Targeted drug delivery using genetically engineered diatom biosilica

Nature Communications

Volumn 6, Issue , 2015, Pages

  Delalat, Bahman ^a   Sheppard, Vonda C ^b   Rasi Ghaemi, Soraya ^a   Rao, Shasha ^a   Prestidge, Clive A ^a   McPhee, Gordon ^a   Rogers, Mary Louise ^c   Donoghue, Jacqueline F ^d,e   Pillay, Vinochani ^d,e   Johns, Terrance G ^d,e   Kröger, Nils ^b,f   Voelcker, Nicolas H ^a  

^a UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^c FLINDERS UNIVERSITY   (Australia)

^d HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

^e MONASH UNIVERSITY   (Australia)

^f DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; ANTIBODY; ANTINEOPLASTIC AGENT; CD20 ANTIBODY; CETRIMIDE; GOLD NANOPARTICLE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; IMMUNOGLOBULIN G; NANOCARRIER; NEUROTROPHIN RECEPTOR P75; PROTEIN G; SILICA NANOPARTICLE; SYNTHETIC DNA; CAMPTOTHECIN; LIPOSOME; MICELLE; NANOPARTICLE; SILICON DIOXIDE;

ANTIBODY; CANCER; DIATOM; DRUG; MICROALGA; NANOPARTICLE; TUMOR;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN BINDING; ARTICLE; B LYMPHOCYTE; BINDING AFFINITY; CONTROLLED STUDY; CROSS LINKING; DIATOM; FLUORESCENCE MICROSCOPY; FUSION GENE; GENETIC ENGINEERING; HYDROPHOBICITY; IN VITRO STUDY; LYMPHOMA CELL; MICELLE; MICROALGA; MOLECULARLY TARGETED THERAPY; MOUSE; NEUROBLASTOMA; NONHUMAN; PROTEIN DOMAIN; QUANTITATIVE ANALYSIS; STATIC ELECTRICITY; T LYMPHOCYTE; THALASSIOSIRA PSEUDONANA; TUMOR GROWTH; TUMOR REGRESSION; ANIMAL; DRUG DELIVERY SYSTEM; GENE EXPRESSION REGULATION; GENETICS; LYMPHOMA, B-CELL; METABOLISM; MOLECULAR CLONING; NEOPLASMS, EXPERIMENTAL; PARTICLE SIZE; TUMOR CELL LINE; XENOGRAFT;

BACILLARIOPHYTA; THALASSIOSIRA PSEUDONANA;

ANIMALS; ANTIBODIES; ANTINEOPLASTIC AGENTS; CAMPTOTHECIN; CELL LINE, TUMOR; CLONING, MOLECULAR; DIATOMS; DRUG DELIVERY SYSTEMS; GENE EXPRESSION REGULATION; GENETIC ENGINEERING; IMMUNOGLOBULIN G; LIPOSOMES; LYMPHOMA, B-CELL; MICE; MICELLES; NANOPARTICLES; NEOPLASMS, EXPERIMENTAL; NEUROBLASTOMA; PARTICLE SIZE; RECOMBINANT FUSION PROTEINS; SILICON DIOXIDE; TRANSPLANTATION, HETEROLOGOUS;

EID: 84946935108     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms9791     Document Type: Article

References (42)

1. Vallet-Regí, M., Balas, F. & Arcos, D. Mesoporous materials for drug delivery. Angew. Chem. Int. Ed. Engl. 46, 7548-7558 (2007).
2. McInnes, S. J., Irani, Y., Williams, K. A. & Voelcker, N. H. Controlled drug delivery from composites of nanostructured porous silicon and poly (L-lactide). Nanomedicine 7, 995-1016 (2012).
3. Simovic, S., Ghouchi-Eskandar, N., Moom Sinn, A., Losic, D. & Prestidge, C. A. Silica materials in drug delivery applications. Curr. Drug Discov. Technol. 8, 250-268 (2011).
4. McInnes, S. J. & Voelcker, N. H. Silicon-polymer hybrid materials for drug delivery. Future Med. Chem. 1, 1051-1074 (2009).
5. Kröger, N. & Poulsen, N. Diatoms-from cell wall biogenesis to nanotechnology. Annu. Rev. Genet. 42, 83-107 (2008).
6. Perry, C. In: Biomineralization: Chemical and Biochemical Perspectives (eds Mann, S., Webb, J. & Williams, R.) 223-256 (VCH, 1989).
7. Hamm, C. E. et al. Architecture and material properties of diatom shells provide effective mechanical protection. Nature 421, 841-843 (2003).
8. Aw, M. S., Simovic, S., Yu, Y., Addai-Mensah, J. & Losic, D. Porous silica microshells from diatoms as biocarrier for drug delivery applications. Powder Technol. 223, 52-58 (2012).
9. Aw, M. S., Simovic, S., Addai-Mensah, J. & Losic, D. Silica microcapsules from diatoms as new carrier for delivery of therapeutics. Nanomedicine 6, 1159-1173 (2011).
10. Bariana, M., Aw, M. S. & Losic, D. Tailoring morphological and interfacial properties of diatom silica microparticles for drug delivery applications. Adv. Powder Technol. 24, 757-763 (2013).
11. Kumeria, T. et al. Graphene oxide decorated diatom silica particles as new nano-hybrids: towards smart natural drug microcarriers. J. Mater. Chem. B 1, 6302-6311 (2013).
12. Townley, H. E., Parker, A. R. & White-Cooper, H. Exploitation of diatom frustules for nanotechnology: tethering active biomolecules. Adv. Funct. Mater. 18, 369-374 (2008).
13. Gale, D. K., T. G., Jiao, J., Chang, C.-H. & Rorrer, G. L. Photoluminescence detection of biomolecules by antibody-functionalized diatom biosilica. Adv. Funct. Mater. 926-933 (2009).
14. Brannon-Peppas, L. & Blanchette, J. O. Nanoparticle and targeted systems for cancer therapy. Adv. Drug Deliv. Rev. 56, 1649-1659 (2004).
15. Natarajan, S. K. & Selvaraj, S. Mesoporous silica nanoparticles: importance of surface modifications and its role in drug delivery. RSC Adv. 4, 14328-14334 (2014).
16. Chen, F. et al. In vivo tumor targeting and image-guided drug delivery with antibody-conjugated, radiolabeled mesoporous silica nanoparticles. ACS Nano 7, 9027-9039 (2013).
17. Poulsen, N., Berne, C., Spain, J. & Kroeger, N. Silica immobilization of an enzyme through genetic engineering of the diatom Thalassiosira pseudonana. Angew. Chem. Int. Ed. Engl. 46, 1843-1846 (2007).
18. Sheppard, V., Scheffel, A., Poulsen, N. & Kröger, N. Live diatom silica immobilization of multimeric and redox-active enzymes. Appl. Environ. Microbiol. 78, 211-218 (2012).
19. Gronenborn, A. M. & Clore, G. M. Structural studies of immunoglobulinbinding domains of streptococcal protein G. Immunomethods 2, 3-8 (1993).
20. Blanco, E. et al. Multistage delivery of chemotherapeutic nanoparticles for breast cancer treatment. Cancer Lett. 334, 245-252 (2013).
21. Tanaka, T. et al. Sustained small interfering RNA delivery by mesoporous silicon particles. Cancer Res. 70, 3687-3696 (2010).
22. Poulsen, N. & Kröger, N. Silica morphogenesis by alternative processing of silaffins in the diatom Thalassiosira pseudonana. J. Biol. Chem. 279, 42993-42999 (2004).
23. Poulsen, N., Scheffel, A., Sheppard, V. C., Chesley, P. M. & Kröger, N. Pentalysine clusters mediate silica targeting of silaffins in Thalassiosira pseudonana. J. Biol. Chem. 288, 20100-20109 (2013).
24. Marshall, K. E., Robinson, E. W., Hengel, S. M., Pasa-Tolic, L. & Roesijadi, G. FRET imaging of diatoms expressing a biosilica-localized ribose sensor. PLoS ONE 7, e33771 (2012).
25. Poulsen, N., Chesley, P. M. & Kröger, N. Molecular genetic manipulation of the diatom Thalassiosira pseudonana (bacillariophyceae) 1. J. Phycol. 42, 1059-1065 (2006).
26. Rasi Ghaemi, S., Harding, F., Delalat, B., Vasani, R. & Voelcker, N. H. Surface engineering for long-term culturing of mesenchymal stem cell microarrays. Biomacromolecules 14, 2675-2683 (2013).
27. Vecchio, G., Fenech, M., Pompa, P. P. & Voelcker, N. H. Lab-on-a-chip-based high-throughput screening of the genotoxicity of engineered nanomaterials. Small 10, 2721-2734 (2014).
28. Anglin, E. J. et al. Sorted cell microarrays as platforms for high-content informational bioassays. Lab Chip 10, 3413-3421 (2010).
29. Sætern, A. M., Flaten, G. E. & Brandl, M. A method to determine the incorporation capacity of camptothecin in liposomes. AAPS PharmSciTech 5, 30-37 (2004).
30. Basak, R. & Bandyopadhyay, R. Encapsulation of hydrophobic drugs in pluronic F127 micelles: effects of drug hydrophobicity, solution temperature, and pH. Langmuir 29, 4350-4356 (2013).
31. Sarzaeem, A., Mirakabadi, A. Z., Moradhaseli, S. & Sayad, A. Comparative study for toxic effects of camptothecin in cancer and normal cells. J. Biol. 2, 188-201 (2013).
32. Zhang, H. et al. Novel SN38 conjugate-forming nanoparticles as anticancer prodrug: In vitro and in vivo studies. J. Control Release 166, 147-158 (2013).
33. Swiston, A. J. et al. Surface functionalization of living cells with multilayer patches. Nano Lett. 8, 4446-4453 (2008).
34. Secret, E. et al. Antibody functionalized porous silicon nanoparticles for vectorization of hydrophobic drugs. Adv. Healthc. Mater. 2, 718-727 (2013).
35. Bala, V., Rao, S., Boyd, B. J. & Prestidge, C. A. Prodrug and nanomedicine approaches for the delivery of the camptothecin analogue SN38. J. Control Release 172, 48-61 (2013).
36. Wang, H. et al. Magnetic-Fe/Fe3O4-nanoparticle-bound SN38 as carboxylesterase-cleavable prodrug for the delivery to tumors within monocytes/macrophages. Beilstein J. Nanotechnol. 3, 444-455 (2012).
37. Cuellar, T. L. et al. Systematic evaluation of antibody-mediated siRNA delivery using an industrial platform of THIOMAB-siRNA conjugates. Nucleic Acids Res. 43, 1189-1203 (2015).
38. Yu, T., Hubbard, D., Ray, A. & Ghandehari, H. In vivo biodistribution and pharmacokinetics of silica nanoparticles as a function of geometry, porosity and surface characteristics. J. Control Release 163, 46-54 (2012).
39. Ivanov, S. et al. In vivo toxicity of intravenously administered silica and silicon nanoparticles. Materials 5, 1873-1889 (2012).
40. Nomellini, J. F., Duncan, G., Dorocicz, I. R. & Smit, J. S-layer-mediated display of the immunoglobulin G-binding domain of streptococcal protein G on the surface of Caulobacter crescentus: development of an immunoactive reagent. Appl. Environ. Microbiol. 73, 3245-3253 (2007).
41. Rogers, M.-L. et al. Functional monoclonal antibodies to p75 neurotrophin receptor raised in knockout mice. J. Neurosci. Methods 158, 109-120 (2006).
42. Rasi Ghaemi, S. et al. Synergistic influence of collagen I and BMP 2 drives osteogenic differentiation of mesenchymal stem cells: A cell microarray analysis. Acta Biomater. (In the press) doi: 10.1016/j.actbio.2015.07.027 (2015).