Chinese herbal formulas Si-Wu-Tang and Er-Miao-San synergistically ameliorated hyperuricemia and renal impairment in rats induced by adenine and potassium oxonate

Cellular Physiology and Biochemistry

Volumn 37, Issue 4, 2015, Pages 1491-1502

  Guo, Yongping ^a   Jiang, Qian ^b   Gui, Dingkun ^a   Wang, Niansong ^a  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b TONGJI UNIVERSITY   (China)

Author keywords

Chinese herbal formula; Er Miao San; Hyperuricemia; OAT1; OAT3; Si Wu Tang

Indexed keywords

ADENINE; BENZBROMARONE; CHOLESTEROL; CREATININE; ER MIAO SAN; HERBACEOUS AGENT; ORGANIC ANION TRANSPORTER 1; ORGANIC ANION TRANSPORTER 3; OTERACIL POTASSIUM; SI WU TANG; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; URIC ACID; XANTHINE OXIDASE; ER-MIAO-SAN; ORGANIC ANION TRANSPORTER; OTERACIL; PLANT EXUDATE; SI-WU-TANG; SLC22A6 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVITY; EXPERIMENTAL RENAL FAILURE; HISTOPATHOLOGY; HYPERURICEMIA; MICROALBUMINURIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RENAL PROTECTION; UREA NITROGEN BLOOD LEVEL; URIC ACID BLOOD LEVEL; URIC ACID URINE LEVEL; WESTERN BLOTTING; ADMINISTRATION AND DOSAGE; ANIMAL; BLOOD; CHEMISTRY; DRUG EFFECTS; KIDNEY; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; PATHOLOGY; PHARMACOLOGY; PLANT EXUDATE; SPRAGUE DAWLEY RAT; URINE;

ADENINE; ADMINISTRATION, ORAL; ANIMALS; BENZBROMARONE; CREATININE; DRUG SYNERGISM; DRUGS, CHINESE HERBAL; HYPERURICEMIA; KIDNEY; MALE; ORGANIC ANION TRANSPORT PROTEIN 1; ORGANIC ANION TRANSPORTERS, SODIUM-INDEPENDENT; OXONIC ACID; PLANT EXUDATES; RATS; RATS, SPRAGUE-DAWLEY; URIC ACID; XANTHINE OXIDASE;

EID: 84946811235     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000438517     Document Type: Article

References (38)

1. Zhang L, Wang F, Wang L, Wang W, Liu B, Liu J, Chen M, He Q, Liao Y, Yu X, Chen N, Zhang JE, Hu Z, Liu F, Hong D, Ma L, Liu H, Zhou X, Chen J, Pan L, Chen W, Wang W, Li X, Wang H. Prevalence of chronic kidney disease in China: a cross-sectional survey. Lancet 2012;379:815-822.
2. Lin B, Shao L, Luo Q, Ou-Yang L, Zhou F, Du B, He Q, Wu J, Xu N, Chen J. Prevalence of chronic kidney disease and its association with metabolic diseases: a cross-sectional survey in Zhejiang province, Eastern China. BMC Nephrol 2014;15:36.
3. Sedaghat S, Hoorn EJ, van Rooij FJ, Hofman A, Franco OH, Witteman JC, Dehghan A. Serum uric acid and chronic kidney disease: the role of hypertension. PLoS One 2013;18:e76827.
4. Storhaug HM, Norvik JV, Toft I, Eriksen BO, Løchen ML, Zykova S, Solbu M, White S, Chadban S, Jenssen T. Uric acid is a risk factor for ischemic stroke and all-cause mortality in the general population: a gender specific analysis from The Tromsø Study. BMC Cardiovasc Disord 2013;13:115.
5. Chen JH, Chuang SY, Chen HJ, Yeh WT, Pan WH. Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study. Arthritis Rheum 2009;61:225-232.
6. Chen IH, Kuo MC, Hwang SJ, Chang JM, Chen HC. Allopurinol-induced severe hypersensitivity with acute renal failure. Kaohsiung J Med Sci 2005;21:228-232.
7. Horiuchi H, Ota M, Nishimura S, Kaneko H., Kasahara Y, Ohta T, Komoriya K. Allopurinol induces renal toxicity by impairing pyrimidine metabolism in mice. Life Sci 2000;66:2051-2070.
8. Mari E, Ricci F, Imberti D, Gallerani M. Agranulocytosis: an adverse effect of allopurinol treatment. Italian J Med 2011;5:120-123.
9. Pluim HJ, Deuren MV, Wetzels JFM. The allopurinol hypersensitivity syndrome. Neth J Med 1998;52:107-110.
10. Ahmad NS, FarmanM, Najmi MH, Mian KB, Hasan A. Pharmacological basis for use of Pistacia integerrima leaves in hyperuricemia and gout. J Ethnopharmacol 2008;117:478-482.
11. An J, Yang HJ, Park K, Lee J, Kim BW. Reparatory and preventive effects of oriental herb extract mixture (OHEM) on hyperuricemia and gout. Food Sci Biotechnol 2010;19:517-524.
12. Liang QD , Lu XQ , Ma ZC , Tan HL , Ma BP , Gao Y , Wang SQ. Preliminary study on hematopoietic constituents of Si-Wu-Dang. Zhongguo Zhong Yao Za Zhi 2004;29:546-549.
13. Dai Y, But PP, Chan YP, Matsuda H, Kubo M. Antipruritic and antiinflammatory effects of aqueous extract from Si-Wu-Dang. Biol Pharm Bull 2002;25:1175-1178.
14. Kong LD, Yang C, Ge F, Wang HD, Guo YS. A Chinese herbal medicine Ermiao wan reduces serum uric acid level and inhibits liver xanthine dehydrogenase and xanthine oxidase in mice. J Ethnopharmacol 2004;93:325-330.
15. Kramer HM, Curhan G. The association between gout and nephrolithiasis: the National Health and Nutrition Examination Survey III, 1988-1994. Am J Kidney Dis 2002;40:37-42.
16. Li Y, Stamler J, Xiao Z, Folsom A, Tao S, Zhang, H. Serum uric acid and its correlates in Chinese adult populations, urban and rural, of Beijing: the PRC-USA collaborative study in cardiovascular and cardiopulmonary epidemiology. Int J Epidemiol 1997;26:288-296.
17. Brulé D, Sarwar G, Savoie L, Campbell J, Van Zeggelaar M. Differences in uricogenic effects of dietary purine bases, nucleosides and nucleotides in rats. J Nutr 1988;118:780-786.
18. Hou SX, Zhu WJ, Pang MQ, Jeffry J, Zhou LL. Protective effect of iridoid glycosides from Paederia scandens (LOUR) MERRILL (Rubiaceae) on uric acid nephropathy rats induced by yeast and potassium oxonate. Food Chem Toxicol 2014;64:57-64.
19. Yan H, Ma Y, Liu M, Zhou L. The dual actions of Paederia scandens extract as a hypouricemic agent: xanthine oxidase inhibitory activity and uricosuric effect. Planta Med 2008;74:1345-1350.
20. Gibbings S, Elkins ND, Fitzgerald H, Tiao J, Weyman ME, Shibao G, Fini MA, Wright RM. Xanthine oxidoreductase promotes the inflammatory state of mononuclear phagocytes through effects on chemokine expression, peroxisome proliferator-Activated receptor-γ sumoylation, and HIF-1α. J Biol Chem 2011;286:961-975.
21. Pacher P, Nivorozhkin A, Szabo C. Therapeutic effects of xanthine oxidase inhibitors: renaissance half a century after the discovery of allopurinol. Pharmacol Rev 2006;58:87-114.
22. Houston M, Estevez A, Chumley P, Aslan M, Marklund S, Parks DA, Freeman BA. Binding of xanthine oxidase to vascular endothelium: kinetic characterization and oxidative impairment of nitric oxide-dependent signaling. J Biol Chem 1999;274:4985-4994.
23. Liu M, Ravula R, Wang Z, Zuo Z, Chow MS, Thakkar A, Prabhu S, Andresen B, Huang Y. Traditional Chinese medicinal formula Si-Wu-Dang prevents oxidative damage by activating Nrf2-mediated detoxifying/antioxidant genes. Cell Biosci 2014;4:8.
24. Endo K, Taguchi T, Taguchi F, Hikino H, Yamahara J, Fujimura H. Anti-inflammatory principles of Atractylodes rhizomes. Chem Pharm Bull (Tokyo) 1979;27:2954-2958.
25. Yamahara J, Matsuda H, Naitoh Y, Fujimura H, Tamai Y. Antianoxic action and active constituents of atractylodis lanceae rhizoma. Chem Pharm Bull (Tokyo) 1990;38:2033-2034.
26. Resch M, Steigel A, Chen ZL, Bauer R: 5-Lipoxygenase and cyclooxygenase-1 inhibitory active compounds from Atractylodes lancea. J Nat Prod 1998; 61:347-350.
27. Lee YH, Kim H, Hong EK, Kang BH, Kim SJ. Water extract of 1:1 mixture of phellodendron cortex and aralia cortex has inhibitory effects on oxidative stress in kidney of diabetic rats. J Ethnopharmacol 2000;73:429-436.
28. Bobulescu IA, Moe OW. Renal transport of uric acid: evolving concepts and uncertainties. Adv Chronic Kidney Dis 2012;19:358-371.
29. Eraly SA, Vallon V, Rieg T, Gangoiti JA, Wikoff WR, Siuzdak G, Barshop BA, Nigam SK. Multiple organic anion transporters contribute to net renal excretion of uric acid. Physiol Genomics 2008;33:180-192.
30. Habu Y, Yano I, Takeuchi A, Saito H, Okuda M, Fukatsu A, Inui K. Decreased activity of basolateral organic ion transports in hyperuricemic rat kidney: roles of organic I on transporters, rOAT1, rOAT3 and rOCT2. Biochem Pharmacol 2003;66:1107-1114.
31. Zhu W, Pang M, Dong L, Huang X, Wang S, Zhou L. Anti-inflammatory and immunomodulatory effects of iridoid glycosides from Paederia scandens (LOUR) MERRILL (Rubiaceae) on uric acid nephropathy rats. Life Sci 2012;91:369-376.
32. Salati LM, Gross CJ, Henderson LM, Savaiano DA. Absorption and metabolism of adenine, adenosine-5'-monophosphate, adenosine and hypoxanthine by the isolated vascularly perfused rat small intestine. J Nutr 1984;114:753-760.
33. Yang X, Gao K, Wang Y, Zhang Y, Guo H, Su H. Effects of Different Extracts of Modified Siwu Siteng Decoction on Uric Acid and Xanthine Oxidase in Rats with Hyperuricemia. Chin J Inform Traditional Chin Med 2014;21:66-68.
34. Hu Y, Guo C, Li J, Wang B, Wu S. Supplemented Siwu Decoction for type 2 diabetes with asymptomatic hyperuricemia: a clinical observation of 38 cases. J Tradit Chin Med 2007;48:515-517.
35. Hong Q, Yu S, Mei Y, Lv Y, Chen D, Wang Y, Geng W, Wu D, Cai G, Chen X. Smilacis Glabrae Rhizoma reduces oxidative stress caused by hyperuricemia via up regulation of catalase. Cell Physiol Biochem 2014;34:1675-1685.
36. Xu C, Liu S, Liu Z, Song F. Screening of Xanthine Oxidase Inhibitors in Traditional Chinese Herbal Formulae Ermiaowan Using Ultrafiltration UPLC-MS. Chem J Chinese Univ 2014, 35:1640-1645.
37. Chen G, Li KK, Fung CH, Liu CL, Wong HL, Leung PC, Ko CH. Er-Miao-San, a traditional herbal formula containing Rhizoma Atractylodis and Cortex Phellodendri inhibits inflammatory mediators in LPS-stimulated RAW264.7 macrophages through inhibition of NF-κB pathway and MAPKs activation. J Ethnopharmacol 2014;154:711-718.
38. Yin L, Deng H, Zhu X, Li X, Duan J, Ding A. Study on role for protecting HUVEC damaged by urate and content variation of alkaloids components in Ermiao Wan categorized formula. Chem J Chinese Univ 2009;30:1522-1527.