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Volumn 7, Issue 11, 2015, Pages 9163-9170

Iron metabolism dysregulation and cognitive dysfunction in pediatric obesity: Is there a connection?

Author keywords

Children; Cognitive dysfunction; Hepcidin; Iron deficiency; Obesity

Indexed keywords

HEPCIDIN; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; IRON;

EID: 84946887221     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu7115458     Document Type: Review
Times cited : (20)

References (63)
  • 1
    • 58149401815 scopus 로고    scopus 로고
    • Effect of the rs997509 polymorphism on the association between ectonucleotide pyrophosphatase phosphodiesterase 1 and metabolic syndrome and impaired glucose tolerance in childhood obesity
    • [CrossRef] [PubMed]
    • Santoro, N.; Cirillo, G.; Lepore, M.G.; Palma, A.; Amato, A.; Savarese, P.; Marzuillo, P.; Grandone, A.; Perrone, L.; del Giudice, E.M. Effect of the rs997509 polymorphism on the association between ectonucleotide pyrophosphatase phosphodiesterase 1 and metabolic syndrome and impaired glucose tolerance in childhood obesity. J. Clin. Endocrinol. Metab. 2009, 94, 300-305. [CrossRef] [PubMed]
    • (2009) J. Clin. Endocrinol Metab , vol.94 , pp. 300-305
    • Santoro, N.1    Cirillo, G.2    Lepore, M.G.3    Palma, A.4    Amato, A.5    Savarese, P.6    Marzuillo, P.7    Grandone, A.8    Perrone, L.9    del Giudice, E.M.10
  • 2
    • 84917683547 scopus 로고    scopus 로고
    • Novel association between a nonsynonymous variant (R270H) of the G-protein-coupled receptor 120 and liver injury in children and adolescents with obesity
    • [CrossRef] [PubMed]
    • Marzuillo, P.; Grandone, A.; Conte, M.; Capuano, F.; Cirillo, G.; di Sessa, A.; Umano, G.R.; Romano, R.; Perrone, L.; del Giudice, E.M. Novel association between a nonsynonymous variant (R270H) of the G-protein-coupled receptor 120 and liver injury in children and adolescents with obesity. J. Pediatr. Gastroenterol. Nutr. 2014, 59, 472-475. [CrossRef] [PubMed]
    • (2014) J. Pediatr. Gastroenterol Nutr , vol.59 , pp. 472-475
    • Marzuillo, P.1    Grandone, A.2    Conte, M.3    Capuano, F.4    Cirillo, G.5    di Sessa, A.6    Umano, G.R.7    Romano, R.8    Perrone, L.9    del Giudice, E.M.10
  • 3
    • 84885952502 scopus 로고    scopus 로고
    • Weight loss allows the dissection of the interaction between abdominal fat and PNPLA3 (adiponutrin) in the liver damage of obese children
    • [CrossRef] [PubMed]
    • Marzuillo, P.; Grandone, A.; Perrone, L.; del Giudice, E.M. Weight loss allows the dissection of the interaction between abdominal fat and PNPLA3 (adiponutrin) in the liver damage of obese children. J. Hepatol. 2013, 59, 1143-1144. [CrossRef] [PubMed]
    • (2013) J Hepatol , vol.59 , pp. 1143-1144
    • Marzuillo, P.1    Grandone, A.2    Perrone, L.3    del Giudice, E.M.4
  • 4
    • 84901234098 scopus 로고    scopus 로고
    • Pediatric non-alcoholic fatty liver disease: New insights and future directions
    • [CrossRef] [PubMed]
    • Marzuillo, P.; del Giudice, E.M.; Santoro, N. Pediatric non-alcoholic fatty liver disease: New insights and future directions. World J. Hepatol. 2014, 6, 217-225. [CrossRef] [PubMed]
    • (2014) World J Hepatol , vol.6 , pp. 217-225
    • Marzuillo, P.1    del Giudice, E.M.2    Santoro, N.3
  • 5
    • 84910087314 scopus 로고    scopus 로고
    • Iron deficiency and cognitive functions
    • [CrossRef] [PubMed]
    • Jáuregui-Lobera, I. Iron deficiency and cognitive functions. Neuropsychiatr. Dis. Treat. 2014, 10, 2087-2095. [CrossRef] [PubMed]
    • (2014) Neuropsychiatr. Dis Treat , vol.10 , pp. 2087-2095
    • Jáuregui-Lobera, I.1
  • 6
    • 0034169248 scopus 로고    scopus 로고
    • Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy
    • [CrossRef] [PubMed]
    • Lozoff, B.; Jimenez, E.; Hagen, J.; Mollen, E.; Wolf, A.W. Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy. Pediatrics 2000, 105, E51. [CrossRef] [PubMed]
    • (2000) Pediatrics , vol.105
    • Lozoff, B.1    Jimenez, E.2    Hagen, J.3    Mollen, E.4    Wolf, A.W.5
  • 9
    • 3042821673 scopus 로고
    • Hypoferraemia in obese adolescents
    • [CrossRef]
    • Wenzel, B.J.; Stults, H.B.; Mayer, J. Hypoferraemia in obese adolescents. Lancet 1962, 2, 327-328. [CrossRef]
    • (1962) Lancet , vol.2 , pp. 327-328
    • Wenzel, B.J.1    Stults, H.B.2    Mayer, J.3
  • 11
    • 3042800605 scopus 로고    scopus 로고
    • Overweight children and adolescents: A risk group for iron deficiency
    • [CrossRef] [PubMed]
    • Nead, K.G.; Halterman, J.S.; Kaczorowski, J.M.; Auinger, P.; Weitzman, M. Overweight children and adolescents: A risk group for iron deficiency. Pediatrics 2004, 114, 104-108. [CrossRef] [PubMed]
    • (2004) Pediatrics , vol.114 , pp. 104-108
    • Nead, K.G.1    Halterman, J.S.2    Kaczorowski, J.M.3    Auinger, P.4    Weitzman, M.5
  • 13
    • 0035003922 scopus 로고    scopus 로고
    • Association of serum ferritin and indices of body fat distribution and obesity in Mexican American men-The Third National Health and Nutrition Examination Survey
    • [CrossRef] [PubMed]
    • Gillum, R.F. Association of serum ferritin and indices of body fat distribution and obesity in Mexican American men-The Third National Health and Nutrition Examination Survey. Int. J. Obes. Relat. Metab. Disord. 2001, 25, 639-645. [CrossRef] [PubMed]
    • (2001) Int. J. Obes. Relat. Metab Disord , vol.25 , pp. 639-645
    • Gillum, R.F.1
  • 14
    • 70349971162 scopus 로고    scopus 로고
    • Overweight children have higher circulating hepcidin concentrations and lower iron status but have dietary iron intakes and bioavailability comparable with normal weight children
    • [CrossRef] [PubMed]
    • Aeberli, I.; Hurrell, R.F.; Zimmermann, M.B. Overweight children have higher circulating hepcidin concentrations and lower iron status but have dietary iron intakes and bioavailability comparable with normal weight children. Int. J. Obes. (Lond.) 2009, 33, 1111-1117. [CrossRef] [PubMed]
    • (2009) Int. J. Obes (Lond.) , vol.33 , pp. 1111-1117
    • Aeberli, I.1    Hurrell, R.F.2    Zimmermann, M.B.3
  • 15
    • 84907214696 scopus 로고    scopus 로고
    • Obesity as an emerging risk factor for iron deficiency
    • [CrossRef] [PubMed]
    • Aigner, E.; Feldman, A.; Datz, C. Obesity as an emerging risk factor for iron deficiency. Nutrients 2014, 6, 3587-3600. [CrossRef] [PubMed]
    • (2014) Nutrients , vol.6 , pp. 3587-3600
    • Aigner, E.1    Feldman, A.2    Datz, C.3
  • 16
    • 84898041036 scopus 로고    scopus 로고
    • Neurocognitive correlates of obesity and obesity-related behaviors in children and adolescents
    • [CrossRef] [PubMed]
    • Liang, J.; Matheson, B.E.; Kaye, W.H.; Boutelle, K.N. Neurocognitive correlates of obesity and obesity-related behaviors in children and adolescents. Int. J. Obes. (Lond.) 2014, 38, 494-506. [CrossRef] [PubMed]
    • (2014) Int. J. Obes (Lond.) , vol.38 , pp. 494-506
    • Liang, J.1    Matheson, B.E.2    Kaye, W.H.3    Boutelle, K.N.4
  • 17
    • 33750133047 scopus 로고    scopus 로고
    • Regulation of iron metabolism by hepcidin
    • [CrossRef] [PubMed]
    • Nemeth, E.; Ganz, T. Regulation of iron metabolism by hepcidin. Annu. Rev. Nutr. 2006, 26, 323-342. [CrossRef] [PubMed]
    • (2006) Annu. Rev Nutr , vol.26 , pp. 323-342
    • Nemeth, E.1    Ganz, T.2
  • 18
    • 84857728171 scopus 로고    scopus 로고
    • Rethinking iron regulation and assessment in iron deficiency, anemia of chronic disease, and obesity: Introducing hepcidin
    • [CrossRef] [PubMed]
    • Tussing-Humphreys, L.; Pusatcioglu, C.; Nemeth, E.; Braunschweig, C. Rethinking iron regulation and assessment in iron deficiency, anemia of chronic disease, and obesity: Introducing hepcidin. J. Acad. Nutr. Diet. 2012, 112, 391-400. [CrossRef] [PubMed]
    • (2012) J. Acad. Nutr Diet , vol.112 , pp. 391-400
    • Tussing-Humphreys, L.1    Pusatcioglu, C.2    Nemeth, E.3    Braunschweig, C.4
  • 19
    • 0041672570 scopus 로고    scopus 로고
    • Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
    • [CrossRef] [PubMed]
    • Ganz, T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood 2003, 102, 783-788. [CrossRef] [PubMed]
    • (2003) Blood , vol.102 , pp. 783-788
    • Ganz, T.1
  • 20
    • 55949134725 scopus 로고    scopus 로고
    • Hepcidin regulation of iron transport
    • [CrossRef] [PubMed]
    • Collins, J.F.; Wessling-Resnick, M.; Knutson, M.D. Hepcidin regulation of iron transport. J. Nutr. 2008, 138, 2284-2288. [CrossRef] [PubMed]
    • (2008) J Nutr , vol.138 , pp. 2284-2288
    • Collins, J.F.1    Wessling-Resnick, M.2    Knutson, M.D.3
  • 21
    • 54949147441 scopus 로고    scopus 로고
    • Immunoassay for human serum hepcidin
    • [CrossRef] [PubMed]
    • Ganz, T.; Olbina, G.; Girelli, D.; Nemeth, E.;Westerman, M. Immunoassay for human serum hepcidin. Blood 2008, 112, 4292-4297. [CrossRef] [PubMed]
    • (2008) Blood , vol.112 , pp. 4292-4297
    • Ganz, T.1    Olbina, G.2    Girelli, D.3    Nemeth, E.4    Westerman, M.5
  • 22
    • 70450214396 scopus 로고    scopus 로고
    • The role of hepcidin in iron metabolism
    • [CrossRef] [PubMed]
    • Nemeth, E.; Ganz, T. The role of hepcidin in iron metabolism. Acta Haematol. 2009, 122, 78-86. [CrossRef] [PubMed]
    • (2009) Acta Haematol , vol.122 , pp. 78-86
    • Nemeth, E.1    Ganz, T.2
  • 23
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • [CrossRef] [PubMed]
    • Nemeth, E.; Tuttle, M.S.; Powelson, J.; Vaughn, M.B.; Donovan, A.; Ward, D.M.; Ganz, T.; Kaplan, J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004, 306, 2090-2093. [CrossRef] [PubMed]
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.B.4    Donovan, A.5    Ward, D.M.6    Ganz, T.7    Kaplan, J.8
  • 24
    • 0036791486 scopus 로고    scopus 로고
    • The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    • [CrossRef] [PubMed]
    • Nicolas, G.; Chauvet, C.; Viatte, L.; Danan, J.L.; Bigard, X.; Devaux, I.; Beaumont, C.; Kahn, A.; Vaulont, S. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J. Clin. Investig. 2002, 110, 1037-1044. [CrossRef] [PubMed]
    • (2002) J. Clin Investig , vol.110 , pp. 1037-1044
    • Nicolas, G.1    Chauvet, C.2    Viatte, L.3    Danan, J.L.4    Bigard, X.5    Devaux, I.6    Beaumont, C.7    Kahn, A.8    Vaulont, S.9
  • 25
    • 0037111732 scopus 로고    scopus 로고
    • Inappropriate expression of hepcidin is associated with iron refractory anemia: Implications for the anemia of chronic disease
    • [CrossRef] [PubMed]
    • Weinstein, D.A.; Roy, C.N.; Fleming, M.D.; Loda, M.F.; Wolfsdorf, J.I.; Andrews, N.C. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 2002, 100, 3776-3781. [CrossRef] [PubMed]
    • (2002) Blood , vol.100 , pp. 3776-3781
    • Weinstein, D.A.1    Roy, C.N.2    Fleming, M.D.3    Loda, M.F.4    Wolfsdorf, J.I.5    Andrews, N.C.6
  • 27
    • 84940163075 scopus 로고    scopus 로고
    • Mutual interaction between iron homeostasis and obesity pathogenesis
    • [CrossRef] [PubMed]
    • Nikonorov, A.A.; Skalnaya, M.G.; Tinkov, A.A.; Skalny, A.V. Mutual interaction between iron homeostasis and obesity pathogenesis. J. Trace Elem. Med. Biol. 2015, 30, 207-214. [CrossRef] [PubMed]
    • (2015) J. Trace Elem. Med Biol , vol.30 , pp. 207-214
    • Nikonorov, A.A.1    Skalnaya, M.G.2    Tinkov, A.A.3    Skalny, A.V.4
  • 28
    • 33846851525 scopus 로고    scopus 로고
    • Energy intake, diet composition, energy expenditure, and body fatness of adolescents in northern Greece
    • [CrossRef] [PubMed]
    • Hassapidou, M.; Fotiadou, E.; Magiara, E.; Papadopoulou, S.K. Energy intake, diet composition, energy expenditure, and body fatness of adolescents in northern Greece. Obesity 2006, 14, 855-862. [CrossRef] [PubMed]
    • (2006) Obesity , vol.14 , pp. 855-862
    • Hassapidou, M.1    Fotiadou, E.2    Magiara, E.3    Papadopoulou, S.K.4
  • 29
    • 37349102255 scopus 로고    scopus 로고
    • Obesity-related hypoferremia is not explained by differences in reported intake of heme and nonheme iron or intake of dietary factors that can affect iron absorption
    • [CrossRef] [PubMed]
    • Menzie, C.M.; Yanoff, L.B.; Denkinger, B.I.; McHugh, T.; Sebring, N.G.; Calis, K.A.; Yanovski, J.A. Obesity-related hypoferremia is not explained by differences in reported intake of heme and nonheme iron or intake of dietary factors that can affect iron absorption. J. Am. Diet. Assoc. 2008, 108, 145-148. [CrossRef] [PubMed]
    • (2008) J. Am. Diet Assoc , vol.108 , pp. 145-148
    • Menzie, C.M.1    Yanoff, L.B.2    Denkinger, B.I.3    McHugh, T.4    Sebring, N.G.5    Calis, K.A.6    Yanovski, J.A.7
  • 30
    • 84928705272 scopus 로고    scopus 로고
    • Diet-induced obese rats have higher iron requirements and are more vulnerable to iron deficiency
    • [CrossRef] [PubMed]
    • Bertinato, J.; Aroche, C.; Plouffe, L.J.; Lee, M.; Murtaza, Z.; Kenney, L.; Lavergne, C.; Aziz, A. Diet-induced obese rats have higher iron requirements and are more vulnerable to iron deficiency. Eur. J. Nutr. 2014, 53, 885-895. [CrossRef] [PubMed]
    • (2014) Eur. J Nutr , vol.53 , pp. 885-895
    • Bertinato, J.1    Aroche, C.2    Plouffe, L.J.3    Lee, M.4    Murtaza, Z.5    Kenney, L.6    Lavergne, C.7    Aziz, A.8
  • 33
    • 84882449718 scopus 로고    scopus 로고
    • Iron homeostasis and serum hepcidin-25 levels in obese children and adolescents: Relation to body mass index
    • [CrossRef] [PubMed]
    • Hamza, R.T.; Hamed, A.I.; Kharshoum, R.R. Iron homeostasis and serum hepcidin-25 levels in obese children and adolescents: Relation to body mass index. Horm. Res. Paediatr. 2013, 80, 11-17. [CrossRef] [PubMed]
    • (2013) Horm. Res Paediatr , vol.80 , pp. 11-17
    • Hamza, R.T.1    Hamed, A.I.2    Kharshoum, R.R.3
  • 34
    • 33845973764 scopus 로고    scopus 로고
    • Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans
    • [CrossRef] [PubMed]
    • Wang, Y.; Lam, K.S.; Kraegen, E.W.; Sweeney, G.; Zhang, J.; Tso, A.W.; Chow, W.S.; Wat, N.M.; Xu, J.Y.; Hoo, R.L.; et al. Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans. Clin. Chem. 2007, 53, 34-41. [CrossRef] [PubMed]
    • (2007) Clin Chem , vol.53 , pp. 34-41
    • Wang, Y.1    Lam, K.S.2    Kraegen, E.W.3    Sweeney, G.4    Zhang, J.5    Tso, A.W.6    Chow, W.S.7    Wat, N.M.8    Xu, J.Y.9    Hoo, R.L.10
  • 35
    • 34948856953 scopus 로고    scopus 로고
    • The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance
    • [CrossRef] [PubMed]
    • Yan, Q.W.; Yang, Q.; Mody, N.; Graham, T.E.; Hsu, C.H.; Xu, Z.; Houstis, N.E.; Kahn, B.B.; Rosen, E.D. The adipokine lipocalin 2 is regulated by obesity and promotes insulin resistance. Diabetes 2007, 56, 2533-2540. [CrossRef] [PubMed]
    • (2007) Diabetes , vol.56 , pp. 2533-2540
    • Yan, Q.W.1    Yang, Q.2    Mody, N.3    Graham, T.E.4    Hsu, C.H.5    Xu, Z.6    Houstis, N.E.7    Kahn, B.B.8    Rosen, E.D.9
  • 36
    • 81855185259 scopus 로고    scopus 로고
    • Upregulation of lipocalin 2 in adipose tissues of severely obese women: Positive relationship with proinflammatory cytokines
    • [CrossRef] [PubMed]
    • Auguet, T.; Quintero, Y.; Terra, X.; Martínez, S.; Lucas, A.; Pellitero, S.; Aguilar, C.; Hernández, M.; del Castillo, D.; Richart, C. Upregulation of lipocalin 2 in adipose tissues of severely obese women: Positive relationship with proinflammatory cytokines. Obesity 2011, 19, 2295-2300. [CrossRef] [PubMed]
    • (2011) Obesity , vol.19 , pp. 2295-2300
    • Auguet, T.1    Quintero, Y.2    Terra, X.3    Martínez, S.4    Lucas, A.5    Pellitero, S.6    Aguilar, C.7    Hernández, M.8    del Castillo, D.9    Richart, C.10
  • 37
    • 84865639214 scopus 로고    scopus 로고
    • The association of serum lipocalin-2 levels with metabolic and clinical parameters in obese children: A pilot study
    • [CrossRef] [PubMed]
    • Akelma, A.Z.; Abaci, A.; Ozdemir, O.; Celik, A.; Avci, Z.; Razi, C.H.; Hizli, S.; Akin, O. The association of serum lipocalin-2 levels with metabolic and clinical parameters in obese children: A pilot study. J. Pediatr. Endocrinol. Metab. 2012, 25, 525-528. [CrossRef] [PubMed]
    • (2012) J. Pediatr. Endocrinol Metab , vol.25 , pp. 525-528
    • Akelma, A.Z.1    Abaci, A.2    Ozdemir, O.3    Celik, A.4    Avci, Z.5    Razi, C.H.6    Hizli, S.7    Akin, O.8
  • 38
    • 84858690481 scopus 로고    scopus 로고
    • Effect of chronic iron deficiency on neuropsychological domains in infants
    • [CrossRef] [PubMed]
    • Beltrán-Navarro, B.; Matute, E.; Vásquez-Garibay, E.; Zarabozo, D. Effect of chronic iron deficiency on neuropsychological domains in infants. J. Child Neurol. 2012, 27, 297-303. [CrossRef] [PubMed]
    • (2012) J Child Neurol , vol.27 , pp. 297-303
    • Beltrán-Navarro, B.1    Matute, E.2    Vásquez-Garibay, E.3    Zarabozo, D.4
  • 39
    • 0038332144 scopus 로고    scopus 로고
    • The metabolic tune-up: Metabolic harmony and disease prevention
    • [PubMed]
    • Ames, B.N. The metabolic tune-up: Metabolic harmony and disease prevention. J. Nutr. 2003, 133, 1544S-1548S. [PubMed]
    • (2003) J Nutr , vol.133 , pp. 1544S-1548S
    • Ames, B.N.1
  • 40
    • 0029155660 scopus 로고
    • One person's view of iron deficiency, development, and cognitive function
    • [PubMed]
    • Beard, J. One person's view of iron deficiency, development, and cognitive function. Am. J. Clin. Nutr. 1995, 62, 709-710. [PubMed]
    • (1995) Am. J. Clin Nutr , vol.62 , pp. 709-710
    • Beard, J.1
  • 41
    • 0029973761 scopus 로고    scopus 로고
    • The role of nutrition in the development of normal cognition
    • [PubMed]
    • Kretchmer, N.; Beard, J.L.; Carlson, S. The role of nutrition in the development of normal cognition. Am. J. Clin. Nutr. 1996, 63, 997S-1001S. [PubMed]
    • (1996) Am. J. Clin Nutr , vol.63 , pp. 997S-1001S
    • Kretchmer, N.1    Beard, J.L.2    Carlson, S.3
  • 42
    • 0032713135 scopus 로고    scopus 로고
    • The role of micronutrients in psychomotor and cognitive development
    • [CrossRef] [PubMed]
    • Grantham-McGregor, S.M.; Ani, C.C. The role of micronutrients in psychomotor and cognitive development. Br. Med. Bull. 1999, 55, 511-527. [CrossRef] [PubMed]
    • (1999) Br. Med Bull , vol.55 , pp. 511-527
    • Grantham-McGregor, S.M.1    Ani, C.C.2
  • 43
    • 0035152903 scopus 로고    scopus 로고
    • The developmental and probabilistic nature of the functional consequences of iron-deficiency anemia in children
    • [PubMed]
    • Pollitt, E. The developmental and probabilistic nature of the functional consequences of iron-deficiency anemia in children. J. Nutr. 2001, 131, 669S-675S. [PubMed]
    • (2001) J Nutr , vol.131 , pp. 669S-675S
    • Pollitt, E.1
  • 44
    • 79955507698 scopus 로고    scopus 로고
    • Early iron deficiency has brain and behavior effects consistent with dopaminergic dysfunction
    • [CrossRef] [PubMed]
    • Lozoff, B. Early iron deficiency has brain and behavior effects consistent with dopaminergic dysfunction. J. Nutr. 2011, 141, 740S-746S. [CrossRef] [PubMed]
    • (2011) J Nutr , vol.141 , pp. 740S-746S
    • Lozoff, B.1
  • 45
    • 48749091561 scopus 로고    scopus 로고
    • Overweight is associated with decreased cognitive functioning among school-age children and adolescents
    • [CrossRef] [PubMed]
    • Li, Y.; Dai, Q.; Jackson, J.C.; Zhang, J. Overweight is associated with decreased cognitive functioning among school-age children and adolescents. Obesity 2008, 16, 1809-1815. [CrossRef] [PubMed]
    • (2008) Obesity , vol.16 , pp. 1809-1815
    • Li, Y.1    Dai, Q.2    Jackson, J.C.3    Zhang, J.4
  • 46
    • 79959649105 scopus 로고    scopus 로고
    • Disinhibited eating in obese adolescents is associated with orbitofrontal volume reductions and executive dysfunction
    • [CrossRef] [PubMed]
    • Maayan, L.; Hoogendoorn, C.; Sweat, V.; Convit, A. Disinhibited eating in obese adolescents is associated with orbitofrontal volume reductions and executive dysfunction. Obesity 2011, 19, 1382-1387. [CrossRef] [PubMed]
    • (2011) Obesity , vol.19 , pp. 1382-1387
    • Maayan, L.1    Hoogendoorn, C.2    Sweat, V.3    Convit, A.4
  • 47
    • 79958053605 scopus 로고    scopus 로고
    • Fitness, fatness, cognition, behavior, and academic achievement among overweight children: Do cross-sectional associations correspond to exercise trial outcomes? Prev
    • [CrossRef] [PubMed]
    • Davis, C.L.; Cooper, S. Fitness, fatness, cognition, behavior, and academic achievement among overweight children: Do cross-sectional associations correspond to exercise trial outcomes? Prev. Med. 2011, 52, S65-S69. [CrossRef] [PubMed]
    • (2011) Med , vol.52 , pp. S65-S69
    • Davis, C.L.1    Cooper, S.2
  • 48
    • 79953660392 scopus 로고    scopus 로고
    • Impaired mental rotation performance in overweight children
    • [CrossRef] [PubMed]
    • Jansen, P.; Schmelter, A.; Kasten, L.; Heil, M. Impaired mental rotation performance in overweight children. Appetite 2011, 56, 766-769. [CrossRef] [PubMed]
    • (2011) Appetite , vol.56 , pp. 766-769
    • Jansen, P.1    Schmelter, A.2    Kasten, L.3    Heil, M.4
  • 49
    • 34250851356 scopus 로고    scopus 로고
    • Associations between obesity and developmental functioning in pre-school children: A population-based study
    • [CrossRef] [PubMed]
    • Mond, J.M.; Stich, H.; Hay, P.J.; Kraemer, A.; Baune, B.T. Associations between obesity and developmental functioning in pre-school children: A population-based study. Int. J. Obes. (Lond.) 2007, 31, 1068-1073. [CrossRef] [PubMed]
    • (2007) Int. J. Obes (Lond.) , vol.31 , pp. 1068-1073
    • Mond, J.M.1    Stich, H.2    Hay, P.J.3    Kraemer, A.4    Baune, B.T.5
  • 50
    • 84857291384 scopus 로고    scopus 로고
    • The motor and cognitive development of overweight preschool children
    • [CrossRef]
    • Krombholz, H. The motor and cognitive development of overweight preschool children. Early Years 2012, 32, 61-70. [CrossRef]
    • (2012) Early Years , vol.32 , pp. 61-70
    • Krombholz, H.1
  • 51
    • 80052911898 scopus 로고    scopus 로고
    • Movement skill mastery in a clinical sample of overweight and obese children
    • [CrossRef] [PubMed]
    • Cliff, D.P.; Okely, A.D.; Magarey, A.M. Movement skill mastery in a clinical sample of overweight and obese children. Int. J. Pediatr. Obes. 2011, 6, 473-475. [CrossRef] [PubMed]
    • (2011) Int. J. Pediatr Obes , vol.6 , pp. 473-475
    • Cliff, D.P.1    Okely, A.D.2    Magarey, A.M.3
  • 52
    • 84860308708 scopus 로고    scopus 로고
    • Proficiency deficiency: Mastery of fundamental movement skills and skill components in overweight and obese children
    • [CrossRef] [PubMed]
    • Cliff, D.P.; Okely, A.D.; Morgan, P.J.; Jones, R.A.; Steele, J.R.; Baur, L.A. Proficiency deficiency: Mastery of fundamental movement skills and skill components in overweight and obese children. Obesity 2012, 20, 1024-1033. [CrossRef] [PubMed]
    • (2012) Obesity , vol.20 , pp. 1024-1033
    • Cliff, D.P.1    Okely, A.D.2    Morgan, P.J.3    Jones, R.A.4    Steele, J.R.5    Baur, L.A.6
  • 53
    • 80052998042 scopus 로고    scopus 로고
    • Gross motor skill performance in a sample of overweight and non-overweight preschool children
    • [CrossRef] [PubMed]
    • Morano, M.; Colella, D.; Caroli, M. Gross motor skill performance in a sample of overweight and non-overweight preschool children. Int. J. Pediatr. Obes. 2011, 6, 42-46. [CrossRef] [PubMed]
    • (2011) Int. J. Pediatr Obes , vol.6 , pp. 42-46
    • Morano, M.1    Colella, D.2    Caroli, M.3
  • 54
    • 12744260579 scopus 로고    scopus 로고
    • Relationships between body composition and fundamental movement skills among children and adolescents
    • [CrossRef] [PubMed]
    • Okely, A.D.; Booth, M.L.; Chey, T. Relationships between body composition and fundamental movement skills among children and adolescents. Res. Q. Exerc. Sport 2004, 75, 238-247. [CrossRef] [PubMed]
    • (2004) Res. Q. Exerc Sport , vol.75 , pp. 238-247
    • Okely, A.D.1    Booth, M.L.2    Chey, T.3
  • 55
    • 84856364555 scopus 로고    scopus 로고
    • Obesity, academic performance and reasoning ability in Portuguese students between 6 and 12 years old
    • [CrossRef] [PubMed]
    • Barrigas, C.; Fragoso, I. Obesity, academic performance and reasoning ability in Portuguese students between 6 and 12 years old. J. Biosoc. Sci. 2012, 44, 165-179. [CrossRef] [PubMed]
    • (2012) J. Biosoc Sci , vol.44 , pp. 165-179
    • Barrigas, C.1    Fragoso, I.2
  • 56
    • 0034184778 scopus 로고    scopus 로고
    • The neurochemical basis of cognitive deficits induced by brain iron deficiency: Involvement of dopamine-opiate system
    • [PubMed]
    • Youdim, M.B.; Yehuda, S. The neurochemical basis of cognitive deficits induced by brain iron deficiency: Involvement of dopamine-opiate system. Cell Mol. Biol. 2000, 46, 491-500. [PubMed]
    • (2000) Cell Mol Biol , vol.46 , pp. 491-500
    • Youdim, M.B.1    Yehuda, S.2
  • 57
    • 77952303185 scopus 로고    scopus 로고
    • Iron-deficiency anemia in infancy and mother-infant interaction during feeding
    • [CrossRef] [PubMed]
    • Armony-Sivan, R.; Kaplan-Estrin, M.; Jacobson, S.W.; Lozoff, B. Iron-deficiency anemia in infancy and mother-infant interaction during feeding. J. Dev. Behav. Pediatr. 2010, 31, 326-332. [CrossRef] [PubMed]
    • (2010) J. Dev. Behav Pediatr , vol.31 , pp. 326-332
    • Armony-Sivan, R.1    Kaplan-Estrin, M.2    Jacobson, S.W.3    Lozoff, B.4
  • 58
    • 84901323597 scopus 로고    scopus 로고
    • Iron supplementation in infancy contributes to more adaptive behavior at 10 years of age
    • [CrossRef] [PubMed]
    • Lozoff, B.; Castillo, M.; Clark, K.M.; Smith, J.B.; Sturza, J. Iron supplementation in infancy contributes to more adaptive behavior at 10 years of age. J. Nutr. 2014, 144, 838-845. [CrossRef] [PubMed]
    • (2014) J Nutr , vol.144 , pp. 838-845
    • Lozoff, B.1    Castillo, M.2    Clark, K.M.3    Smith, J.B.4    Sturza, J.5
  • 59
    • 33846106154 scopus 로고    scopus 로고
    • Long lasting effects of infancy iron deficiency-Preliminary results
    • [PubMed]
    • Yehuda, S.; Yehuda, M. Long lasting effects of infancy iron deficiency-Preliminary results. J. Neural. Transm. Suppl. 2006, 71, 197-200. [PubMed]
    • (2006) J. Neural. Transm Suppl , vol.71 , pp. 197-200
    • Yehuda, S.1    Yehuda, M.2
  • 60
    • 84855167863 scopus 로고    scopus 로고
    • Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study
    • [CrossRef] [PubMed]
    • Sanad, M.; Osman, M.; Gharib, A. Obesity modulate serum hepcidin and treatment outcome of iron deficiency anemia in children: A case control study. Ital. J. Pediatr. 2011, 37, 34. [CrossRef] [PubMed]
    • (2011) Ital. J Pediatr , vol.37 , pp. 34
    • Sanad, M.1    Osman, M.2    Gharib, A.3
  • 61
    • 47249153165 scopus 로고    scopus 로고
    • Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification
    • [CrossRef] [PubMed]
    • Zimmermann, M.B.; Zeder, C.; Muthayya, S.; Winichagoon, P.; Chaouki, N.; Aeberli, I.; Hurrell, R.F. Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification. Int. J. Obes. (Lond.) 2008, 32, 1098-1104. [CrossRef] [PubMed]
    • (2008) Int. J. Obes (Lond.) , vol.32 , pp. 1098-1104
    • Zimmermann, M.B.1    Zeder, C.2    Muthayya, S.3    Winichagoon, P.4    Chaouki, N.5    Aeberli, I.6    Hurrell, R.F.7
  • 62
    • 78650155191 scopus 로고    scopus 로고
    • Effect of body mass index reduction on serum hepcidin levels and iron status in obese children
    • [CrossRef] [PubMed]
    • Amato, A.; Santoro, N.; Calabrò, P.; Grandone, A.; Swinkels, D.W.; Perrone, L.; del Giudice, E.M. Effect of body mass index reduction on serum hepcidin levels and iron status in obese children. Int. J. Obes. (Lond.) 2010, 34, 1772-1774. [CrossRef] [PubMed]
    • (2010) Int. J. Obes (Lond.) , vol.34 , pp. 1772-1774
    • Amato, A.1    Santoro, N.2    Calabrò, P.3    Grandone, A.4    Swinkels, D.W.5    Perrone, L.6    del Giudice, E.M.7
  • 63
    • 84896546141 scopus 로고    scopus 로고
    • Weight loss, inflammatory markers, and improvements of iron status in overweight and obese children
    • [CrossRef] [PubMed]
    • Gong, L.; Yluan, F.; Teng, J.; Li, X.; Zheng, S.; Lin, L.; Deng, H.; Ma, G.; Sun, C.; Li, Y. Weight loss, inflammatory markers, and improvements of iron status in overweight and obese children. J. Pediatr. 2014, 164, 795-800. [CrossRef] [PubMed]
    • (2014) J Pediatr , vol.164 , pp. 795-800
    • Gong, L.1    Yluan, F.2    Teng, J.3    Li, X.4    Zheng, S.5    Lin, L.6    Deng, H.7    Ma, G.8    Sun, C.9    Li, Y.10


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