Photosensitizer-Loaded Branched Polyethylenimine-PEGylated Ceria Nanoparticles for Imaging-Guided Synchronous Photochemotherapy

ACS Applied Materials and Interfaces

Volumn 7, Issue 43, 2015, Pages 24218-24228

  Yang, Zhang You ^a   Li, Hong ^a   Zeng, Yi Ping ^a   Hao, Yu Hui ^a   Liu, Cong ^a   Liu, Jing ^a   Wang, Wei Dong ^b   Li, Rong ^a  

^a THIRD MILITARY MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY AFFILIATED SIXTH PEOPLE S HOSPITAL   (China)

Author keywords

ceria nanoparticles; imaging guided; lysosome targeted; photochemotherapy; synchronous

Indexed keywords

CELL DEATH; CHEMOTHERAPY; DRUG DOSAGE; ENZYME INHIBITION; HIGH RESOLUTION TRANSMISSION ELECTRON MICROSCOPY; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY; MASS SPECTROMETRY; MEDICAL APPLICATIONS; PHOTOSENSITIZERS; SOLUTIONS; TRANSMISSION ELECTRON MICROSCOPY;

BIOMEDICAL APPLICATIONS; CERIA NANOPARTICLES; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRIES (ICPMS); LYSOSOMAL INTEGRITY; LYSOSOME-TARGETED; MULTIFUNCTIONAL NANOCARRIER; PHOTOCHEMOTHERAPY; SYNCHRONOUS;

NANOPARTICLES;

ANTINEOPLASTIC AGENT; BIOMATERIAL; CERIUM; GREEN FLUORESCENT PROTEIN; MACROGOL DERIVATIVE; NANOPARTICLE; PHOTOSENSITIZING AGENT; PHYTOCHLORIN; POLYETHYLENEIMINE; PORPHYRIN;

APOPTOSIS; CELL SURVIVAL; CHEMISTRY; CONFOCAL MICROSCOPY; HELA CELL LINE; HUMAN; LASER; LYSOSOME; METABOLISM; NANOTECHNOLOGY; NEOPLASMS; PHOTOCHEMOTHERAPY; PROCEDURES; SOLUBILITY; TRANSMISSION ELECTRON MICROSCOPY; TUMOR CELL LINE; ULTRAVIOLET SPECTROPHOTOMETRY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BIOCOMPATIBLE MATERIALS; CELL LINE, TUMOR; CELL SURVIVAL; CERIUM; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; LASERS; LYSOSOMES; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; NANOTECHNOLOGY; NEOPLASMS; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; POLYETHYLENE GLYCOLS; POLYETHYLENEIMINE; PORPHYRINS; SOLUBILITY; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 84946779982     PISSN: 19448244     EISSN: 19448252     Source Type: Journal    
DOI: 10.1021/acsami.5b07702     Document Type: Article

References (54)

1. Zhou, M.; Liu, S.; Jiang, Y.; Ma, H.; Shi, M.; Wang, Q.; Zhong, W.; Liao, W.; Xing, M. M. Doxorubicin-Loaded Single Wall Nanotube Thermo-Sensitive Hydrogel for Gastric Cancer Chemo-Photothermal Therapy Adv. Funct. Mater. 2015, 25, 4730-4739 10.1002/adfm.201501434
2. Wang, T.; Zhang, L.; Su, Z.; Wang, C.; Liao, Y.; Fu, Q. Multifunctional Hollow Mesoporous Silica Nanocages for Cancer Cell Detection and the Combined Chemotherapy and Photodynamic Therapy ACS Appl. Mater. Interfaces 2011, 3, 2479-2486 10.1021/am200364e
3. Fan, W.; Shen, B.; Bu, W.; Chen, F.; Zhao, K.; Zhang, S.; Zhou, L.; Peng, W.; Xiao, Q.; Xing, H. et al. Rattle-Structured Multifunctional Nanotheranostics for Synergetic Chemo-/Radiotherapy and Simultaneous Magnetic/Luminescent Dual-Mode Imaging J. Am. Chem. Soc. 2013, 135, 6494-6503
4. Josefsen, L. B.; Boyle, R. W. Unique Diagnostic and Therapeutic Roles of Porphyrins and Phthalocyanines in Photodynamic Therapy, Imaging and Theranostics Theranostics 2012, 2, 916-966 10.7150/thno.4571
5. Juarranz, á.; Jaén, P.; Sanz-Rodríguez, F.; Cuevas, J.; González, S. Photodynamic Therapy of Cancer, Basic principles and applications Clin. Transl. Oncol. 2008, 10, 148-154 10.1007/s12094-008-0172-2
6. Dolmans, D. E.; Fukumura, D.; Jain, R. K. Photodynamic Therapy for Cancer Nat. Rev. Cancer 2003, 3, 380-387 10.1038/nrc1071
7. Hill, J. E.; Linder, M. K.; Davies, K. S.; Sawada, G. A.; Morgan, J.; Ohulchanskyy, T. Y.; Detty, M. R. Selenorhodamine Photosensitizers for Photodynamic Therapy of P-Glycoprotein-Expressing Cancer Cells J. Med. Chem. 2014, 57, 8622-8634 10.1021/jm501259v
8. Agostinis, P.; Berg, K.; Cengel, K. A.; Foster, T. H.; Girotti, A. W.; Gollnick, S. O.; Hahn, S. M.; Hamblin, M. R.; Juzeniene, A.; Kessel, D.; Korbelik, M.; Moan, J.; Mroz, P.; Nowis, D.; Piette, J.; Wilson, B. C.; Golab, J. PhotodynamicTherapy of Cancer: an Update Ca-Cancer J. Clin. 2011, 61, 250-281 10.3322/caac.20114
9. Cheng, L.; Wang, C.; Feng, L.; Yang, K.; Liu, Z. Functional Nanomaterials for Phototherapies of Cancer Chem. Rev. 2014, 114, 10869-10939 10.1021/cr400532z
10. Ding, F.; Li, H. J.; Wang, J. X.; Tao, W.; Zhu, Y. H.; Yu, Y.; Yang, X. Z. Chlorin e6-Encapsulated Polyphosphoester Based Nanocarriers with Viscous Flow Core for Effective Treatment of Pancreatic Cancer ACS Appl. Mater. Interfaces 2015, 7, 18856-18865 10.1021/acsami.5b05724
11. Nair, L. V.; Nazeer, S. S.; Jayasree, R. S.; Ajayaghosh, A. Fluorescence Imaging Assisted Photodynamic Therapy Using Photosensitizer Linked Gold Quantum Clusters ACS Nano 2015, 9, 5825-5832 10.1021/acsnano.5b00406
12. Xu, J.; Zeng, F.; Wu, H.; Yu, C.; Wu, S. Dual-Targeting Nanosystem for Enhancing Photodynamic Therapy Efficiency ACS Appl. Mater. Interfaces 2015, 7, 9287-9296 10.1021/acsami.5b02297
13. Yan, X.; Niu, G.; Lin, J.; Jin, A. J.; Hu, H.; Tang, Y.; Zhang, Y.; Wu, A.; Lu, J.; Zhang, S.; Huang, P.; Shen, J. B.; Chen, X. Enhanced Fluorescence Imaging Guided Photodynamic Therapy of Sinoporphyrin Sodium Loaded Graphene Oxide Biomaterials 2015, 42, 94-102 10.1016/j.biomaterials.2014.11.040
14. Yu, M.; Guo, F.; Wang, J.; Tan, F.; Li, N. Photosensitizer-Loaded pH-Responsive Hollow Gold Nanospheres for Single Light-Induced Photothermal/Photodynamic Therapy ACS Appl. Mater. Interfaces 2015, 7, 17592-17597 10.1021/acsami.5b05763
15. Zhang, C.; Li, C.; Liu, Y.; Zhang, J.; Bao, C.; Liang, S.; Wang, Q.; Yang, Y.; Fu, H.; Wang, K.; Cui, H. Gold Nanoclusters-Based Nanoprobes for Simultaneous Fluorescence Imaging and Targeted Photodynamic Therapy with Superior Penetration and Retention Behavior in Tumors Adv. Funct. Mater. 2015, 25, 1314-1325 10.1002/adfm.201403095
16. Tian, J.; Ding, L.; Xu, H.-J.; Shen, Z.; Ju, H.; Jia, L.; Bao, L.; Yu, J.-S. Cell-specific and pH-activatable Rubyrin-loaded Nanoparticles for Highly Selective Near-Infrared Photodynamic Therapy Against Cancer J. Am. Chem. Soc. 2013, 135, 18850-18858 10.1021/ja408286k
17. Idris, N. M.; Gnanasammandhan, M. K.; Zhang, J.; Ho, P. C.; Mahendran, R.; Zhang, Y. In Vivo Photodynamic Therapy using Upconversion Nanoparticles as Remote-Controlled Nanotransducers Nat. Med. 2012, 18, 1580-1585 10.1038/nm.2933
18. Peng, J.; Zhao, L.; Zhu, X.; Sun, Y.; Feng, W.; Gao, Y.; Wang, L.; Li, F. Hollow Silica Nanoparticles Loaded with Hydrophobic Phthalocyanine for Near-Infrared Photodynamic and Photothermal Combination Therapy Biomaterials 2013, 34, 7905-7912 10.1016/j.biomaterials.2013.07.027
19. Deng, X.; Liang, Y.; Peng, X.; Su, T.; Luo, S.; Cao, J.; Gu, Z.; He, B. A Facile Strategy to Generate Polymeric Nanoparticles for Synergistic Chemo-Photodynamic Therapy Chem. Commun. 2015, 51, 4271-4274 10.1039/C4CC10226F
20. Yao, X.; Chen, L.; Chen, X.; Xie, Z.; Ding, J.; He, C.; Zhang, J.; Chen, X. pH-Responsive Metallo-Supramolecular Nanogel for Synergistic Chemo- Photodynamic Therapy Acta Biomater. 2015, 25, 162-171 10.1016/j.actbio.2015.07.024
21. Rajaputra, P.; Bio, M.; Nkepang, G.; You, Y. Visible/NIR-activatable Prodrug Strategy for Treating Local Tumors by the Combination of Photodynamic Therapy and Local Chemotherapy Cancer Res. 2014, 74, 4919-4919 10.1158/1538-7445.AM2014-4919
22. He, C.; Liu, D.; Lin, W. Self-Assembled Core-Shell Nanoparticles for Combined Chemotherapy and Photodynamic Therapy of Resistant Head and Neck Cancers ACS Nano 2015, 9, 991-1003 10.1021/nn506963h
23. Chen, Q.; Wang, X.; Wang, C.; Feng, L.; Li, Y.; Liu, Z. Drug-Induced Self-Assembly of Modified Albumins as Nano-Theranostics for Tumor-Targeted Combination Therapy ACS Nano 2015, 9, 5223-5233 10.1021/acsnano.5b00640
24. Pagliari, F.; Mandoli, C.; Forte, G.; Magnani, E.; Pagliari, S.; Nardone, G.; Licoccia, S.; Traversa, E.; Minieri, M.; Di Nardo, P. Cerium Oxide Nanoparticles Protect Cardiac Progenitor Cells from Oxidative Stress ACS Nano 2012, 6, 3767-3775 10.1021/nn2048069
25. 2 Nanoparticles in PLGA Scaffolds with Improved Bioactivity for Regenerative Medicine Adv. Funct. Mater. 2010, 20, 1617-1624 10.1002/adfm.200902363
26. Celardo, I.; Pedersen, J. Z.; Traversa, E.; Ghibelli, L. Pharmacological Potential of Cerium Oxide Nanoparticles Nanoscale 2011, 3, 1411-1420 10.1039/c0nr00875c
27. Li, H.; Yang, Z.-Y.; Liu, C.; Zeng, Y.-P.; Hao, Y.-H.; Gu, Y.; Wang, W.-D.; Li, R. PEGylated Ceria Nanoparticles Used for Radioprotection on Human Liver Cells Under γ-ray Irradiation Free Radical Biol. Med. 2015, 87, 26-35 10.1016/j.freeradbiomed.2015.06.010
28. Korsvik, C.; Patil, S.; Seal, S.; Self, W. T. Superoxide Dismutase Mimetic Properties Exhibited by Vacancy Engineered Ceria Nanoparticles Chem. Commun. 2007, 1056-1058 10.1039/b615134e
29. Pirmohamed, T.; Dowding, J. M.; Singh, S.; Wasserman, B.; Heckert, E.; Karakoti, A. S.; King, J. E.; Seal, S.; Self, W. T. Nanoceria Exhibit Redox State-Dependent Catalase Mimetic Activity Chem. Commun. 2010, 46, 2736-2738 10.1039/b922024k
30. Asati, A.; Santra, S.; Kaittanis, C.; Nath, S.; Perez, J. M. Oxidase-Like Activity of Polymer-Coated Cerium Oxide Nanoparticles Angew. Chem., Int. Ed. 2009, 48, 2308-2312 10.1002/anie.200805279
31. Xu, C.; Qu, X. Cerium Oxide Nanoparticle: A Remarkably Versatile Rare Earth Nanomaterial for Biological Applications NPG Asia Mater. 2014, 6, e90 10.1038/am.2013.88
32. Tarnuzzer, R. W.; Colon, J.; Patil, S.; Seal, S. Vacancy Engineered Ceria Nanostructures for Protection from Radiation-Induced Cellular Damage Nano Lett. 2005, 5, 2573-2577 10.1021/nl052024f
33. Asati, A.; Santra, S.; Kaittanis, C.; Perez, J. M. Surface-Charge-Dependent Cell Localization and Cytotoxicity of Cerium Oxide Nanoparticles ACS Nano 2010, 4, 5321-5331 10.1021/nn100816s
34. Wason, M. S.; Colon, J.; Das, S.; Seal, S.; Turkson, J.; Zhao, J.; Baker, C. H. Sensitization of Pancreatic Cancer Cells to Radiation by Cerium Oxide Nanoparticle-Induced ROS Production Nanomedicine (N. Y., NY, U. S.) 2013, 9, 558-569 10.1016/j.nano.2012.10.010
35. Wason, M. S.; Zhao, J. Cerium Oxide Nanoparticles: Potential Applications for Cancer and Other Diseases Am. J. Transl. Res. 2013, 5, 126-131
36. Gao, Y.; Chen, K.; Ma, J.-l.; Gao, F. Cerium Oxide Nanoparticles in Cancer OncoTargets Ther. 2014, 7, 835-840 10.2147/OTT.S62057
37. Pešić, M.; Podolski-Renić, A.; Stojković, S.; Matović, B.; Zmejkoski, D.; Kojić, V.; Bogdanović, G.; Pavićević, A.; Mojović, M.; Savić, A.; Milenković, I.; Kalauzi, A.; Radotić, K. Anti-cancer Effects of Cerium Oxide Nanoparticles and Its Intracellular Redox Activity Chem.-Biol. Interact. 2015, 232, 85-93 10.1016/j.cbi.2015.03.013
38. Giri, S.; Karakoti, A.; Graham, R. P.; Maguire, J. L.; Reilly, C. M.; Seal, S.; Rattan, R.; Shridhar, V. Nanoceria: A Rare-Earth Nanoparticle as a Novel Anti-Angiogenic Therapeutic Agent in Ovarian Cancer PLoS One 2013, 8, e54578 10.1371/journal.pone.0054578
39. Lord, M. S.; Tsoi, B.; Gunawan, C.; Teoh, W. Y.; Amal, R.; Whitelock, J. M. Anti-Angiogenic Activity of Heparin Functionalised Cerium Oxide Nanoparticles Biomaterials 2013, 34, 8808-8818 10.1016/j.biomaterials.2013.07.083
40. Sack, M.; Alili, L.; Karaman, E.; Das, S.; Gupta, A.; Seal, S.; Brenneisen, P. Combination of Conventional Chemotherapeutics with Redox-Active Cerium Oxide Nanoparticles-A Novel Aspect in Cancer Therapy Mol. Cancer Ther. 2014, 13, 1740-1749 10.1158/1535-7163.MCT-13-0950
41. Das, S.; Dowding, J. M.; Klump, K. E.; McGinnis, J. F.; Self, W.; Seal, S. Cerium Oxide Nanoparticles: Applications and Prospects in Nanomedicine Nanomedicine 2013, 8, 1483-1508 10.2217/nnm.13.133
42. Karakoti, A. S.; Das, S.; Thevuthasan, S.; Seal, S. PEGylated Inorganic Nanoparticles Angew. Chem., Int. Ed. 2011, 50, 1980-1994 10.1002/anie.201002969
43. Yang, Z.-Y.; Luo, S.-L.; Li, H.; Dong, S.-W.; He, J.; Jiang, H.; Li, R.; Yang, X.-C. Alendronate as A Robust Anchor for Ceria Nanoparticle Surface Coating: Facile Binding and Improved Biological Properties RSC Adv. 2014, 4, 59965-59969 10.1039/C4RA12007H
44. Zeng, Y.; Yang, Z.; Luo, S.; Li, H.; Liu, C.; Hao, Y.; Liu, J.; Wang, W.; Li, R. Fast and Facile Preparation of PEGylated Graphene from Graphene Oxide by Lysosome Targeting Delivery of Photosensitizer to Efficiently Enhance Photodynamic Therapy RSC Adv. 2015, 5, 57725-57734 10.1039/C5RA07535A
45. Russell, R. G.; Watts, N. B.; Ebetino, F. H.; Rogers, M. J. Mechanisms of Action of Bisphosphonates: Similarities and Differences and Their Potential Influence on Clinical Efficacy Osteoporosis Int. 2008, 19, 733-759 10.1007/s00198-007-0540-8
46. Jäger, M.; Schubert, S.; Ochrimenko, S.; Fischer, D.; Schubert, U. S. Branched and Linear Poly(ethyleneimine)-Based Conjugates: Synthetic Modification, Characterization, and Application Chem. Soc. Rev. 2012, 41, 4755-4767 10.1039/c2cs35146c
47. Kim, H.; Kim, W. J. Photothermally Controlled Gene Delivery by Reduced Graphene Oxide-Polyethylenimine Nanocomposite Small 2014, 10, 117-126 10.1002/smll.201202636
48. Zhao, Z.; Shi, S.; Huang, Y.; Tang, S.; Chen, X. Simultaneous Photodynamic and Photothermal Therapy Using Photosensitizer-Functionalized Pd Nanosheets by Single Continuous Wave Laser ACS Appl. Mater. Interfaces 2014, 6, 8878-8885 10.1021/am501608c
49. Kessel, D. Subcellular Targets for Photodynamic Therapy: Implications for Initiation of Apoptosis and Autophagy J. Natl. Compr. Cancer Network 2012, 56-59
50. Chou, L. Y.; Ming, K.; Chan, W. C. Strategies for the Intracellular Delivery of Nanoparticles Chem. Soc. Rev. 2011, 40, 233-245 10.1039/C0CS00003E
51. Verma, A.; Stellacci, F. Effect of Surface Properties on Nanoparticle-Cell Interactions Small 2010, 6, 12-21 10.1002/smll.200901158
52. Appelqvist, H.; Waster, P.; Kagedal, K.; Ollinger, K. The Lysosome: from Waste Bag to Potential Therapeutic Target J. Mol.Cell Biol. 2013, 5, 214-226 10.1093/jmcb/mjt022
53. Song, W.; Soo Lee, S.; Savini, M.; Popp, L.; Colvin, V. L.; Segatori, L. Ceria Nanoparticles Stabilized by Organic Surface Coatings Activate the Lysosome- Autophagy Systemand Enhance Autophagic Clearance ACS Nano 2014, 8, 10328-10342 10.1021/nn505073u
54. Tian, B.; Wang, C.; Zhang, S.; Feng, L.; Liu, Z. Photothermally Enhanced Photodynamic Therapy Delivered by Nano-Graphene Oxide ACS Nano 2011, 5, 7000-7009 10.1021/nn201560b