3D printed bioceramics for dual antibiotic delivery to treat implant-associated bone infection

European Cells and Materials

Volumn 30, Issue , 2015, Pages 232-247

  Inzana, J A ^a,b   Trombetta, R P ^a,b   Schwarz, E M ^a,b   Kates, S L ^a   Awad, Hani A ^a,b  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b University of Rochester   (United States)

Author keywords

Antibiotics; Bone; Calcium phosphate; Ceramics; Drug delivery; Osteomyelitis; Rifampin; Staphylococcus aureus; Three dimensional printing; Vancomycin

Indexed keywords

ANTIINFECTIVE AGENT; BIOCERAMICS; BONE CEMENT; CALCIUM PHOSPHATE SCAFFOLD; POLY(METHYL METHACRYLATE); RIFAMPICIN; RIFAMPICIN PLUS VANCOMYCIN; UNCLASSIFIED DRUG; VANCOMYCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL COLONIZATION; BACTERIAL LOAD; BACTERICIDAL ACTIVITY; BIOFILM; BONE PLATE; BONE SCREW; COLONY FORMING UNIT; CONTROLLED STUDY; DEVICE INFECTION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG EFFICACY; DRUG IMPLANT; FEMALE; IN VITRO STUDY; IN VIVO STUDY; LOCAL THERAPY; LOW DRUG DOSE; MONOTHERAPY; MOUSE; NONHUMAN; OSTEOMYELITIS; OUTCOME ASSESSMENT; STAPHYLOCOCCUS INFECTION; SUSTAINED DRUG RELEASE; SYSTEMIC THERAPY; THREE DIMENSIONAL PRINTING; ANIMAL; BONE DISEASES; CERAMICS; DISEASE MODEL; DRUG EFFECTS; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

ANIMALS; ANTI-BACTERIAL AGENTS; BONE CEMENTS; BONE DISEASES; CERAMICS; DISEASE MODELS, ANIMAL; MICE; OSTEOMYELITIS; PRINTING, THREE-DIMENSIONAL; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; VANCOMYCIN;

EID: 84947062378     PISSN: 14732262     EISSN: None     Source Type: Journal    
DOI: 10.22203/eCM.v030a16     Document Type: Article

References (50)

1. Ahola N, Veiranto M, Mannisto N, Karp M, Rich J, Efimov A, Seppala J, Kellomaki M (2012) Processing and sustained in vitro release of rifampicin containing composites to enhance the treatment of osteomyelitis. Biomatter 2: 213-225.
2. Beeching NJ, Thomas MG, Roberts S, Lang SD (1986) Comparative in-vitro activity of antibiotics incorporated in acrylic bone cement. J Antimicrob Chemother 17: 173-184.
3. Bonev B, Hooper J, Parisot J (2008) Principles of assessing bacterial susceptibility to antibiotics using the agar diffusion method. J Antimicrob Chemother 61: 1295- 1301.
4. Bose S, Tarafder S (2011) Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review. Acta Biomater 8: 1401-1421.
5. Crandon JL, Kuti JL, Nicolau DP (2010) Comparative efficacies of human simulated exposures of telavancin and vancomycin against methicillin-resistant Staphylococcus aureus with a range of vancomycin MICs in a murine pneumonia model. Antimicrobial agents and chemotherapy 54: 5115-5119.
6. Darouiche RO (2004) Treatment of infections associated with surgical implants. N Engl J Med 350: 1422-1429.
7. Darouiche RO, Mansouri MD, Zakarevicz D, Alsharif A, Landon GC (2007) In vivo efficacy of antimicrobial-coated devices. J Bone Joint Surg Am 89: 792-797.
8. Deresinski S (2009) Vancomycin in combination with other antibiotics for the treatment of serious methicillin-resistant Staphylococcus aureus infections. Clin Infect Dis 49: 1072-1079.
9. Drancourt M, Stein A, Argenson JN, Roiron R, Groulier P, Raoult D (1997) Oral treatment of Staphylococcus spp. infected orthopaedic implants with fusidic acid or ofloxacin in combination with rifampicin. J Antimicrob Chemother 39: 235-240.
10. Duewelhenke N, Krut O, Eysel P (2007) Influence on mitochondria and cytotoxicity of different antibiotics administered in high concentrations on primary human osteoblasts and cell lines. Antimicrob Agents Chemother 51: 54-63.
11. Garrigos C, Murillo O, Euba G, Verdaguer R, Tubau F, Cabellos C, Cabo J, Ariza J (2010) Efficacy of usual and high doses of daptomycin in combination with rifampin versus alternative therapies in experimental foreign-body infection by methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 54: 5251-5256.
12. Gbureck U, Hölzel T, Doillon CJ, Müller FA, Barralet JE (2007a) Direct printing of bioceramic implants with spatially localized angiogenic factors. Advanced materials 19: 795-800.
13. Gbureck U, Hölzel T, Klammert U, Würzler K, Müller FA, Barralet JE (2007b) Resorbable dicalcium phosphate bone substitutes prepared by 3D powder printing. Advanced Functional Materials 17: 3940-3945.
14. Ginebra MP, Traykova T, Planell JA (2006) Calcium phosphate cements as bone drug delivery systems: a review. J Control Release. J Control Release 113: 102-110.
15. Gogia JS, Meehan JP, Di Cesare PE, Jamali AA (2009) Local antibiotic therapy in osteomyelitis. Semin Plast Surg 23: 100-107.
16. Gu Y, Chen X, Lee JH, Monteiro DA, Wang H, Lee WY (2012) Inkjet printed antibiotic- and calcium-eluting bioresorbable nanocomposite micropatterns for orthopedic implants. Acta Biomater 8: 424-431.
17. Inzana JA, Olvera D, Fuller SM, Kelly JP, Graeve OA, Schwarz EM, Kates SL, Awad HA (2014) 3D printing of composite calcium phosphate and collagen scaffolds for bone regeneration. Biomaterials 35: 4026-4034.
18. Inzana JA, Schwarz EM, Kates SL, Awad HA (2015) A novel murine model of established Staphylococcal bone infection in the presence of a fracture fixation plate to study therapies utilizing antibiotic-laden spacers after revision surgery. Bone 72: 128-136.
19. Jaeblon T (2010) Polymethylmethacrylate: properties and contemporary uses in orthopaedics. J Am Acad Orthop Surg 18: 297-305.
20. John AK, Baldoni D, Haschke M, Rentsch K, Schaerli P, Zimmerli W, Trampuz A (2009) Efficacy of daptomycin in implant-associated infection due to methicillin-resistant Staphylococcus aureus: importance of combination with rifampin. Antimicrob Agents Chemother 53: 2719-2724.
21. Kaplan JB (2010) Biofilm dispersal: mechanisms, clinical implications, and potential therapeutic uses. J Dent Res 89: 205-218.
22. Keren I, Kaldalu N, Spoering A, Wang Y, Lewis K (2004) Persister cells and tolerance to antimicrobials. FEMS Microbiol Lett 230: 13-18.
23. Klammert U, Gbureck U, Vorndran E, Rodiger J, Meyer-Marcotty P, Kubler AC (2010) 3D powder printed calcium phosphate implants for reconstruction of cranial and maxillofacial defects. J Craniomaxillofac Surg 38: 565-570.
24. Konig DP, Schierholz JM, Munnich U, Rutt J (2001) Treatment of staphylococcal implant infection with rifampicin-ciprofloxacin in stable implants. Arch Orthop Trauma Surg 121: 297-299.
25. Mariconda M, Ascione T, Balato G, Rotondo R, Smeraglia F, Costa GG, Conte M (2013) Sonication of antibiotic-loaded cement spacers in a two-stage revision protocol for infected joint arthroplasty. BMC Musculoskelet Disord 14: 193.
26. Mihailescu R, Furustrand Tafin U, Corvec S, Oliva A, Betrisey B, Borens O, Trampuz A (2014) High activity of fosfomycin and rifampin against methicillin-resistant Staphylococcus aureus biofilm in vitro and in an experimental foreign-body infection model. Antimicrobial agents and chemotherapy 58: 2547-2553.
27. Molina-Manso D, Manzano M, Doadrio JC, Del Prado G, Ortiz-Perez A, Vallet-Regi M, Gomez-Barrena E, Esteban J (2012) Usefulness of SBA-15 mesoporous ceramics as a delivery system for vancomycin, rifampicin and linezolid: a preliminary report. Int J Antimicrob Agents 40: 252-256.
28. Niska JA, Shahbazian JH, Ramos RI, Francis KP, Bernthal NM, Miller LS (2013) Vancomycin-rifampin combination therapy has enhanced efficacy against an experimental Staphylococcus aureus prosthetic joint infection. Antimicrob Agents Chemother 57: 5080-5086.
29. O'hara P, Hickey AJ (2000) Respirable PLGA microspheres containing rifampicin for the treatment of tuberculosis: manufacture and characterization. Pharm Res 17: 955-961.
30. Parra-Ruiz J, Vidaillac C, Rose WE, Rybak MJ (2010) Activities of high-dose daptomycin, vancomycin, and moxifloxacin alone or in combination with clarithromycin or rifampin in a novel in vitro model of Staphylococcus aureus biofilm. Antimicrobial agents and chemotherapy 54: 4329-4334.
31. Pribaz JR, Bernthal NM, Billi F, Cho JS, Ramos RI, Guo Y, Cheung AL, Francis KP, Miller LS (2012) Mouse model of chronic post-arthroplasty infection: noninvasive in vivo bioluminescence imaging to monitor bacterial burden for long-term study. J Orthop Res 30: 335-340.
32. Rani SA, Pitts B, Beyenal H, Veluchamy RA, Lewandowski Z, Davison WM, Buckingham-Meyer K, Stewart PS (2007) Spatial patterns of DNA replication, protein synthesis, and oxygen concentration within bacterial biofilms reveal diverse physiological states. J Bacteriol 189: 4223-4233.
33. Rathbone CR, Cross JD, Brown KV, Murray CK, Wenke JC (2011) Effect of various concentrations of antibiotics on osteogenic cell viability and activity. J Orthop Res 29: 1070-1074.
34. Saginur R, Stdenis M, Ferris W, Aaron SD, Chan F, Lee C, Ramotar K (2006) Multiple combination bactericidal testing of staphylococcal biofilms from implant-associated infections. Antimicrob Agents Chemother 50: 55-61.
35. Saleh-Mghir A, Muller-Serieys C, Dinh A, Massias L, Cremieux AC (2011) Adjunctive rifampin is crucial to optimizing daptomycin efficacy against rabbit prosthetic joint infection due to methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 55: 4589-4593.
36. Schmolders J, Hischebeth GT, Friedrich MJ, Randau TM, Wimmer MD, Kohlhof H, Molitor E, Gravius S (2014) Evidence of MRSE on a gentamicin and vancomycin impregnated polymethyl-methacrylate (PMMA) bone cement spacer after two-stage exchange arthroplasty due to periprosthetic joint infection of the knee. BMC Infect Dis 14: 144.
37. Tang HJ, Chen CC, Cheng KC, Wu KY, Lin YC, Zhang CC, Weng TC, Yu WL, Chiu YH, Toh HS, Chiang SR, Su BA, Ko WC, Chuang YC (2013) In vitro efficacies and resistance profiles of rifampin-based combination regimens for biofilm-embedded methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 57: 5717-5720.
38. Trampuz A, Widmer AF (2006) Infections associated with orthopedic implants. Curr Opin Infect Dis 19: 349- 356.
39. Trampuz A, Zimmerli W (2005) Prosthetic joint infections: update in diagnosis and treatment. Swiss Med Wkly 135: 243-251.
40. Trampuz A, Zimmerli W (2006) Diagnosis and treatment of infections associated with fracture-fixation devices. Injury 37 Suppl 2: S59-66.
41. Trebse R, Pisot V, Trampuz A (2005) Treatment of infected retained implants. J Bone Joint Surg Br Volume 87: 249-256.
42. Valour F, Karsenty J, Bouaziz A, Ader F, Tod M, Lustig S, Laurent F, Ecochard R, Chidiac C, Ferry T, Lyon BJISG (2014) Antimicrobial-related severe adverse events during treatment of bone and joint infection due to methicillin-susceptible Staphylococcus aureus. Antimicrob Agents Chemother 58: 746-755.
43. Vergidis P, Rouse MS, Euba G, Karau MJ, Schmidt SM, Mandrekar JN, Steckelberg JM, Patel R (2011) Treatment with linezolid or vancomycin in combination with rifampin is effective in an animal model of methicillin-resistant Staphylococcus aureus foreign body osteomyelitis. Antimicrob Agents Chemother 55: 1182-1186.
44. Vorndran E, Klammert U, Ewald A, Barralet JE, Gbureck U (2010) Simultaneous Immobilization of Bioactives During 3D Powder Printing of Bioceramic Drug-Release Matrices. Advanced Functional Materials 20: 1585-1591.
45. Waeiss RA, Negrini TC, Arthur RA, Bottino MC (2014) Antimicrobial effects of drug-containing electrospun matrices on osteomyelitis-associated pathogens. J Oral Maxillofac Surg 72: 1310-1319.
46. Widmer AF, Gaechter A, Ochsner PE, Zimmerli W (1992) Antimicrobial treatment of orthopedic implant-related infections with rifampin combinations. Clin Infect Dis 14: 1251-1253.
47. Yun HC, Branstetter JG, Murray CK (2008) Osteomyelitis in military personnel wounded in Iraq and Afghanistan J Trauma 64: S163-168; discussion S168.
48. Zimmerli W, Trampuz A, Ochsner PE (2004) Prosthetic-joint infections N Engl J Med 351: 1645-1654.
49. Zimmerli W, Widmer AF, Blatter M, Frei R, Ochsner PE (1998) Role of rifampin for treatment of orthopedic implant-related staphylococcal infections: a randomized controlled trial. Foreign-Body Infection (FBI) Study Group JAMA 279: 1537-1541.
50. Fraimow HS (2009) Systemic antimicrobial therapy in osteomyelitis. Semin Plast Surg 23: 90-99.