There's life in the old dog yet: Vitamin C as a therapeutic option in endothelial dysfunction

Critical Care

Volumn 18, Issue 4, 2014, Pages

  Rodemeister, Sandra ^a   Biesalski, Hans K ^a  

^a UNIVERSITY OF HOHENHEIM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ASCORBIC ACID; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PEROXYNITRITE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; TETRAHYDROBIOPTERIN; ANTIOXIDANT; VITAMIN;

BLOOD VESSEL TONE; CRITICALLY ILL PATIENT; DISEASE SEVERITY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG MEGADOSE; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; HUMAN; MOLECULAR INTERACTION; NONHUMAN; NOTE; OXIDATIVE STRESS; PRIORITY JOURNAL; SURVIVAL RATE; VITAMIN SUPPLEMENTATION; ANIMAL; PATHOPHYSIOLOGY; PHYSIOLOGY; REPERFUSION INJURY; SEPSIS;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; HUMANS; OXIDATIVE STRESS; REPERFUSION INJURY; SEPSIS; VITAMINS;

EID: 84946571365     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/s13054-014-0461-9     Document Type: Note

References (12)

1. Biesalski HK, McGregor GP: Antioxidant therapy in critical care - is the microcirculation the primary target? Crit Care Med 2007, 35(9 Suppl):S577-S583.
2. Oudemans-van Straaten HM, Spoelstra-de Man AM, de Waard MC: Vitamin C revisited. Crit Care 2014, 18:460.
3. Sena CM, Pereira AM, Seica R: Endothelial dysfunction - a major mediator of diabetic vascular disease. Biochim Biophys Acta 2013, 1832:2216-2231.
4. Kietadisorn R, Juni RP, Moens AL: Tackling endothelial dysfunction by modulating NOS uncoupling: new insights into its pathogenesis and therapeutic possibilities. Am J Physiol Endocrinol Metab 2012, 302:E481-E495.
5. Schmidt TS, Alp NJ: Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease. Clin Sci (Lond) 2007, 113:47-63.
6. Heart Protection Study Collaborative Group: MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002, 360:23-33.
7. Padayatty SJ, Sun H, Wang Y, Riordan HD, Hewitt SM, Katz A, Wesley RA, Levine M: Vitamin C pharmacokinetics: implications for oral and intravenous use. Ann Intern Med 2004, 140:533-537.
8. Lassnigg A, Punz A, Barker R, Keznickl P, Manhart N, Roth E, Hiesmayr M: Influence of intravenous vitamin E supplementation in cardiac surgery on oxidative stress: a double-blinded, randomized, controlled study. Br J Anaesth 2003, 90:148-154.
9. Rodemeister S, Duquesne M, Adolph M, Nohr D, Biesalski HK, Unertl K: Massive and long-lasting decrease in vitamin C plasma levels as a consequence of extracorporeal circulation. Nutrition 2014, 30:673-678.
10. Cowley HC, Bacon PJ, Goode HF, Webster NR, Jones JG, Menon DK: Plasma antioxidant potential in severe sepsis: a comparison of survivors and nonsurvivors. Crit Care Med 1996, 24:1179-1183.
11. Long CL, Maull KI, Krishnan RS, Laws HL, Geiger JW, Borghesi L, Franks W, Lawson TC, Sauberlich HE: Ascorbic acid dynamics in the seriously ill and injured. J Surg Res 2003, 109:144-148.
12. Muhlhofer A, Mrosek S, Schlegel B, Trommer W, Rozario F, Bohles H, Schremmer D, Zoller WG, Biesalski HK: High-dose intravenous vitamin C is not associated with an increase of pro-oxidative biomarkers. Eur J Clin Nutr 2004, 58:1151-1158.