Stimulation of Wound Healing by Electroactive, Antibacterial, and Antioxidant Polyurethane/Siloxane Dressing Membranes: In Vitro and in Vivo Evaluations

ACS Applied Materials and Interfaces

Volumn 7, Issue 43, 2015, Pages 24296-24311

  Gharibi, Reza ^a   Yeganeh, Hamid ^a   Rezapour Lactoee, Alireza ^b   Hassan, Zuhair M ^c  

^a IRAN POLYMER AND PETROCHEMICAL INSTITUTE   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TARBIAT MODARES UNIVERSITY   (Iran)

Author keywords

antimicrobial; antioxidant; electroactivity; polyurethane siloxane; wound healing

Indexed keywords

ANTIOXIDANTS; ASSAYS; BIOACTIVITY; BIOMATERIALS; CELL CULTURE; ESTERS; FIBROBLASTS; MICROORGANISMS; POLYURETHANES; SOL-GELS; TENSILE STRENGTH;

ANTI-MICROBIAL ACTIVITY; ANTIMICROBIAL; BIOLOGICAL PROPERTIES; COLLAGEN DEPOSITION; ELECTRO-ACTIVITY; WATER VAPOR TRANSMISSION RATE; WOUND HEALING; WOUND HEALING PROCESS;

WATER ABSORPTION;

ANILINE; ANILINE DERIVATIVE; ANTIINFECTIVE AGENT; ANTIOXIDANT; ESTER; POLYMER; POLYURETHAN; SCAVENGER; SILOXANE;

ANIMAL; CELL ADHESION; CELL PROLIFERATION; CHEMISTRY; ELASTICITY; ELECTROCHEMISTRY; FIBROBLAST; METABOLISM; MOUSE; PHASE TRANSITION; PROCEDURES; RAT; TENSILE STRENGTH; VISCOSITY; WOUND HEALING;

ANILINE COMPOUNDS; ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; ANTIOXIDANTS; CELL ADHESION; CELL PROLIFERATION; ELASTICITY; ELECTROCHEMISTRY; ESTERS; FIBROBLASTS; FREE RADICAL SCAVENGERS; MICE; PHASE TRANSITION; POLYMERS; POLYURETHANES; RATS; SILOXANES; TENSILE STRENGTH; VISCOSITY; WOUND HEALING;

EID: 84946893499     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/acsami.5b08376     Document Type: Article

References (60)

1. Boateng, J.; Matthews, K. Wound Healing Dressings and Drug Delivery Systems: A Review J. Pharm. Sci. 2008, 97, 2892-2923 10.1002/jps.21210
2. Sweeney, I. R.; Miraftab, M.; Collyer, G. A Critical Review of Modern and Emerging Absorbent Dressings Used to Treat Exuding Wounds Int. Wound J. 2012, 9, 601-612 10.1111/j.1742-481X.2011.00923.x
3. Xu, H.; Chang, J.; Chen, Y.; Fan, H.; Shi, B. Asymmetric Polyurethane Membrane with Inflammation-Responsive Antibacterial Activity for Potential Wound Dressing Application J. Mater. Sci. 2013, 48, 6625-6639 10.1007/s10853-013-7461-z
4. Miao, S.; Wang, P.; Su, Z.; Zhang, S. Vegetable-Oil-Based Polymers as Future Polymeric Biomaterials Acta Biomater. 2014, 10, 1692-1704 10.1016/j.actbio.2013.08.040
5. Pfister, D. P.; Xia, Y.; Larock, R. C. Recent Advances in Vegetable Oil-Based Polyurethanes ChemSusChem 2011, 4, 703-717 10.1002/cssc.201000378
6. Pereira-Júnior, O. C. M.; Rahal, S. C.; Iamaguti, P.; Felisbino, S. L.; Pavan, P. T.; Vulcano, L. C. Comparison between Polyurethanes Containing Castor Oil (soft Segment) and Cancellous Bone Autograft in the Treatment of Segmental Bone Defect Induced in Rabbits J. Biomater. Appl. 2007, 21, 283-297 10.1177/0885328206063526
7. Li, G.; Li, D.; Niu, Y.; He, T.; Chen, K. C.; Xu, K. Alternating Block Polyurethanes Based on PCL and PEG as Potential Nerve Regeneration Materials J. Biomed. Mater. Res., Part A 2014, 102, 685-697 10.1002/jbm.a.34732
8. Gultekin, G.; Atalay-Oral, C.; Erkal, S.; Sahin, F.; Karastova, D.; Tantekin-Ersolmaz, S. B.; Guner, F. S. Fatty Acid-Based Polyurethane Films for Wound Dressing Applications J. Mater. Sci.: Mater. Med. 2009, 20, 421-431 10.1007/s10856-008-3572-5
9. Vieira, C.; Evangelista, S.; Cirillo, R.; Lippi, a; Maggi, C. a; Manzini, S. Effect of Ricinoleic Acid in Acute and Subchronic Experimental Models of Inflammation Mediators Inflammation 2000, 9, 223-228 10.1080/09629350020025737
10. Yari, A.; Yeganeh, H.; Bakhshi, H.; Gharibi, R. Preparation and Characterization of Novel Antibacterial Castor Oil-Based Polyurethane Membranes for Wound Dressing Application J. Biomed. Mater. Res., Part A 2014, 102, 84-96 10.1002/jbm.a.34672
11. Noble, T. A.; Carr, D. S.; Gonzalez, M. F. Use of a Trypsin, Peru Balsam, and Castor Oil Spray on the Oral Mucosa: Case Report and Review of the Literature Pharmacother. J. Hum. Pharmacol. Drug Ther. 1989, 9, 386-388
12. Kumar, P. T. S.; Lakshmanan, V.-K.; Anilkumar, T. V.; Ramya, C.; Reshmi, P.; Unnikrishnan, A. G.; Nair, S. V.; Jayakumar, R. Flexible and Microporous Chitosan Hydrogel/nano ZnO Composite Bandages for Wound Dressing: In Vitro and in Vivo Evaluation ACS Appl. Mater. Interfaces 2012, 4, 2618-2629 10.1021/am300292v
13. Chaloupka, K.; Malam, Y.; Seifalian, A. M. Nanosilver as a New Generation of Nanoproduct in Biomedical Applications Trends Biotechnol. 2010, 28, 580-588 10.1016/j.tibtech.2010.07.006
14. Gizdavic-Nikolaidis, M. R.; Bennett, J. R.; Swift, S.; Easteal, A. J.; Ambrose, M. Broad Spectrum Antimicrobial Activity of Functionalized Polyanilines Acta Biomater. 2011, 7, 4204-4209 10.1016/j.actbio.2011.07.018
15. Gizdavic-Nikolaidis, M. R.; Bennett, J.; Zujovic, Z.; Swift, S.; Bowmaker, G. a. Characterization and Antimicrobial Efficacy of Acetone Extracted Aniline Oligomers Synth. Met. 2012, 162, 1114-1119 10.1016/j.synthmet.2012.04.031
16. Guo, B.; Glavas, L.; Albertsson, A.-C. Biodegradable and Electrically Conducting Polymers for Biomedical Applications Prog. Polym. Sci. 2013, 38, 1263-1286 10.1016/j.progpolymsci.2013.06.003
17. Cui, H.; Cui, L.; Zhang, P.; Huang, Y.; Wei, Y.; Chen, X. In Situ Electroactive and Antioxidant Supramolecular Hydrogel Based on Cyclodextrin/copolymer Inclusion for Tissue Engineering Repair Macromol. Biosci. 2014, 14, 440-450 10.1002/mabi.201300366
18. Gizdavic-Nikolaidis, M.; Travas-Sejdic, J.; Bowmaker, G. A.; Cooney, R. P.; Kilmartin, P. A. Conducting Polymers as Free Radical Scavengers Synth. Met. 2004, 140, 225-232 10.1016/S0379-6779(03)00372-2
19. Baheiraei, N.; Yeganeh, H.; Ai, J.; Gharibi, R.; Azami, M.; Faghihi, F. Synthesis, Characterization and Antioxidant Activity of a Novel Electroactive and Biodegradable Polyurethane for Cardiac Tissue Engineering Application Mater. Sci. Eng., C 2014, 44, 24-37 10.1016/j.msec.2014.07.061
20. Gharibi, R.; Yeganeh, H.; Gholami, H.; Hassan, Z. M. Aniline Tetramer Embedded Polyurethane/siloxane Membranes and Their Corresponding Nanosilver Composites as Intelligent Wound Dressing Materials RSC Adv. 2014, 4, 62046-62060 10.1039/C4RA11454J
21. Romero, R.; Martlnez, S. L.; Ramos, M. J.; Martlnez, A.; Natividad, R.; Pena, R. Transesterification of Castor Oil: Effect of Catalyst and Co-Solvent Ind. Eng. Chem. Res. 2009, 48, 1186-1189 10.1021/ie8005929
22. Yoo, H.-J.; Kim, H.-D. Synthesis and Properties of Waterborne Polyurethane Hydrogels for Wound Healing Dressings J. Biomed. Mater. Res., Part B 2008, 85B, 326-333 10.1002/jbm.b.30950
23. Jeon, H. T.; Jang, M. K.; Kim, B. K.; Kim, K. H. Synthesis and Characterizations of Waterborne Polyurethane-silica Hybrids Using Sol-gel Process Colloids Surf., A 2007, 302, 559-567 10.1016/j.colsurfa.2007.03.043
24. Yu, W.; Du, M.; Zhang, D.; Lin, Y.; Zheng, Q. Influence of Dangling Chains on Molecular Dynamics of Polyurethanes Macromolecules 2013, 46, 7341-7351 10.1021/ma401260d
25. Xu, Y.; Petrovic, Z.; Das, S.; Wilkes, G. L. Morphology and Properties of Thermoplastic Polyurethanes with Dangling Chains in Ricinoleate-Based Soft Segments Polymer 2008, 49, 4248-4258 10.1016/j.polymer.2008.07.027
26. Guo, B.; Finne-Wistrand, A.; Albertsson, A.-C. Facile Synthesis of Degradable and Electrically Conductive Polysaccharide Hydrogels Biomacromolecules 2011, 12, 2601-2609 10.1021/bm200389t
27. Guo, B.; Sun, Y.; Finne-Wistrand, A.; Mustafa, K.; Albertsson, A. C. Electroactive Porous Tubular Scaffolds with Degradability and Non-Cytotoxicity for Neural Tissue Regeneration Acta Biomater. 2012, 8, 144-153 10.1016/j.actbio.2011.09.027
28. Huang, L.; Zhuang, X.; Hu, J.; Lang, L.; Zhang, P.; Wang, Y.; Chen, X.; Wei, Y.; Jing, X. Synthesis of Biodegradable and Electroactive Multiblock Polylactide and Aniline Pentamer Copolymer for Tissue Engineering Applications Biomacromolecules 2008, 9, 850-858 10.1021/bm7011828
29. Rivers, T. J.; Hudson, T. W.; Schmidt, C. E. Synthesis of a Novel, Biodegradable Electrically Conducting Polymer for Biomedical Applications Adv. Funct. Mater. 2002, 12, 33-37 10.1002/1616-3028(20020101)12:1<33::AID-ADFM33>3.0.CO;2-E
30. Seaman, S. Dressing Selection in Chronic Wound Management J. Am. Podiatr. Med. Assoc. 2002, 92, 24-33 10.7547/87507315-92-1-24
31. Elsner, J. J.; Shefy-Peleg, A.; Zilberman, M. Novel Biodegradable Composite Wound Dressings with Controlled Release of Antibiotics: Microstructure, Mechanical and Physical Properties J. Biomed. Mater. Res., Part B 2010, 93B, 425-435 10.1002/jbm.b.31599
32. Elsner, J. J.; Berdicevsky, I.; Zilberman, M. In Vitro Microbial Inhibition and Cellular Response to Novel Biodegradable Composite Wound Dressings with Controlled Release of Antibiotics Acta Biomater. 2011, 7, 325-336 10.1016/j.actbio.2010.07.013
33. Guo, B.; Finne-Wistrand, A.; Albertsson, A.-C. Versatile Functionalization of Polyester Hydrogels with Electroactive Aniline Oligomers J. Polym. Sci., Part A: Polym. Chem. 2011, 49, 2097-2105 10.1002/pola.24643
34. Liu, Y.; Cui, H.; Zhuang, X.; Wei, Y.; Chen, X. Acta Biomaterialia Electrospinning of Aniline Pentamer-Graft-Gelatin/PLLA Nanofibers for Bone Tissue Engineering Acta Biomater. 2014, 10, 5074-5080 10.1016/j.actbio.2014.08.036
35. Niple, J. C.; Daigle, J. P.; Zaffanella, L. E.; Sullivan, T.; Kavet, R. A Portable Meter for Measuring Low Frequency Currents in the Human Body Bioelectromagnetics 2004, 25, 369-373 10.1002/bem.20000
36. Guimard, N. K.; Gomez, N.; Schmidt, C. E. Conducting Polymers in Biomedical Engineering Prog. Polym. Sci. 2007, 32, 876-921 10.1016/j.progpolymsci.2007.05.012
37. Jeong, S. I.; Jun, I. D.; Choi, M. J.; Nho, Y. C.; Lee, Y. M.; Shin, H. Development of Electroactive and Elastic Nanofibers That Contain Polyaniline and poly(L-Lactide-Co-Epsilon-Caprolactone) for the Control of Cell Adhesion Macromol. Biosci. 2008, 8, 627-637 10.1002/mabi.200800005
38. Cui, H.; Liu, Y.; Deng, M.; Pang, X.; Zhang, P.; Wang, X.; Chen, X.; Wei, Y. Synthesis of Biodegradable and Electroactive Tetraaniline Grafted Poly(ester Amide) Copolymers for Bone Tissue Engineering Biomacromolecules 2012, 13, 2881-2889 10.1021/bm300897j
39. Hu, J.; Huang, L.; Zhuang, X.; Zhang, P.; Lang, L.; Chen, X.; Wei, Y.; Jing, X. Electroactive Aniline Pentamer Cross-Linking Chitosan for Stimulation Growth of Electrically Sensitive Cells Biomacromolecules 2008, 9, 2637-2644 10.1021/bm800705t
40. Tan, J.; Gemeinhart, R. A.; Ma, M.; Saltzman, W. M. Improved Cell Adhesion and Proliferation on Synthetic Phosphonic Acid-Containing Hydrogels Biomaterials 2005, 26, 3663-3671 10.1016/j.biomaterials.2004.09.053
41. Liu, Y.; Cui, H.; Zhuang, X.; Zhang, P.; Cui, Y.; Wang, X.; Wei, Y.; Chen, X. Nano-Hydroxyapatite Surfaces Grafted with Electroactive Aniline Tetramers for Bone-Tissue Engineering Macromol. Biosci. 2013, 13, 356-365 10.1002/mabi.201200345
42. Ma, X.; Ge, J.; Li, Y.; Guo, B.; Ma, P. X. Nanofibrous Electroactive Scaffolds from a Chitosan-Grafted-Aniline Tetramer by Electrospinning for Tissue Engineering RSC Adv. 2014, 4, 13652 10.1039/c4ra00083h
43. Liu, Y.; Hu, J.; Zhuang, X.; Zhang, P.; Wei, Y.; Wang, X.; Chen, X. Synthesis and Characterization of Novel Biodegradable and Electroactive Hydrogel Based on Aniline Oligomer and Gelatin Macromol. Biosci. 2012, 12, 241-250 10.1002/mabi.201100227
44. Gizdavic-Nikolaidis, M.; Ray, S.; Bennett, J. R.; Easteal, A. J.; Cooney, R. P. Electrospun Functionalized Polyaniline Copolymer-Based Nanofibers with Potential Application in Tissue Engineering Macromol. Biosci. 2010, 10, 1424-1431 10.1002/mabi.201000237
45. Moseley, R.; Walker, M.; Waddington, R. J.; Chen, W. Y. J. Comparison of the Antioxidant Properties of Wound Dressing Materials-carboxymethylcellulose, Hyaluronan Benzyl Ester and Hyaluronan, towards Polymorphonuclear Leukocyte-Derived Reactive Oxygen Species Biomaterials 2003, 24, 1549-1557 10.1016/S0142-9612(02)00540-9
46. Gizdavic-Nikolaidis, M.; Travas-Sejdic, J.; Kilmartin, P. A.; Bowmaker, G. A.; Cooney, R. P. Evaluation of Antioxidant Activity of Aniline and Polyaniline Curr. Appl. Phys. 2004, 4, 343-346 10.1016/j.cap.2003.11.044
47. Cui, H.; Liu, Y.; Cheng, Y.; Zhang, Z.; Zhang, P.; Chen, X.; Wei, Y. In Vitro Study of Electroactive Tetraaniline-Containing Thermosensitive Hydrogels for Cardiac Tissue Engineering Biomacromolecules 2014, 15, 1115-1123 10.1021/bm4018963
48. Ambrogi, V.; Donnadio, A.; Pietrella, D.; Latterini, L.; Proietti, F. A.; Marmottini, F.; Padeletti, G.; Kaciulis, S.; Giovagnoli, S.; Ricci, M. Chitosan Films Containing Mesoporous SBA-15 Supported Silver Nanoparticles for Wound Dressing J. Mater. Chem. B 2014, 2, 6054 10.1039/C4TB00927D
49. Alvarez, G. S.; Hélary, C.; Mebert, A. M.; Wang, X.; Coradin, T.; Desimone, M. F. Antibiotic-Loaded Silica Nanoparticle-collagen Composite Hydrogels with Prolonged Antimicrobial Activity for Wound Infection Prevention J. Mater. Chem. B 2014, 2, 4660 10.1039/c4tb00327f
50. Gizdavic-Nikolaidis, M.; Ray, S.; Bennett, J.; Swift, S.; Bowmaker, G.; Easteal, A. Electrospun Poly(aniline-Co-Ethyl 3-Aminobenzoate)/poly(lactic Acid) Nanofibers and Their Potential in Biomedical Applications J. Polym. Sci., Part A: Polym. Chem. 2011, 49, 4902-4910 10.1002/pola.24946
51. Jennings, M. C.; Minbiole, K. P. C.; Wuest, W. M. Quaternary Ammonium Compounds: An Antimicrobial Mainstay and Platform for Innovation to Address Bacterial Resistance ACS Infect. Dis. 2015, 1, 288-303 10.1021/acsinfecdis.5b00047
52. Inta, O.; Yoksan, R.; Limtrakul, J. Hydrophobically Modified Chitosan: A Bio-Based Material for Antimicrobial Active Film Mater. Sci. Eng., C 2014, 42, 569-577 10.1016/j.msec.2014.05.076
53. Jhong, J. F.; Venault, A.; Hou, C. C.; Chen, S. H.; Wei, T. C.; Zheng, J.; Huang, J.; Chang, Y. Surface Zwitterionization of Expanded Poly(tetrafluoroethylene) Membranes via Atmospheric Plasma-Induced Polymerization for Enhanced Skin Wound Healing ACS Appl. Mater. Interfaces 2013, 5, 6732-6742 10.1021/am401669q
54. Lin, Y.-J.; Lee, G.-H.; Chou, C.-W.; Chen, Y.-P.; Wu, T.-H.; Lin, H.-R. Stimulation of Wound Healing by PU/hydrogel Composites Containing Fibroblast Growth Factor-2 J. Mater. Chem. B 2015, 3, 1931-1941 10.1039/C4TB01638F
55. Jhong, J.-F.; Venault, A.; Liu, L.; Zheng, J.; Chen, S.-H.; Higuchi, A.; Huang, J.; Chang, Y. Introducing Mixed-Charge Copolymers as Wound Dressing Biomaterials ACS Appl. Mater. Interfaces 2014, 6, 9858-9870 10.1021/am502382n
56. Thakral, G.; LaFontaine, J.; Najafi, B.; Talal, T. K.; Kim, P.; Lavery, L. A. Electrical Stimulation to Accelerate Wound Healing Diabet. Foot Ankle 2013, 4, 1-9 10.3402/dfa.v4i0.22081
57. Balint, R.; Cassidy, N. J.; Cartmell, S. H. Electrical Stimulation: A Novel Tool Tissue Eng., Part B 2013, 19, 48-57 10.1089/ten.teb.2012.0183
58. Titushkin, I.; Cho, M. Regulation of Cell Cytoskeleton and Membrane Mechanics by Electric Field: Role of Linker Proteins Biophys. J. 2009, 96, 717-728 10.1016/j.bpj.2008.09.035
59. McDougall, S.; Dallon, J.; Sherratt, J.; Maini, P. Fibroblast Migration and Collagen Deposition during Dermal Wound Healing: Mathematical Modelling and Clinical Implications Philos. Trans. R. Soc., A 2006, 364, 1385-1405 10.1098/rsta.2006.1773
60. Lee, Y.; Bae, J. W.; Lee, J. W.; Suh, W.; Park, K. D. Enzyme-Catalyzed in Situ Forming Gelatin Hydrogels as Bioactive Wound Dressings: Effects of Fibroblast Delivery on Wound Healing Efficacy J. Mater. Chem. B 2014, 2, 7712-7718 10.1039/C4TB01111B