Cellular and molecular inflammatory profile of the choroid plexus in depression and suicide

Frontiers in Psychiatry

Volumn 6, Issue OCT, 2015, Pages

  Devorak, Julia ^a,b   Torres Platas, Susana Gabriela ^a,b   Davoli, Maria Antonietta ^a   Prud'homme, Josée ^a   Turecki, Gustavo ^a,b   Mechawar, Naguib ^a,b  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

Choroid plexus; Cytokines; Depression; Human; Macrophages; Neuroinflammation; Suicide

Indexed keywords

BIOLOGICAL MARKER; CELL PROTEIN; IBA1 PROTEIN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ADULT; ARTICLE; CELL DENSITY; CELL MIGRATION; CELLULAR DISTRIBUTION; CHOROID PLEXUS; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; DOWN REGULATION; ENCEPHALITIS; FEMALE; GENE; GENE EXPRESSION; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IBA1 GENE; INTRACELLULAR SIGNALING; MACROPHAGE; MALE; NEUROPATHOLOGY; PROTEIN DETERMINATION; PROTEIN PROTEIN INTERACTION; SUICIDE;

EID: 84947051726     PISSN: None     EISSN: 16640640     Source Type: Journal    
DOI: 10.3389/fpsyt.2015.00138     Document Type: Article

References (53)

1. World Health Organization. Media Centre Fact Sheet No. 369. (2012). Available from: http://www.who.int/mediacentre/factsheets/fs369/en/
2. Nierenberg AA, Gray SM, Grandin LD. Mood disorders and suicide. J Clin Psychiatry (2001) 62:27-30.
3. Sanchez LE, Le LT. Suicide in mood disorders. Depress Anxiety (2001) 14:177-82. doi: 10.1002/da.1063
4. Chen YW, Dilsaver SC. Lifetime rates of suicide attempts among subjects with bipolar and disorders relative to subjects with other Axis I disorders. Biol Psychiatry (1996) 39:896-9. doi:10.1016/0006-3223(95)00295-2
5. World Health Organization. Media Centre Fact Sheet No. 398. (2014). Available from: http://www.who.int/mediacentre/factsheets/fs398/en/
6. Smith RS. The macrophage theory of depression. Med Hypotheses (1991) 35:298-306. doi:10.1016/0306-9877(91)90272-Z
7. Denicoff KD, Rubinow DR, Papa MZ, Simpson C, Seipp CA, Lotze MT, et al. The neuropsychiatric effects of treatment with interleukin-2 and lymphokine-actived activated killer cells. Ann Intern Med (1987) 107:293-300. doi:10.7326/0003-4819-107-2-293
8. Renault PF, Hoofnagle JH, Park Y, Mullen KD, Peters M, Jones DB, et al. Psychiatric complications of long-term interferon alfa therapy. Arch Intern Med (1987) 147:1557-80. doi:10.1001/archinte.1987.00370090055011
9. Maes M, Smith R, Scharpe S. The monocyte-T-lymphocyte hypothesis of depression. Psychoneuroendocrinology (1995) 20:111-6. doi:10.1016/0306-4530(94)00066-J
10. Bluthé RM, Pawlowski M, Suarez S, Parnet P, Pittman Q, Kelley KW, et al. Synergy between tumor necrosis factor a and interleukin-1 in the induction of sickness behavior in mice. Psychoneuroendocrinology (1994) 19:197-207. doi:10.1016/0306-4530(94)90009-4
11. Felger JC, Alagbe O, Hu F, Mook D, Freeman AA, Sanchez MM, et al. Effects of interferon-alpha on rhesus monkeys: a nonhuman primate model of cytokine-induced depression. Biol Psychiatry (2007) 62:1324-33. doi:10.1016/j.biopsych.2007.05.026
12. Janssen HLA, Brouwer JT, van der Mast RC, Schalm SW. Suicide associated with alfa-interferon therapy for chronic viral hepatitis. J Hepatol (1994) 21:241-3. doi:10.1016/S0168-8278(05)80402-7
13. Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW. From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci (2008) 9:46-56. doi:10.1038/nrn2297
14. Maes M, Bosmans E, Suy E, Vandervorst C, DeJonckheere C, Raus J. Depression-related disturbances in mitogen-induced lymphocyte responses and interleukin-1β and soluble interleukin-2 receptor production. Acta Psychiatr Scand (1991) 84:379-86. doi:10.1111/j.1600-0447.1991.tb03163.x
15. Maes M, Meltzer HY, Bosmans E, Bergmans R, Vandoolaeghe E, Ranjan R, et al. Increased plasma concentrations of interleukin-6, soluble interleukin-6, soluble interleukin-2 and transferrin receptor in major depression. J Affect Disord (1995) 34:301-9. doi:10.1016/0165-0327(95)00028-L
16. Mikova O, Yakimova R, Bosmans E, Kenis G, Maes M. Increased serum tumor necrosis factor alpha concentrations in major depression and multiple sclerosis. Eur Neuropsychopharmacol (2001) 11:203-8. doi:10.1016/S0924-977X(01)00081-5
17. Howren MB, Lamkin DM, Suls J. Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med (2009) 71:171-86. doi:10.1097/PSY.0b013e3181907c1b
18. Dowlati Y, Herrmann N, Swardfager W, Liu H, Sham L, Reim EK, et al. A meta-analysis of cytokines in major depression. Biol Psychiatry (2010) 67:446-57. doi:10.1016/j.biopsych.2009.09.033
19. Liu Y, Ho RC, Mak A. Interleukin (IL)-6, tumor necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression. J Affect Disord (2012) 139:230-9. doi:10.1016/j.jad.2011.08.003
20. Janelidze S, Mattei D, Westrin Å, Träskman-Bendz L, Brundin L. Cytokine levels in the blood may distinguish suicide attempters from depressed patients. Brain Behav Immun (2011) 25:335-9. doi:10.1016/j.bbi.2010.10.010
21. Tonelli LH, Stiller J, Rujescu D, Giegling I, Schneider B, Maurer K, et al. Elevated cytokine expression in the orbitofrontal cortex of victims of suicide. Acta Psychiatr Scand (2008) 117:198-206. doi:10.1111/j.1600-0447.2007.01128.x
22. Pandey GN, Rizavi HS, Ren X, Fareed J, Hoppensteadt DA, Roberts RC, et al. Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims. J Psychiatr Res (2012) 46:57-63. doi:10.1016/j.jpsychires.2011.08.006
23. Steiner J, Bielau H, Brisch R, Danos P, Ullrich O, Mawrin C, et al. Immunological aspects in the neurobiology of suicide: elevated microglial density in schizophrenia and depression is associated with suicide. J Psychiatr Res (2008) 42:151-7. doi:10.1016/j.jpsychires.2006.10.013
24. Torres-Platas SG, Hercher C, Davoli MA, Maussion G, Labonté B, Turecki G, et al. Astrocytic hypertrophy in anterior cingulate white matter of depressed suicides. Neuropsychopharmacology (2011) 36:2650-8. doi:10.1038/npp.2011.154
25. Schnieder TP, Trencevska I, Rosoklija G, Stankov A, Mann JJ, Smiley J, et al. Microglia of prefrontal white matter in suicide. J Neuropathol Exp Neurol (2014) 73:880-90. doi:10.1097/NEN.0000000000000107
26. Torres-Platas SG, Cruceanu C, Chen GG, Turecki G, Mechawar N. Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides. Brain Behav Immun (2014) 42:50-9. doi:10.1016/j.bbi.2014.05.007
27. Levine J, Barak Y, Chengappa KNR, Rapoport A, Rebey M, Barak V. Cerebrospinal cytokine levels in patients with acute depression. Neuropsychobiology (1999) 40:171-6. doi:10.1159/000026615
28. Lindqvist D, Janelidze S, Hagell P, Erhardt S, Samuelsson M, Minthon L, et al. Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to related to symptom severity. Biol Psychiatry (2009) 66:287-92. doi:10.1016/j.biopsych.2009.01.030
29. Wohleb ES, McKim DB, Sheridan JF, Godbout JP. Monocyte trafficking to the brain with stress and inflammation: a novel axis of immune-to-brain communication that influences mood and behavior. Front Neurosci (2015) 8:447. doi:10.3389/fnins.2014.00447
30. Emerich DF, Skinner SJ, Borlongan CV, Vasconcellos AV, Thanos CG. The choroid plexus in the rise, fall and repair of the brain. Bioessays (2005) 27:262-74. doi:10.1002/bies.20193
31. Wolburg H, Paulus W. Choroid plexus: biology and pathology. Acta Neuropathol (2010) 119:75-88. doi:10.1007/s00401-009-0627-8
32. Sathyanesan M, Girgenti MJ, Banasr M, Stone K, Bruce C, Guilchicek E, et al. A molecular characterization of the choroid plexus and stress-induced gene regulation. Transl Psychiatry (2012) 2:e139. doi:10.1038/tp.2012.64
33. Ericsson A, Liu C, Hart RP, Sawchenko PE. Type 1 interleukin-1 receptor in the rat brain: distribution, regulation, and relationship to sites of IL-1-induced cellular activation. J Comp Neurol (1995) 361:681-98. doi:10.1002/cne.903610410
34. Dragunow M. Meningeal and choroid plexus cells-novel drug targets for CNS disorders. Brain Res (2013) 1501:32-55. doi:10.1016/j.brainres.2013.01.013
35. Meeker RB, Williams K, Killebrew DA, Hudson LC. Cell trafficking through the choroid plexus. Cell Adh Migr (2012) 6:390-6. doi:10.4161/cam.21054
36. Quan N, Whiteside M, Herkenham M. Time course and localization of interleukin-1beta messenger RNA expression in brain and pituitary after peripheral administration of lipopolysaccharide. Neuroscience (1998) 83:281-93. doi:10.1016/S0306-4522(97)00350-3
37. Mitchell K, Yang HY, Berk JD, Tran JH, Iadarola MJ. Monocyte chemoattractant protein-1 in the choroid plexus: a potential link between vascular pro-inflammatory mediators and the CNS during peripheral tissue inflammation. Neuroscience (2009) 158:885-95. doi:10.1016/j.neuroscience.2008.10.047
38. Turner CA, Thompson RC, Bunney WE, Schatzberg AF, Barchas JD, Myers RM, et al. Altered choroid plexus gene expression in major depressive disorder. Front Hum Neurosci (2014) 8:238. doi:10.3389/fnhum.2014.00238
39. Maes M, Vandoolaeghe E, Ranjan R, Bosmans E, Bergmans R, Desnyder R. Increased serum interleukin-1-receptor-antagonist concentrations in major depression. J Affect Disord (1995) 36:29-36. doi:10.1016/0165-0327(95)00049-6
40. Dumais A, Lesage AD, Alda M, Rouleau G, Dumont M, Chawky N, et al. Risk factors for suicide completion in major depression: a case-control study of impulsive and aggressive behaviors in men. Am J Psychiatry (2005) 162:2116-24. doi:10.1176/appi.ajp.162.11.2116
41. Sluzewska A, Rybakowski JK, Laciak M, Mackiewicz A, Sobieska M, Wiktorowicz K. Interleukin-6 serum levels in depressed patients before and after treatment with fluoxetine. Ann N Y Acad Sci (1995) 726:474-6. doi:10.1111/j.1749-6632.1995.tb32372.x
42. Hernández ME, Mendieta D, Martínez-Fong D, Loría F, Moreno J, Estrada I, et al. Variations in circulating cytokine levels during 52 week course of treatment with SSRI for major depressive disorder. Eur Neuropsychopharmacol (2008) 18:917-24. doi:10.1016/j.euroneuro.2008.08.001
43. Hannestad J, DellaGioia N, Bloch M. The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis. Neuropsychopharmacology (2011) 36:2452-9. doi:10.1038/npp.2011.132
44. Maes M. Evidence for an immune response in major depression: a review and hypothesis. Prog Neuropsychopharmacol Biol Psychiatry (1995) 19:11-38. doi:10.1016/0278-5846(94)00101-M
45. Garabedian BV, Lemaigre-Dubreuil Y, Mariani J. Central origin of IL-1beta produced during peripheral inflammation: role of meninges. Mol Brain Res (2000) 75:259-63. doi:10.1016/S0169-328X(99)00320-4
46. Johanson C, Stopa E, McMillan P, Roth D, Funk J, Krinke G. The distributional nexus of choroid plexus to cerebrospinal fluid, ependyma and brain: toxicologic/pathologic phenomena, periventricular destabilization, and lesion spread. Toxicol Pathol (2011) 39:186-212. doi:10.1177/0192623310394214
47. Anisman H, Gibb J, Hayley S. Influence of continuous infusion of interleukin-1beta on depression-related processes in mice: corticosterone, circulating cytokines, brain monoamines, and cytokine mRNA expression. Psychopharmacology (Berl) (2008) 199:231-44. doi:10.1007/s00213-008-1166-z
48. Maes M, Berk M, Goehler L, Song C, Anderson G, Galecki P, et al. Depression and sickness behavior are Janus-faced responses to shared inflammatory pathways. BMC Med (2012) 10:66. doi:10.1186/1741-7015-10-66
49. Steffen BJ, Breier G, Butcher EC, Schulz M, Engelhardt B. ICAM-1, VCAM-1, and MAdCAM-1 are epressed on choroid plexus epithelium but not endothelium and mediate binding of lymphocytes in vitro. Am J Pathol (1996) 148:1819-38.
50. Maes M, Bosmans E, De Jongh R, Kenis G, Vandoolaeghe E, Neels H. Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression. Cytokine (1997) 9:853-8. doi:10.1006/cyto.1997.0238
51. Maes M, Mihaylova I, Kubera M, Ringel K. Activation of cell-mediated immunity in depression: association with inflammation, melancholia, clinical staging and the fatigue and somatic symptom cluster of depression. Prog Neuropsychopharmacol Biol Psychiatry (2012) 36:169-75. doi:10.1016/j.pnpbp.2011.09.006
52. Kaestner F, Hettich M, Peters M, Sibrowski W, Hetzel G, Ponath G, et al. Different activation patterns of proinflammatory cytokines in melancholic and non-melancholic major depression are associated with HPA axis activity. J Affect Disord (2005) 87:305-11. doi:10.1016/j.jad.2005.03.012
53. Dunjic-Kostic B, Ivkovic M, Radonjic NV, Petronijevic ND, Pantovic M, Damjanovic A, et al. Melancholic and atypical major depression-connection between cytokines, psychopathology and treatment. Prog Neuropsychopharmacol Biol Psychiatry (2013) 43:1-6. doi:10.1016/j.pnpbp.2012.11.009