Birth, life, and death of the MAGE3 hypothesis of alopecia areata pathobiology

Journal of Dermatological Science

Volumn 72, Issue 3, 2013, Pages 327-330

  Ito, Taisuke ^a   Bertolini, Marta ^b   Funakoshi, Atsuko ^a   Ito, Natsuho ^a   Takayama, Tatsuya ^a   Biro, Tamas ^c   Paus, Ralf ^b,d   Tokura, Yoshiki ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF LÜBECK   (Germany)

^c UNIVERSITY OF DEBRECEN   (Hungary)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIGEN; GAMMA INTERFERON; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MELANOMA ANTIGEN 3; PREDNISOLONE;

ALOPECIA AREATA; CD8+ T LYMPHOCYTE; CHRONIC DISEASE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; DRUG TARGETING; HAIR FOLLICLE; HAIR ROOT; HUMAN; HUMAN CELL; LETTER; LYMPHOCYTE COUNT; MELANOGENESIS; PATHOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TREATMENT DURATION; TREATMENT OUTCOME;

ADOLESCENT; ADULT; AGED; ALOPECIA AREATA; ANTIGENS, NEOPLASM; CASE-CONTROL STUDIES; CD8-POSITIVE T-LYMPHOCYTES; CHILD; FEMALE; HAIR FOLLICLE; HUMANS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; YOUNG ADULT;

EID: 84887183094     PISSN: 09231811     EISSN: 1873569X     Source Type: Journal    
DOI: 10.1016/j.jdermsci.2013.07.014     Document Type: Letter

References (10)

1. Gilhar A., Etzioni A., Paus R. Alopecia areata. N Engl J Med 2012, 366:1515-1525.
2. Ito T., Ito N., Saathoff M., Stampachiacchiere B., Bettermann A., Bulfone-Paus S., et al. Collapse and restoration of MHC class-I-dependent immune privilege: exploiting the human hair follicle as a model. Am J Pathol 2004, 164:623-634.
3. Gilhar A., Landau M., Assy B., Shalaginov R., Serafimovich S., Kalish R.S. Melanocyte-associated T cell epitopes can function as autoantigens for transfer of alopecia areata to human scalp explants on Prkdc(scid) mice. J Invest Dermatol 2001, 117:1357-1362.
4. Yagi H., Hashizume H., Horibe T., Yoshinari Y., Hata M., Ohshima A., et al. Induction of therapeutically relevant cytotoxic T lymphocytes in humans by percutaneous peptide immunization. Cancer Res 2006, 66:10136-10144.
5. Ito T., Hashizume H., Shimauchi T., Funakoshi A., Ito N., Fukamizu H., et al. CXCL10 produced from hair follicles induces Th1 and Tc1 cell infiltration in the acute phase of alopecia areata followed by sustained Tc1 accumulation in the chronic phase. J Dermatol Sci 2013, 69:140-147.
6. Russo V., Pilla L., Lunghi F., Crocchiolo R., Greco R., Ciceri F., et al. Clinical and immunologic responses in melanoma patients vaccinated with MAGE-A3-genetically modified lymphocytes. Int J Cancer 2013, 132:2557-2566.
7. Moeller I., Spagnoli G.C., Finke J., Veelken H., Houet L. Uptake routes of tumor-antigen MAGE-A3 by dendritic cells determine priming of naïve T-cell subtypes. Cancer Immunol Immunother 2012, 61:2079-2090.
8. Jungbluth A.A., Silva W.A, Iversen K., Frosina D., Zaidi B., Coplan K., et al. Expression of cancer-testis (CT) antigens in placenta. Cancer Immun 2007, 7:15.
9. Becker J.C., Gillitzer R., Bröcker E.B. A member of the melanoma antigen-encoding gene (MAGE) family is expressed in human skin during wound healing. Int J Cancer 1994, 58:346-348.
10. Rimoldi D., Salvi S., Schultz-Thater E., Spagnoli G.C., Cerottini J.C. Anti-MAGE-3 antibody 57B and anti-MAGE-1 antibody 6C1 can be used to study different proteins of the MAGE-A family. Int J Cancer 2000, 86:749-751.