-
1
-
-
33751187547
-
Challenges and obstacles of ocular pharmacokinetics and drug delivery
-
Urtti A. Challenges and obstacles of ocular pharmacokinetics and drug delivery. Adv Drug Deliv Rev 2006; 58: 1131-1135.
-
(2006)
Adv Drug Deliv Rev
, vol.58
, pp. 1131-1135
-
-
Urtti, A.1
-
2
-
-
0035999073
-
Ocular preparations: The formulation approach
-
Kaur IP, Kanwar M. Ocular preparations: the formulation approach. Drug Dev Ind Pharm 2002; 28: 473-493.
-
(2002)
Drug Dev Ind Pharm
, vol.28
, pp. 473-493
-
-
Kaur, I.P.1
Kanwar, M.2
-
3
-
-
0842283719
-
Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera
-
Hämäläinen KM, Kananen K, Auriola S, Kontturi K, Urtti A. Characterization of paracellular and aqueous penetration routes in cornea, conjunctiva, and sclera. Invest Ophthalmol Vis Sci 1997; 38: 627-634.
-
(1997)
Invest Ophthalmol Vis Sci
, vol.38
, pp. 627-634
-
-
Hämäläinen, K.M.1
Kananen, K.2
Auriola, S.3
Kontturi, K.4
Urtti, A.5
-
4
-
-
0026085443
-
Limits on optimizing ocular drug delivery
-
Keister JC, Cooper ER, Missel PJ, Lang JC, Hager DF. Limits on optimizing ocular drug delivery. J Pharm Sci 1991; 80: 50-53.
-
(1991)
J Pharm Sci
, vol.80
, pp. 50-53
-
-
Keister, J.C.1
Cooper, E.R.2
Missel, P.J.3
Lang, J.C.4
Hager, D.F.5
-
5
-
-
0025210446
-
Ocular drug delivery: Pharmacokinetics considerations
-
Schoenwald RD. Ocular drug delivery: pharmacokinetics considerations. Clin Pharmacokinet 1990; 18: 255-269.
-
(1990)
Clin Pharmacokinet
, vol.18
, pp. 255-269
-
-
Schoenwald, R.D.1
-
7
-
-
0034750070
-
Predicted permeability of the corneal to topical drugs
-
Edwards A, Prausnitz MR. Predicted permeability of the corneal to topical drugs. Pharm Res 2001; 18: 1497-1508.
-
(2001)
Pharm Res
, vol.18
, pp. 1497-1508
-
-
Edwards, A.1
Prausnitz, M.R.2
-
8
-
-
33751172725
-
Drug transport in corneal epithelium and blooderetina barrier: Emerging role of transporters in ocular pharmacokinetics
-
Mannermaa E, Vellonen KS, Urtti A. Drug transport in corneal epithelium and blooderetina barrier: emerging role of transporters in ocular pharmacokinetics. Adv Drug Deliv Rev 2006; 58: 1136-1163.
-
(2006)
Adv Drug Deliv Rev
, vol.58
, pp. 1136-1163
-
-
Mannermaa, E.1
Vellonen, K.S.2
Urtti, A.3
-
9
-
-
39149121847
-
A shift to the posterior segment
-
Amo EMd, Urtti A. Current and future ophthalmic drug delivery systems. A shift to the posterior segment. Drug Discov Today 2008; 13: 135-143.
-
(2008)
Drug Discov Today
, vol.13
, pp. 135-143
-
-
Emd, A.1
Current, U.A.2
Systems, F.O.3
-
11
-
-
85039823608
-
-
Tekmira Pharmaceuticals Corporation - Leader in the Development of RNAi Therapeutic Agents. http://www.ic.gc.ca/app/ccc/srch/nvgt.do?lang=eng&prtl=1&sbPrtl =&estblmntNo=123456161461&profile=cmpltPrfl&profileId=201 &app=sold.
-
Leader in the Development of Rnai Therapeutic Agents
-
-
-
12
-
-
84861993060
-
Strategies for ocular siRNA delivery: Potential and limitations of non-viral nanocarriers
-
Thakur A, Fitzpatrick S, Zaman A, et al. Strategies for ocular siRNA delivery: Potential and limitations of non-viral nanocarriers. J Biol Eng 2012; 6: 7.
-
(2012)
J Biol Eng
, vol.6
, pp. 7
-
-
Thakur, A.1
Fitzpatrick, S.2
Zaman, A.3
-
14
-
-
59849103061
-
Drug delivery of siRNA therapeutics: Potentials and limits of nanosystems
-
Reischl D, Zimmer A. Drug delivery of siRNA therapeutics: potentials and limits of nanosystems. Nanomed Nanotechnol Biol Med 2009; 5: 8-20.
-
(2009)
Nanomed Nanotechnol Biol Med
, vol.5
, pp. 8-20
-
-
Reischl, D.1
Zimmer, A.2
-
16
-
-
77956650867
-
Viral vector-mediated RNA interference
-
Couto L, High K. Viral vector-mediated RNA interference. Curr Opin Pharmacol 2010; 10: 534-542.
-
(2010)
Curr Opin Pharmacol
, vol.10
, pp. 534-542
-
-
Couto, L.1
High, K.2
-
17
-
-
33746871883
-
Biophysical and structural characterization of polyethylenimine-mediated siRNA delivery in vitro
-
Grayson A, Doody A, Putnam D. Biophysical and structural characterization of polyethylenimine-mediated siRNA delivery in vitro. Pharm Res 2006; 23: 1868-1876.
-
(2006)
Pharm Res
, vol.23
, pp. 1868-1876
-
-
Grayson, A.1
Doody, A.2
Putnam, D.3
-
18
-
-
9644275599
-
Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: Therapeutic strategy for herpetic stromal keratitis
-
Kim B, Tang Q, Biswas P, et al. Inhibition of ocular angiogenesis by siRNA targeting vascular endothelial growth factor pathway genes: therapeutic strategy for herpetic stromal keratitis. Am J Pathol 2004; 165: 2177-2185.
-
(2004)
Am J Pathol
, vol.165
, pp. 2177-2185
-
-
Kim, B.1
Tang, Q.2
Biswas, P.3
-
19
-
-
79952317711
-
Polyethylenimines for RNAi-mediated gene targeting in vivo and siRNA delivery to the lung
-
Günther M, Lipka J, Malek A, Gutsch D, Kreyling W, Aigner A. Polyethylenimines for RNAi-mediated gene targeting in vivo and siRNA delivery to the lung. Eur J Pharm Biopharm 2011; 77: 438-449.
-
(2011)
Eur J Pharm Biopharm
, vol.77
, pp. 438-449
-
-
Günther, M.1
Lipka, J.2
Malek, A.3
Gutsch, D.4
Kreyling, W.5
Aigner, A.6
-
20
-
-
58149354432
-
Cationic nanocopolymers mediated IKKbeta targeting siRNA inhibit the proliferation of human Te- non's capsule fibroblasts in vitro
-
Duan Y, Guan X, Ge J, et al. Cationic nanocopolymers mediated IKKbeta targeting siRNA inhibit the proliferation of human Te- non's capsule fibroblasts in vitro. Mol Vis 2008; 14: 2616-2628.
-
(2008)
Mol Vis
, vol.14
, pp. 2616-2628
-
-
Duan, Y.1
Guan, X.2
Ge, J.3
-
21
-
-
78650798166
-
Cationic nano-copolymers mediated IKK targeting siRNA to modulate wound healing in a monkey model of glaucoma filtration surgery
-
Ye H, Qian Y, Lin M, et al. Cationic nano-copolymers mediated IKK targeting siRNA to modulate wound healing in a monkey model of glaucoma filtration surgery. Mol Vis 2010; 16: 2502-2510.
-
(2010)
Mol Vis
, vol.16
, pp. 2502-2510
-
-
Ye, H.1
Qian, Y.2
Lin, M.3
-
22
-
-
0021025270
-
Targeted and nontargeted liposomes for in vivo transfer to rat liver cells of a plasmid containing the preproinsulin I gene
-
Soriano P, Dijkstra J, Legrand A, et al. Targeted and nontargeted liposomes for in vivo transfer to rat liver cells of a plasmid containing the preproinsulin I gene. Proc Natl Acad Sci USA 1983; 80: 7128-7131.
-
(1983)
Proc Natl Acad Sci USA
, vol.80
, pp. 7128-7131
-
-
Soriano, P.1
Dijkstra, J.2
Legrand, A.3
-
23
-
-
80052386408
-
A Lipid Nanoparticle System Improves siRNA Efficacy in RPE Cells and a Laser-Induced Murine CNV Model
-
Liu H, Liu Y, Ma Z, Wang J, Zhang Q. A Lipid Nanoparticle System Improves siRNA Efficacy in RPE Cells and a Laser-Induced Murine CNV Model. Invest Ophthalmol Vis Sci 2011; 52: 4789-4794.
-
(2011)
Invest Ophthalmol Vis Sci
, vol.52
, pp. 4789-4794
-
-
Liu, H.1
Liu, Y.2
Ma, Z.3
Wang, J.4
Zhang, Q.5
-
24
-
-
14844300910
-
Albuminprotamine-oligonucleotide nanoparticles as a new an- tisense delivery system. Part 1: Physicochemical characterization
-
Lochmann D, Weyermann J, Georgens C, Prassl R, Zimmer A. Albuminprotamine-oligonucleotide nanoparticles as a new an- tisense delivery system. Part 1: Physicochemical characterization. Eur J Pharm Biopharm 2005; 59: 419-429.
-
(2005)
Eur J Pharm Biopharm
, vol.59
, pp. 419-429
-
-
Lochmann, D.1
Weyermann, J.2
Georgens, C.3
Prassl, R.4
Zimmer, A.5
-
25
-
-
37549064689
-
Cell-penetrating peptide for enhanced delivery of nucleic acids and drugs to ocular tissues including retina and cornea
-
Johnson L, Cashman S, Kumar-Singh R. Cell-penetrating peptide for enhanced delivery of nucleic acids and drugs to ocular tissues including retina and cornea. Mol Ther 2008; 16: 107-114.
-
(2008)
Mol Ther
, vol.16
, pp. 107-114
-
-
Johnson, L.1
Cashman, S.2
Kumar-Singh, R.3
-
26
-
-
59849091278
-
Peptide-mediated cellular delivery of oligonu-cleotide-based therapeutics in vitro: Quantitative evaluation of Nanoplatforms for Delivery of siRNA to the Eye overall efficacy employing easy to handle reporter systems
-
Laufer S, Restle T. Peptide-mediated cellular delivery of oligonu-cleotide-based therapeutics in vitro: quantitative evaluation of Nanoplatforms for Delivery of siRNA to the Eye overall efficacy employing easy to handle reporter systems. Curr Pharm Des 2008; 14: 3637-3655.
-
(2008)
Curr Pharm Des
, vol.14
, pp. 3637-3655
-
-
Laufer, S.1
Restle, T.2
-
27
-
-
80052876653
-
Nanovectors for the ocular delivery of nucleic acid-based therapeutics
-
Khar R, Jain G, Warsi M, et al. Nanovectors for the ocular delivery of nucleic acid-based therapeutics. Indian J Pharm Sci 2010; 72: 675-688.
-
(2010)
Indian J Pharm Sci
, vol.72
, pp. 675-688
-
-
Khar, R.1
Jain, G.2
Warsi, M.3
-
28
-
-
4544332801
-
Inhibition of in vitro VEGF expression and choroidal neovascularization by synthetic dendrimer peptide mediated delivery of a sense oligonucleotide
-
Marano R, Wimmer N, Kearns P, et al. Inhibition of in vitro VEGF expression and choroidal neovascularization by synthetic dendrimer peptide mediated delivery of a sense oligonucleotide. Exp Eye Res 2004; 79: 525-535.
-
(2004)
Exp Eye Res
, vol.79
, pp. 525-535
-
-
Marano, R.1
Wimmer, N.2
Kearns, P.3
-
29
-
-
27544499791
-
Dendrimer delivery of an anti-VEGF oligonucleotide into the eye: A long-term study into inhibition of laser-induced CNV, distribution, uptake and toxicity
-
Marano R, Toth I, Wimmer N, Brankov M, Rakoczy P. Dendrimer delivery of an anti-VEGF oligonucleotide into the eye: a long-term study into inhibition of laser-induced CNV, distribution, uptake and toxicity. Gene Ther 2005; 12: 1544-1550.
-
(2005)
Gene Ther
, vol.12
, pp. 1544-1550
-
-
Marano, R.1
Toth, I.2
Wimmer, N.3
Brankov, M.4
Rakoczy, P.5
-
30
-
-
70349551739
-
Functional delivery of siRNA in mice using dendriworms
-
Agrawal A, Min D, Singh N, Zhu H, Bhatia S. Functional delivery of siRNA in mice using dendriworms. ACS Nano 2009; 3: 2495-2504.
-
(2009)
ACS Nano
, vol.3
, pp. 2495-2504
-
-
Agrawal, A.1
Min, D.2
Singh, N.3
Zhu, H.4
Bhatia, S.5
-
31
-
-
77950948806
-
Tat-BMPs-PAMAM conjugates enhance therapeutic effect of small interference RNA on U251 glioma cells in vitro and in vivo
-
Han L, Zhang A, Wang H, et al. Tat-BMPs-PAMAM conjugates enhance therapeutic effect of small interference RNA on U251 glioma cells in vitro and in vivo. Hum Gene Ther 2010; 21: 417-426.
-
(2010)
Hum Gene Ther
, vol.21
, pp. 417-426
-
-
Han, L.1
Zhang, A.2
Wang, H.3
-
32
-
-
77953909544
-
RNAi-based treatment for neovascular age-related macular degeneration by Sirna-027
-
Kaiser PK, Symons RA, Shah SM, et al. RNAi-based treatment for neovascular age-related macular degeneration by Sirna-027. Am J Ophthalmol 2010; 150(1): 33-39.
-
(2010)
Am J Ophthalmol
, vol.150
, Issue.1
, pp. 33-39
-
-
Kaiser, P.K.1
Symons, R.A.2
Shah, S.M.3
-
34
-
-
77953909544
-
RNAi-based treatment for neovascular age-related macular degeneration by Sirna-027
-
Kaiser P, Symons R, Shah S, Quinlan E, Nguyen Q. RNAi-based treatment for neovascular age-related macular degeneration by Sirna-027. Am J Ophthalmol 2010; 150: 33-39.
-
(2010)
Am J Ophthalmol
, vol.150
, pp. 33-39
-
-
Kaiser, P.1
Symons, R.2
Shah, S.3
Quinlan, E.4
Nguyen, Q.5
-
38
-
-
77952043572
-
RNAi-based therapeutics-current status, challenges and prospects
-
Tiemann K, Rossi J. RNAi-based therapeutics-current status, challenges and prospects. EMBO Mol Med 2009; 1: 142-151.
-
(2009)
EMBO Mol Med
, vol.1
, pp. 142-151
-
-
Tiemann, K.1
Rossi, J.2
-
42
-
-
84885113592
-
Small-interfering RNAs (SiRNAs) as a promising tool for ocular therapy
-
Guzman-Aranguez A, Loma P, Pintor J. Small-interfering RNAs (siRNAs) as a promising tool for ocular therapy. Br J Pharmacol 2013; 170: 730-747.
-
(2013)
Br J Pharmacol
, vol.170
, pp. 730-747
-
-
Guzman-Aranguez, A.1
Loma, P.2
Pintor, J.3
-
43
-
-
84878581041
-
RNA interference--a silent but an efficient therapeutic tool
-
Ramachandran PV, Ignacimuthu S. RNA interference--a silent but an efficient therapeutic tool. Appl Biochem Biotechnol 2013; 169: 1774-1789.
-
(2013)
Appl Biochem Biotechnol
, vol.169
, pp. 1774-1789
-
-
Ramachandran, P.V.1
Ignacimuthu, S.2
-
44
-
-
80053299068
-
An assessment of the health and economic burdens of glaucoma
-
Varma R, Lee PP, Goldberg I, Kotak S. An assessment of the health and economic burdens of glaucoma. Am J Ophthalmol 2011; 152: 515-522.
-
(2011)
Am J Ophthalmol
, vol.152
, pp. 515-522
-
-
Varma, R.1
Lee, P.P.2
Goldberg, I.3
Kotak, S.4
-
46
-
-
84914098971
-
Gene therapy in glaucoma-3: Therapeutic approaches
-
Mahdy MA-MS. Gene therapy in glaucoma-3: Therapeutic approaches. Oman J Ophthalmol 2010; 3: 109-116.
-
(2010)
Oman J Ophthalmol
, vol.3
, pp. 109-116
-
-
Mahdy, M.M.S.1
-
48
-
-
33645139836
-
Potential applications for RNAi to probe pathogenesis and develop new treatments for ocular disorders
-
Campochiaro PA. Potential applications for RNAi to probe pathogenesis and develop new treatments for ocular disorders. Gene Ther 2006; 13: 559-562.
-
(2006)
Gene Ther
, vol.13
, pp. 559-562
-
-
Campochiaro, P.A.1
-
50
-
-
65749117793
-
Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy
-
Aggarwal P, Hall J, McLeland C, Dobrovolskaia A, McNeil S. Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy. Adv Drug Deliv Rev 2009; 61: 428-437.
-
(2009)
Adv Drug Deliv Rev
, vol.61
, pp. 428-437
-
-
Aggarwal, P.1
Hall, J.2
McLeland, C.3
Dobrovolskaia, A.4
McNeil, S.5
-
51
-
-
23444444512
-
Biodegradable long-circulating polymeric nanospheres
-
Gref R, Minamitake Y, Peracchia M, Trubetskoy V, Torchilin V, R RL. Biodegradable long-circulating polymeric nanospheres. Sci- ence 1994; 263: 1600-1603.
-
(1994)
Sci- Ence
, vol.263
, pp. 1600-1603
-
-
Gref, R.1
Minamitake, Y.2
Peracchia, M.3
Trubetskoy, V.4
Torchilin, V.5
Rl, R.6
-
52
-
-
41649115210
-
Sequence- and target independent angiogenesis suppression by siRNA via TLR3
-
Kleinman ME, Yamada K, Takeda A, et al. Sequence- and target independent angiogenesis suppression by siRNA via TLR3. Nature 2008; 452: 591-597.
-
(2008)
Nature
, vol.452
, pp. 591-597
-
-
Kleinman, M.E.1
Yamada, K.2
Takeda, A.3
-
53
-
-
79952291790
-
Multistage nanoparticle delivery system for deep penetration into tumor tissue
-
Wong C, Stylianopoulos T, Cui J, Martin J, Fukumura D. Multistage nanoparticle delivery system for deep penetration into tumor tissue. PNAS 2011; 108: 2426-2431.
-
(2011)
PNAS
, vol.108
, pp. 2426-2431
-
-
Wong, C.1
Stylianopoulos, T.2
Cui, J.3
Martin, J.4
Fukumura, D.5
-
54
-
-
50149110878
-
The effect of particle design on cellular internalization pathways
-
Gratton S, Ropp P, Pohlhaus P, et al. The effect of particle design on cellular internalization pathways. PNAS 2008; 105: 11613-11618.
-
(2008)
PNAS
, vol.105
, pp. 11613-11618
-
-
Gratton, S.1
Ropp, P.2
Pohlhaus, P.3
-
55
-
-
77955175216
-
Strategies in the design of nanoparticles for therapeutic applications
-
Petros R, DeSimone J. Strategies in the design of nanoparticles for therapeutic applications. Nat Rev Drug Discov 2010; 9: 615-627.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 615-627
-
-
Petros, R.1
Desimone, J.2
-
56
-
-
40149106154
-
Albumin-conjugated PEG liposome enhances tumor distribution of liposomal doxorubicin in rats
-
Yokoe J, Sakuragi S, Yamamoto K, et al. Albumin-conjugated PEG liposome enhances tumor distribution of liposomal doxorubicin in rats. Int J Pharm 2008; 353: 28-34.
-
(2008)
Int J Pharm
, vol.353
, pp. 28-34
-
-
Yokoe, J.1
Sakuragi, S.2
Yamamoto, K.3
-
57
-
-
33845593187
-
Effect of coupling of albumin onto surface of PEG liposome on its in vivo disposition
-
Furumoto K, Yokoe J, Ogawara K, et al. Effect of coupling of albumin onto surface of PEG liposome on its in vivo disposition. Int J Pharm 2007; 329: 110-116.
-
(2007)
Int J Pharm
, vol.329
, pp. 110-116
-
-
Furumoto, K.1
Yokoe, J.2
Ogawara, K.3
-
58
-
-
77951132901
-
Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles
-
Davis M, Zuckerman J, Choi C, Seligson D, Ribas A. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles. Nature 2010; 464: 1067-1070.
-
(2010)
Nature
, vol.464
, pp. 1067-1070
-
-
Davis, M.1
Zuckerman, J.2
Choi, C.3
Seligson, D.4
Ribas, A.5
-
59
-
-
80052406557
-
Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans
-
Breitbach C, Burke J, Jonker D, Stephenson J, Haas A, Kirn D. Intravenous delivery of a multi-mechanistic cancer-targeted oncolytic poxvirus in humans. Nature 2011; 477: 99-102.
-
(2011)
Nature
, vol.477
, pp. 99-102
-
-
Breitbach, C.1
Burke, J.2
Jonker, D.3
Stephenson, J.4
Haas, A.5
Kirn, D.6
-
60
-
-
65249102723
-
Cytosolic delivery mediated via electrostatic surface binding of protein, virus, or siRNA cargos to pH-responsive core-shell gel particles
-
Hu Y, Atukorale P, Lu J, et al. Cytosolic delivery mediated via electrostatic surface binding of protein, virus, or siRNA cargos to pH-responsive core-shell gel particles. Biomacromolecules 2009; 10: 756-765.
-
(2009)
Biomacromolecules
, vol.10
, pp. 756-765
-
-
Hu, Y.1
Atukorale, P.2
Lu, J.3
|