The disruption of Sox21-mediated hair shaft cuticle differentiation causes cyclic alopecia in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 23, 2009, Pages 9292-9297

  Kiso, Makoto ^a   Tanaka, Shigekazu ^a   Saba, Rie ^a   Matsuda, Satoru ^b   Shimizu, Atsushi ^b   Ohyama, Manabu ^b   Okano, Hirotaka James ^b   Shiroishi, Toshihiko ^a,c   Okano, Hideyuki ^b   Saga, Yumiko ^a,c  

^a NATIONAL INSTITUTE OF GENETICS   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c GRADUATE UNIVERSITY FOR ADVANCED STUDIES   (Japan)

Author keywords

Epidermal hyperplasia; Hair follicle; Keratin

Indexed keywords

BINDING PROTEIN; KERATIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR SOX21; UNCLASSIFIED DRUG;

ALOPECIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; CYCLIC ALOPECIA; DOWN REGULATION; GENE; GENE EXPRESSION; HAIR; HAIR GROWTH; HAIR LOSS; HAIR SHAFT CUTICLE; HUMAN; HUMAN CELL; MORPHOGENESIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SOX21 GENE; STEM CELL;

ALOPECIA; ANIMALS; CELL DIFFERENTIATION; HAIR; HAIR FOLLICLE; KERATINS; MICE; MICE, KNOCKOUT; SOXB2 TRANSCRIPTION FACTORS; STEM CELLS;

MUS;

EID: 67249121958     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0808324106     Document Type: Article

References (29)

1. Stenn KS, Paus R (2001) Controls of hair follicle cycling. Physiol Rev 81:449-494. (Pubitemid 32096181)
2. Fuchs E, Merrill BJ, Jamora C, DasGupta R (2001) At the roots of a never-ending cycle. Dev Cell 1:13-25. (Pubitemid 33586065)
3. Plikus MV, Chuong CM (2008) Complex hair cycle domain patterns and regenerative hair waves in living rodents. J Invest Dermatol 128:1071-1080. (Pubitemid 351543215)
4. Huelsken J, Vogel R, Erdmann B, Cotsarelis G, BirchmeierW(2001) β-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. Cell 105:533-545. (Pubitemid 32520858)
5. Niemann C, Owens DM, Hulsken J, Birchmeier W, Watt FM (2002) Expression of DeltaNLef1 in mouse epidermis results in differentiation of hair follicles into squamous epidermal cysts and formation of skin tumors. Development 129:95-109. (Pubitemid 34863779)
6. MaL, et al. (2003) Cyclic alopecia in Msx2 mutants: Defects in hair cycling and hair shaft differentiation. Development 130:379-389. (Pubitemid 36175934)
7. Oshima H, Rochat A, Kedzia C, Kobayashi K, Barrandon Y (2001) Morphogenesis and renewal of hair follicles from adult multipotent stem cells. Cell 104:233-245. (Pubitemid 32174839)
8. Legue E, Nicolas JF (2005) Hair follicle renewal: Organization of stem cells in the matrix and the role of stereotyped lineages and behaviors. Development 132:4143-4154. (Pubitemid 41488863)
9. Langbein L, et al. (1999) The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle. J Biol Chem 274:19874-19884. (Pubitemid 129519439)
10. Langbein L, Rogers MA,Winter H, Praetzel S, Schweizer J (2001) The catalog of human hair keratins. II. Expression of the six type II members in the hair follicle and the combined catalog of human type I and II keratins. J Biol Chem 276:35123-35132. (Pubitemid 37384520)
11. UchikawaM, Kamachi Y, KondohH(1999)Twodistinct subgroups of group B Sox genes for transcriptional activators and repressors: Their expression during embryonic organogenesis of the chicken. Mech Dev 84:103-120. (Pubitemid 29331657)
12. Bowles J, Schepers G,KoopmanP (2000) Phylogeny of theSOXfamily of developmental transcription factors based on sequence and structural indicators. Dev Biol 227:239-255. (Pubitemid 30945248)
13. Ohba H, et al. (2004) Sox21 is a repressor of neuronal differentiation and is antagonized by YB-1. Neurosci Lett 358:157-160. (Pubitemid 38368193)
14. Sandberg M, Kallstrom M, Muhr J (2005) Sox21 promotes the progression of vertebrate neurogenesis. Nat Neurosci 8:995-1001. (Pubitemid 41061509)
15. Langbein L, Spring H, Rogers MA, Praetzel S, Schweizer J (2004) Hair keratins and hair follicle-specific epithelial keratins. Methods Cell Biol 78:413-451. (Pubitemid 39752631)
16. Morioka K (2005) Hair Follicle: Differentiation Under the Electron Microscope: An Atlas (Springer, New York).
17. Rogers MA, Langbein L, Praetzel-Wunder S, Winter H, Schweizer J (2006) Human hair keratin-associated proteins (KAPs). Int Rev Cytol 251:209-263. (Pubitemid 44382676)
18. Potter CS, et al. (2006) Evidence that the satin hair mutant gene Foxq1 is among multiple and functionally diverse regulatory targets for Hoxc13 during hair follicle differentiation. J Biol Chem 281:29245-29255. (Pubitemid 44507068)
19. Johns SA, Soullier S, Rashbass P, Cunliffe VT (2005) Foxn1 is required for tissue assembly and desmosomal cadherin expression in the hair shaft. Dev Dyn 232:1062-1068. (Pubitemid 40463959)
20. Reginelli AD, Wang YQ, Sassoon D, Muneoka K (1995) Digit tip regeneration correlates with regions of Msx1 (Hox 7) expression in fetal and newborn mice. Development 121:1065-1076.
21. Tkatchenko AV, et al. (2001) Overexpression of Hoxc13 in differentiating keratinocytes results in down-regulation of a novel hair keratin gene cluster and alopecia. Development 128:1547-1558. (Pubitemid 32514839)
22. Rogers GE (2004) Hair follicle differentiation and regulation. Int J Dev Biol 48:163-170. (Pubitemid 38807930)
23. Argenton F, et al. (2004) Ectopic expression and knockdown of a zebrafish sox21 reveal its role as a transcriptional repressor in early development. Mech Dev 121:131-142. (Pubitemid 38368819)
24. Langbein L, et al. (2006) K25 (K25irs1), K26 (K25irs2), K27 (K25irs3), and K28 (K25irs4) represent the type I inner root sheath keratins of the human hair follicle. J Invest Dermatol 126:2377-2386. (Pubitemid 44582258)
25. Cotsarelis G, Sun TT, Lavker RM (1990) Label-retaining cells reside in the bulge area of pilosebaceous unit: Implications for follicular stem cells, hair cycle, and skin carcinogenesis. Cell 61:1329-1337. (Pubitemid 20208836)
26. Ito M, KizawaK,HamadaK, CotsarelisG(2004) Hair follicle stem cells in the lower bulge form the secondary germ, a biochemically distinct but functionally equivalent progenitor cell population, at the termination of catagen. Differentiation 72:548-557. (Pubitemid 41702109)
27. Price VH,GummerCL (1989) Loose anagen syndrome. JAmAcad Dermatol 20:249-256. (Pubitemid 19055633)
28. Muller-Rover S, et al. (2001) A comprehensive guide for the accurate classification of murine hair follicles in distinct hair cycle stages. J Invest Dermatol 117:3-15. (Pubitemid 32652434)
29. Reynolds ES (1963) The use of lead citrate at high pH as an electron-opaque stain in electron microscopy. J Cell Biol 17:208-212.