Disruption of pulmonary lipid homeostasis drives cigarette smoke-induced lung inflammation in mice

European Respiratory Journal

Volumn 46, Issue 5, 2015, Pages 1451-1460

  Morissette, Mathieu C ^a   Shen, Pamela ^b   Thayaparan, Danya ^b   Stämpfli, Martin R ^a,c  

^a MCMASTER UNIVERSITY   (Canada)

^b MCMASTER UNIVERSITY   (Canada)

^c MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CIGARETTE SMOKE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; OXIDIZED LOW DENSITY LIPOPROTEIN; PHOSPHOLIPID; TOLL LIKE RECEPTOR 4; LOW DENSITY LIPOPROTEIN; TLR4 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; FOAM CELL; LIPID HOMEOSTASIS; LIPID STORAGE; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; MOUSE; NONHUMAN; PNEUMONIA; PRIORITY JOURNAL; SMOKING; ADVERSE EFFECTS; ANIMAL; BRONCHOALVEOLAR LAVAGE FLUID; C3H MOUSE; C57BL MOUSE; CHEMICALLY INDUCED; DISEASE MODEL; HOMEOSTASIS; HUMAN; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; DISEASE MODELS, ANIMAL; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HOMEOSTASIS; HUMANS; INTERLEUKIN-1ALPHA; INTERLEUKIN-1BETA; LIPOPROTEINS, LDL; MACROPHAGES, ALVEOLAR; MICE; MICE, INBRED C3H; MICE, INBRED C57BL; PNEUMONIA; SMOKING; TOLL-LIKE RECEPTOR 4;

EID: 84946605874     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00216914     Document Type: Article

References (24)

1. US Dept of Health and Human Services. The Health Consequences of Smoking: 50 Years of Progress. A Report of the Surgeon General. Atlanta, US Dept of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2014.
2. Martin RR. Altered morphology and increased acid hydrolase content of pulmonary macrophages from cigarette smokers. Am Rev Respir Dis 1973; 107: 596-601.
3. Pratt SA, Finley TN, Smith MH, et al. A comparison of alveolar macrophages and pulmonary surfactant(?) obtained from the lungs of human smokers and nonsmokers by endobronchial lavage. Anat Rec 1969; 163: 497-507.
4. Guilliams M, Lambrecht BN, Hammad H. Division of labor between lung dendritic cells and macrophages in the defense against pulmonary infections. Mucosal Immunol 2013; 6: 464-473.
5. Carey B, Trapnell BC. The molecular basis of pulmonary alveolar proteinosis. Clin Immunol 2010; 135: 223-235.
6. Finley TN, Ladman AJ. Low yield of pulmonary surfactant in cigarette smokers. N Engl J Med 1972; 286: 223-227.
7. Morissette MC, Lamontagne M, Berube JC, et al. Impact of cigarette smoke on the human and mouse lungs: a gene-expression comparison study. PLoS One 2014; 9: e92498.
8. Rahman I, van Schadewijk AA, Crowther AJ, et al. 4-Hydroxy-2-nonenal, a specific lipid peroxidation product, is elevated in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2002; 166: 490-495.
9. Aoshiba K, Koinuma M, Yokohori N, et al. Immunohistochemical evaluation of oxidative stress in murine lungs after cigarette smoke exposure. Inhal Toxicol 2003; 15: 1029-1038.
10. Malhotra D, Thimmulappa R, Navas-Acien A, et al. Decline in NRF2-regulated antioxidants in chronic obstructive pulmonary disease lungs due to loss of its positive regulator, DJ-1. Am J Respir Crit Care Med 2008; 178: 592-604.
11. Botelho FM, Gaschler GJ, Kianpour S, et al. Innate immune processes are sufficient for driving cigarette smoke-induced inflammation in mice. Am J Respir Cell Mol Biol 2010; 42: 394-403.
12. Botelho FM, Bauer CM, Finch D, et al. IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice. PLoS One 2011; 6: e28457.
13. Lundberg AM, Hansson GK. Innate immune signals in atherosclerosis. Clin Immunol 2010; 134: 5-24.
14. Moore KJ, Sheedy FJ, Fisher EA. Macrophages in atherosclerosis: a dynamic balance. Nat Rev Immunol 2013; 13: 709-721.
15. Botelho FM, Nikota JK, Bauer CM, et al. Cigarette smoke-induced accumulation of lung dendritic cells is interleukin-1α-dependent in mice. Respir Res 2012; 13: 81.
16. Agassandian M, Mallampalli RK. Surfactant phospholipid metabolism. Biochim Biophys Acta 2013; 1831: 612-625.
17. Vlahos R, Bozinovski S, Chan SP, et al. Neutralizing granulocyte/macrophage colony-stimulating factor inhibits cigarette smoke-induced lung inflammation. Am J Respir Crit Care Med 2010; 182: 34-40.
18. Doz E, Noulin N, Boichot E, et al. Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent. J Immunol 2008; 180: 1169-1178.
19. Maes T, Bracke KR, Vermaelen KY, et al. Murine TLR4 is implicated in cigarette smoke-induced pulmonary inflammation. Int Arch Allergy Immunol 2006; 141: 354-368.
20. Hirama N, Shibata Y, Otake K, et al. Increased surfactant protein-D and foamy macrophages in smoking-induced mouse emphysema. Respirology 2007; 12: 191-201.
21. Wilson AM, Nair P, Hargreave FE, et al. Lipid and smoker's inclusions in sputum macrophages in patients with airway diseases. Respir Med 2011; 105: 1691-1695.
22. Pauwels NS, Bracke KR, Dupont LL, et al. Role of IL-1α and the Nlrp3/caspase-1/IL-1β axis in cigarette smoke-induced pulmonary inflammation and COPD. Eur Respir J 2011; 38: 1019-1028.
23. Botelho FM, Nikota JK, Bauer C, et al. A mouse GM-CSF receptor antibody attenuates neutrophilia in mice exposed to cigarette smoke. Eur Respir J 2011; 38: 285-294.
24. Nikota JK, Shen P, Morissette MC, et al. Cigarette smoke primes the pulmonary environment to IL-1α/CXCR-2-dependent nontypeable Haemophilus influenzae-exacerbated neutrophilia in mice. J Immunol 2014; 193: 3134-3145.