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Volumn 7, Issue 2, 2016, Pages 75-83

Metabolic Syndrome and Prostate Cancer: a Review of Complex Interplay Amongst Various Endocrine Factors in the Pathophysiology and Progression of Prostate Cancer

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; LEPTIN; TESTOSTERONE; ADIPOQ PROTEIN, HUMAN;

EID: 84946780254     PISSN: 18688497     EISSN: 18688500     Source Type: Journal    
DOI: 10.1007/s12672-015-0238-x     Document Type: Review
Times cited : (28)

References (87)
  • 1
    • 84920837701 scopus 로고    scopus 로고
    • Cancer statistics, 2015
    • Siegel R, Miller KD, Jemal A. et al (2015) Cancer statistics, 2015. CA Cancer J Clin 65(1):5–29
    • (2015) CA Cancer J Clin , vol.65 , Issue.1 , pp. 5-29
  • 2
    • 84963855843 scopus 로고    scopus 로고
    • WHO. Overweight/obesity 2008. 2014 31/10/2014]; Available from
    • WHO. Overweight/obesity 2008. 2014 31/10/2014]; Available from: http://gamapserver.who.int/gho/interactive_charts/ncd/risk_factors/overweight_obesity/atlas.html
  • 3
    • 70350245011 scopus 로고    scopus 로고
    • Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
    • Alberti KG, Eckel RH, Grundy SM et al (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120(16):1640–5
    • (2009) Circulation , vol.120 , Issue.16 , pp. 1640-1645
    • Alberti, K.G.1    Eckel, R.H.2    Grundy, S.M.3
  • 4
    • 34548187720 scopus 로고    scopus 로고
    • Overweight, obesity and metabolic syndrome in rural southeastern Australia
    • Janus ED, Laatikainen T, Dunbar JA et al (2007) Overweight, obesity and metabolic syndrome in rural southeastern Australia. Med J Aust 187(3):147–52
    • (2007) Med J Aust , vol.187 , Issue.3 , pp. 147-152
    • Janus, E.D.1    Laatikainen, T.2    Dunbar, J.A.3
  • 5
    • 32644479927 scopus 로고    scopus 로고
    • National Heart Foundation of Australia and the Cardiac Society of Australia and New Zealand: position statement on lipid management—2005
    • Tonkin A, Barter P, Best J et al (2005) National Heart Foundation of Australia and the Cardiac Society of Australia and New Zealand: position statement on lipid management—2005. Heart Lung Circ 14(4):275–91
    • (2005) Heart Lung Circ , vol.14 , Issue.4 , pp. 275-291
    • Tonkin, A.1    Barter, P.2    Best, J.3
  • 6
    • 77957198071 scopus 로고    scopus 로고
    • The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis
    • Mottillo S, Filion KB, Genest J et al (2010) The metabolic syndrome and cardiovascular risk a systematic review and meta-analysis. J Am Coll Cardiol 56(14):1113–32
    • (2010) J Am Coll Cardiol , vol.56 , Issue.14 , pp. 1113-1132
    • Mottillo, S.1    Filion, K.B.2    Genest, J.3
  • 8
    • 38949108241 scopus 로고    scopus 로고
    • Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies
    • Renehan AG1, Tyson M, Egger M, Heller RF, Zwahlen M (2008) Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 371(9612):569–78
    • (2008) Lancet , vol.371 , Issue.9612 , pp. 569-578
    • AG1, R.1    Tyson, M.2    Egger, M.3    Heller, R.F.4    Zwahlen, M.5
  • 9
    • 85027951435 scopus 로고    scopus 로고
    • Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5 · 24 million UK adults
    • Bhaskaran K, Douglas I, Forbes H et al (2014) Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5 · 24 million UK adults. Lancet 384(9945):755–765
    • (2014) Lancet , vol.384 , Issue.9945 , pp. 755-765
    • Bhaskaran, K.1    Douglas, I.2    Forbes, H.3
  • 10
    • 4944223630 scopus 로고    scopus 로고
    • Metabolic syndrome and the risk of prostate cancer in Finnish men: a population-based study
    • Laukkanen JA, Laaksonen DE, Niskanen L et al (2004) Metabolic syndrome and the risk of prostate cancer in Finnish men: a population-based study. Cancer Epidemiol Biomarkers Prev 13(10):1646–50
    • (2004) Cancer Epidemiol Biomarkers Prev , vol.13 , Issue.10 , pp. 1646-1650
    • Laukkanen, J.A.1    Laaksonen, D.E.2    Niskanen, L.3
  • 11
    • 13744261448 scopus 로고    scopus 로고
    • Obesity and prostate cancer clinical risk factors at presentation: data from CaPSURE
    • Kane CJ, Bassett WW, Sadetsky N et al (2005) Obesity and prostate cancer clinical risk factors at presentation: data from CaPSURE. J Urol 173(3):732–6
    • (2005) J Urol , vol.173 , Issue.3 , pp. 732-736
    • Kane, C.J.1    Bassett, W.W.2    Sadetsky, N.3
  • 12
    • 77949684390 scopus 로고    scopus 로고
    • Finasteride modifies the relation between serum C-peptide and prostate cancer risk: results from the Prostate Cancer Prevention Trial
    • Neuhouser ML, Till C, Kristal A et al (2010) Finasteride modifies the relation between serum C-peptide and prostate cancer risk: results from the Prostate Cancer Prevention Trial. Cancer Prev Res (Phila) 3(3):279–89
    • (2010) Cancer Prev Res (Phila) , vol.3 , Issue.3 , pp. 279-289
    • Neuhouser, M.L.1    Till, C.2    Kristal, A.3
  • 13
    • 79955872008 scopus 로고    scopus 로고
    • Body mass index, prostate cancer-specific mortality, and biochemical recurrence: a systematic review and meta-analysis
    • Cao Y, Ma J (2011) Body mass index, prostate cancer-specific mortality, and biochemical recurrence: a systematic review and meta-analysis. Cancer Prev Res (Phila) 4(4):486–501
    • (2011) Cancer Prev Res (Phila) , vol.4 , Issue.4 , pp. 486-501
    • Cao, Y.1    Ma, J.2
  • 14
    • 54349083481 scopus 로고    scopus 로고
    • Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis
    • Ma J, Li H, Giovannucci E et al (2008) Prediagnostic body-mass index, plasma C-peptide concentration, and prostate cancer-specific mortality in men with prostate cancer: a long-term survival analysis. Lancet Oncol 9(11):1039–47
    • (2008) Lancet Oncol , vol.9 , Issue.11 , pp. 1039-1047
    • Ma, J.1    Li, H.2    Giovannucci, E.3
  • 15
    • 27744444278 scopus 로고    scopus 로고
    • Impact of obesity on prostate cancer recurrence after radical prostatectomy: data from CaPSURE
    • Bassett WW, Cooperberg MR, Sadestsky N et al (2005) Impact of obesity on prostate cancer recurrence after radical prostatectomy: data from CaPSURE. Urology 66(5):1060–5
    • (2005) Urology , vol.66 , Issue.5 , pp. 1060-1065
    • Bassett, W.W.1    Cooperberg, M.R.2    Sadestsky, N.3
  • 16
    • 84882456861 scopus 로고    scopus 로고
    • Hyperglycemia and prostate cancer recurrence in men treated for localized prostate cancer
    • Wright JL, Plymate SR, Porter MP et al (2013) Hyperglycemia and prostate cancer recurrence in men treated for localized prostate cancer. Prostate Cancer Prostatic Dis 16(2):204–208
    • (2013) Prostate Cancer Prostatic Dis , vol.16 , Issue.2 , pp. 204-208
    • Wright, J.L.1    Plymate, S.R.2    Porter, M.P.3
  • 18
    • 37049016720 scopus 로고    scopus 로고
    • Obesity and mortality in men with locally advanced prostate cancer
    • Efstathiou JA, Bae K, Shipley WU et al (2007) Obesity and mortality in men with locally advanced prostate cancer. Cancer 110(12):2691–2699
    • (2007) Cancer , vol.110 , Issue.12 , pp. 2691-2699
    • Efstathiou, J.A.1    Bae, K.2    Shipley, W.U.3
  • 19
    • 79953328519 scopus 로고    scopus 로고
    • Presence of the metabolic syndrome is associated with shorter time to castration-resistant prostate cancer
    • Flanagan J, Gray PK, Hahn N et al (2011) Presence of the metabolic syndrome is associated with shorter time to castration-resistant prostate cancer. Ann Oncol 22(4):801–7
    • (2011) Ann Oncol , vol.22 , Issue.4 , pp. 801-807
    • Flanagan, J.1    Gray, P.K.2    Hahn, N.3
  • 20
    • 84892436174 scopus 로고    scopus 로고
    • Elevated insulin-like growth factor binding protein-1 (IGFBP-1) in men with metastatic prostate cancer starting androgen deprivation therapy (ADT) is associated with shorter time to castration resistance and overall survival
    • Sharma J, Gray KP, Evan C et al (2014) Elevated insulin-like growth factor binding protein-1 (IGFBP-1) in men with metastatic prostate cancer starting androgen deprivation therapy (ADT) is associated with shorter time to castration resistance and overall survival. Prostate 74(3):225–34
    • (2014) Prostate , vol.74 , Issue.3 , pp. 225-234
    • Sharma, J.1    Gray, K.P.2    Evan, C.3
  • 21
    • 84924421740 scopus 로고    scopus 로고
    • Prostate cancer, prostate cancer death, and death from other causes, among men with metabolic aberrations
    • Haggstrom C, Stocks T, Nagel G et al (2014) Prostate cancer, prostate cancer death, and death from other causes, among men with metabolic aberrations. Epidemiology 25(6):823–8
    • (2014) Epidemiology , vol.25 , Issue.6 , pp. 823-828
    • Haggstrom, C.1    Stocks, T.2    Nagel, G.3
  • 22
    • 52449087273 scopus 로고    scopus 로고
    • Systematic review of prostate cancer's association with body size in childhood and young adulthood
    • Robinson WR, Poole C, Godley PA (2008) Systematic review of prostate cancer's association with body size in childhood and young adulthood. Cancer Causes Control 19(8):793–803
    • (2008) Cancer Causes Control , vol.19 , Issue.8 , pp. 793-803
    • Robinson, W.R.1    Poole, C.2    Godley, P.A.3
  • 24
    • 48649095772 scopus 로고    scopus 로고
    • Serum prostate-specific antigen levels in men with type 2 diabetes
    • Fukui M, Tanaka M, Kadono M et al (2008) Serum prostate-specific antigen levels in men with type 2 diabetes. Diabetes Care 31(5):930–1
    • (2008) Diabetes Care , vol.31 , Issue.5 , pp. 930-931
    • Fukui, M.1    Tanaka, M.2    Kadono, M.3
  • 25
    • 36348982774 scopus 로고    scopus 로고
    • Obesity-related plasma hemodilution and PSA concentration among men with prostate cancer
    • Banez LL, Hamilton RJ, Partin AW et al (2007) Obesity-related plasma hemodilution and PSA concentration among men with prostate cancer. JAMA 298(19):2275–80
    • (2007) JAMA , vol.298 , Issue.19 , pp. 2275-2280
    • Banez, L.L.1    Hamilton, R.J.2    Partin, A.W.3
  • 26
    • 84861081470 scopus 로고    scopus 로고
    • The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer
    • Gunter JH, Lubik AA, McKenzie I, Pollak M, Nelson CC (2012) The Interactions between Insulin and Androgens in Progression to Castrate-Resistant Prostate Cancer. Adv Urol 2012:248607
    • (2012) Adv Urol , vol.2012
    • Gunter, J.H.1    Lubik, A.A.2    McKenzie, I.3    Pollak, M.4    Nelson, C.C.5
  • 27
    • 30344476141 scopus 로고    scopus 로고
    • Obesity, serum prostate specific antigen and prostate size: implications for prostate cancer detection
    • Freedland SJ, Platz EA, Presi JC Jr et al (2006) Obesity, serum prostate specific antigen and prostate size: implications for prostate cancer detection. J Urol 175(2):500–4, discussion 504
    • (2006) J Urol 175(2):500–4, discussion , pp. 504
    • Freedland, S.J.1    Platz, E.A.2    Presi, J.C.3
  • 28
    • 84894531752 scopus 로고    scopus 로고
    • AMP-activated protein kinase (AMPK) beyond metabolism: a novel genomic stress sensor participating in the DNA damage response pathway
    • Sanli T, Steinberg GR, Singh G, Tsakiridis T (2014) AMP-activated protein kinase (AMPK) beyond metabolism: a novel genomic stress sensor participating in the DNA damage response pathway. Cancer Biol Ther 15(2):156–69
    • (2014) Cancer Biol Ther , vol.15 , Issue.2 , pp. 156-169
    • Sanli, T.1    Steinberg, G.R.2    Singh, G.3    Tsakiridis, T.4
  • 29
    • 84861872213 scopus 로고    scopus 로고
    • Distinct perturbation of the translatome by the antidiabetic drug metformin
    • Larsson O, Morita M, Topisirovic I et al (2012) Distinct perturbation of the translatome by the antidiabetic drug metformin. Proc Natl Acad Sci U S A 109(23):8977–82
    • (2012) Proc Natl Acad Sci U S A , vol.109 , Issue.23 , pp. 8977-8982
    • Larsson, O.1    Morita, M.2    Topisirovic, I.3
  • 30
    • 84876334434 scopus 로고    scopus 로고
    • Association of metformin use with cancer incidence and mortality: a meta-analysis
    • Zhang P, Li H, Tan X, Chen L, Wang S (2013) Association of metformin use with cancer incidence and mortality: a meta-analysis. Cancer Epidemiol 37(3):207–18
    • (2013) Cancer Epidemiol , vol.37 , Issue.3 , pp. 207-218
    • Zhang, P.1    Li, H.2    Tan, X.3    Chen, L.4    Wang, S.5
  • 31
    • 78649302320 scopus 로고    scopus 로고
    • Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis
    • Decensi A, Puntoni M, Goodwin P et al (2010) Metformin and cancer risk in diabetic patients: a systematic review and meta-analysis. Cancer Prev Res 3(11):1451–61
    • (2010) Cancer Prev Res , vol.3 , Issue.11 , pp. 1451-1461
    • Decensi, A.1    Puntoni, M.2    Goodwin, P.3
  • 32
    • 84866991538 scopus 로고    scopus 로고
    • Statin use and risk of prostate cancer: a meta-analysis of observational studies
    • Bansal D, Undela K, D'Cruz S, Schifano F (2012) Statin use and risk of prostate cancer: a meta-analysis of observational studies. PLoS ONE 7(10), e46691
    • (2012) PLoS ONE , vol.7 , Issue.10 , pp. e46691
    • Bansal, D.1    Undela, K.2    D'Cruz, S.3    Schifano, F.4
  • 33
    • 0028952799 scopus 로고
    • Prostate cancer in relation to diet, physical activity, and body size in blacks, whites, and Asians in the United States and Canada
    • Whittemore AS, Kolonel LN, Wu AH et al (1995) Prostate cancer in relation to diet, physical activity, and body size in blacks, whites, and Asians in the United States and Canada. J Natl Cancer Inst 87(9):652–61
    • (1995) J Natl Cancer Inst , vol.87 , Issue.9 , pp. 652-661
    • Whittemore, A.S.1    Kolonel, L.N.2    Wu, A.H.3
  • 34
    • 52649084792 scopus 로고    scopus 로고
    • Obesity and positive surgical margins by anatomic location after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital database
    • SEARCH Database Study Group, Jayachandran J, Aronson WJ, Terris MK et al (2008) Obesity and positive surgical margins by anatomic location after radical prostatectomy: results from the Shared Equal Access Regional Cancer Hospital database. BJU Int 102(8):964–8
    • (2008) BJU Int , vol.102 , Issue.8 , pp. 964-968
  • 35
    • 33947202141 scopus 로고    scopus 로고
    • Obesity is associated with increased risks of prostate cancer metastasis and death after initial cancer diagnosis in middle-aged men
    • Gong Z, Agalliu I, Lin DW, Stanford JL, Kristal AR (2007) Obesity is associated with increased risks of prostate cancer metastasis and death after initial cancer diagnosis in middle-aged men. Cancer 109(6):1192–202
    • (2007) Cancer , vol.109 , Issue.6 , pp. 1192-1202
    • Gong, Z.1    Agalliu, I.2    Lin, D.W.3    Stanford, J.L.4    Kristal, A.R.5
  • 36
    • 33845493476 scopus 로고    scopus 로고
    • Prevalence and determinants of insulin resistance among U.S. adolescents: a population-based study
    • Lee JM, Okumura MJ, Davis MM, Herman WH, Gurney JG (2006) Prevalence and determinants of insulin resistance among U.S. adolescents: a population-based study. Diabetes Care 29(11):2427–32
    • (2006) Diabetes Care , vol.29 , Issue.11 , pp. 2427-2432
    • Lee, J.M.1    Okumura, M.J.2    Davis, M.M.3    Herman, W.H.4    Gurney, J.G.5
  • 37
    • 84867449014 scopus 로고    scopus 로고
    • Prevalence of metabolic syndrome and insulin resistance in overweight and obese women according to the different diagnostic criteria
    • Kocelak P, Chudek J, Olszanecka-Glinianowicz M (2012) Prevalence of metabolic syndrome and insulin resistance in overweight and obese women according to the different diagnostic criteria. Minerva Endocrinol 37(3):247–54
    • (2012) Minerva Endocrinol , vol.37 , Issue.3 , pp. 247-254
    • Kocelak, P.1    Chudek, J.2    Olszanecka-Glinianowicz, M.3
  • 38
    • 70849120946 scopus 로고    scopus 로고
    • Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease
    • Belfiore A, Frasca F, Pandini G, Sciacca L, Vigneri R (2009) Insulin receptor isoforms and insulin receptor/insulin-like growth factor receptor hybrids in physiology and disease. Endocr Rev 30(6):586–623
    • (2009) Endocr Rev , vol.30 , Issue.6 , pp. 586-623
    • Belfiore, A.1    Frasca, F.2    Pandini, G.3    Sciacca, L.4    Vigneri, R.5
  • 39
    • 33845398283 scopus 로고    scopus 로고
    • Transcriptional regulation by insulin: from the receptor to the gene
    • Mounier C, Posner BI (2006) Transcriptional regulation by insulin: from the receptor to the gene. Can J Physiol Pharmacol 84(7):713–24
    • (2006) Can J Physiol Pharmacol , vol.84 , Issue.7 , pp. 713-724
    • Mounier, C.1    Posner, B.I.2
  • 40
    • 84870900365 scopus 로고    scopus 로고
    • Insulin receptor isoforms A and B as well as insulin receptor substrates-1 and −2 are differentially expressed in prostate cancer
    • Heni M, Hennenlotter J, Scharpf M et al (2012) Insulin receptor isoforms A and B as well as insulin receptor substrates-1 and −2 are differentially expressed in prostate cancer. PLoS ONE 7(12), e50953 [Electronic Resource]
    • (2012) PLoS ONE 7(12) , vol.e50953 , Issue.[Electronic Resource]
    • Heni, M.1    Hennenlotter, J.2    Scharpf, M.3
  • 41
    • 58149339692 scopus 로고    scopus 로고
    • Insulin receptor expression by human prostate cancers
    • Cox ME, Gleave ME, Zakikhani M et al (2009) Insulin receptor expression by human prostate cancers. Prostate 69:33–40
    • (2009) Prostate , vol.69 , pp. 33-40
    • Cox, M.E.1    Gleave, M.E.2    Zakikhani, M.3
  • 42
    • 80052225259 scopus 로고    scopus 로고
    • Insulin increases de novo steroidogenesis in prostate cancer cells
    • Lubik AA, Gunter JH, Hendy SC et al (2011) Insulin increases de novo steroidogenesis in prostate cancer cells. Cancer Res 71(17):5754–64
    • (2011) Cancer Res , vol.71 , Issue.17 , pp. 5754-5764
    • Lubik, A.A.1    Gunter, J.H.2    Hendy, S.C.3
  • 43
    • 84876776416 scopus 로고    scopus 로고
    • IGF2 increases de novo steroidogenesis in prostate cancer cells
    • Lubik AA, Gunter JH, Hollier BG et al (2013) IGF2 increases de novo steroidogenesis in prostate cancer cells. Endocr Relat Cancer 20(2):173–86
    • (2013) Endocr Relat Cancer , vol.20 , Issue.2 , pp. 173-186
    • Lubik, A.A.1    Gunter, J.H.2    Hollier, B.G.3
  • 44
    • 79951790560 scopus 로고    scopus 로고
    • Leptin increases motility and integrin up-regulation in human prostate cancer cells
    • Huang CY, Yu HS, Lai TY et al (2011) Leptin increases motility and integrin up-regulation in human prostate cancer cells. J Cell Physiol 226(5):1274–82
    • (2011) J Cell Physiol , vol.226 , Issue.5 , pp. 1274-1282
    • Huang, C.Y.1    Yu, H.S.2    Lai, T.Y.3
  • 45
    • 84859414102 scopus 로고    scopus 로고
    • Next generation sequencing of prostate cancer from a patient identifies a deficiency of methylthioadenosine phosphorylase, an exploitable tumor target
    • Collins CC, Volik SV, Lapuk AV et al (2012) Next generation sequencing of prostate cancer from a patient identifies a deficiency of methylthioadenosine phosphorylase, an exploitable tumor target. Mol Cancer Ther 11(3):775–83
    • (2012) Mol Cancer Ther , vol.11 , Issue.3 , pp. 775-783
    • Collins, C.C.1    Volik, S.V.2    Lapuk, A.V.3
  • 46
    • 84941759913 scopus 로고    scopus 로고
    • Cholesterol levels in blood and the risk of prostate cancer: a meta-analysis of 14 prospective studies
    • YuPeng L, LuXue Z, PengFei L et al (2015) Cholesterol levels in blood and the risk of prostate cancer: a meta-analysis of 14 prospective studies. Cancer Epidemiol Biomarkers Prev 24(7):1086–93
    • (2015) Cancer Epidemiol Biomarkers Prev , vol.24 , Issue.7 , pp. 1086-1093
    • YuPeng, L.1    LuXue, Z.2    PengFei, L.3
  • 47
    • 84922498435 scopus 로고    scopus 로고
    • Dissecting the association between metabolic syndrome and prostate cancer risk: analysis of a large clinical cohort
    • Bhindi B, Locke J, Alibhai SM et al. (2014) Dissecting the association between metabolic syndrome and prostate cancer risk: analysis of a large clinical cohort. Eur Urol 67(10):64–70
    • (2014) Eur Urol , vol.67 , Issue.10 , pp. 64-70
    • Bhindi, B.1    Locke, J.2    Alibhai, S.M.3
  • 48
    • 84930027355 scopus 로고    scopus 로고
    • The metabolic syndrome and cancer: is the metabolic syndrome useful for predicting cancer risk above and beyond its individual components? Diabetes Metab
    • Harding J, Sooriyakumaran M, Anstey KJ et al. (2015) The metabolic syndrome and cancer: is the metabolic syndrome useful for predicting cancer risk above and beyond its individual components? Diabetes Metab. doi:10.1016/j.diabet.2015.04.006
    • (2015) doi:10.1016/j.diabet.2015.04.006
    • Harding, J.1    Sooriyakumaran, M.2    Anstey, K.J.3
  • 49
    • 84925590056 scopus 로고    scopus 로고
    • Hypertriglyceridemia is a potential preoperative predictor for biochemical recurrence after radical prostatectomy
    • Kang M, Jeong CW, Ku JH, Kwak C, Kim HH (2015) Hypertriglyceridemia is a potential preoperative predictor for biochemical recurrence after radical prostatectomy. PLoS ONE 10(3), e0122438
    • (2015) PLoS ONE 10(3) , vol.e0122438
    • Kang, M.1    Jeong, C.W.2    Ku, J.H.3    Kwak, C.4    Kim, H.H.5
  • 51
    • 84890221321 scopus 로고    scopus 로고
    • Bone marrow adipocytes promote tumor growth in bone via FABP4-dependent mechanisms
    • Herroon MK, Rajagurubandara E, Hardaway AL et al (2013) Bone marrow adipocytes promote tumor growth in bone via FABP4-dependent mechanisms. Oncotarget 4(11):2108–23
    • (2013) Oncotarget , vol.4 , Issue.11 , pp. 2108-2123
    • Herroon, M.K.1    Rajagurubandara, E.2    Hardaway, A.L.3
  • 52
    • 84892439065 scopus 로고    scopus 로고
    • Periprostatic adipose tissue from obese prostate cancer patients promotes tumor and endothelial cell proliferation: a functional and MR imaging pilot study
    • Venkatasubramanian PN, Brendler CB, Plunkett BA et al (2014) Periprostatic adipose tissue from obese prostate cancer patients promotes tumor and endothelial cell proliferation: a functional and MR imaging pilot study. Prostate 74(3):326–35
    • (2014) Prostate , vol.74 , Issue.3 , pp. 326-335
    • Venkatasubramanian, P.N.1    Brendler, C.B.2    Plunkett, B.A.3
  • 53
    • 69749128387 scopus 로고    scopus 로고
    • Periprostatic adipose tissue as a modulator of prostate cancer aggressiveness
    • Finley DS, Calvert VS, Inokuchi J et al (2009) Periprostatic adipose tissue as a modulator of prostate cancer aggressiveness. J Urol 182(4):1621–7
    • (2009) J Urol , vol.182 , Issue.4 , pp. 1621-1627
    • Finley, D.S.1    Calvert, V.S.2    Inokuchi, J.3
  • 54
    • 78650499168 scopus 로고    scopus 로고
    • Periprostatic fat correlates with tumour aggressiveness in prostate cancer patients
    • van Roermund JG, Hinnen KA, Tolman CJ et al (2011) Periprostatic fat correlates with tumour aggressiveness in prostate cancer patients. BJU Int 107(11):1775–9
    • (2011) BJU Int , vol.107 , Issue.11 , pp. 1775-1779
    • van Roermund, J.G.1    Hinnen, K.A.2    Tolman, C.J.3
  • 55
    • 0037464510 scopus 로고    scopus 로고
    • Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults
    • Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ (2003) Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348(17):1625–38
    • (2003) N Engl J Med , vol.348 , Issue.17 , pp. 1625-1638
    • Calle, E.E.1    Rodriguez, C.2    Walker-Thurmond, K.3    Thun, M.J.4
  • 57
    • 84920271526 scopus 로고    scopus 로고
    • The effects of nonspecific HIF1alpha inhibitors on development of castrate resistance and metastases in prostate cancer
    • Ranasinghe WK, Sengupta S, Williams S et al (2014) The effects of nonspecific HIF1alpha inhibitors on development of castrate resistance and metastases in prostate cancer. Cancer Med 3(2):245–51
    • (2014) Cancer Med , vol.3 , Issue.2 , pp. 245-251
    • Ranasinghe, W.K.1    Sengupta, S.2    Williams, S.3
  • 58
    • 84937859955 scopus 로고    scopus 로고
    • Non-canonical Wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansion
    • Fuster JJ, Zuriaga MA, Ngo DT et al. (2014) Non-canonical Wnt signaling promotes obesity-induced adipose tissue inflammation and metabolic dysfunction independent of adipose tissue expansion. Diabetes,
    • (2014) Diabetes
    • Fuster, J.J.1    Zuriaga, M.A.2    Ngo, D.T.3
  • 59
    • 79956126860 scopus 로고    scopus 로고
    • IL-6 promotes prostate tumorigenesis and progression through autocrine cross-activation of IGF-IR
    • Rojas A, Liu G, Coleman I et al (2011) IL-6 promotes prostate tumorigenesis and progression through autocrine cross-activation of IGF-IR. Oncogene 30(20):2345–55
    • (2011) Oncogene , vol.30 , Issue.20 , pp. 2345-2355
    • Rojas, A.1    Liu, G.2    Coleman, I.3
  • 60
    • 84905757105 scopus 로고    scopus 로고
    • Metformin--mode of action and clinical implications for diabetes and cancer
    • Pernicova I, Korbonits M (2014) Metformin--mode of action and clinical implications for diabetes and cancer. Nat Rev Endocrinol 10(3):143–56
    • (2014) Nat Rev Endocrinol , vol.10 , Issue.3 , pp. 143-156
    • Pernicova, I.1    Korbonits, M.2
  • 61
    • 84901761589 scopus 로고    scopus 로고
    • A novel PI3K inhibitor displays potent preclinical activity against an androgen-independent and PTEN-deficient prostate cancer model established from the cell line PC3
    • Shi M, Zhou X, Zhang Z et al (2014) A novel PI3K inhibitor displays potent preclinical activity against an androgen-independent and PTEN-deficient prostate cancer model established from the cell line PC3. Toxicology Letters 228(3):133–9
    • (2014) Toxicology Letters , vol.228 , Issue.3 , pp. 133-139
    • Shi, M.1    Zhou, X.2    Zhang, Z.3
  • 62
    • 84893166763 scopus 로고    scopus 로고
    • Metformin anti-tumor effect via disruption of the MID1 translational regulator complex and AR downregulation in prostate cancer cells
    • Demir U, Koehler A, Scnieder R, Schweiger S, Klocker H (2014) Metformin anti-tumor effect via disruption of the MID1 translational regulator complex and AR downregulation in prostate cancer cells. BMC Cancer 14:52
    • (2014) BMC Cancer , vol.14 , pp. 52
    • Demir, U.1    Koehler, A.2    Scnieder, R.3    Schweiger, S.4    Klocker, H.5
  • 63
    • 32944456100 scopus 로고    scopus 로고
    • Metformin monotherapy for type 2 diabetes mellitus. Cochrane Database Syst Rev, (3): p
    • Saenz A, Fernandez-Esteban I, Mataix A et al. (2005) Metformin monotherapy for type 2 diabetes mellitus. Cochrane Database Syst Rev, (3): p. CD002966
    • (2005) CD002966
    • Saenz, A.1    Fernandez-Esteban, I.2    Mataix, A.3
  • 64
    • 69549097703 scopus 로고    scopus 로고
    • New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes
    • Libby G, Donnelly LA, Donnan PT et al (2009) New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes. Diabetes Care 32(9):1620–5
    • (2009) Diabetes Care , vol.32 , Issue.9 , pp. 1620-1625
    • Libby, G.1    Donnelly, L.A.2    Donnan, P.T.3
  • 65
    • 84874538282 scopus 로고    scopus 로고
    • Metformin and prostate cancer: reduced development of castration-resistant disease and prostate cancer mortality
    • Spratt DE, Zhang C, Zumsteg ZS et al (2013) Metformin and prostate cancer: reduced development of castration-resistant disease and prostate cancer mortality. Eur Urol 63(4):709–16
    • (2013) Eur Urol , vol.63 , Issue.4 , pp. 709-716
    • Spratt, D.E.1    Zhang, C.2    Zumsteg, Z.S.3
  • 66
    • 84860351010 scopus 로고    scopus 로고
    • A prospective, randomized pilot study evaluating the effects of metformin and lifestyle intervention on patients with prostate cancer receiving androgen deprivation therapy
    • Nobes JP, Langley SE, Klopper R, Russell-Jones D, Laing RW (2012) A prospective, randomized pilot study evaluating the effects of metformin and lifestyle intervention on patients with prostate cancer receiving androgen deprivation therapy. BJU Int 109(10):1495–502
    • (2012) BJU Int , vol.109 , Issue.10 , pp. 1495-1502
    • Nobes, J.P.1    Langley, S.E.2    Klopper, R.3    Russell-Jones, D.4    Laing, R.W.5
  • 67
    • 84905914439 scopus 로고    scopus 로고
    • Metformin in Chemotherapy-naive Castration-resistant Prostate Cancer: A Multicenter Phase 2 Trial (SAKK 08/09)
    • Rothermundt C, Hayoz S, Templeton AJ et al. (2014) Metformin in Chemotherapy-naive Castration-resistant Prostate Cancer: A Multicenter Phase 2 Trial (SAKK 08/09). Eur Urol 66(3):468–74
    • (2014) Eur Urol , vol.66 , Issue.3 , pp. 468-474
    • Rothermundt, C.1    Hayoz, S.2    Templeton, A.J.3
  • 68
    • 0036570532 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator-activated receptor (PPAR) in human prostate cancer
    • Segawa Y, Yoshimura R, Hase T et al (2002) Expression of peroxisome proliferator-activated receptor (PPAR) in human prostate cancer. Prostate 51(2):108–16
    • (2002) Prostate , vol.51 , Issue.2 , pp. 108-116
    • Segawa, Y.1    Yoshimura, R.2    Hase, T.3
  • 69
    • 84870685371 scopus 로고    scopus 로고
    • Thiazolidinedione use and cancer incidence in type 2 diabetes: a systematic review and meta-analysis
    • Colmers IN, Bowker SL, Johnson JA (2012) Thiazolidinedione use and cancer incidence in type 2 diabetes: a systematic review and meta-analysis. Diabetes Metab 38(6):475–84
    • (2012) Diabetes Metab , vol.38 , Issue.6 , pp. 475-484
    • Colmers, I.N.1    Bowker, S.L.2    Johnson, J.A.3
  • 70
    • 84875925089 scopus 로고    scopus 로고
    • Simvastatin induces apoptosis in castrate resistant prostate cancer cells by deregulating nuclear factor-B pathway
    • Park YH, Seo SY, Lee E et al (2013) Simvastatin induces apoptosis in castrate resistant prostate cancer cells by deregulating nuclear factor-B pathway. J Urol 189(4):1547–52
    • (2013) J Urol , vol.189 , Issue.4 , pp. 1547-1552
    • Park, Y.H.1    Seo, S.Y.2    Lee, E.3
  • 71
    • 77950799056 scopus 로고    scopus 로고
    • Is statin use associated with prostate cancer aggressiveness?
    • Loeb S, Kan D, Helfand BT, Nadler RB, Catalona WJ (2010) Is statin use associated with prostate cancer aggressiveness? BJU Int 105(9):1222–5
    • (2010) BJU Int , vol.105 , Issue.9 , pp. 1222-1225
    • Loeb, S.1    Kan, D.2    Helfand, B.T.3    Nadler, R.B.4    Catalona, W.J.5
  • 72
    • 84925356385 scopus 로고    scopus 로고
    • The risk of prostate cancer for men on aspirin, statin or antidiabetic medications
    • Nordstrom T, Clements M, Karlsson R, Adolfsson J, Gronberg H (2015) The risk of prostate cancer for men on aspirin, statin or antidiabetic medications. Eur J Cancer 51(6):725–33
    • (2015) Eur J Cancer , vol.51 , Issue.6 , pp. 725-733
    • Nordstrom, T.1    Clements, M.2    Karlsson, R.3    Adolfsson, J.4    Gronberg, H.5
  • 73
    • 84903999475 scopus 로고    scopus 로고
    • Atorvastatin prevents ATP-driven invasiveness via P2X7 and EHBP1 signaling in PTEN-expressing prostate cancer cells
    • Ghalali A, Wiklund F, Zheng H, Stenius U, Hogberg J (2014) Atorvastatin prevents ATP-driven invasiveness via P2X7 and EHBP1 signaling in PTEN-expressing prostate cancer cells. Carcinogenesis 35(7):1547–55
    • (2014) Carcinogenesis , vol.35 , Issue.7 , pp. 1547-1555
    • Ghalali, A.1    Wiklund, F.2    Zheng, H.3    Stenius, U.4    Hogberg, J.5
  • 74
    • 84927936581 scopus 로고    scopus 로고
    • Combination simvastatin and metformin induces G1-phase cell cycle arrest and Ripk1- and Ripk3-dependent necrosis in C4-2B osseous metastatic castration-resistant prostate cancer cells
    • Babcook MA, Sramkoski RM, Fujioka H et al. (2014) Combination simvastatin and metformin induces G1-phase cell cycle arrest and Ripk1- and Ripk3-dependent necrosis in C4-2B osseous metastatic castration-resistant prostate cancer cells. Cell Death Dis e1536
    • (2014) Cell Death Dis , vol.e1536
    • Babcook, M.A.1    Sramkoski, R.M.2    Fujioka, H.3
  • 75
    • 84862575958 scopus 로고    scopus 로고
    • A phase II pharmacodynamic study of preoperative figitumumab in patients with localized prostate cancer
    • Chi KN, Gleave ME, Fazli L et al (2012) A phase II pharmacodynamic study of preoperative figitumumab in patients with localized prostate cancer. Clin Cancer Res 18(12):3407–13
    • (2012) Clin Cancer Res , vol.18 , Issue.12 , pp. 3407-3413
    • Chi, K.N.1    Gleave, M.E.2    Fazli, L.3
  • 76
    • 84864426790 scopus 로고    scopus 로고
    • Weight change and prostate cancer incidence and mortality
    • Bassett JK, Severi G, Baglietto L et al (2012) Weight change and prostate cancer incidence and mortality. Int J Cancer 131(7):1711–9
    • (2012) Int J Cancer , vol.131 , Issue.7 , pp. 1711-1719
    • Bassett, J.K.1    Severi, G.2    Baglietto, L.3
  • 77
    • 77954048490 scopus 로고    scopus 로고
    • American College of Sports Medicine roundtable on exercise guidelines for cancer survivors
    • Schmitz KH, Courneya KS, Matthews C et al (2010) American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc 42(7):1409–26
    • (2010) Med Sci Sports Exerc , vol.42 , Issue.7 , pp. 1409-1426
    • Schmitz, K.H.1    Courneya, K.S.2    Matthews, C.3
  • 78
    • 67349233901 scopus 로고    scopus 로고
    • Australian Association for Exercise and Sport Science position stand: optimising cancer outcomes through exercise
    • Hayes SC, Spence RR, Galvao DA, Newton RU (2009) Australian Association for Exercise and Sport Science position stand: optimising cancer outcomes through exercise. J Sci Med Sport 12(4):428–34
    • (2009) J Sci Med Sport , vol.12 , Issue.4 , pp. 428-434
    • Hayes, S.C.1    Spence, R.R.2    Galvao, D.A.3    Newton, R.U.4
  • 79
    • 84879474222 scopus 로고    scopus 로고
    • Cardiovascular risk and bone loss in men undergoing androgen deprivation therapy for non-metastatic prostate cancer: implementation of standardized management guidelines
    • Cheung AS, Pattison D, Bretherton I et al (2013) Cardiovascular risk and bone loss in men undergoing androgen deprivation therapy for non-metastatic prostate cancer: implementation of standardized management guidelines. Androl 1(4):583–9
    • (2013) Androl , vol.1 , Issue.4 , pp. 583-589
    • Cheung, A.S.1    Pattison, D.2    Bretherton, I.3
  • 80
    • 84964266910 scopus 로고    scopus 로고
    • Adverse effects of androgen deprivation therapy in prostate cancer and their management
    • Rhee H, Gunter JH, Heathcote P et al. (2014) Adverse effects of androgen deprivation therapy in prostate cancer and their management. BJU Int 15(Suppl5):3–13
    • (2014) BJU Int , vol.15 , pp. 3-13
    • Rhee, H.1    Gunter, J.H.2    Heathcote, P.3
  • 81
    • 84921613945 scopus 로고    scopus 로고
    • Can Supervised exercise prevent treatment toxicity in prostate cancer patients initiating androgen deprivation therapy: a randomised controlled trial
    • Cormie P, Galvao GA, Spry N et al. (2014) Can Supervised exercise prevent treatment toxicity in prostate cancer patients initiating androgen deprivation therapy: a randomised controlled trial. BJU Int
    • (2014) BJU Int
    • Cormie, P.1    Galvao, G.A.2    Spry, N.3
  • 82
    • 84897018986 scopus 로고    scopus 로고
    • Effects of exercise on treatment-related adverse effects for patients with prostate cancer receiving androgen-deprivation therapy: a systematic review
    • Gardner JR, Livingston PM, Fraser SF (2014) Effects of exercise on treatment-related adverse effects for patients with prostate cancer receiving androgen-deprivation therapy: a systematic review. J Clin Oncol 32(4):335–46
    • (2014) J Clin Oncol , vol.32 , Issue.4 , pp. 335-346
    • Gardner, J.R.1    Livingston, P.M.2    Fraser, S.F.3
  • 83
    • 84876049811 scopus 로고    scopus 로고
    • The relationship between nutrition and prostate cancer: is more always better?
    • Masko EM, Allott EH, Freedland SJ (2013) The relationship between nutrition and prostate cancer: is more always better? Eur Urol 63(5):810–820
    • (2013) Eur Urol , vol.63 , Issue.5 , pp. 810-820
    • Masko, E.M.1    Allott, E.H.2    Freedland, S.J.3
  • 84
    • 84963840809 scopus 로고    scopus 로고
    • Alliance, N.-N.V.D.P. Guidelines for the Management of Absolute Cardiovascular Disease Risk. 2012 [cited 2014 06/05]; Available from:
    • Alliance, N.-N.V.D.P. Guidelines for the Management of Absolute Cardiovascular Disease Risk. 2012 [cited 2014 06/05]; Available from: http://strokefoundation.com.au/site/media/AbsoluteCVD_GL_webready.pdf
  • 85
    • 84876253782 scopus 로고    scopus 로고
    • Effect of metabolic syndrome and its components on prostate cancer risk: meta-analysis
    • Esposito K, Chiodini P, Capuano A et al (2013) Effect of metabolic syndrome and its components on prostate cancer risk: meta-analysis. J Endocrinol Investig 36(2):132–9
    • (2013) J Endocrinol Investig , vol.36 , Issue.2 , pp. 132-139
    • Esposito, K.1    Chiodini, P.2    Capuano, A.3
  • 86
    • 4043163432 scopus 로고    scopus 로고
    • Antihypertensive drug use and the risk of prostate cancer (Canada)
    • Perron L, Bairati I, Harel F, Meyer F (2004) Antihypertensive drug use and the risk of prostate cancer (Canada). Cancer Causes Control 15(6):535–541
    • (2004) Cancer Causes Control , vol.15 , Issue.6 , pp. 535-541
    • Perron, L.1    Bairati, I.2    Harel, F.3    Meyer, F.4
  • 87
    • 40449119093 scopus 로고    scopus 로고
    • Antihypertensive medication and their impact on cancer incidence: a mixed treatment comparison meta-analysis of randomized controlled trials
    • Coleman CI, Baker WL, Kluger J, White CM (2008) Antihypertensive medication and their impact on cancer incidence: a mixed treatment comparison meta-analysis of randomized controlled trials. J Hypertens 26(4):622–629
    • (2008) J Hypertens , vol.26 , Issue.4 , pp. 622-629
    • Coleman, C.I.1    Baker, W.L.2    Kluger, J.3    White, C.M.4


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