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Volumn 201, Issue 3, 2015, Pages 1253-1262

Identification of the bile acid transporter Slco1a6 as a candidate gene that broadly affects gene expression in mouse pancreatic islets

Author keywords

Diabetes; EQTL; Fine mapping; Obesity; Positional cloning

Indexed keywords

LEPTIN; ORGANIC ANION TRANSPORTING POLYPEPTIDE 1A6; PROLINE; PROTEIN; SERINE; SOLUTE CARRIER ORGANIC ANION TRANSPORTER 1A5; TAUROCHOLIC ACID; UNCLASSIFIED DRUG; BILE ACID BINDING PROTEINS; CARRIER PROTEIN; MEMBRANE PROTEIN; ORGANIC ANION TRANSPORTER; SLCO1A1 PROTEIN, MOUSE;

EID: 84946926477     PISSN: 00166731     EISSN: 19432631     Source Type: Journal    
DOI: 10.1534/genetics.115.179432     Document Type: Article
Times cited : (17)

References (32)
  • 1
    • 77954272440 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides
    • Abe, M., T. Toyohara, A. Ishii, T. Suzuki, N. Noguchi et al., 2010 The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides. Drug Metab. Pharmacokinet. 25: 274-282.
    • (2010) Drug Metab. Pharmacokinet , vol.25 , pp. 274-282
    • Abe, M.1    Toyohara, T.2    Ishii, A.3    Suzuki, T.4    Noguchi, N.5
  • 2
    • 84925089678 scopus 로고    scopus 로고
    • The role of regulatory variation in complex traits and disease
    • Albert, F. W., and L. Kruglyak, 2015 The role of regulatory variation in complex traits and disease. Nat. Rev. Genet. 16: 197-212.
    • (2015) Nat. Rev. Genet , vol.16 , pp. 197-212
    • Albert, F.W.1    Kruglyak, L.2
  • 3
  • 4
    • 0037177625 scopus 로고    scopus 로고
    • Genetic dissection of transcriptional regulation in budding yeast
    • Brem, R. B., G. Yvert, R. Clinton, and L. Kruglyak, 2002 Genetic dissection of transcriptional regulation in budding yeast. Science 296: 752-755.
    • (2002) Science , vol.296 , pp. 752-755
    • Brem, R.B.1    Yvert, G.2    Clinton, R.3    Kruglyak, L.4
  • 5
    • 15044344834 scopus 로고    scopus 로고
    • Mapping expression in randomized rodent genomes
    • Broman, K. W., 2005 Mapping expression in randomized rodent genomes. Nat. Genet. 37: 209-210.
    • (2005) Nat. Genet , vol.37 , pp. 209-210
    • Broman, K.W.1
  • 7
    • 84943428325 scopus 로고    scopus 로고
    • Identification and correction of sample mix-ups in expression genetic data: A case study
    • Broman, K. W., M. P. Keller, A. T. Broman, C. Kendziorski, B. S. Yandell et al., 2015 Identification and correction of sample mix-ups in expression genetic data: a case study. G3 (Bethesda) 5: 2177-2186.
    • (2015) G3 (Bethesda) , vol.5 , pp. 2177-2186
    • Broman, K.W.1    Keller, M.P.2    Broman, A.T.3    Kendziorski, C.4    Yandell, B.S.5
  • 8
    • 0000710382 scopus 로고
    • Stocks for detecting linkage in the mouse, and the theory of their design
    • Carter, T. C., and D. S. Falconer, 1951 Stocks for detecting linkage in the mouse, and the theory of their design. J. Genet. 50: 307-323.
    • (1951) J. Genet , vol.50 , pp. 307-323
    • Carter, T.C.1    Falconer, D.S.2
  • 9
    • 0037370311 scopus 로고    scopus 로고
    • Natural variation in human gene expression assessed in lymphoblastoid cells
    • Cheung, V. G., L. K. Conlin, T. M. Weber, M. Arcaro, K. Y. Jen et al., 2003 Natural variation in human gene expression assessed in lymphoblastoid cells. Nat. Genet. 33: 422-425.
    • (2003) Nat. Genet , vol.33 , pp. 422-425
    • Cheung, V.G.1    Conlin, L.K.2    Weber, T.M.3    Arcaro, M.4    Jen, K.Y.5
  • 10
    • 0034810502 scopus 로고    scopus 로고
    • Cloning, expression, and ontogeny of mouse organic anion-transporting polypeptide-5, a kidney-specific organic anion transporter
    • Choudhuri, S., K. Ogura, and C. D. Klaassen, 2001 Cloning, expression, and ontogeny of mouse organic anion-transporting polypeptide-5, a kidney-specific organic anion transporter. Biochem. Biophys. Res. Commun. 280: 92-98.
    • (2001) Biochem. Biophys. Res. Commun , vol.280 , pp. 92-98
    • Choudhuri, S.1    Ogura, K.2    Klaassen, C.D.3
  • 11
    • 0028803358 scopus 로고
    • Advanced intercross lines, an experimental population for fine genetic mapping
    • Darvasi, A., and M. Soller, 1995 Advanced intercross lines, an experimental population for fine genetic mapping. Genetics 141: 1199-1207.
    • (1995) Genetics , vol.141 , pp. 1199-1207
    • Darvasi, A.1    Soller, M.2
  • 12
    • 84861880073 scopus 로고    scopus 로고
    • Bile acids acutely stimulate insulin secretion of mouse b-cells via farnesoid X receptor activation and K(ATP) channel inhibition
    • Düfer, M., K. Hörth, R. Wagner, B. Schittenhelm, S. Prowald et al., 2012 Bile acids acutely stimulate insulin secretion of mouse b-cells via farnesoid X receptor activation and K(ATP) channel inhibition. Diabetes 61: 1479-1489.
    • (2012) Diabetes , vol.61 , pp. 1479-1489
    • Düfer, M.1    Hörth, K.2    Wagner, R.3    Schittenhelm, B.4    Prowald, S.5
  • 13
    • 84857467272 scopus 로고    scopus 로고
    • Joint modelling of confounding factors and prominent genetic regulators provides increased accuracy in genetical genomics studies
    • Fusi, N., O. Stegle, and N. D. Lawrence, 2012 Joint modelling of confounding factors and prominent genetic regulators provides increased accuracy in genetical genomics studies. PLoS Comp. Biol. 8: e1002330.
    • (2012) PLoS Comp. Biol , vol.8
    • Fusi, N.1    Stegle, O.2    Lawrence, N.D.3
  • 14
    • 84862250978 scopus 로고    scopus 로고
    • Using control genes to correct for unwanted variation in microarray data
    • Gagnon-Bartsch, J. A., and T. P. Speed, 2012 Using control genes to correct for unwanted variation in microarray data. Biostatistics 13: 539-552.
    • (2012) Biostatistics , vol.13 , pp. 539-552
    • Gagnon-Bartsch, J.A.1    Speed, T.P.2
  • 15
    • 84875163715 scopus 로고    scopus 로고
    • The SLCO (former SLC21) superfamily of transporters
    • Hagenbuch, B., and B. Stieger, 2013 The SLCO (former SLC21) superfamily of transporters. Mol. Aspects Med. 34: 396-412.
    • (2013) Mol. Aspects Med , vol.34 , pp. 396-412
    • Hagenbuch, B.1    Stieger, B.2
  • 16
    • 33646942472 scopus 로고
    • A simple regression method for mapping quantitative trait loci in line crosses using flanking markers
    • Haley, C. S., and S. A. Knott, 1992 A simple regression method for mapping quantitative trait loci in line crosses using flanking markers. Heredity 69: 315-324.
    • (1992) Heredity , vol.69 , pp. 315-324
    • Haley, C.S.1    Knott, S.A.2
  • 17
    • 0000736325 scopus 로고
    • Obese, a new mutation in the house mouse
    • Ingalls, A. M., M. M. Dickie, and G. D. Snell, 1950 Obese, a new mutation in the house mouse. J. Hered. 41: 317-318.
    • (1950) J. Hered , vol.41 , pp. 317-318
    • Ingalls, A.M.1    Dickie, M.M.2    Snell, G.D.3
  • 18
    • 0035400051 scopus 로고    scopus 로고
    • Genetical genomics: The added value from segregation
    • Jansen, R. C., and J. P. Nap, 2001 Genetical genomics: the added value from segregation. Trends Genet. 17: 388-389.
    • (2001) Trends Genet , vol.17 , pp. 388-389
    • Jansen, R.C.1    Nap, J.P.2
  • 19
    • 61849171085 scopus 로고    scopus 로고
    • Accurate discovery of expression quantitative trait loci under confounding from spurious and genuine regulatory hotspots
    • Kang, H. M., C. Ye, and E. Eskin, 2008 Accurate discovery of expression quantitative trait loci under confounding from spurious and genuine regulatory hotspots. Genetics 180: 1909-1925.
    • (2008) Genetics , vol.180 , pp. 1909-1925
    • Kang, H.M.1    Ye, C.2    Eskin, E.3
  • 20
    • 43149125186 scopus 로고    scopus 로고
    • A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility
    • Keller, M. P., Y. Choi, P. Wang, D. B. Davis, M. E. Rabaglia et al., 2008 A gene expression network model of type 2 diabetes links cell cycle regulation in islets with diabetes susceptibility. Genome Res. 18: 706-716.
    • (2008) Genome Res , vol.18 , pp. 706-716
    • Keller, M.P.1    Choi, Y.2    Wang, P.3    Davis, D.B.4    Rabaglia, M.E.5
  • 21
    • 34848914038 scopus 로고    scopus 로고
    • Capturing heterogeneity in gene expression studies by surrogate variable analysis
    • Leek, J. T., and J. D. Storey, 2007 Capturing heterogeneity in gene expression studies by surrogate variable analysis. PLoS Genet. 3: e161.
    • (2007) PLoS Genet , vol.3
    • Leek, J.T.1    Storey, J.D.2
  • 22
    • 78049312702 scopus 로고    scopus 로고
    • Correction for hidden confounders in the genetic analysis of gene expression
    • Listgarten, J., C. Kadie, E. E. Schadt, and D. Heckerman, 2010 Correction for hidden confounders in the genetic analysis of gene expression. Proc. Natl. Acad. Sci. USA 107: 16465- 16470.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 16465-16470
    • Listgarten, J.1    Kadie, C.2    Schadt, E.E.3    Heckerman, D.4
  • 23
    • 33646442476 scopus 로고    scopus 로고
    • Organic anion transporting polypeptides of the OATP/SLCO superfamily: Identification of new members in nonmammalian species, comparative modeling and a potential transport mode
    • Meier-Abt, F., Y. Mokrab, and K. Mizuguchi, 2005 Organic anion transporting polypeptides of the OATP/SLCO superfamily: identification of new members in nonmammalian species, comparative modeling and a potential transport mode. J. Membr. Biol. 208: 213-227.
    • (2005) J. Membr. Biol , vol.208 , pp. 213-227
    • Meier-Abt, F.1    Mokrab, Y.2    Mizuguchi, K.3
  • 24
    • 4043128071 scopus 로고    scopus 로고
    • Genetic analysis of genome-wide variation in human gene expression
    • Morley, M., C. M. Molony, T. M. Weber, J. L. Devlin, K. G. Ewens et al., 2004 Genetic analysis of genome-wide variation in human gene expression. Nature 430: 743-747.
    • (2004) Nature , vol.430 , pp. 743-747
    • Morley, M.1    Molony, C.M.2    Weber, T.M.3    Devlin, J.L.4    Ewens, K.G.5
  • 25
  • 28
    • 84857092984 scopus 로고    scopus 로고
    • OATPs, OATs and OCTs: The organic anion and cation transporters of the SLCO and SLC22A gene superfamilies
    • Roth, M., A. Obaidat, and B. Hagenbuch, 2012 OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies. Br. J. Pharmacol. 165: 1260-1287.
    • (2012) Br. J. Pharmacol , vol.165 , pp. 1260-1287
    • Roth, M.1    Obaidat, A.2    Hagenbuch, B.3
  • 29
    • 0037456823 scopus 로고    scopus 로고
    • Genetics of gene expression surveyed in maize, mouse and man
    • Schadt, E. E., S. A. Monks, T. A. Drake, A. J. Lusis, N. Che et al., 2003 Genetics of gene expression surveyed in maize, mouse and man. Nature 422: 297-302.
    • (2003) Nature , vol.422 , pp. 297-302
    • Schadt, E.E.1    Monks, S.A.2    Drake, T.A.3    Lusis, A.J.4    Che, N.5
  • 30
    • 77955300958 scopus 로고    scopus 로고
    • Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs
    • van de Steeg, E., E.Wagenaar, C. M. van der Kruijssen, J. E. Burggraaff, D. R. de Waart et al., 2010 Organic anion transporting polypeptide 1a/1b-knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs. J. Clin. Invest. 120: 2942- 2952.
    • (2010) J. Clin. Invest , vol.120 , pp. 2942-2952
    • van de Steeg, E.1    Wagenaar, E.2    van der Kruijssen, C.M.3    Burggraaff, J.E.4    de Waart, D.R.5
  • 31
    • 77955505742 scopus 로고    scopus 로고
    • A Bayesian framework to account for complex non-genetic factors in gene expression levels greatly increases power in eQTL studies
    • Stegle, O., L. Parts, R. Durbin, and J. Winn, 2010 A Bayesian framework to account for complex non-genetic factors in gene expression levels greatly increases power in eQTL studies. PLoS Comp. Biol. 6: e1000770.
    • (2010) PLoS Comp. Biol , vol.6
    • Stegle, O.1    Parts, L.2    Durbin, R.3    Winn, J.4
  • 32
    • 0042856391 scopus 로고    scopus 로고
    • Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors
    • Yvert, G., R. B. Brem, J. Whittle, J. M. Akey, E. Foss et al., 2003 Trans-acting regulatory variation in Saccharomyces cerevisiae and the role of transcription factors. Nat. Genet. 35: 57-64.
    • (2003) Nat. Genet , vol.35 , pp. 57-64
    • Yvert, G.1    Brem, R.B.2    Whittle, J.3    Akey, J.M.4    Foss, E.5


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