Estrogenic activity in Finnish municipal wastewater effluents

Water Research

Volumn 88, Issue , 2016, Pages 740-749

  Välitalo, Pia ^a,b   Perkola, Noora ^a   Seiler, Thomas Benjamin ^c   Sillanpää, Markus ^a   Kuckelkorn, Jochen ^c   Mikola, Anna ^b   Hollert, Henner ^c   Schultz, Eija ^a  

^a FINNISH ENVIRONMENT INSTITUTE   (Finland)

^b AALTO UNIVERSITY   (Finland)

^c RWTH AACHEN UNIVERSITY   (Germany)

Author keywords

Chemical analysis; Estrogenic activity; In vitro; Wastewater effluent

Indexed keywords

BIOASSAY; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; WASTEWATER TREATMENT;

BISPHENOL A; BISPHENOLS-A; ERΑ; ESTROGENIC ACTIVITIES; ESTROGENIC COMPOUNDS; FINNISH; IN-VITRO; LIMIT OF QUANTIFICATIONS; MUNICIPAL WASTEWATERS; WASTEWATER EFFLUENTS;

EFFLUENTS;

4,4' ISOPROPYLIDENEDIPHENOL; ENDOCRINE DISRUPTOR; ESTRADIOL; ESTRIOL; ESTRONE; ETHINYLESTRADIOL; ESTROGEN; WASTE WATER; WATER POLLUTANT;

BIOASSAY; CHEMICAL ANALYSIS; CONCENTRATION (COMPOSITION); EFFLUENT; ESTROGENIC COMPOUND; FEASIBILITY STUDY; LABORATORY METHOD; WASTEWATER; WATER TREATMENT;

AQUATIC ENVIRONMENT; AQUATIC SPECIES; ARTICLE; BIOASSAY; CALIBRATION; CHEMICAL ANALYSIS; DAPHNIA MAGNA; ENZYME LINKED IMMUNOSORBENT ASSAY; FINLAND; IN VITRO STUDY; LIQUID CHROMATOGRAPHY; PRIORITY JOURNAL; SOLID PHASE EXTRACTION; TOXICITY TESTING; WASTE WATER MANAGEMENT; WASTE WATER TREATMENT PLANT; ALIIVIBRIO FISCHERI; ANALYSIS; ANIMAL; CHEMISTRY; DAPHNIA; DRUG EFFECTS; REPRODUCTION; SEWAGE; TANDEM MASS SPECTROMETRY; TOXICITY; WASTE WATER; WATER POLLUTANT;

FINLAND;

ALIIVIBRIO FISCHERI; ANIMALS; CHROMATOGRAPHY, LIQUID; DAPHNIA; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESTROGENS; FINLAND; REPRODUCTION; TANDEM MASS SPECTROMETRY; TOXICITY TESTS; WASTE DISPOSAL, FLUID; WASTE WATER; WATER POLLUTANTS, CHEMICAL;

EID: 84946781345     PISSN: 00431354     EISSN: 18792448     Source Type: Journal    
DOI: 10.1016/j.watres.2015.10.056     Document Type: Article

References (70)

1. Aerni H.-R., Kobler B., Rutishauser B., Wettstein F., Fischer R., Giger W., Hungerbühler A., Marazuela M.D., Peter A., Schönenberger R., Vögeli A.C., Suter M.F., Eggen R.L. Combined biological and chemical assessment of estrogenic activities in wastewater treatment plant effluents. Anal. Bioanal. Chem. 2004, 378(3):688-696.
2. Allinson M., Shiraishi F., Salzman S.A., Allinson G. Vitro and immunological assessment of the estrogenic activity and concentrations of 17β-estradiol, estrone, and ethinyl estradiol in treated effluent from 45 wastewater treatment plants in Victoria, Australia. Arch. Environ. Contam. Toxicol. 2010, 58(3):576-586.
3. Bain P.A., Williams M., Kumar A. Assessment of multiple hormonal activities in wastewater at different stages of treatment. Environ. Toxicol. Chem. 2014, 33(10):2297-2307.
4. BDS Analysis of Estrogen Receptor Mediated Luciferase Activity in ER CALUX Cells 2007, P-BDS-011(H).
5. Behera S.K., Kim H.W., Oh J.E., Park H.S. Occurrence and removal of antibiotics, hormones and several other pharmaceuticals in wastewater treatment plants of the largest industrial city of Korea. Sci. Total Environ. 2011, 409(20):4351-4360.
6. Belfroid A.C., Van der Horst A., Vethaak A.D., Schäfer A.J., Rijs G.B.J., Wegener J., Cofino W.P. Analysis and occurrence of estrogenic hormones and their glucuronides in surface water and waste water in The Netherlands. Sci. Total Environ. 1999, 225(1-2):101-108.
7. Birceanu O., Servos M.R., Vijayan M.M. Bisphenol A accumulation in eggs disrupts the endocrine regulation of growth in rainbow trout larvae. Aquat. Toxicol. 2015, 161(0):51-60.
8. Bolong N., Ismail A.F., Salim M.R., Matsuura T. A review of the effects of emerging contaminants in wastewater and options for their removal. Desalination 2009, 239(1-3):229-246.
9. Brix R., Noguerol T.-N., Piña B., Balaam J., Nilsen A.J., Tollefsen K.-E., Levy W., Schramm K.-W., Barceló D. Evaluation of the suitability of recombinant yeast-based estrogenicity assays as a pre-screening tool in environmental samples. Environ. Int. 2010, 36(4):361-367.
10. Carballa M., Omil F., Lema J.M., Llompart M.a., García-Jares C., Rodríguez I., Gómez M., Ternes T. Behavior of pharmaceuticals, cosmetics and hormones in a sewage treatment plant. Water Res. 2004, 38(12):2918-2926.
11. Caron E., Sheedy C., Farenhorst A. Development of competitive ELISAs for 17beta-estradiol and 17beta-estradiol +estrone+estriol using rabbit polyclonal antibodies. J. Environ. Sci. Health B 2010, 45(2):145-151.
12. Chang H., Wan Y., Wu S., Fan Z., Hu J. Occurrence of androgens and progestogens in wastewater treatment plants and receiving river waters: comparison to estrogens. Water Res. 2011, 45(2):732-740.
13. Clara M., Kreuzinger N., Strenn B., Gans O., Kroiss H. The solids retention time-a suitable design parameter to evaluate the capacity of wastewater treatment plants to remove micropollutants. Water Res. 2005, 39(1):97-106.
14. Colborn T. Environmental estrogens: health implications for humans and wildlife. Environ. Health Perspect. 1995, 103(Suppl. 7):135-136.
15. Fühacker M. Bisphenol A emission factors from industrial sources and elimination rates in a sewage treatment plant. Water Sci. Technol. 2003, 47(10):117-122.
16. Fürhacker M., Scharf S., Weber H. Bisphenol A: emissions from point sources. Chemosphere 2000, 41(5):751-756.
17. Gabet-Giraud V., Miège C., Jacquet R., Coquery M. Impact of wastewater treatment plants on receiving surface waters and a tentative risk evaluation: the case of estrogens and beta blockers. Environ. Sci. Pollut. Res. 2014, 21(3):1708-1722.
18. Guedes-Alonso R., Santana-Viera S., Sosa-Ferrera Z., Santana-Rodríguez J.J. Molecularly imprinted solid-phase extraction coupled with ultra high performance liquid chromatography and fluorescence detection for the determination of estrogens and their metabolites in wastewater. J. Sep. Sci. 2015, 10.1002/jssc.201500764.
19. Guerra P., Kim M., Teslic S., Alaee M., Smyth S.A. Bisphenol-A removal in various wastewater treatment processes: operational conditions, mass balance, and optimization. J. Environ. Manag. 2015, 152:192-200.
20. Guo F., Liu Q., Qu G.-b., Song S.-j., Sun J.-t., Shi J.-b., Jiang G.-b. Simultaneous determination of five estrogens and four androgens in water samples by online solid-phase extraction coupled with high-performance liquid chromatography-tandem mass spectrometry. J. Chromatogr. A 2013, 1281:9-18.
21. Hanselman T.A., Graetz D.A., Wilkie A.C. Comparison of three enzyme immunoassays for measuring 17β-Estradiol in flushed dairy manure wastewater. J. Environ. Qual. 2004, 33(5):1919-1923.
22. Hernando M.D., Fernández-Alba A.R., Tauler R., Barceló D. Toxicity assays applied to wastewater treatment. Talanta 2005, 65(2):358-366.
23. Honkanen J.O., Holopainen I.J., Kukkonen J.V.K. Bisphenol A induces yolk-sac oedema and other adverse effects in landlocked salmon (Salmo salar m. sebago) yolk-sac fry. Chemosphere 2004, 55(2):187-196.
24. Huang C.-H., Sedlak D.L. Analysis of estrogenic hormones in municipal wastewater effluent and surface water using enzyme-linked immunosorbent assay and gas chromatography/tandem mass spectrometry. Environ. Toxicol. Chem. 2001, 20(1):133-139.
25. Huhtala S., Munne P., Nakari T., Nuutinen J., Perkola N., Sainio P., Schultz E., Schultz L. WP3 Innovative Approaches to Chemical Controls of Hazardous Substances 2011, Country Report of Finland, COHIBA, Control of Hazardous Substances in the Baltic Sea Region.
26. Ihara M., Ihara M.O., Kumar V., Narumiya M., Hanamoto S., Nakada N., Yamashita N., Miyagawa S., Iguchi T., Tanaka H. Co-occurrence of estrogenic and antiestrogenic activities in wastewater: quantitative evaluation of balance by in vitro ERα reporter gene assay and chemical analysis. Environ. Sci. Technol. 2014, 48(11):6366-6373.
27. Ihara M., Kitamura T., Kumar V., Park C.-B., Ihara M.O., Lee S.-J., Yamashita N., Miyagawa S., Iguchi T., Okamoto S., Suzuki Y., Tanaka H. Evaluation of estrogenic activity of wastewater: comparison among in vitro ERα reporter gene assay, in vivo vitellogenin induction, and chemical analysis. Environ. Sci. Technol. 2015, 49(10):6319-6326.
28. Ingrand V., Herry G., Beausse J., de Roubin M.-R. Analysis of steroid hormones in effluents of wastewater treatment plants by liquid chromatoraphy-tandem mass spectrometry. J. Chromatogr. A 2003, 1020(1):99-104.
29. Isobe T., Serizawa S., Horiguchi T., Shibata Y., Managaki S., Takada H., Morita M., Shiraishi H. Horizontal distribution of steroid estrogens in surface sediments in Tokyo Bay. Environ. Pollut. 2006, 144(2):632-638.
30. Jarošová B., Bláha L., Giesy J.P., Hilscherová K. What level of estrogenic activity determined by in vitro assays in municipal waste waters can be considered as safe?. Environ. Int. 2014, 64(0):98-109.
31. Jarošová B., Erseková A., Hilscherová K., Loos R., Gawlik B., Giesy J., Bláha L. Europe-wide survey of estrogenicity in wastewater treatment plant effluents: the need for the effect-based monitoring. Environ. Sci. Pollut. Res. 2014, 21(18):10970-10982.
32. Jemec A., Tišler T., Erjavec B., Pintar A. Antioxidant responses and whole-organism changes in Daphnia magna acutely and chronically exposed to endocrine disruptor bisphenol A. Ecotoxicol. Environ. Saf. 2012, 86(0):213-218.
33. Kolodziej E.P., Gray J.L., Sedlak D.L. Quantification of steroid hormones with pheromonal properties in municipal wastewater effluent. Environ. Toxicol. Chem. 2003, 22(11):2622-2629.
34. Körner W., Hanf V., Schuller W., Kempter C., Metzger J., Hagenmaier H. Development of a sensitive E-screen assay for quantitative analysis of estrogenic activity in municipal sewage plant effluents. Sci. Total Environ. 1999, 225(1-2):33-48.
35. Laganà A., Bacaloni A., De Leva I., Faberi A., Fago G., Marino A. Analytical methodologies for determining the occurrence of endocrine disrupting chemicals in sewage treatment plants and natural waters. Anal. Chim. Acta 2004, 501(1):79-88.
36. Lee H.-B., Peart T.E., Chan J., Gris G. Occurrence of endocrine-disrupting chemicals in sewage and sludge samples in Toronto, Canada. Water Qual. Res. J. Can. 2004, 39(1):57-63.
37. Legler J., van den Brink C.E., Brouwer A., Murk A.J., van der Saag P.T., Vethaak A.D., van der Burg B. Development of a stably transfected estrogen receptor-mediated luciferase reporter gene assay in the human T47D breast cancer cell line. Toxicol. Sci. 1999, 48(1):55-66.
38. Leusch F.D.L., Khan S.J., Gagnon M.M., Quayle P., Trinh T., Coleman H., Rawson C., Chapman H.F., Blair P., Nice H., Reitsema T. Assessment of wastewater and recycled water quality: a comparison of lines of evidence from in vitro, in vivo and chemical analyses. Water Res. 2014, 50:420-431.
39. Lintelmann J., Katayama A., Kurihara N., Shore L., Wenzel A. Endocrine disruptors in the environment (IUPAC Technical Report). Pure Appl. Chem. 2003, 75(5):631-681.
40. Liu Z.-h., Kanjo Y., Mizutani S. Urinary excretion rates of natural estrogens and androgens from humans, and their occurrence and fate in the environment: a review. Sci. Total Environ. 2009, 407(18):4975-4985.
41. Ma M., Rao K., Wang Z. Occurrence of estrogenic effects in sewage and industrial wastewaters in Beijing, China. Environ. Pollut. 2007, 147(2):331-336.
42. Maletz S., Floehr T., Beier S., Klümper C., Brouwer A., Behnisch P., Higley E., Giesy J.P., Hecker M., Gebhardt W., Linnemann V., Pinnekamp J., Hollert H. In vitro characterization of the effectiveness of enhanced sewage treatment processes to eliminate endocrine activity of hospital effluents. Water Res. 2013, 47(4):1545-1557.
43. Manickum T., John W. Occurrence, fate and environmental risk assessment of endocrine disrupting compounds at the wastewater treatment works in Pietermaritzburg (South Africa). Sci. Total Environ. 2014, 468-469:584-597.
44. Mendonça E., Picado A., Paixão S.M., Silva L., Cunha M.A., Leitão S., Moura I., Cortez C., Brito F. Ecotoxicity tests in the environmental analysis of wastewater treatment plants: case study in Portugal. J. Hazard. Mater. 2009, 163(2-3):665-670.
45. Metcalfe C.D., Metcalfe T.L., Kiparissis Y., Koenig B.G., Khan C., Hughes R.J., Croley T.R., March R.E., Potter T. Estrogenic potency of chemicals detected in sewage treatment plant effluents as determined by in vivo assays with Japanese medaka (Oryzias latipes). Environ. Toxicol. Chem. 2001, 20(2):297-308.
46. Murk A.J., Legler J., van Lipzig M.M.H., Meerman J.H.N., Belfroid A.C., Spenkelink A., van der Burg B., Rijs G.B.J., Vethaak D. Detection of estrogenic potency in wastewater and surface water with three in vitro bioassays. Environ. Toxicol. Chem. 2002, 21(1):16-23.
47. Nakada N., Nyunoya H., Nakamura M., Hara A., Iguchi T., Takada H. Identification of estrogenic compounds in wastewater effluent. Environ. Toxicol. Chem. 2004, 23(12):2807-2815.
48. Nakada N., Tanishima T., Shinohara H., Kiri K., Takada H. Pharmaceutical chemicals and endocrine disrupters in municipal wastewater in Tokyo and their removal during activated sludge treatment. Water Res. 2006, 40(17):3297-3303.
49. Nelson J., Bishay F., van Roodselaar A., Ikonomou M., Law F.C.P. The use of in vitro bioassays to quantify endocrine disrupting chemicals in municipal wastewater treatment plant effluents. Sci. Total Environ. 2007, 374(1):80-90.
50. Oehlmann J., Oetken M., Schulte-Oehlmann U. A critical evaluation of the environmental risk assessment for plasticizers in the freshwater environment in Europe, with special emphasis on bisphenol A and endocrine disruption. Environ. Res. 2008, 108(2):140-149.
51. Oehlmann J., Schulte-Oehlmann U., Tillmann M., Markert B. Effects of endocrine disruptors on Prosobranch snails (Mollusca: Gastropoda) in the laboratory. Part I: bisphenol a and octylphenol as xeno-estrogens. Ecotoxicology 2000, 9(6):383-397.
52. Pedrouzo M., Borrull F., Pocurull E., Marcé R. Presence of pharmaceuticals and hormones in waters from sewage treatment plants. Water Air Soil Pollut. 2011, 217(1-4):267-281.
53. Pessala P. Tracking and Identifying Wastewater Toxicants and Assessing Their Biodegradation Products 2008, Doctoral thesis, University of Helsinki, Helsinki.
54. Pessala P., Schultz E., Nakari T., Joutti A., Herve S. Evaluation of wastewater effluents by small-scale biotests and a fractionation procedure. Ecotoxicol. Environ. Saf. 2004, 59(2):263-272.
55. Petrović M., Gonzalez S., Barceló D. Analysis and removal of emerging contaminants in wastewater and drinking water. TrAC Trends Anal. Chem. 2003, 22(10):685-696.
56. Pothitou P., Voutsa D. Endocrine disrupting compounds in municipal and industrial wastewater treatment plants in Northern Greece. Chemosphere 2008, 73(11):1716-1723.
57. Roepke T.A., Snyder M.J., Cherr G.N. Estradiol and endocrine disrupting compounds adversely affect development of sea urchin embryos at environmentally relevant concentrations. Aquat. Toxicol. 2005, 71(2):155-173.
58. Roig B., Mnif W., Hadj Hassine A.I., Zidi I., Bayle S., Bartegi A., Thomas O. Endocrine disrupting chemicals and human health risk assessment: a critical review. Crit. Rev. Environ. Sci. Technol. 2012, 43(21):2297-2351.
59. Salvador A., Moretton C., Piram A., Faure R. On-line solid-phase extraction with on-support derivatization for high-sensitivity liquid chromatography tandem mass spectrometry of estrogens in influent/effluent of wastewater treatment plants. J. Chromatogr. A 2007, 1145(1-2):102-109.
60. Silva C.P., Lima D.L.D., Schneider R.J., Otero M., Esteves V.I. Development of ELISA methodologies for the direct determination of 17β-estradiol and 17α-ethinylestradiol in complex aqueous matrices. J. Environ. Manag. 2013, 124(0):121-127.
61. Sim W.-J., Lee J.-W., Shin S.-K., Song K.-B., Oh J.-E. Assessment of fates of estrogens in wastewater and sludge from various types of wastewater treatment plants. Chemosphere 2011, 82(10):1448-1453.
62. Smital T., Terzic S., Zaja R., Senta I., Pivcevic B., Popovic M., Mikac I., Tollefsen K.E., Thomas K.V., Ahel M. Assessment of toxicological profiles of the municipal wastewater effluents using chemical analyses and bioassays. Ecotoxicol. Environ Saf. 2011, 74(4):844-851.
63. Sonneveld E., Riteco J.A.C., Jansen H.J., Pieterse B., Brouwer A., Schoonen W.G., van der Burg B. Comparison of in vitro and in vivo screening models for androgenic and estrogenic activities. Toxicol. Sci. 2006, 89(1):173-187.
64. Sousa A., Schönenberger R., Jonkers N., Suter M.F., Tanabe S., Barroso C. Chemical and Biological Characterization of Estrogenicity in Effluents from WWTPs in Ria de Aveiro (NW Portugal). Arch. Environ. Contam. Toxicol. 2010, 58(1):1-8.
65. Stasinakis A.S., Gatidou G., Mamais D., Thomaidis N.S., Lekkas T.D. Occurrence and fate of endocrine disrupters in Greek sewage treatment plants. Water Res. 2008, 42(6-7):1796-1804.
66. Sun Q., Deng S., Huang J., Shen G., Yu G. Contributors to estrogenic activity in wastewater from a large wastewater treatment plant in Beijing, China. Environ. Toxicol. Pharmacol. 2008, 25(1):20-26.
67. Tan B.L.L., Hawker D.W., Müller J.F., Leusch F.D.L., Tremblay L.A., Chapman H.F. Comprehensive study of endocrine disrupting compounds using grab and passive sampling at selected wastewater treatment plants in South East Queensland, Australia. Environ. Int. 2007, 33(5):654-669.
68. van der Linden S.C., Heringa M.B., Man H.-Y., Sonneveld E., Puijker L.M., Brouwer A., van der Burg B. Detection of multiple hormonal activities in wastewater effluents and surface water, using a panel of steroid receptor CALUX bioassays. Environ. Sci. Technol. 2008, 42(15):5814-5820.
69. Vethaak A.D., Lahr J., Schrap S.M., Belfroid A.C., Rijs G.B.J., Gerritsen A., de Boer J., Bulder A.S., Grinwis G.C.M., Kuiper R.V., Legler J., Murk T.A.J., Peijnenburg W., Verhaar H.J.M., de Voogt P. An integrated assessment of estrogenic contamination and biological effects in the aquatic environment of The Netherlands. Chemosphere 2005, 59(4):511-524.
70. Vieno N. Haitalliset Aineet Jätevedenpuhdistamoilla - Hankkeen Loppuraportti 2014, 273. Vesilaitosyhdistys, Helsinki.