]-10 11 14, 15-Detrahydro-4, 9:16, 21-dimetheno-1H, 13H-dibenzo[e, k]pyrrolo[3, 4-h][1, 4, 13]oxadiazacyclohexadecene-1, 3(2H)-dione (LY333531) and related analogues: Isozyme selective inhibitors of protein kinase Cβ
    • Jirousek MR, Gillig JR, Gonzalez CM, et al. (S)-13-[(dimethylamino)methyl]-10, 11, 14, 15-Detrahydro-4, 9:16, 21-dimetheno-1H, 13H-dibenzo[e, k]pyrrolo[3, 4-h][1, 4, 13]oxadiazacyclohexadecene-1, 3(2H)-dione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase Cβ . J Med Chem 1996; 39:2664-2671.
    • (1996) J Med Chem , vol.39 , pp. 2664-2671
    • Jirousek, M.R.1    Gillig, J.R.2    Gonzalez, C.M.3
  • 32
    • 0036707614 scopus 로고    scopus 로고
    • The interactions of a selective protein kinase β inhibitor with the human cytochromes P450
    • Ring BJ, Gillespie JS, Binkley SN, et al. The interactions of a selective protein kinase β inhibitor with the human cytochromes P450. Drug Metab Dispos 2002; 30:957-961.
    • (2002) Drug Metab Dispos , vol.30 , pp. 957-961
    • Ring, B.J.1    Gillespie, J.S.2    Binkley, S.N.3
  • 34
    • 15644366961 scopus 로고    scopus 로고
    • Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor
    • Aiello LP, Bursell SE, Clermont A, et al. Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. Diabetes 1997; 46:1473-1480.
    • (1997) Diabetes , vol.46 , pp. 1473-1480
    • Aiello, L.P.1    Bursell, S.E.2    Clermont, A.3
  • 35
    • 0034053336 scopus 로고    scopus 로고
    • Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes
    • Koya D, Haneda M, Nakagawa H, et al. Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes. FASEB J 2000; 14:439-447.
    • (2000) FASEB J , vol.14 , pp. 439-447
    • Koya, D.1    Haneda, M.2    Nakagawa, H.3
  • 36
    • 0031964664 scopus 로고    scopus 로고
    • Inhibition of intraocular neovascularization caused by retinal ischemia in pigs by PKCβ inhibition with LY333531
    • Danis RP, Bingaman DP, Jirousek M, et al. Inhibition of intraocular neovascularization caused by retinal ischemia in pigs by PKCβ inhibition with LY333531. Invest Ophthalmol Vis Sci 1998; 39:171-179.
    • (1998) Invest Ophthalmol Vis Sci , vol.39 , pp. 171-179
    • Danis, R.P.1    Bingaman, D.P.2    Jirousek, M.3
  • 37
    • 34147152341 scopus 로고    scopus 로고
    • A 6-month, randomized, double-masked, placebo-controlled study evaluating the effects of the protein kinase Cβ inhibitor ruboxistaurin on skin microvascular blood flow and other measures of diabetic peripheral neuropathy
    • Casselini CM, Barlow PM, Rice AL, et al. A 6-month, randomized, double-masked, placebo-controlled study evaluating the effects of the protein kinase Cβ inhibitor ruboxistaurin on skin microvascular blood flow and other measures of diabetic peripheral neuropathy. Diabetes Care 2007; 30:896-902.
    • (2007) Diabetes Care , vol.30 , pp. 896-902
    • Casselini, C.M.1    Barlow, P.M.2    Rice, A.L.3
  • 38
    • 25844459952 scopus 로고    scopus 로고
    • Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C β-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, double-blind clinical trial
    • Vinik AI, Bril V, Kempler P, et al. Treatment of symptomatic diabetic peripheral neuropathy with the protein kinase C β-inhibitor ruboxistaurin mesylate during a 1-year, randomized, placebo-controlled, double-blind clinical trial. Clin Ther 2005; 27:1164-1180.
    • (2005) Clin Ther , vol.27 , pp. 1164-1180
    • Vinik, A.I.1    Bril, V.2    Kempler, P.3
  • 39
    • 28644442122 scopus 로고    scopus 로고
    • The effect of ruboxistaurin on nephropathy in type 2 diabetes
    • Tuttle KR, Bakris GL, Tot RD, et al. The effect of ruboxistaurin on nephropathy in type 2 diabetes. Diabetes Care 2005; 28:2686-2690.
    • (2005) Diabetes Care , vol.28 , pp. 2686-2690
    • Tuttle, K.R.1    Bakris, G.L.2    Tot, R.D.3
  • 40
    • 32944465911 scopus 로고    scopus 로고
    • Effect of ruboxistaurin on blood-retinal barrier permeability in relation to severity of leakage in diabetic macular edema
    • Strom C, Sander B, Klemp K, et al. Effect of ruboxistaurin on blood-retinal barrier permeability in relation to severity of leakage in diabetic macular edema. Invest Ophthalmol Vis Sci 2005; 46:3855-3858.
    • (2005) Invest Ophthalmol Vis Sci , vol.46 , pp. 3855-3858
    • Strom, C.1    Sander, B.2    Klemp, K.3
  • 41
    • 33644842187 scopus 로고    scopus 로고
    • Inhibition of PKCβ by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients
    • Aiello LP, Clermont A, Arora V, et al. Inhibition of PKCβ by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients. Invest Ophthalmol Vis Sci 2006; 47:86-92.
    • (2006) Invest Ophthalmol Vis Sci , vol.47 , pp. 86-92
    • Aiello, L.P.1    Clermont, A.2    Arora, V.3
  • 42
    • 21344435254 scopus 로고    scopus 로고
    • The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: Initial results of the Protein Kinase C β Inhibitor Diabetic Retinopathy Study (PKC-DRS) multicenter randomized clinical trial
    • PKC-DRS Study Group.
    • PKC-DRS Study Group: The effect of ruboxistaurin on visual loss in patients with moderately severe to very severe nonproliferative diabetic retinopathy: initial results of the Protein Kinase C β Inhibitor Diabetic Retinopathy Study (PKC-DRS) multicenter randomized clinical trial. Diabetes 2005; 54:2188-2197.
    • (2005) Diabetes , vol.54 , pp. 2188-2197
  • 43
    • 33947236725 scopus 로고    scopus 로고
    • Effect of ruboxistaurin in patients with diabetic macular edema: Thirty-month results of the randomized PKC-DMES clinical trial
    • PKC-DMES Study Group.
    • PKC-DMES Study Group: Effect of ruboxistaurin in patients with diabetic macular edema: thirty-month results of the randomized PKC-DMES clinical trial. Arch Ophthalmol 2007; 125:318-324.
    • (2007) Arch Ophthalmol , vol.125 , pp. 318-324
  • 44
    • 33751520614 scopus 로고    scopus 로고
    • Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy
    • PKC-DRS2 Group
    • PKC-DRS2 Group, Aiello LP, Davis MD, et al. Effect of ruboxistaurin on visual loss in patients with diabetic retinopathy. Ophthalmology 2006; 113:2221-2230.
    • (2006) Ophthalmology , vol.113 , pp. 2221-2230
    • Aiello, L.P.1    Davis, M.D.2
  • 45
    • 79958295090 scopus 로고    scopus 로고
    • Effect of ruboxistaurin (rbx) on visual acuity decline over a 6-year period with cessation and reinstititution of therapy: Results of an open-label extension of the protein kinase c diabetic retinopathy study 2 (pkc-drs2)
    • Mbdv Study Group.
    • Sheetz MJ, Aielleo LP, Shahri N, Davis MD, Kles KA, Danis RP; Mbdv Study Group: Effect of ruboxistaurin (RBX) on visual acuity decline over a 6-year period with cessation and reinstititution of therapy: results of an open-label extension of the Protein Kinase C Diabetic Retinopathy Study 2 (PKC-DRS2). Retina 2011; 31:1053-1059.
    • (2011) Retina , vol.31 , pp. 1053-1059
    • Sheetz, M.J.1    Aielleo, L.P.2    Shahri, N.3    Davis, M.D.4    Kles, K.A.5    Danis, R.P.6
  • 46
    • 33644898830 scopus 로고    scopus 로고
    • Pharmacokinetics of ruboxistaurin are significantly altered by rifampicin-mediated CYP3A4 induction
    • Yeo KP, Lowe SL, Lim MT, et al. Pharmacokinetics of ruboxistaurin are significantly altered by rifampicin-mediated CYP3A4 induction. Br J Clin Pharmacol 2005; 61:200-210.
    • (2005) Br J Clin Pharmacol , vol.61 , pp. 200-210
    • Yeo, K.P.1    Lowe, S.L.2    Lim, M.T.3


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