Percutaneous injection of autologous, culture-expanded mesenchymal stem cells into carpometacarpal hand joints: A case series with an untreated comparison group

Wiener Medizinische Wochenschrift

Volumn 164, Issue 5-6, 2014, Pages 83-87

  Centeno, Christopher J ^a   Freeman, Michael D ^b,c,d  

^a Centeno Schultz Clinic   (United States)

^b OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^c UMEÅ UNIVERSITY   (Sweden)

^d AARHUS UNIVERSITY   (Denmark)

Author keywords

Adult autologous stem cell therapy; Carpometacarpal; Osteoarthritis

Indexed keywords

ADULT; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; CARPOMETACARPAL JOINT; CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; FOLLOW UP; HAND OSTEOARTHRITIS; HUMAN; HUMAN CELL; JOINT FUNCTION; MALE; MESENCHYMAL STEM CELL TRANSPLANTATION; MIDDLE AGED; OUTCOME ASSESSMENT; STEM CELL EXPANSION; THUMB; COMPARATIVE STUDY; EPIDEMIOLOGY; INTRAARTICULAR DRUG ADMINISTRATION; OSTEOARTHRITIS; PATHOPHYSIOLOGY; PHYSIOLOGY; PROCEDURES;

CARPOMETACARPAL JOINTS; CONTROLLED BEFORE-AFTER STUDIES; HUMANS; INJECTIONS, INTRA-ARTICULAR; MESENCHYMAL STEM CELL TRANSPLANTATION; OSTEOARTHRITIS;

EID: 84897439795     PISSN: 00435341     EISSN: 1563258X     Source Type: Journal    
DOI: 10.1007/s10354-013-0222-4     Document Type: Article

References (37)

1. Alhadlaq A, Mao JJ. Mesenchymal stem cells: isolation and therapeutics. Stem Cells Dev. 2004;13(4):436-48. (Pubitemid 39223294)
2. Arnoczky SP. Building a meniscus. Biologic considerations. Clin Orthop Relat Res. 1999;(367 Suppl):244-53.
3. Wakitani S, et al. Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects in five knees. J Tissue Eng Regen Med. 2007;1(1):74-9.
4. Wakitani S, et al. Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months. J Tissue Eng Regen Med. 2010;5(2):146-50.
5. Nejadnik H, et al. Autologous bone marrow-derived mesenchymal stem cells versus autologous chondrocyte implantation: an observational cohort study. Am J Sports Med. 2010;38(6):1110-6.
6. Centeno CJ, et al. Regeneration of meniscus cartilage in a knee treated with percutaneously implanted autologous mesenchymal stem cells. Med Hypotheses. 2008;71(6):900-8.
7. Centeno CJ, et al. Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician. 2008;11(3):343-53. (Pubitemid 351959424)
8. Centeno CJ, et al. Partial regeneration of the human hip via autologous bone marrow nucleated cell transfer: a case study. Pain Physician. 2006;9(3):253-6. (Pubitemid 44227398)
9. Centeno CJ, et al. Safety and complications reporting on the reimplantation of culture-expanded mesenchymal stem cells using autologous platelet lysate technique. Curr Stem Cell Res Ther. 2010;5(1):81-93.
10. Kalichman L, Hernandez-Molina G. Hand osteoarthritis: an epidemiological perspective. Semin Arthritis Rheum. 2010;39(6):465-76.
11. Schoffl VR, et al. Radiographic adaptations to the stress of high-level rock climbing in junior athletes: a 5-year longitudinal study of the German Junior National Team and a group of recreational climbers. Am J Sports Med. 2007;35(1):86-92. (Pubitemid 46018653)
12. Lee KB, et al. Acute calcific periarthritis of proximal interphalangeal joint in a professional golfer's hand. J Korean Med Sci. 2004;19(6):904-6.
13. Buterbaugh GA, Brown TR, Horn PC. Ulnar-sided wrist pain in athletes. Clin Sports Med. 1998;17(3):567-83. (Pubitemid 28359558)
14. Bollen SR, Wright V. Radiographic changes in the hands of rock climbers. Br J Sports Med. 1994;28(3):185-6. (Pubitemid 24305746)
15. Earp BE, et al. Arthroscopic hemitrapeziectomy with tendon interposition for arthritis at the first carpometacarpal joint. Tech Hand Up Extrem Surg. 2008;12(1):38-42. (Pubitemid 351499331)
16. Wollstein R, et al. Long-term durability of tendon arthroplasty with excision of the trapezium in stage 1 osteoarthritis of the thumb CMC joint. Ann Plast Surg. 2009;62(4):358-60.
17. Hofmeister EP, et al. Arthroscopic hemitrapeziectomy for first carpometacarpal arthritis: results at 7-year follow-up. Hand (NY). 2009;4(1):24-8.
18. Hansen TB, Vainorius D. High loosening rate of the Moje Acamo prosthesis for treating osteoarthritis of the trapeziometacarpal joint. J Hand Surg Eur Vol. 2008;33(5):571-4.
19. Nilsson A, et al. The Artelon CMC spacer compared with tendon interposition arthroplasty. Acta Orthop. 2010;81(2):239-46.
20. Badia A, Sambandam SN. Total joint arthroplasty in the treatment of advanced stages of thumb carpometacarpal joint osteoarthritis. J Hand Surg Am. 2006;31(10):1605-14.
21. Bernardo ME, et al. Optimization of in vitro expansion of human multipotent mesenchymal stromal cells for celltherapy approaches: further insights in the search for a fetal calf serum substitute. J Cell Physiol. 2007;211(1):121-30. (Pubitemid 46363901)
22. Capelli C, et al. Human platelet lysate allows expansion and clinical grade production of mesenchymal stromal cells from small samples of bone marrow aspirates or marrow filter washouts. Bone Marrow Transplant. 2007;40(8):785-91. (Pubitemid 47521539)
23. Doucet C, et al. Platelet lysates promote mesenchymal stem cell expansion: a safety substitute for animal serum in cell-based therapy applications. J Cell Physiol. 2005;205(2):228-36. (Pubitemid 41428905)
24. Lange C, et al. Accelerated and safe expansion of human mesenchymal stromal cells in animal serum-free medium for transplantation and regenerative medicine. J Cell Physiol. 2007;213(1):18-26. (Pubitemid 47378788)
25. Muller I, et al. Animal serum-free culture conditions for isolation and expansion of multipotent mesenchymal stromal cells from human BM. Cytotherapy. 2006;8(5):437-44. (Pubitemid 44596996)
26. Schallmoser K, et al. Human platelet lysate can replace fetal bovine serum for clinical-scale expansion of functional mesenchymal stromal cells. Transfusion. 2007;47(8):1436-46. (Pubitemid 47101060)
27. Sodha S, et al. Prevalence of osteoarthrosis of the trapeziometacarpal joint. J Bone Joint Surg Am. 2005;87(12):2614-8. (Pubitemid 41747026)
28. Katsube Y, et al. Correlation between proliferative activity and cellular thickness of human mesenchymal stem cells. Biochem Biophys Res Commun. 2008;368(2):256-60.
29. Agashi K, Chau DY, Shakesheff KM. The effect of delivery via narrow-bore needles on mesenchymal cells. Regen Med. 2009;4(1):49-64.
30. Sharma L. Comment on: varus malalignment negates the structure-modifying benefits of doxycycline in obese women with knee osteoarthritis. Osteoarthr Cartil. 2010;18(8):1006-7.
31. Nuesch E, et al. Doxycycline for osteoarthritis of the knee or hip. Cochrane Database Syst Rev. 2009;4:CD007323.
32. Hunter DJ, Hellio Le Graverand-Gastineau MP. How close are we to having structure-modifying drugs available? Rheum Dis Clin North Am. 2008;34(3):789-802.
33. Le Graverand MP, et al. Assessment of the radioanatomic positioning of the osteoarthritic knee in serial radiographs: comparison of three acquisition techniques. Osteoarthr Cartil. 2006;14(Suppl A):A37-43.
34. Brandt KD, Mazzuca SA. Experience with a placebo-controlled randomized clinical trial of a disease-modifying drug for osteoarthritis: the doxycycline trial. Rheum Dis Clin North Am. 2006;32(1):217-34, xi-xii. (Pubitemid 43290601)
35. Filardo G, et al. Platelet-rich plasma intraarticular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis. Knee Surg Sports Traumatol Arthrosc. 2010;19(4)528-35.
36. Gobbi A, Bathan L. Biological approaches for cartilage repair. J Knee Surg. 2009;22(1):36-44.
37. Sanchez M, et al. Intra-articular injection of an autologous preparation rich in growth factors for the treatment of knee OA: a retrospective cohort study. Clin Exp Rheumatol. 2008;26(5):910-3.