Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13-Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation

Journal of Investigative Dermatology

Volumn 135, Issue 11, 2015, Pages 2603-2610

  Liu, Kai Ming ^a,b   Chen, Yi Ju ^c   Shen, Li Fen ^a   Haddad, Amir N S ^a,d   Song, I Wen ^a,e   Chen, Li Ying ^a,f   Chen, Yu Ju ^c   Wu, Jer Yuarn ^a   Yen, Jeffrey J Y ^a   Chen, Yuan Tsong ^a,b,g  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c INSTITUTE OF CHEMISTRY   (Taiwan)

^d UNIVERSITY OF TORONTO   (Canada)

^e NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^f ACADEMIA SINICA   (Taiwan)

^g DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE; CORNIFELIN; DHHC13 ENZYME; PROTEIN; UNCLASSIFIED DRUG; CORNIFELIN PROTEIN, MOUSE; MEMBRANE PROTEIN; PROTEIN PRECURSOR; ZDHHC13 PROTEIN, MOUSE;

ALOPECIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CUTICLE OF HAIR SHAFT; CYCLIC ALOPECIA; EPIDERMIS; GENE; GENE EXPRESSION; HAIR; HAIR FOLLICLE; HYPERKERATOSIS; KERATINOCYTE; MOUSE; NONHUMAN; PALMITOYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN; SKIN PERMEABILITY; ZDHHC13 GENE; ANIMAL; C57BL MOUSE; CONGENITAL SKIN DISEASE; DEFICIENCY; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; IMMUNOHISTOCHEMISTRY; METABOLISM; METHYLATION; NEWBORN; PATHOLOGY; SENSITIVITY AND SPECIFICITY; SKIN ABSORPTION; TRANSGENIC MOUSE; WESTERN BLOTTING;

ACYLTRANSFERASES; ALOPECIA; ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; GENE EXPRESSION REGULATION; HAIR; IMMUNOHISTOCHEMISTRY; MEMBRANE PROTEINS; METHYLATION; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROTEIN PRECURSORS; SENSITIVITY AND SPECIFICITY; SKIN ABNORMALITIES; SKIN ABSORPTION;

EID: 84947047426     PISSN: 0022202X     EISSN: 15231747     Source Type: Journal    
DOI: 10.1038/jid.2015.240     Document Type: Article

References (34)

1. Alonso L, Fuchs E (2006) The hair cycle. J Cell Sci 119:391-3
2. Bartels DJ, Mitchell DA, Dong X et al. (1999) Erf2, a novel gene product that affects the localization and palmitoylation of Ras2 in Saccharomyces cerevisiae. Mol Cell Biol 19:6775-87
3. Berchtold LA, Storling ZM, Ortis F et al. (2011) Huntingtin-interacting protein 14 is a type 1 diabetes candidate protein regulating insulin secretion and betacell apoptosis. Proc Natl Acad Sci USA 108:E681-8
4. Blaskovic S, Adibekian A, Blanc M et al. (2014) Mechanistic effects of protein palmitoylation and the cellular consequences thereof. Chem Phy Lipids 180:44-52
5. Candi E, Schmidt R, Melino G (2005) The cornified envelope: a model of cell death in the skin. Nat Rev Mol Cell Biol 6:328-40
6. Charollais J, Van Der Goot FG (2009) Palmitoylation of membrane proteins (review). Mol Membr Biol 26:55-66
7. Chen YJ, Ku WC, Lin PY et al. (2010) S-alkylating labeling strategy for sitespecific identification of the s-nitrosoproteome. J Proteome Res 9:6417-39
8. Fukata M, Fukata Y, Adesnik H et al. (2004) Identification of PSD-95 palmitoylating enzymes. Neuron 44:987-96
9. Grantham ML, Wu WH, Lalime EN et al. (2009) Palmitoylation of the influenza A virus M2 protein is not required for virus replication in vitro but contributes to virus virulence. J Virol 83:8655-61
10. Huang K, Sanders S, Singaraja R et al. (2009) Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity. FASEB J 23:2605-15
11. Iwanaga T, Tsutsumi R, Noritake J et al. (2009) Dynamic protein palmitoylation in cellular signaling. Prog Lipid Res 48:117-27
12. Kiso M, Tanaka S, Saba R et al. (2009) The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice. Proc Natl Acad Sci USA 106:9292-7
13. Koch PJ, de Viragh PA, Scharer E et al. (2000) Lessons from loricrin-deficient mice: compensatory mechanisms maintaining skin barrier function in the absence of a major cornified envelope protein. J Cell Biol 151:389-400
14. Korycka J, Lach A, Heger E et al. (2012) Human DHHC proteins: a spotlight on the hidden player of palmitoylation. Eur J Cell Biol 91:107-17
15. Kuramoto N, Takizawa T, Takizawa T et al. (2002) Development of ichthyosiform skin compensates for defective permeability barrier function in mice lacking transglutaminase 1. J Clin Invest 109:243-50
16. Ma L, Liu J,Wu T et al. (2003) 'Cyclic alopecia' in Msx2 mutants: defects in hair cycling and hair shaft differentiation. Development 130:379-89
17. Michibata H, Chiba H, Wakimoto K et al. (2004) Identification and characterization of a novel component of the cornified envelope, cornifelin. Biochem Biophys Res Commun 318:803-13
18. Mill P, Lee AW, Fukata Y et al. (2009) Palmitoylation regulates epidermal homeostasis and hair follicle differentiation. PLoS Genet 5:e1000748
19. Milnerwood AJ, Parsons MP, Young FB et al. (2013) Memory and synaptic deficits in Hip14/DHHC17 knockout mice. Proc Natl Acad Sci USA 110: 20296-301
20. Nemes Z, Steinert PM (1999) Bricks and mortar of the epidermal barrier. Exp Mol Med 31:5-19
21. Ohno Y, Kihara A, Sano T et al. (2006) Intracellular localization and tissue-specific distribution of human and yeast DHHC cysteine-rich domain-containing proteins. Biochim Biophys Acta 1761:474-83
22. Roth AF, Feng Y, Chen L et al. (2002) The yeast DHHC cysteine-rich domain protein Akr1p is a palmitoyl transferase. J Cell Biol 159:23-8
23. Rousso I, Mixon MB, Chen BK et al. (2000) Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity. Proc Natl Acad Sci USA 97:13523-5
24. Saleem AN, Chen YH, Baek HJ et al. (2010) Mice with alopecia, osteoporosis, and systemic amyloidosis due to mutation in Zdhhc13, a gene coding for palmitoyl acyltransferase. PLoS Genet 6:e1000985
25. Sevilla LM, Nachat R, Groot KR et al. (2007) Mice deficient in involucrin, envoplakin, and periplakin have a defective epidermal barrier. J Cell Biol 179:1599-612
26. Singaraja RR, Hadano S, Metzler M et al. (2002) HIP14, a novel ankyrin domain-containing protein, links huntingtin to intracellular trafficking and endocytosis. Hum Mol Genet 11:2815-28
27. Singaraja RR, Huang K, Sanders SS et al. (2011) Altered palmitoylation and neuropathological deficits in mice lacking HIP14. Hum Mol Genet 20: 3899-909
28. Song IW, Li WR, Chen LY et al. (2014) Palmitoyl acyltransferase, Zdhhc13, facilitates bone mass acquisition by regulating postnatal epiphyseal development and endochondral ossification: a mouse model. PloS One 9:e92194
29. Sutton LM, Sanders SS, Butland SL et al. (2013) Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease. Hum Mol Genet 22:452-65
30. Wan J, Roth AF, Bailey AO et al. (2007) Palmitoylated proteins: purification and identification. Nat Protoc 2:1573-84
31. Wei G, Bhushan B (2006) Nanotribological and nanomechanical characterization of human hair using a nanoscratch technique. Ultramicroscopy 106: 742-54
32. Xin Y, Lu Q, Li Q (2010) 14-3-3sigma is required for club hair retention. J Investig Dermatol Symp Proc 130:1934-6
33. Yanai A, Huang K, Kang R et al. (2006) Palmitoylation of huntingtin by HIP14 is essential for its trafficking and function. Nat Neurosci 9:824-31
34. Yu L, Reader JC, Chen C et al. (2011) Activation of a novel palmitoyltransferase ZDHHC14 in acute biphenotypic leukemia and subsets of acute myeloid leukemia. Leukemia 25:367-71