Platelet-rich plasma intra-articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis

Knee Surgery, Sports Traumatology, Arthroscopy

Volumn 19, Issue 4, 2011, Pages 528-535

  Filardo, Giuseppe ^a   Kon, Elizaveta ^a   Buda, Roberto ^a   Timoncini, Antonio ^a   Di Martino, Alessandro ^a   Cenacchi, Annarita ^a   Fornasari, Pier Maria ^a   Giannini, Sandro ^a   Marcacci, Maurilio ^a  

^a RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

Author keywords

Cartilage; Intra articular injection; Knee; PRP

Indexed keywords

ADULT; AGED; ANALYSIS OF VARIANCE; ARTICLE; ARTICULAR CARTILAGE; COHORT ANALYSIS; COMPARATIVE STUDY; CONNECTIVE TISSUE DISEASE; FEMALE; FOLLOW UP; HOSPITALIZATION; HUMAN; INTRAARTICULAR DRUG ADMINISTRATION; KNEE OSTEOARTHRITIS; MALE; MIDDLE AGED; NONPARAMETRIC TEST; PATHOPHYSIOLOGY; PHYSIOLOGY; REGENERATION; RISK ASSESSMENT; THROMBOCYTE RICH PLASMA; TIME; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; ANALYSIS OF VARIANCE; CARTILAGE, ARTICULAR; COHORT STUDIES; CONNECTIVE TISSUE DISEASES; FEMALE; FOLLOW-UP STUDIES; HUMANS; INJECTIONS, INTRA-ARTICULAR; MALE; MIDDLE AGED; OSTEOARTHRITIS, KNEE; PLATELET-RICH PLASMA; REGENERATION; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC; TIME FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 79952993026     PISSN: 09422056     EISSN: 14337347     Source Type: Journal    
DOI: 10.1007/s00167-010-1238-6     Document Type: Article

References (33)

1. Ab-Rahim S, Selvaratnam L, Kamarul T (2008) The effect of TGF-beta1 and beta-estradiol on glycosaminoglycan and type II collagen distribution in articular chondrocyte cultures. Cell Biol Int 32: 841-847.
2. Bai X, Xiao Z, Pan Y, Hu J, Pohl J, Wen J, Li L (2004) Cartilage-derived morphogenetic protein-1 promotes the differentiation of mesenchymal stem cells into chondrocytes. Biochem Biophys Res Commun 325: 453-460.
3. Baltzer AW, Moser C, Jansen SA, Krauspe R (2009) Autologous conditioned serum (Orthokine) is an effective treatment for knee osteoarthritis. Osteoarthr Cartil 17: 152-160.
4. Bellamy N, Campbell J, Robinson V et al (2006) Intra-articular corticosteroid for treatment of osteoarthritis of the knee. Cochrane Database Syst Rev 19: CD005328.
5. Bosnakovski D, Mizuno M, Kim G, Takagi S, Okumura M, Fujinaga T (2006) Chondrogenic differentiation of bovine bone marrow mesenchymal stem cells (MSCs) in different hydrogels: influence of collagen type II extracellular matrix on MSC chondrogenesis. Biotechnol Bioeng 93: 1152-1163.
6. Buckwalter JA, Mankin HJ (1997) Articular cartilage. J Bone Joint Surg 79: 600-611.
7. Buckwalter JA, Mankin HJ (1997) Articular cartilage. Part II: degeneration and osteoarthrosis, repair, regeneration, and tranplantation. J Bone Joint Surg 79: 612-632.
8. Clegg DO, Reda DJ, Harris CL et al (2006) Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med 354: 795-808.
9. Foster TE, Puskas BL, Mandelbaum BR, Gerhardt MB, Rodeo SA (2009) Platelet-rich plasma: from basic science to clinical applications. Am J Sports Med 37: 2259-2272.
10. Frisbie DD, Kawcak CE, Werpy NM, Park RD, McIlwraith CW (2007) Clinical, biochemical, and histologic effects of intra-articular administration of autologous conditioned serum in horses with experimentally induced osteoarthritis. Am J Vet Res 68: 290-296.
11. Gaissmaier C, Fritz J, Krackhardt T, Flesch I, Aicher WK, Ashammakhi N (2005) Effect of human platelet supernatant on proliferation and matrix synthesis of human articular chondrocytes in monolayer and three-dimensional alginate cultures. Biomaterials 26: 1953-1960.
12. Harvey WF, Hunter DJ (2008) The role of analgesics and intra-articular injections in disease management. Rheum Dis Clin North Am 34: 777-788.
13. Hayami T (2008) Osteoarthritis of the knee joint as a cause of musculoskeletal ambulation disability symptom complex (MADS). Clin Calcium 18: 1574-1580.
14. Hickey DG, Frenkel SR, Di Cesare PE (2003) Clinical applications of growth factors for articular cartilage repair. Am J Orthop 32: 70-76.
15. Kon E, Buda R, Filardo G, Di Martino A, Timoncini A, Cenacchi A, Fornasari PM, Giannini S, Marcacci M (2010) Platelet-rich plasma: intra-articular knee injections produced favorable results on degenerative cartilage lesions. Knee Surg Sports Traumatol Arthrosc 18: 472-479.
16. Loeser RF, Pacione CA, Chubinskaya S (2003) The combination of insulin-like growth factor 1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human articular chondrocytes. Arthritis Rheum 48: 2188-2196.
17. Martin JA, Buckwalter JA (2000) The role of chondrocyte-matrix interactions in maintaining and repairing articular cartilage. Biorheology 37: 129-140.
18. Nakazawa F, Matsuno H, Yudoh K, Watanabe Y, Katayama R, Kimura T (2002) Corticosteroid treatment induces chondrocyte apoptosis in an experimental arthritis model and in chondrocyte cultures. Clin Exp Rheumatol 20: 773-781.
19. O'Keefe RJ, Crabb ID, Puzas JE, Rosier RN (1994) Effects of transforming growth factor-beta 1 and fibroblast growth factor on DNA synthesis in growth plate chondrocytes are enhanced by insulin-like growth factor-I. J Orthop Res 12(3): 299-310.
20. Pujol JP, Chadjichristos C, Legendre F, Bauge C, Beauchef G, Andriamanalijaona R, Galera P, Boumediene K (2008) Interleukin-1 and transforming growth factor-beta 1 as crucial factors in osteoarthritic cartilage metabolism. Connect Tissue Res 49: 293-297.
21. Reichenbach S, Trelle S et al (2007) Efficacy and safety of intra-articular hylan or hyaluronic acids for osteoarthritis of the knee: a randomized controlled trial. Arthritis Rheum 56: 3610-3619.
22. Safran MR, Seiber K (2010) The evidence for surgical repair of articular cartilage in the knee. J Am Acad Orthop Surg 18: 259-266.
23. Saito M, Takahashi KA, Arai Y, Inoue A, Sakao K, Tonomura H, Honjo K, Nakagawa S, Inoue H, Tabata Y, Kubo T (2009) Intraarticular administration of platelet-rich plasma with biodegradable gelatin hydrogel microspheres prevents osteoarthritis progression in the rabbit knee. Clin Exp Rheumatol 27: 201-207.
24. Sánchez M, Anitua E, Azofra J, Aguirre JJ, Andia I (2008) Intra-articular injection of an autologous preparation rich in growth factors for the treatment of knee OA: a retrospective cohort study. Clin Exp Rheumatol 26: 910-913.
25. Sánchez M, Anitua E, Orive G, Mujika I, Andia I (2009) Platelet-rich therapies in the treatment of orthopaedic sport injuries. Sports Med 39: 345-354.
26. Sánchez M, Azofra J, Anitua E, Andía I, Padilla S, Santisteban J, Mujika I (2003) Plasma rich in growth factors to treat an articular cartilage avulsion: a case report. Med Sci Sports Exerc 35: 1648-1652.
27. Schmidt MB, Chen EH, Lynch SE (2006) A review of the effects of insulin-like growth factor and platelet derived growth factor on in vivo cartilage healing and repair. Osteoarthr Cartil 14: 403-412.
28. Simon LS, Grierson LM, Naseer Z, Bookman AA, Zev Shainhouse J (2009) Efficacy and safety of topical diclofenac containing dimethyl sulfoxide (DMSO) compared with those of topical placebo, DMSO vehicle and oral diclofenac for knee osteoarthritis. Pain 143: 238-245.
29. Tchetina EV, Antoniou J, Tanzer M, Zukor DJ, Poole AR (2006) Transforming growth factor-beta2 suppresses collagen cleavage in cultured human osteoarthritic cartilage, reduces expression of genes associated with chondrocyte hypertrophy and degradation, and increases prostaglandin E(2) production. Am J Pathol 168: 131-140.
30. Ulrich-Vinther M, Maloney MD, Schwarz EM, Rosier R, O'Keefe RJ (2003) Articular cartilage biology. J Am Acad Orthop Surg 11: 421-430.
31. Widuchowski W, Widuchowski J, Trzaska T (2007) Articular cartilage defects: study of 25, 124 knee arthroscopies. Knee 14: 177-182.
32. Wu W, Chen F, Liu Y, Ma Q, Mao T (2007) Autologous injectable tissue-engineered cartilage by using platelet-rich plasma: experimental study in a rabbit model. J Oral Maxillofac Surg 65: 1951-1957.
33. Zhang W, Moskovitz R, Nuki G et al (2008) OARSI recommendations for the management of hip and knee osteoarthritis. Part II: OARSI evidence-based, expert consensus guidelines. Osteoarthr Cartil 16: 137-162.