68Ga-DOTA-Siglec-9 - a new imaging tool to detect synovitis

Arthritis Research and Therapy

Volumn 17, Issue 1, 2015, Pages

  Virtanen, Helena ^a   Autio, Anu ^a   Siitonen, Riikka ^a   Liljenbäck, Heidi ^a   Saanijoki, Tiina ^a   Lankinen, Petteri ^a   Mäkilä, Jussi ^a   Käkelä, Meeri ^a   Teuho, Jarmo ^a   Savisto, Nina ^a   Jaakkola, Kimmo ^b   Jalkanen, Sirpa ^c   Roivainen, Anne ^a  

^a UNIVERSITY OF TURKU   (Finland)

^b VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^c UNIVERSITY OF TURKU   (Finland)

Author keywords

Gallium 68; Inflammation; PET; Rabbit; Vascular adhesion protein 1

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GADOTERATE MEGLUMINE; RADIOPHARMACEUTICAL AGENT; TETRAXETAN SIALIC ACID BINDING IMMUNOGLOBULIN LIKE LECTIN 9 GA 68; UNCLASSIFIED DRUG; VASCULAR ADHESION PROTEIN 1; 1,4,7,10-TETRAAZACYCLODODECANE- 1,4,7,10-TETRAACETIC ACID; AMINE OXIDASE (COPPER CONTAINING); AOC3 PROTEIN, HUMAN; CELL ADHESION MOLECULE; GALLIUM; LEUKOCYTE ANTIGEN; SIALIC ACID BINDING IMMUNOGLOBULIN LIKE LECTIN; SIGLEC9 PROTEIN, HUMAN; SINGLE HETEROCYCLIC RINGS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; DRUG STRUCTURE; FEASIBILITY STUDY; GAMMA COUNTER; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; POSITRON EMISSION TOMOGRAPHY; PROTEIN BINDING; PROTEIN EXPRESSION; RABBIT; RADIOCHEMISTRY; STAINING; SYNOVITIS; ANIMAL; CHEMISTRY; DIAGNOSTIC IMAGING; DISEASE MODEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; METABOLISM; PROCEDURES; PROTEIN STABILITY; RHEUMATOID ARTHRITIS;

AMINE OXIDASE (COPPER-CONTAINING); ANIMALS; ANTIGENS, CD; ARTHRITIS, RHEUMATOID; CELL ADHESION MOLECULES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DISEASE MODELS, ANIMAL; GALLIUM RADIOISOTOPES; HETEROCYCLIC COMPOUNDS, 1-RING; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; POSITRON-EMISSION TOMOGRAPHY; PROTEIN STABILITY; RABBITS; RADIOPHARMACEUTICALS; SIALIC ACID BINDING IMMUNOGLOBULIN-LIKE LECTINS; SYNOVITIS;

EID: 84946739410     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/s13075-015-0826-8     Document Type: Article

References (38)

1. Davis LS, Sackler M, Brezinschek RI, Lightfoot E, Bailey JL, Oppenheimer-Marks N, et al. Inflammation, immune reactivity, and angiogenesis in a severe combined immunodeficiency model of rheumatoid arthritis. Am J Pathol. 2002;160:357-67.
2. Silverman MD, Haas CS, Rad AM, Arbab AS, Koch AE. The role of vascular cell adhesion molecule 1/ very late activation antigen 4 in endothelial progenitor cell recruitment to rheumatoid arthritis synovium. Arthritis Rheum. 2007;56:1817-26.
3. McQueen FM. Imaging in early rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2013;27:499-522.
4. Roivainen A, Jalkanen S, Nanni C. Gallium-labelled peptides for imaging of inflammation. Eur J Nucl Med Mol Imaging. 2011;39:S68-77.
5. Autio A, Jalkanen S, Roivainen A. Nuclear imaging of inflammation: homing-associated molecules as targets. EJNMMI Res. 2013;3:1.
6. Salmi M, Jalkanen S. A 90-kilodalton endothelial cell molecule mediating lymphocyte binding in humans. Science. 1992;257:1407-9.
7. Jaakkola K, Nikula T, Holopainen R, Vähäsilta T, Matikainen MT, Laukkanen ML, et al. In vivo detection of vascular adhesion protein-1 in experimental inflammation. Am J Pathol. 2000;157:463-71.
8. 68Ga-DOTAVAP-P1 PET imaging capable of demonstrating the phase of inflammation in healing bones and the progress of infection in osteomyelitic bones. Eur J Nucl Med Mol Imaging. 2008;35:352-64.
9. 68Ga labeling and preliminary evaluation of DOTA peptide binding vascular adhesion protein-1: a potential PET imaging agent for diagnosing osteomyelitis. Nucl Med Biol. 2009;36:631-41.
10. 18F]-FDG. Eur J Nucl Med Mol Imaging. 2010;37:1918-25.
11. 68Ga]-DOTAVAP-P1 peptide improves PET imaging of inflammation. EJNMMI Res. 2011;1:10.
12. Autio A, Vainio PJ, Suilamo S, Mali A, Vainio J, Saanijoki T, et al. Preclinical evaluation of a radioiodinated fully human antibody for in vivo imaging of vascular adhesion protein-1-positive vasculature in inflammation. J Nucl Med. 2013;54:1315-9.
13. Crocker PR, Varki A. Siglecs, sialic acids and innate immunity. Trends Immunol. 2001;22:337-42.
14. Kivi E, Elima K, Aalto K, Nymalm Y, Auvinen K, Koivunen E, et al. Human Siglec-10 can bind to vascular adhesion protein-1 and serves as its substrate. Blood. 2009;114:5385-92.
15. Aalto K, Autio A, Kiss EA, Elima K, Nymalm Y, Veres TZ, et al. Siglec-9 is a novel leukocyte ligand for vascular adhesion protein-1 and can be used in PET imaging of inflammation and cancer. Blood. 2011;118:3725-33.
16. 68Ga-DOTA-Siglec-9 PET/CT imaging of peri-implant tissue responses and staphylococcal infections. EJNMMI Res. 2014;4:45.
17. 18F]-fluoro-2-deoxy-D-glucose using aminopolyether supported nucleophilic substitution. J Nucl Med. 1986;27:235-8.
18. de Jong HWAM, van Velden FHP, Kloet RW, Buijs FL, Boellaard R, Lammertsma AA. Performance evaluation of the ECAT HRRT: an LSO-LYSO double layer high resolution, high sensitivity scanner. Phys Med Biol. 2007;52:1505-26.
19. http://www.turkupetcentre.fi/carimas
20. Zaidi H, Ojha N, Morich M, Griesmer J, Hu Z, Maniawski P, et al. Design and performance evaluation of a whole-body Ingenuity TF PET-MRI system. Phys Med Biol. 2011;56:3091-106.
21. Basu S, Zhuang H, Torigian DA, Rosenbaum J, Chen W, Alavi A. Functional imaging of inflammatory diseases using nuclear medicine techniques. Semin Nucl Med. 2009;39:124-45.
22. 18F-FDG-labeled leukocytes. Q J Nucl Med Mol Imaging. 2006;50:143-6.
23. 18F-FDG PET. J Nucl Med. 2004;45:956-64.
24. 18F-fluoro-2-deoxy-D-glucose in comparison with magnetic resonance imaging for the assessment of inflammatory proliferation of synovium. Arthritis Rheum. 2003;48:3077-84.
25. 11C-(R)-PK11195 and positron emission tomography. Arthritis Rheum. 2008;58:3350-5.
26. 18F]fluoro-PEG-folate for macrophage targeting in a rat model of arthritis. Arthritis Res Ther. 2013;15:R37.
27. Gent YY, Weijers K, Molthoff CF, Windhorst AD, Huisman MC, Kassiou M, et al. Promising potential of new generation translocator protein tracers providing enhanced contrast of arthritis imaging by positron emission tomography in a rat model of arthritis. Arthritis Res Ther. 2014;16:R70.
28. Blezer EL, Deddens LH, Kooij G, Drexhage J, van der Pol SM, Reijerkerk A, et al. In vivo MR imaging of intercellular adhesion molecule-1 expression in an animal model of multiple sclerosis. Contrast Media Mol Imaging. 2014;10:111-21.
29. Gompels LL, Madden L, Lim NH, Inglis JJ, McConnell E, Vincent TL, et al. In vivo fluorescence imaging of E-selectin: quantitative detection of endothelial activation in a mouse model of arthritis. Arthritis Rheum. 2011;63:107-17.
30. Salmi M, Yegutkin GG, Lehvonen R, Koskinen K, Salminen T, Jalkanen S. A cell surface amine oxidase directly controls lymphocyte migration. Immunity. 2001;14:265-76.
31. Danese S, Panés J. Development of drugs to target interactions between leukocytes and endothelial cells and treatment algorithms for inflammatory bowel diseases. Gastroenterology. 2014;147:981-9.
32. Salmi M, Jalkanen S. Ectoenzymes in leukocyte migration and their therapeutic potential. Semin Immunopathol. 2014;36:163-76.
33. Libby P. Inflammation in atherosclerosis. Arterioscler Thromb Vasc Biol. 2012;32:2045-51.
34. Put S, Westhovens R, Lahoutte T, Matthys P. Molecular imaging of rheumatoid arthritis: emerging markers, tools, and techniques. Arthritis Res Ther. 2014;16:208.
35. Trentham DE, Townes AS, Kang AH. Autoimmunity to type II collagen: an experimental model of arthritis. J Exp Med. 1977;146:857-68.
36. Lin PW, Liu RS, Liou TH, Pan LC, Chen CH. Correlation between joint [F-18] FDG PET uptake and synovial TNF-a concentration: A study with two rabbit models of acute inflammatory arthritis. Appl Radiat Isot. 2007;65:1221-6.
37. Yoo TJ, Kim SY, Stuart JM, Floyd RA, Olson GA, Cremer MA, et al. Induction of arthritis in monkeys by immunization with type II collagen. J Exp Med. 1988;168:777-82.
38. Salmi M, Jalkanen S. VAP-1: an adhesin and an enzyme. Trends Immunol. 2001;22:211-6.