Knockout of Lmod2 results in shorter thin filaments followed by dilated cardiomyopathy and juvenile lethality

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 44, 2015, Pages 13573-13578

  Pappas, Christopher T ^a,b   Mayfield, Rachel M ^a,b   Henderson, Christine ^a,b   Jamilpour, Nima ^c   Cover, Cathleen ^a,b   Hernandez, Zachary ^a,b   Hutchinson, Kirk R ^a,b   Chu, Miensheng ^a,b   Nam, Ki Hwan ^c   Valdez, Jose M ^c   Wong, Pak Kin ^c   Granzier, Henk L ^a,b   Gregorio, Carol C ^a,b  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

^c University of Arizona   (United States)

Author keywords

Actin thin filaments; Cardiomyopathy; Cytoskeletal dynamics

Indexed keywords

ACTIN BINDING PROTEIN; ALPHA ACTININ; ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; ELONGATION FACTOR; LEIOMODIN 2; LEIOMODIN 3; MYOSIN; PROTEIN P15; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; TROPOMODULIN; TROPOMODULIN 1; UNCLASSIFIED DRUG; CYTOSKELETON PROTEIN; LEIOMODIN PROTEIN, MOUSE; MUSCLE PROTEIN; PHOTOPROTEIN;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL WALL THICKNESS; ARTICLE; BODY WEIGHT; CAUSE OF DEATH; CELL SHAPE; CELL STIMULATION; CELL ULTRASTRUCTURE; CONGESTIVE CARDIOMYOPATHY; CONTROLLED STUDY; DISEASE COURSE; DOWN REGULATION; ECHOCARDIOGRAPHY; EMBRYO; ENZYME ACTIVITY; EXON; GENE INACTIVATION; GENE OVEREXPRESSION; GENOTYPE; HEART LEFT VENTRICLE HYPERTROPHY; HEART MUSCLE CELL; HEART MUSCLE CONTRACTILE FORCE; HEART WEIGHT; HETEROZYGOTE; IN VITRO STUDY; IN VIVO STUDY; LETHALITY; LIFESPAN; MITOCHONDRION SWELLING; MOLECULAR DYNAMICS; MOUSE; MUSCLE FIBRIL; NEWBORN; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN ASSEMBLY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SARCOMERE LENGTH; SIGNAL TRANSDUCTION; SURVIVAL RATE; SYSTOLIC DYSFUNCTION; THERAPY EFFECT; VIRAL GENE DELIVERY SYSTEM; ANIMAL; CARDIAC MUSCLE; CELL CULTURE; EMBRYOLOGY; FLUORESCENCE MICROSCOPY; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GENETICS; HEART; IMMUNOBLOTTING; KNOCKOUT MOUSE; LETHAL GENE; METABOLISM; MUSCLE CONTRACTION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SARCOMERE; SKELETAL MUSCLE; SURVIVAL ANALYSIS; TRANSGENIC MOUSE; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE;

ACTIN CYTOSKELETON; ANIMALS; ANIMALS, NEWBORN; CARDIOMYOPATHY, DILATED; CELLS, CULTURED; CYTOSKELETAL PROTEINS; FLUORESCENCE RECOVERY AFTER PHOTOBLEACHING; GENES, LETHAL; HEART; IMMUNOBLOTTING; LUMINESCENT PROTEINS; MICE, KNOCKOUT; MICE, TRANSGENIC; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; MUSCLE CONTRACTION; MUSCLE PROTEINS; MUSCLE, SKELETAL; MYOCARDIUM; SARCOMERES; SURVIVAL ANALYSIS;

EID: 84946607233     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1508273112     Document Type: Article

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