-
1
-
-
84908622807
-
Budgets up at NIH, NCI, and FDA
-
Anonymous. 2014. Budgets up at NIH, NCI, and FDA. Cancer Discovery 4:263. doi: 10.1158/2159-8290.CD-NB2014-016.
-
(2014)
Cancer Discovery
, vol.4
, pp. 263
-
-
Anonymous1
-
2
-
-
2442669093
-
Preclinical evaluation of the tyrosine kinase inhibitor SU11248 as a single agent and in combination with 'standard of care' therapeutic agents for the treatment of breast cancer
-
Abrams TJ, Murray LJ, Pesenti E, Holway VW, Colombo T, Lee LB, Cherrington JM, Pryer NK. 2003. Preclinical evaluation of the tyrosine kinase inhibitor SU11248 as a single agent and in combination with 'standard of care' therapeutic agents for the treatment of breast cancer. Molecular Cancer Therapeutics 2:1011-1021.
-
(2003)
Molecular Cancer Therapeutics
, vol.2
, pp. 1011-1021
-
-
Abrams, T.J.1
Murray, L.J.2
Pesenti, E.3
Holway, V.W.4
Colombo, T.5
Lee, L.B.6
Cherrington, J.M.7
Pryer, N.K.8
-
3
-
-
33645675960
-
Estimating the cost of new drug development: Is it really 802 million dollars?
-
Adams CP, Brantner VV. 2006. Estimating the cost of new drug development: is it really 802 million dollars? Health Affairs 25:420-428. doi: 10.1377/hlthaff.25.2.420.
-
(2006)
Health Affairs
, vol.25
, pp. 420-428
-
-
Adams, C.P.1
Brantner, V.V.2
-
4
-
-
57349166617
-
What is the translational efficacy of chemotherapeutic drug research in neuro-oncology? A systematic review and meta-analysis of the efficacy of BCNU and CCNU in animal models of glioma
-
Amarasingh S, Macleod MR, Whittle IR. 2009. What is the translational efficacy of chemotherapeutic drug research in neuro-oncology? A systematic review and meta-analysis of the efficacy of BCNU and CCNU in animal models of glioma. Journal of Neuro-Oncology 91:117-125. doi: 10.1007/s11060-008-9697-z.
-
(2009)
Journal of Neuro-Oncology
, vol.91
, pp. 117-125
-
-
Amarasingh, S.1
Macleod, M.R.2
Whittle, I.R.3
-
5
-
-
33645077600
-
YM-359445, an orally bioavailable vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, has highly potent antitumor activity against established tumors
-
Amino N, Ideyama Y, Yamano M, Kuromitsu S, Tajinda K, Samizu K, Hisamichi H, Matsuhisa A, Shirasuna K, Kudoh M, Shibasaki M. 2006. YM-359445, an orally bioavailable vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, has highly potent antitumor activity against established tumors. Clinical Cancer Research 12:1630-1638. doi: 10.1158/1078-0432.CCR-05-2028.
-
(2006)
Clinical Cancer Research
, vol.12
, pp. 1630-1638
-
-
Amino, N.1
Ideyama, Y.2
Yamano, M.3
Kuromitsu, S.4
Tajinda, K.5
Samizu, K.6
Hisamichi, H.7
Matsuhisa, A.8
Shirasuna, K.9
Kudoh, M.10
Shibasaki, M.11
-
6
-
-
84881304772
-
Six red flags for suspect work
-
Begley CG. 2013a. Six red flags for suspect work. Nature 497:433-434. doi: 10.1038/497433a.
-
(2013)
Nature
, vol.497
, pp. 433-434
-
-
Begley, C.G.1
-
7
-
-
84923367585
-
An unappreciated challenge to oncology drug discovery: Pitfalls in preclinical research
-
Begley CG. 2013b. An unappreciated challenge to oncology drug discovery: pitfalls in preclinical research. American Society of Clinical Oncology Educational Book 2013:466-468. doi: 10.1200/EdBook_AM.2013.33.466.
-
(2013)
American Society of Clinical Oncology Educational Book
, vol.2013
, pp. 466-468
-
-
Begley, C.G.1
-
8
-
-
84859169880
-
Drug development: Raise standards for preclinical cancer research
-
Begley CG, Ellis LM. 2012. Drug development: raise standards for preclinical cancer research. Nature 483:531-533. doi: 10.1038/483531a.
-
(2012)
Nature
, vol.483
, pp. 531-533
-
-
Begley, C.G.1
Ellis, L.M.2
-
9
-
-
84920769131
-
Reproducibility in science: Improving the standard for basic and preclinical research
-
Begley CG, Ioannidis JP. 2015. Reproducibility in science: improving the standard for basic and preclinical research. Circulation Research 116:116-126. doi: 10.1161/CIRCRESAHA.114.303819.
-
(2015)
Circulation Research
, vol.116
, pp. 116-126
-
-
Begley, C.G.1
Ioannidis, J.P.2
-
10
-
-
33947504730
-
Sunitinib: From rational design to clinical efficacy
-
Chow LQ, Eckhardt SG. 2007. Sunitinib: from rational design to clinical efficacy. Journal of Clinical Oncology 25:884-896. doi: 10.1200/JCO.2006.06.3602.
-
(2007)
Journal of Clinical Oncology
, vol.25
, pp. 884-896
-
-
Chow, L.Q.1
Eckhardt, S.G.2
-
11
-
-
27644468268
-
How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men
-
Corpet DE, Pierre F. 2005. How good are rodent models of carcinogenesis in predicting efficacy in humans? A systematic review and meta-analysis of colon chemoprevention in rats, mice and men. European Journal of Cancer 41:1911-1922. doi: 10.1016/j.ejca.2005.06.006.
-
(2005)
European Journal of Cancer
, vol.41
, pp. 1911-1922
-
-
Corpet, D.E.1
Pierre, F.2
-
12
-
-
41249090758
-
Empirical evidence of bias in the design of experimental stroke studies: A metaepidemiologic approach
-
Crossley NA, Sena E, Goehler J, Horn J, van der Worp B, Bath PM, Macleod M, Dirnagl U. 2008. Empirical evidence of bias in the design of experimental stroke studies: a metaepidemiologic approach. Stroke 39:929-934. doi: 10.1161/STROKEAHA.107.498725.
-
(2008)
Stroke
, vol.39
, pp. 929-934
-
-
Crossley, N.A.1
Sena, E.2
Goehler, J.3
Horn, J.4
van der Worp, B.5
Bath, P.M.6
Macleod, M.7
Dirnagl, U.8
-
13
-
-
84879409719
-
The Lambeth Conventions (II): Guidelines for the study of animal and human ventricular and supraventricular arrhythmias
-
Curtis MJ, Hancox JC, Farkas A, Wainwright CL, Stables CL, Saint DA, Clements-Jewery H, Lambiase PD, Billman GE, Janse MJ, Pugsley MK, Ng GA, Roden DM, Camm AJ, Walker MJ. 2013. The Lambeth Conventions (II): guidelines for the study of animal and human ventricular and supraventricular arrhythmias. Pharmacology & Therapeutics 139:213-248. doi: 10.1016/j.pharmthera.2013.04.008.
-
(2013)
Pharmacology & Therapeutics
, vol.139
, pp. 213-248
-
-
Curtis, M.J.1
Hancox, J.C.2
Farkas, A.3
Wainwright, C.L.4
Stables, C.L.5
Saint, D.A.6
Clements-Jewery, H.7
Lambiase, P.D.8
Billman, G.E.9
Janse, M.J.10
Pugsley, M.K.11
Ng, G.A.12
Roden, D.M.13
Camm, A.J.14
Walker, M.J.15
-
14
-
-
80054780787
-
A search filter for increasing the retrieval of animal studies in Embase
-
de Vries RB, Hooijmans CR, Tillema A, Leenaars M, Ritskes-Hoitinga M. 2011. A search filter for increasing the retrieval of animal studies in Embase. Laboratory Animals 45:268-270. doi: 10.1258/la.2011.011056.
-
(2011)
Laboratory Animals
, vol.45
, pp. 268-270
-
-
de Vries, R.B.1
Hooijmans, C.R.2
Tillema, A.3
Leenaars, M.4
Ritskes-Hoitinga, M.5
-
16
-
-
84989876837
-
-
Dietz G, Dahabreh IJ, Gurevitch J, Lajeunesse MJ, Schmid CH, Trikalinos TA, Wallace BC. 2014. OpenMEE: software for ecological and evolutionary meta-analysis.
-
(2014)
OpenMEE: Software for ecological and evolutionary meta-analysis
-
-
Dietz, G.1
Dahabreh, I.J.2
Gurevitch, J.3
Lajeunesse, M.J.4
Schmid, C.H.5
Trikalinos, T.A.6
Wallace, B.C.7
-
17
-
-
33644847440
-
Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer
-
Faivre S, Delbaldo C, Vera K, Robert C, Lozahic S, Lassau N, Bello C, Deprimo S, Brega N, Massimini G, Armand JP, Scigalla P, Raymond E. 2006. Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer. Journal of Clinical Oncology 24:25-35. doi: 10.1200/JCO.2005.02.2194.
-
(2006)
Journal of Clinical Oncology
, vol.24
, pp. 25-35
-
-
Faivre, S.1
Delbaldo, C.2
Vera, K.3
Robert, C.4
Lozahic, S.5
Lassau, N.6
Bello, C.7
Deprimo, S.8
Brega, N.9
Massimini, G.10
Armand, J.P.11
Scigalla, P.12
Raymond, E.13
-
18
-
-
66849097996
-
Update of the stroke therapy academic industry roundtable preclinical recommendations
-
Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, Lo EH, STAIR Group. 2009. Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke 40:2244-2250. doi: 10.1161/STROKEAHA.108.541128.
-
(2009)
Stroke
, vol.40
, pp. 2244-2250
-
-
Fisher, M.1
Feuerstein, G.2
Howells, D.W.3
Hurn, P.D.4
Kent, T.A.5
Savitz, S.I.6
Lo, E.H.7
-
19
-
-
84857648355
-
Identification of new epilepsy treatments: Issues in preclinical methodology
-
Galanopoulou AS, Buckmaster PS, Staley KJ, MoshéSL, Perucca E, Engel J Jr, Löscher W, Noebels JL, Pitkänen A, Stables J, White HS, O'Brien TJ, Simonato M, American Epilepsy Society Basic Science Committee And The International League Against Epilepsy Working Group On Recommendations For Preclinical Epilepsy Drug Discovery. 2012. Identification of new epilepsy treatments: issues in preclinical methodology. Epilepsia 53:571-582. doi: 10.1111/j.1528-1167.2011.03391.x.
-
(2012)
Epilepsia
, vol.53
, pp. 571-582
-
-
Galanopoulou, A.S.1
Buckmaster, P.S.2
Staley, K.J.3
Moshé, S.L.4
Perucca, E.5
Engel, J.6
Löscher, W.7
Noebels, J.L.8
Pitkänen, A.9
Stables, J.10
White, H.S.11
O'Brien, T.J.12
Simonato, M.13
American Epilepsy Society Basic Science14
-
20
-
-
84892575232
-
Reducing waste from incomplete or unusable reports of biomedical research
-
Glasziou P, Altman DG, Bossuyt P, Boutron I, Clarke M, Julious S, Michie S, Moher D, Wager E. 2014. Reducing waste from incomplete or unusable reports of biomedical research. Lancet 383:267-276. doi: 10.1016/S0140-6736(13)62228-X.
-
(2014)
Lancet
, vol.383
, pp. 267-276
-
-
Glasziou, P.1
Altman, D.G.2
Bossuyt, P.3
Boutron, I.4
Clarke, M.5
Julious, S.6
Michie, S.7
Moher, D.8
Wager, E.9
-
21
-
-
84872157738
-
A phase II study of sunitinib in patients with relapsed or refractory small cell lung cancer
-
Han JY, Kim HY, Lim KY, Han JH, Lee YJ, Kwak MH, Kim HJ, Yun T, Kim HT, Lee JS. 2013. A phase II study of sunitinib in patients with relapsed or refractory small cell lung cancer. Lung Cancer 79:137-142. doi: 10.1016/j. lungcan.2012.09.019.
-
(2013)
Lung Cancer
, vol.79
, pp. 137-142
-
-
Han, J.Y.1
Kim, H.Y.2
Lim, K.Y.3
Han, J.H.4
Lee, Y.J.5
Kwak, M.H.6
Kim, H.J.7
Yun, T.8
Kim, H.T.9
Lee, J.S.10
-
22
-
-
84892153139
-
Clinical development success rates for investigational drugs
-
Hay M, Thomas DW, Craighead JL, Economides C, Rosenthal J. 2014. Clinical development success rates for investigational drugs. Nature Biotechnology 32:40-51. doi: 10.1038/nbt.2786.
-
(2014)
Nature Biotechnology
, vol.32
, pp. 40-51
-
-
Hay, M.1
Thomas, D.W.2
Craighead, J.L.3
Economides, C.4
Rosenthal, J.5
-
23
-
-
84881240391
-
Threats to validity in the design and conduct of preclinical efficacy studies: A systematic review of guidelines for in vivo animal experiments
-
Henderson VC, Kimmelman J, Fergusson D, Grimshaw JM, Hackam DG. 2013. Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments. PLOS Medicine 10:e1001489. doi: 10.1371/journal.pmed.1001489.
-
(2013)
PLOS Medicine
, vol.10
-
-
Henderson, V.C.1
Kimmelman, J.2
Fergusson, D.3
Grimshaw, J.M.4
Hackam, D.G.5
-
24
-
-
31844443695
-
The environment and disease: Association or causation?
-
Hill AB. 1965. The environment and disease: association or causation? Proceedings of the Royal Society of Medicine 58:295-300.
-
(1965)
Proceedings of the Royal Society of Medicine
, vol.58
, pp. 295-300
-
-
Hill, A.B.1
-
25
-
-
84872557623
-
Systematic review and meta-analysis of temozolomide in animal models of glioma: Was clinical efficacy predicted?
-
Hirst TC, Vesterinen HM, Sena ES, Egan KJ, Macleod MR, Whittle IR. 2013. Systematic review and meta-analysis of temozolomide in animal models of glioma: was clinical efficacy predicted? British Journal of Cancer 108:64-71. doi: 10.1038/bjc.2012.504.
-
(2013)
British Journal of Cancer
, vol.108
, pp. 64-71
-
-
Hirst, T.C.1
Vesterinen, H.M.2
Sena, E.S.3
Egan, K.J.4
Macleod, M.R.5
Whittle, I.R.6
-
26
-
-
77954447104
-
Enhancing search efficiency by means of a search filter for finding all studies on animal experimentation in PubMed
-
Hooijmans CR, Tillema A, Leenaars M, Ritskes-Hoitinga M. 2010. Enhancing search efficiency by means of a search filter for finding all studies on animal experimentation in PubMed. Laboratory Animals 44:170-175. doi: 10.1258/ la.2010.009117.
-
(2010)
Laboratory Animals
, vol.44
, pp. 170-175
-
-
Hooijmans, C.R.1
Tillema, A.2
Leenaars, M.3
Ritskes-Hoitinga, M.4
-
27
-
-
77953033291
-
Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: Results of a pharmacokinetic/pharmacodynamic meta-analysis
-
Houk BE, Bello CL, Poland B, Rosen LS, Demetri GD, Motzer RJ. 2010. Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: results of a pharmacokinetic/pharmacodynamic meta-analysis. Cancer Chemotherapy and Pharmacology 66:357-371. doi: 10.1007/s00280-009-1170-y.
-
(2010)
Cancer Chemotherapy and Pharmacology
, vol.66
, pp. 357-371
-
-
Houk, B.E.1
Bello, C.L.2
Poland, B.3
Rosen, L.S.4
Demetri, G.D.5
Motzer, R.J.6
-
28
-
-
2042458747
-
Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials
-
Johnson JI, Decker S, Zaharevitz D, Rubinstein LV, Venditti JM, Schepartz S, Kalyandrug S, Christian M, Arbuck S, Hollingshead M, Sausville EA. 2001. Relationships between drug activity in NCI preclinical in vitro and in vivo models and early clinical trials. British Journal of Cancer 84:1424-1431. doi: 10.1054/bjoc.2001.1796.
-
(2001)
British Journal of Cancer
, vol.84
, pp. 1424-1431
-
-
Johnson, J.I.1
Decker, S.2
Zaharevitz, D.3
Rubinstein, L.V.4
Venditti, J.M.5
Schepartz, S.6
Kalyandrug, S.7
Christian, M.8
Arbuck, S.9
Hollingshead, M.10
Sausville, E.A.11
-
29
-
-
1542436704
-
Human tumor xenografts as predictive preclinical models for anticancer drug activity in humans: Better than commonly perceived-but they can be improved
-
Kerbel RS. 2003. Human tumor xenografts as predictive preclinical models for anticancer drug activity in humans: better than commonly perceived-but they can be improved. Cancer Biology & Therapy 2(4 Suppl 1):S134-S139.
-
(2003)
Cancer Biology & Therapy
, vol.2
, Issue.4
, pp. S134-S139
-
-
Kerbel, R.S.1
-
30
-
-
85041813459
-
Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research
-
Kilkenny C, Browne WJ, Cuthill IC, Emerson M, Altman DG. 2010. Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research. PLOS Biology 8:e1000412. doi: 10.1371/journal.pbio.1000412.
-
(2010)
PLOS Biology
, vol.8
-
-
Kilkenny, C.1
Browne, W.J.2
Cuthill, I.C.3
Emerson, M.4
Altman, D.G.5
-
31
-
-
76849104977
-
Survey of the quality of experimental design, statistical analysis and reporting of research using animals
-
Kilkenny C, Parsons N, Kadyszewski E, Festing MF, Cuthill IC, Fry D, Hutton J, Altman DG. 2009. Survey of the quality of experimental design, statistical analysis and reporting of research using animals. PLOS ONE 4:e7824. doi: 10.1371/journal.pone.0007824.
-
(2009)
PLOS ONE
, vol.4
-
-
Kilkenny, C.1
Parsons, N.2
Kadyszewski, E.3
Festing, M.F.4
Cuthill, I.C.5
Fry, D.6
Hutton, J.7
Altman, D.G.8
-
32
-
-
77951754469
-
Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained
-
Ko JS, Rayman P, Ireland J, Swaidani S, Li G, Bunting KD, Rini B, Finke JH, Cohen PA. 2010. Direct and differential suppression of myeloid-derived suppressor cell subsets by sunitinib is compartmentally constrained. Cancer Research 70:3526-3536. doi: 10.1158/0008-5472.CAN-09-3278.
-
(2010)
Cancer Research
, vol.70
, pp. 3526-3536
-
-
Ko, J.S.1
Rayman, P.2
Ireland, J.3
Swaidani, S.4
Li, G.5
Bunting, K.D.6
Rini, B.7
Finke, J.H.8
Cohen, P.A.9
-
33
-
-
33748935095
-
The case of the misleading funnel plot
-
Lau J, Ioannidis JP, Terrin N, Schmid CH, Olkin I. 2006. The case of the misleading funnel plot. BMJ 333:597-600. doi: 10.1136/bmj.333.7568.597.
-
(2006)
BMJ
, vol.333
, pp. 597-600
-
-
Lau, J.1
Ioannidis, J.P.2
Terrin, N.3
Schmid, C.H.4
Olkin, I.5
-
34
-
-
2142768247
-
Pooling of animal experimental data reveals influence of study design and publication bias
-
Macleod MR, O'Collins T, Howells DW, Donnan GA. 2004. Pooling of animal experimental data reveals influence of study design and publication bias. Stroke 35:1203-1208. doi: 10.1161/01.STR.0000125719.25853.20.
-
(2004)
Stroke
, vol.35
, pp. 1203-1208
-
-
Macleod, M.R.1
O'Collins, T.2
Howells, D.W.3
Donnan, G.A.4
-
35
-
-
44149115014
-
Initial testing (stage 1) of sunitinib by the pediatric preclinical testing program
-
Maris JM, Courtright J, Houghton PJ, Morton CL, Kolb EA, Lock R, Tajbakhsh M, Reynolds CP, Keir ST, Wu J, Smith MA. 2008. Initial testing (stage 1) of sunitinib by the pediatric preclinical testing program. Pediatric Blood & Cancer 51:42-48. doi: 10.1002/pbc.21535.
-
(2008)
Pediatric Blood & Cancer
, vol.51
, pp. 42-48
-
-
Maris, J.M.1
Courtright, J.2
Houghton, P.J.3
Morton, C.L.4
Kolb, E.A.5
Lock, R.6
Tajbakhsh, M.7
Reynolds, C.P.8
Keir, S.T.9
Wu, J.10
Smith, M.A.11
-
36
-
-
84930652123
-
Time to do something about reproducibility
-
Morrison SJ. 2014. Time to do something about reproducibility. eLife 3:e03981. doi: 10.7554/eLife.03981.
-
(2014)
eLife
, vol.3
-
-
Morrison, S.J.1
-
37
-
-
68949145218
-
Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma
-
Motzer RJ, Hutson TE, Tomczak P, Michaelson MD, Bukowski RM, Oudard S, Negrier S, Szczylik C, Pili R, Bjarnason GA, Garcia-del-Muro X, Sosman JA, Solska E, Wilding G, Thompson JA, Kim ST, Chen I, Huang X, Figlin RA. 2009. Overall survival and updated results for sunitinib compared with interferon alfa in patients with metastatic renal cell carcinoma. Journal of Clinical Oncology 27:3584-3590. doi: 10.1200/JCO.2008.20.1293.
-
(2009)
Journal of Clinical Oncology
, vol.27
, pp. 3584-3590
-
-
Motzer, R.J.1
Hutson, T.E.2
Tomczak, P.3
Michaelson, M.D.4
Bukowski, R.M.5
Oudard, S.6
Negrier, S.7
Szczylik, C.8
Pili, R.9
Bjarnason, G.A.10
Garcia-Del-Muro, X.11
Sosman, J.A.12
Solska, E.13
Wilding, G.14
Thompson, J.A.15
Kim, S.T.16
Chen, I.17
Huang, X.18
Figlin, R.A.19
-
38
-
-
33644833910
-
Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma
-
Motzer RJ, Michaelson MD, Redman BG, Hudes GR, Wilding G, Figlin RA, Ginsberg MS, Kim ST, Baum CM, DePrimo SE, Li JZ, Bello CL, Theuer CP, George DJ, Rini BI. 2006a. Activity of SU11248, a multitargeted inhibitor of vascular endothelial growth factor receptor and platelet-derived growth factor receptor, in patients with metastatic renal cell carcinoma. Journal of Clinical Oncology 24:16-24. doi: 10.1200/JCO.2005.02.2574.
-
(2006)
Journal of Clinical Oncology
, vol.24
, pp. 16-24
-
-
Motzer, R.J.1
Michaelson, M.D.2
Redman, B.G.3
Hudes, G.R.4
Wilding, G.5
Figlin, R.A.6
Ginsberg, M.S.7
Kim, S.T.8
Baum, C.M.9
DePrimo, S.E.10
Li, J.Z.11
Bello, C.L.12
Theuer, C.P.13
George, D.J.14
Rini, B.I.15
-
39
-
-
33744954585
-
Sunitinib in patients with metastatic renal cell carcinoma
-
Motzer RJ, Rini BI, Bukowski RM, Curti BD, George DJ, Hudes GR, Redman BG, Margolin KA, Merchan JR, Wilding G, Ginsberg MS, Bacik J, Kim ST, Baum CM, Michaelson MD. 2006b. Sunitinib in patients with metastatic renal cell carcinoma. JAMA 295:2516-2524. doi: 10.1001/jama.295.21.2516.
-
(2006)
JAMA
, vol.295
, pp. 2516-2524
-
-
Motzer, R.J.1
Rini, B.I.2
Bukowski, R.M.3
Curti, B.D.4
George, D.J.5
Hudes, G.R.6
Redman, B.G.7
Margolin, K.A.8
Merchan, J.R.9
Wilding, G.10
Ginsberg, M.S.11
Bacik, J.12
Kim, S.T.13
Baum, C.M.14
Michaelson, M.D.15
-
40
-
-
33644818304
-
1, 026 experimental treatments in acute stroke
-
O'Collins VE, Macleod MR, Donnan GA, Horky LL, van der Worp BH, Howells DW. 2006. 1, 026 experimental treatments in acute stroke. Annals of Neurology 59:467-477. doi: 10.1002/ana.20741.
-
(2006)
Annals of Neurology
, vol.59
, pp. 467-477
-
-
O'Collins, V.E.1
Macleod, M.R.2
Donnan, G.A.3
Horky, L.L.4
van der Worp, B.H.5
Howells, D.W.6
-
41
-
-
1942422737
-
Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development
-
Peterson JK, Houghton PJ. 2004. Integrating pharmacology and in vivo cancer models in preclinical and clinical drug development. European Journal of Cancer 40:837-844. doi: 10.1016/j.ejca.2004.01.003.
-
(2004)
European Journal of Cancer
, vol.40
, pp. 837-844
-
-
Peterson, J.K.1
Houghton, P.J.2
-
42
-
-
84889576309
-
Reproducibility of research and preclinical validation: Problems and solutions
-
Pusztai L, Hatzis C, Andre F. 2013. Reproducibility of research and preclinical validation: problems and solutions. Nature Reviews Clinical Oncology 10:720-724. doi: 10.1038/nrclinonc.2013.171.
-
(2013)
Nature Reviews Clinical Oncology
, vol.10
, pp. 720-724
-
-
Pusztai, L.1
Hatzis, C.2
Andre, F.3
-
43
-
-
79851482955
-
Sunitinib malate for the treatment of pancreatic neuroendocrine tumors
-
Raymond E, Dahan L, Raoul JL, Bang YJ, Borbath I, Lombard-Bohas C, Valle J, Metrakos P, Smith D, Vinik A, Chen JS, Hörsch D, Hammel P, Wiedenmann B, Van Cutsem E, Patyna S, Lu DR, Blanckmeister C, Chao R, Ruszniewski P. 2011. Sunitinib malate for the treatment of pancreatic neuroendocrine tumors. The New England Journal of Medicine 364:501-513. doi: 10.1056/NEJMoa1003825.
-
(2011)
The New England Journal of Medicine
, vol.364
, pp. 501-513
-
-
Raymond, E.1
Dahan, L.2
Raoul, J.L.3
Bang, Y.J.4
Borbath, I.5
Lombard-Bohas, C.6
Valle, J.7
Metrakos, P.8
Smith, D.9
Vinik, A.10
Chen, J.S.11
Hörsch, D.12
Hammel, P.13
Wiedenmann, B.14
Van Cutsem, E.15
Patyna, S.16
Lu, D.R.17
Blanckmeister, C.18
Chao, R.19
Ruszniewski, P.20
more..
-
44
-
-
79957948408
-
Dopamine agonists in animal models of Parkinson's disease: A systematic review and meta-analysis
-
Rooke ED, Vesterinen HM, Sena ES, Egan KJ, Macleod MR. 2011. Dopamine agonists in animal models of Parkinson's disease: a systematic review and meta-analysis. Parkinsonism & Related Disorders 17:313-320. doi: 10.1016/j.parkreldis.2011.02.010.
-
(2011)
Parkinsonism & Related Disorders
, vol.17
, pp. 313-320
-
-
Rooke, E.D.1
Vesterinen, H.M.2
Sena, E.S.3
Egan, K.J.4
Macleod, M.R.5
-
45
-
-
84878978402
-
A proposal regarding reporting of in vitro testing results
-
Smith MA, Houghton P. 2013. A proposal regarding reporting of in vitro testing results. Clinical Cancer Research 19:2828-2833. doi: 10.1158/1078-0432.CCR-13-0043.
-
(2013)
Clinical Cancer Research
, vol.19
, pp. 2828-2833
-
-
Smith, M.A.1
Houghton, P.2
-
46
-
-
84868382855
-
Reporting of preclinical tumor-graft cancer therapeutic studies
-
Sugar E, Pascoe AJ, Azad N. 2012. Reporting of preclinical tumor-graft cancer therapeutic studies. Cancer Biology & Therapy 13:1262-1268. doi: 10.4161/cbt.21782.
-
(2012)
Cancer Biology & Therapy
, vol.13
, pp. 1262-1268
-
-
Sugar, E.1
Pascoe, A.J.2
Azad, N.3
-
47
-
-
84880934207
-
Evaluation of excess significance bias in animal studies of neurological diseases
-
Tsilidis KK, Panagiotou OA, Sena ES, Aretouli E, Evangelou E, Howells DW, Al-Shahi Salman R, Macleod MR, Ioannidis JP. 2013. Evaluation of excess significance bias in animal studies of neurological diseases. PLOS Biology 11:e1001609. doi: 10.1371/journal.pbio.1001609.
-
(2013)
PLOS Biology
, vol.11
-
-
Tsilidis, K.K.1
Panagiotou, O.A.2
Sena, E.S.3
Aretouli, E.4
Evangelou, E.5
Howells, D.W.6
Al-Shahi Salman, R.7
Macleod, M.R.8
Ioannidis, J.P.9
-
48
-
-
25144439926
-
Methodological quality of animal studies on neuroprotection in focal cerebral ischaemia
-
van der Worp HB, de Haan P, Morrema E, Kalkman CJ. 2005. Methodological quality of animal studies on neuroprotection in focal cerebral ischaemia. Journal of Neurology 252:1108-1114. doi: 10.1007/s00415-005-0802-3.
-
(2005)
Journal of Neurology
, vol.252
, pp. 1108-1114
-
-
van der Worp, H.B.1
de Haan, P.2
Morrema, E.3
Kalkman, C.J.4
-
49
-
-
77950679333
-
Can animal models of disease reliably inform human studies?
-
van der Worp HB, Howells DW, Sena ES, Porritt MJ, Rewell S, O'Collins V, Macleod MR. 2010. Can animal models of disease reliably inform human studies? PLOS Medicine 7:e1000245. doi: 10.1371/journal.pmed.1000245.
-
(2010)
PLOS Medicine
, vol.7
-
-
van der Worp, H.B.1
Howells, D.W.2
Sena, E.S.3
Porritt, M.J.4
Rewell, S.5
O'Collins, V.6
Macleod, M.R.7
-
50
-
-
0141566685
-
Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models
-
Voskoglou-Nomikos T, Pater JL, Seymour L. 2003. Clinical predictive value of the in vitro cell line, human xenograft, and mouse allograft preclinical cancer models. Clinical Cancer Research 9:4227-4239.
-
(2003)
Clinical Cancer Research
, vol.9
, pp. 4227-4239
-
-
Voskoglou-Nomikos, T.1
Pater, J.L.2
Seymour, L.3
-
51
-
-
73649108585
-
Meta-analyst: Software for meta-analysis of binary, continuous and diagnostic data
-
Wallace BC, Schmid CH, Lau J, Trikalinos TA. 2009. Meta-analyst: software for meta-analysis of binary, continuous and diagnostic data. BMC Medical Research Methodology 9:80. doi: 10.1186/1471-2288-9-80.
-
(2009)
BMC Medical Research Methodology
, vol.9
, pp. 80
-
-
Wallace, B.C.1
Schmid, C.H.2
Lau, J.3
Trikalinos, T.A.4
|