Migration and invasion of oral squamous carcinoma cells is promoted by WNT5A, a regulator of cancer progression

Journal of Oral Pathology and Medicine

Volumn 44, Issue 10, 2015, Pages 776-784

  Prgomet, Zdenka ^a,b   Axelsson, Lena ^b   Lindberg, Pia ^a   Andersson, Tommy ^b  

^a MALMÖ UNIVERSITY   (Sweden)

^b LUND UNIVERSITY   (Sweden)

Author keywords

Cell migration and invasion; Oral squamous cell carcinoma; WNT5A

Indexed keywords

CALCIUM CHELATING AGENT; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; SECRETED FRIZZLED RELATED PROTEIN 1; WNT5A PROTEIN; FRIZZLED RELATED PROTEIN-1; HINT1 PROTEIN, HUMAN; MAPT PROTEIN, HUMAN; NERVE PROTEIN; ONCOPROTEIN; PROTEIN; RECOMBINANT PROTEIN; TAU PROTEIN; WNT PROTEIN; WNT5A PROTEIN, HUMAN;

ARTICLE; CALCIUM SIGNALING; CANCER GROWTH; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MOUTH SQUAMOUS CELL CARCINOMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA CELL LINE; WESTERN BLOTTING; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; CARCINOMA, SQUAMOUS CELL; CELL MOTION; DRUG EFFECTS; HEAD AND NECK NEOPLASMS; METABOLISM; MOUTH NEOPLASMS; PATHOLOGY; PHYSIOLOGY; PROGNOSIS; TUMOR CELL LINE; TUMOR INVASION; WNT SIGNALING PATHWAY;

BLOTTING, WESTERN; CALCIUM SIGNALING; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; HEAD AND NECK NEOPLASMS; HUMANS; MOUTH NEOPLASMS; NEOPLASM INVASIVENESS; NERVE TISSUE PROTEINS; PROGNOSIS; PROTEINS; PROTO-ONCOGENE PROTEINS; RECOMBINANT PROTEINS; TAU PROTEINS; WNT PROTEINS; WNT SIGNALING PATHWAY;

EID: 84947034194     PISSN: 09042512     EISSN: 16000714     Source Type: Journal    
DOI: 10.1111/jop.12292     Document Type: Article

References (37)

1. Siu A, Lee C, Dang D, Lee C, Ramos DM. Stem cell markers as predictors of oral cancer invasion. Anticancer Res 2012; 32: 1163-6.
2. Lundqvist L, Stenlund H, Laurell G, Nylander K. The importance of stromal inflammation in squamous cell carcinoma of the tongue. J Oral Pathol Med 2012; 41: 379-83.
3. Chaw SY, Majeed AA, Dalley AJ, Chan A, Stein S, Farah CS. Epithelial to mesenchymal transition (EMT) biomarkers-E-cadherin, beta-catenin, APC and vimentin-in oral squamous cell carcinogenesis and transformation. Oral Oncol 2012; 48: 997-1006.
4. Hamada M, Miki T, Iwai S, Shimizu H, Yura Y. Involvement of RhoA and RalB in geranylgeranyltransferase I inhibitor-mediated inhibition of proliferation and migration of human oral squamous cell carcinoma cells. Cancer Chemother Pharmacol 2011; 68: 559-69.
5. Alam H, Bhate AV, Gangadaran P, et al. Fascin overexpression promotes neoplastic progression in oral squamous cell carcinoma. BMC Cancer 2012; 20: 32.
6. Kramer RH, Shen X, Zhou H. Tumor cell invasion and survival in head and neck cancer. Cancer Metastasis Rev 2005; 24: 35-45.
7. Friedl P, Gilmour D. Collective cell migration in morphogenesis, regeneration and cancer. Nat Rev Mol Cell Biol 2009; 10: 445-57.
8. Yilmaz M, Christofori G. EMT, the cytoskeleton, and cancer cell invasion. Cancer Metastasis Rev 2009; 28: 15-33.
9. Choi S, Myers JN. Molecular pathogenesis of oral squamous cell carcinoma: implications for therapy. J Dent Res 2008; 87: 14-32.
10. Jenei V, Sherwood V, Howlin J, et al. A t-butyloxycarbonyl-modified Wnt5a-derived hexapeptide functions as a potent antagonist of Wnt5a-dependent melanoma cell invasion. Proc Natl Acad Sci U S A 2009; 17: 19473-8.
11. Anastas JN, Moon RT. WNT signalling pathways as therapeutic targets in cancer. Nat Rev Cancer 2013; 13: 11-26.
12. Camilli TC, Weeraratna AT. Striking the target in wnt-y conditions: intervening in wnt signaling during cancer progression. Biochem Pharmacol 2010; 80: 702-11.
13. Nusse R. Wnt signaling and stem cell control. Cell Res 2008; 18: 523-7.
14. Nishita M, Enomoto M, Yamagata K, Minami Y. Cell/tissue-tropic functions of Wnt5a signaling in normal and cancer cells. Trends Cell Biol 2010; 20: 346-54.
15. Kikuchi A, Yamamoto H, Sato A, Matsumoto S. Wnt5a: its signalling, functions and implication in diseases. Acta Physiol (Oxf) 2012; 204: 17-33.
16. Ann EJ, Kim HY, Seo MS, et al. Wnt5a controls Notch1 signaling through CaMKII-mediated degradation of the SMRT corepressor protein. J Biol Chem 2012; 287: 36814-29.
17. Weeraratna AT, Jiang Y, Hostetter G, et al. Wnt5a signaling directly affects cell motility and invasion of metastatic melanoma. Cancer Cell 2002; 1: 279-88.
18. Cohen EE, Lingen MW, Zhu B, et al. Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase. Cancer Res 2006; 66: 6296-303.
19. Liu G, Sengupta PK, Jamal B, et al. N-glycosylation induces the CTHRC1 protein and drives oral cancer cell migration. J Biol Chem 2013; 12: 20217-27.
20. Pannone G, Bufo P, Santoro A, et al. WNT pathway in oral cancer: epigenetic inactivation of WNT-inhibitors. Oncol Rep 2010; 24: 1035-41.
21. Pourreyron C, Reilly L, Proby C, et al. Wnt5a is strongly expressed at the leading edge in non-melanoma skin cancer, forming active gradients, while canonical wnt signalling is repressed. PLoS ONE 2012; 7: e31827.
22. Diaz Prado SM, Medina Villaamil V, Aparicio Gallego G, et al. Expression of wnt gene family and frizzled receptors in head and neck squamous cell carcinomas. Virchows Arch 2009; 455: 67-75.
23. Fracalossi AC, Silva Mde S, Oshima CT, Ribeiro DA. Wnt/beta-catenin signalling pathway following rat tongue carcinogenesis induced by 4-nitroquinoline 1-oxide. Exp Mol Pathol 2010; 88: 176-83.
24. Safholm A, Tuomela J, Rosenkvist J, Dejmek J, Harkonen P, Andersson T. The wnt-5a-derived hexapeptide foxy-5 inhibits breast cancer metastasis in vivo by targeting cell motility. Clin Cancer Res 2008; 15: 6556-63.
25. Kremenevskaja N, von Wasielewski R, Rao AS, Schofl C, Andersson T, Brabant G. Wnt-5a has tumor suppressor activity in thyroid carcinoma. Oncogene 2005; 24: 2144-5.
26. Wang Q, Symes AJ, Kane CA, et al. A novel role for wnt/Ca2 + signaling in actin cytoskeleton remodeling and cell motility in prostate cancer. PLoS ONE 2010; 5: e10456.
27. Prasad CP, Chaurasiya SK, Axelsson L, Andersson T. WNT-5A triggers Cdc42 activation leading to an ERK1/2 dependent decrease in MMP9 activity and invasive migration of breast cancer cells. Mol Oncol 2013; 7: 870-83.
28. Safholm A, Leandersson K, Dejmek J, Nielsen CK, Villoutreix BO, Andersson T. A formylated hexapeptide ligand mimics the ability of wnt-5a to impair migration of human breast epithelial cells. J Biol Chem 2006; 281: 2740-9.
29. Chuang JY, Yang WH, Chen HT, et al. CCL5/CCR5 axis promotes the motility of human oral cancer cells. J Cell Physiol 2009; 220: 418-26.
30. Dang D, Yang Y, Li X, et al. Matrix metalloproteinases and TGFbeta1 modulate oral tumor cell matrix. Biochem Biophys Res Commun 2004; 9: 937-42.
31. Yang CC, Zhu LF, Xu XH, Ning TY, Ye JH, Liu LK. Membrane type 1 matrix metalloproteinase induces an epithelial to mesenchymal transition and cancer stem cell-like properties in SCC9 cells. BMC Cancer 2013; 13: 171.
32. Brusevold IJ, Tveteraas IH, Aasrum M, Odegard J, Sandnes DL, Christoffersen T. Role of LPAR3, PKC and EGFR in LPA-induced cell migration in oral squamous carcinoma cells. BMC Cancer 2014; 14: 432.
33. Chang HJ, Chou CT, Chang HT, et al. Mechanisms of resveratrol-induced changes in cytosolic free calcium ion concentrations and cell viability in OC2 human oral cancer cells. Hum Exp Toxicol 2014; 34: 289-99.
34. Lai KC, Liu CJ, Chang KW, Lee TC. Depleting IFIT2 mediates atypical PKC signaling to enhance the migration and metastatic activity of oral squamous cell carcinoma cells. Oncogene 2013; 32: 3686-97.
35. Rhee CS, Sen M, Lu D, et al. Wnt and frizzled receptors as potential targets for immunotherapy in head and neck squamous cell carcinomas. Oncogene 2002; 21: 6598-605.
36. Cheng R, Sun B, Liu Z, et al. Wnt5a suppresses colon cancer by inhibiting cell proliferation and epithelial-mesenchymal transition. J Cell Physiol 2014; 229: 1908-17.
37. Dissanayake SK, Wade M, Johnson CE, et al. The Wnt5A/protein kinase C pathway mediates motility in melanoma cells via the inhibition of metastasis suppressors and initiation of an epithelial to mesenchymal transition. J Biol Chem 2007; 282: 17259-71.