Toward the Clonotype Analysis of Alopecia Areata-Specific, Intralesional Human CD8+ T Lymphocytes

Journal of Investigative Dermatology Symposium Proceedings

Volumn 17, Issue 2, 2015, Pages 9-12

  Bertolini, Marta ^a   Uchida, Youhei ^a,b   Paus, Ralf ^a,c  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b KAGOSHIMA UNIVERSITY   (Japan)

^c UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALOPECIA AREATA; ANTIGEN RECOGNITION; CD8+ T LYMPHOCYTE; CELL SELECTION; DISEASE COURSE; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; IN VITRO STUDY; LASER MICRODISSECTION; REGULATORY T LYMPHOCYTE; REVIEW; AUTOIMMUNE DISEASE; CHEMISTRY; CYTOLOGY; HAIR FOLLICLE; IMMUNOLOGY; PATHOLOGY;

LYMPHOCYTE ANTIGEN RECEPTOR;

ALOPECIA AREATA; AUTOIMMUNE DISEASES; CD8-POSITIVE T-LYMPHOCYTES; CYTOLOGICAL TECHNIQUES; HAIR FOLLICLE; HUMANS; RECEPTORS, ANTIGEN, T-CELL;

EID: 84946737142     PISSN: 10870024     EISSN: 15291774     Source Type: Journal    
DOI: 10.1038/jidsymp.2015.31     Document Type: Review

References (37)

1. Bhati M, Cole DK, McCluskey J et al. (2014) The versatility of the ab T-cell antigen receptor. Protein Sci 23:260-72
2. Bertolini M, Zilio F, Rossi A et al. (2014) Abnormal interactions between perifollicular mast cells and CD8 T-cells may contribute to the pathogenesis of alopecia areata. PLoS One 9:e94260
3. Cole DK, Miles KM, Madura F et al. (2014) T-cell receptor (TCR)-peptide specificity overrides affinity-enhancing TCR-major histocompatibility complex interactions. J Biol Chem 289:628-38
4. D'Ovidio R (2014) Alopecia Areata: news on diagnosis, pathogenesis and treatment. G Ital Dermatol Venereol 149:25-45
5. Dy LC, Whiting DA (2011) Histopathology of alopecia areata, acute and chronic: why is it important to the clinician? Dermatol Ther 24:369-74
6. Dornmair K, Meinl E, Hohlfeld R (2009) Novel approaches for identifying target antigens of autoreactive human B and T cells. Semin Immunopathol 31:467-77
7. Falto-Aizpurua L, Choudhary S, Tosti A (2014) Emerging treatments in alopecia. Expert Opin Emerg Drugs 19:545-56
8. Gilhar A, Keren A, Paus R (2013) A new humanized mouse model for alopecia areata. J Investig Dermatol Symp Proc 16:S37-8
9. Gilhar A, Keren A, Shemer A et al. (2013) Autoimmune disease induction in a healthy human organ: A humanized mouse model of alopecia areata. J Invest Dermatol 133:844-7
10. Gilhar A, Etzioni A, Paus R (2012) Alopecia areata (Medical Progress, invited review). N Engl J Med 366:1515-25
11. Gilhar A, Landau M, Assy B et al. (2002) Mediation of alopecia areata by cooperation between CD4 and CD8 T lymphocytes: Transfer to human scalp explants on Prkdc(scid) mice. Arch Dermatol 138:916-22
12. Gilhar A, Landau M, Assy B et al. (2001) Melanocyte-associated T cell epitopes can function as autoantigens for transfer of alopecia areata to human scalp explants on Prkdc(scid) mice. J Invest Dermatol 117:1357-62
13. Gilhar A, Ullmann Y, Berkutzki T et al. (1998) Autoimmune hair loss (alopecia areata) transferred by T lymphocytes to human scalp explants on SCID mice. J Clin Invest 101:62-7
14. Gorcey L, Gordon Spratt EA, Leger MC (2014) Alopecia universalis successfully treated with adalimumab. JAMA Dermatol 150:1341-4
15. Harries MJ, Sun J, Paus R et al. (2010) Management of alopecia areata. BMJ 341:c3671
16. Hofbauer M, Wiesener S, Babbe H et al. (2003) Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR, and CDR3-spectratype analysis. Proc Natl Acad Sci USA 100:4090-5
17. Islam N, Leung PS, Huntley AC et al. (2015) The autoimmune basis of alopecia areata: A comprehensive review. Autoimmun Rev 14:81-9
18. Ito T, Bertolini M, Funakoshi A et al. (2013) Birth, life, and death of the MAGE3 hypothesis of alopecia areata pathobiology. J Dermatol Sci 72:327-30
19. Ito T, Ito N, Saatoff M et al. (2008) Maintenance of hair follicle immune privilege is linked to prevention of NK cell attack. J Invest Dermatol 128:1196-206
20. Junker A, Ivanidze J, Malotka J et al. (2007) Multiple sclerosis: T-cell receptor expression in distinct brain regions. Brain 130:2789-99
21. Kasagi S, Zhang P, Che L et al. (2014) In vivo-generated antigen-specific regulatory T cells treat autoimmunity without compromising antibacterial immune response. Sci Transl Med 6:241ra78
22. Kim SM, Bhonsle L, Besgen P et al. (2012) Analysis of the paired TCR a-and bchains of single human T cells. PLoS One 7:e37338
23. Klastersky JA (2014) Adverse events of targeted therapies. Curr Opin Oncol 26:395-402
24. Leung MC, Sutton CW, Fenton DA et al. (2010) Trichohyalin is a potential major autoantigen in human alopecia areata. J Proteome Res 9: 5153-5163
25. McElwee KJ, Gilhar A, Tobin DJ et al. (2013) What causes alopecia areata? Exp Dermatol 22:609-26
26. McElwee KJ, Freyschmidt-Paul P, Hoffmann R et al. (2005) Transfer of CD8() cells induces localized hair loss whereas CD4()/CD25(-) cells promote systemic alopecia areata and CD4()/CD25() cells blockade disease onset in the C3H/HeJ mouse model. J Invest Dermatol 124:947-57
27. McElwee KJ, Spiers EM, Oliver RF (1996) In vivo depletion of CD8 T cells restores hair growth in the DEBR model for alopecia areata. Br J Dermatol 135:211-7
28. McNally JP, Elfers EE, Terrell CE et al. (2014) Eliminating encephalitogenic T cells without undermining protective immunity. J Immunol 192:73-83
29. Paus R, Slominski A, Czarnetzki BM (1993) Is alopecia areata an autoimmuneresponse against melanogenesis-related proteins, exposed by abnormal MHC class I expression in the anagen hair bulb? Yale J Biol Med 66:541- 54
30. Petukhova L, Duvic M, Hordinsky M et al. (2010) Genome-wide association study in alopecia areata implicates both innate and adaptive immunity. Nature 466:113-7
31. Sharma S, Thomas PG (2014) The two faces of heterologous immunity: Protection or immunopathology. J Leukoc Biol 95:405-16
32. Shibuya M, Fujio K, Shoda H et al. (2015) A new T-cell activation mode for suboptimal doses of antigen under the full activation of T cells with different specificity. Eur J Immunol 45:1643-53
33. Seitz S, Schneider CK, Malotka J et al. (2006) Reconstitution of paired T cell receptor alpha-and beta-chains from microdissected single cells of human inflammatory tissues. Proc Natl Acad Sci USA 103:12057-62
34. Siewert K, Malotka J, Kawakami N et al. (2012) Unbiased identification of target antigens of CD8() T cells with combinatorial libraries coding for short peptides. Nat Med 18:824-8
35. Tosti A, Whiting D, Iorizzo M et al. (2008) The role of scalp dermoscopy in the diagnosis of alopecia areata incognita. J Am Acad Dermatol 59: 64-67
36. Weekes MP, Wills MR, Mynard K et al. (1999) The memory cytotoxic T-lymphocyte (CTL) response to human cytomegalovirus infection contains individual peptide-specific CTL clones that have undergone extensive expansion in vivo. J Virol 73:2099-108
37. Xing L, Dai Z, Jabbari A et al. (2014) Alopecia areata is driven by cytotoxic T lymphocytes and is reversed by JAK inhibition. Nat Med 20:1043-9