High-dose intravenous vitamin C is not associated with an increase of pro-oxidative biomakers

European Journal of Clinical Nutrition

Volumn 58, Issue 8, 2004, Pages 1151-1158

  Muhlhofer A ^a   Mrosek, S ^b   Schlegel, B ^b   Trommer, W ^c   Rozario, F ^c   Bohles H ^d   Schremmer, D ^e   Zoller, W G ^a   Biesalski, H K ^b  

^a Division of Gastroenterology   (Germany)

^b UNIVERSITY OF HOHENHEIM   (Germany)

^c University of Koblenz Landau   (Germany)

^d UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^e GKM Gesellschaft Therapieforsch mbH   (Germany)

Author keywords

Ascorbyl free radical kinetics; High dose vitamin C; Lacking pro oxidative damage

Indexed keywords

ASCORBIC ACID; BIOLOGICAL MARKER; FREE RADICAL; GUANOSINE DERIVATIVE; REACTIVE OXYGEN METABOLITE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; TOCOPHEROL;

ADULT; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIET RESTRICTION; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG DOSE REGIMEN; DRUG ELIMINATION; DRUG MECHANISM; DRUG MEGADOSE; HUMAN; KINETICS; MALE; NORMAL HUMAN; OXIDATIVE STRESS; STEADY STATE; URINALYSIS;

ADULT; ANTIOXIDANTS; ASCORBIC ACID; CROSS-OVER STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; FASTING; FREE RADICAL SCAVENGERS; FREE RADICALS; GUANOSINE; HUMANS; INFUSIONS, INTRAVENOUS; MALE; OXIDATION-REDUCTION; OXIDATIVE STRESS; PROSPECTIVE STUDIES; REACTIVE OXYGEN SPECIES; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 4444273747     PISSN: 09543007     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.ejcn.1601943     Document Type: Article

References (32)

1. Bates CJ (1992): Use of homocystein to stabilise ascorbic acid, or to reduce dehydroascorbic acid, during HPLC separation of large volumes of tissue extracts. Clin. Chim. Acta. 205, 249-252.
2. Bergsten P, Amitai G, Kehrl J, Dhanwal KR, Klein HG & Levine M (1990): Millimolar concentrations of ascorbic acid in purified human mononuclear leukocytes. Depletion and reaccumulation. Biochem. J. 265, 2584-2587.
3. Bergsten P, Yu R, Kehrl J & Levine M (1995): Ascorbic acid transport and distribution in human B lymphocytes. Arch. Biochem. Biophys. 317, 208-214.
4. Bianchi J & Rose RC (1986): Dehydroascorbic acid and cell membranes: possible disruptive effects. Toxicology 40, 75-82.
5. Biesalski HK, Greiff H, Brodda K, Hanfer G & Bässler KH (1986): Rapid determination of vitamin A (retinol) and vitamin E (á-tocopherol) in human serum by isocratic adsorption HPLC. Int. J. Nutr. Res. 56, 319-327.
6. Cai L, Koropatnick J & Cherian MG (2001): Roles of vitamin C in radiation-induced DNA -damage in presence and absence of copper. Chem. Biol. Interact. 137, 75-88.
7. Ellis GR, Anderson RA, Chirkov YY, Morris-Thurgood J, Jackson SK, Lewis MJ & Frenneaux MP (2001): Acute effects of vitamin C on platelet responsiveness to nitric oxide donors and endothelial function in patients with chronic heart failure. J. Cardiovasc. Pharmacol. 37, 564-570.
8. Galley HF, Davies MJ & Webster NR (1996): Ascorbyl radical formation in patients with sepsis: effect of ascorbate loading. Free Radic. Biol. Med. 20, 139-143.
9. Goldenberg H, Grebing C & Low H (1983): NADH-monodehydroascorbate reductase in human erythrocyte membranes. Biochem. Int. 6, 1-9.
10. Graumlich JF, Ludden TM, Conry-Cantilena C, Cantilena LR, Yaohui Jr W & Levine M (1997): Pharmacokinetic model of ascorbic acid in healthy volunteers during depletion and repletion. Pharmacol. Res. 14, 1133-1139.
11. Guidarelli A, De Sanctis R, Cellini B, Fiorani M, Dacha M & Cantoni O (2001): Intracellular ascorbic acid enhances the DNA single-strand breakage and toxicity induced by peroxynitrite in U937 cells. Biochem. J. 365, 509-513.
12. Heitzer T, Schlinzig T, Krohn K, Meinertz T & Munzel T (2001): Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 104, 2673-2678.
13. Jentzsch AM, Bachmann H, Fürst P & Biesalski HK (1996): Improved analysis of malondialdehyd in human body fluids. Free Radic. Biol. Med. 20, 251-256.
14. Jones B & Kenward MG (1989): Design and Analysis of Cross-Over Trials. London: Chapman and Hall. pp 51-59.
15. Lee SH, Oe T & Blair IA (2001): Vitamin C-induced decomposition of lipid hydro- peroxides to endogenous genotoxins. Science 292, 2083-2086.
16. Levine M, Conry-Cantilena C, Yaohui Wang J, Welch RW, Washko PW, Dhariwal KR, Park JB, Lazarev A, Graumlich JF, King J & Cantilena LR (1996): Vitamin C pharmacokinetics in healthy volunteers: evidence for a recommended dietary allowance. Proc. Natl. Acad. Sci. USA 93, 3704-3709.
17. Levine M, Wang Y, Padayatty SJ & Morrow J (2001): A new recommended dietary allowance of vitamin C for healthy young women. Proc. Natl. Acad. Sci. USA 98, 9842-9846.
18. Loft S, Vistisen K, Ewertz M, Tjonneland A, Overvad K & Poulsen HE (1992): Oxidative DNA damage estimated by 8-hydroxydeoxyguanosine excretion in humans: influence of smoking, gender, and body mass index. Carcinogenesis. 13, 2241-2247.
19. May JM, Qu Z, Morrow JD & Cobb CE (2000): Ascorbate-dependent protection of human erythrocytes against oxidant stress generated by extracellular diazobenzene sulfonate. Biochem. Pharmacol. 60, 47-53.
20. May JM, Qu Z & Cobb CE (2001): Recycling of the ascorbate free radical by human erythrocyte membranes. Free Radic. Biol. Med. 31, 117-124.
21. Pence LA & Mennear JH (1979): Inhibition effect of dehydroascorbic acid on insulin secretion from mouse pancreatic islets. Toxicol. Appl. Pharmacol. 50, 57-65.
22. Podmore ID, Griffith HR, Karl HE, Mistry N, Mistry P & Lunec J (1998): Vitamin C exhibits pro-oxidant properties. Nature 392, 559-560.
23. Priem H, Loft S, Nyyssönen K, Salonen JT & Poulsen H (1997): No effect of supplementation with vitamin E, ascorbic acid, or coenzyme Q10 on oxidative DNA damage estimated by 8-oxo-7,8-dihydro-2′-deoxyguanosin excretion in smokers. Am. J. Clin. Nutr. 65, 503-507.
24. Rose RC, Choi JL & Bode AM (1992): Short term effects of oxidized ascorbic acid on bovine corneal endothelium and human placenta. Life Sci. 50, 1543-1549.
25. Schneider M, Diemer K, Engelhart K, Zankel H, Trommer WE & Biesalski HK (2001): Protective effects of vitamin C and E on the number of micronuclei in lymphocytes in smokers and their role in ascorbate free radical formation in plasma. Free Radic. Res. 34, 209-219.
26. Tanaka H, Matsuda T, Miyagantani Y, Yukioka T, Matsuda H & Shimazaki S (2000): Reduction of resuscitation fluid volumes in severely burned patients using ascorbic acid administration: a randomized, prospective study. Arch. Surg. 135, 326-331.
27. Van Duijn MM, Karmi T, Van Steveninck J, Van den Broek PAJ & Van der Zee J (2000): Erythrocytes reduce extracellular ascorbate free radicals using intracellular ascorbate as an electron Donor. J. Biol. Chem. 275, 27720-27725.
28. Villalba JM, Canalejo A, Rodriguez-Aguilera JC, Buron MI, Morre DJ & Navas P (1993): NADH-ascorbate free radical and -ferricyanide reductase activities represent different levels of plasma membrane electron transport. J. Bioenerg. Biomembr. 25, 411-417.
29. Washko PW, Rotrosen D & Levine M (1989): Ascorbic acid transport and accumulation in human neutrophils. J. Biol. Chem. 264, 18996-19002.
30. Welch RW, Bergsten P, Butler JD & Levine M (1993): Ascorbic acid accumulation and transport in human fibroblasts. Biochem. J. 294, 505-510, 1993.
31. + and its structural components and their binding to lactate dehydrogenase. Biochem. Biophys. Acta. 452, 292-301.
32. Williams MJ, Sutherland WH, McCormick MP, de Jong SA, McDonald JR & Walker RJ (2001): Vitamin C improves endothelial dysfunction in renal allograft recipients. Nephrol. Dial. Transplant. 16, 1251-1255.