Association study between norepinephrine transporter gene polymorphism and schizophrenia in a Korean population

Psychiatry Investigation

Volumn 12, Issue 4, 2015, Pages 551-558

  Choo, Mira ^a   Hwang, Jung A ^a   Jeon, Sang Won ^a   Oh, So Young ^a   Yoon, Ho Kyung ^a   Lee, Heon Jeong ^a   Kim, Yong Ku ^a  

^a Korea University College of Medicine   (South Korea)

Author keywords

Gene; NET gene; Schizophrenia; Single nucleotide polymorphism

Indexed keywords

CHLORPROMAZINE; NORADRENALIN TRANSPORTER;

ADULT; ARTICLE; CALGARY DEPRESSION SCALE; CLINICAL ASSESSMENT; CONTROLLED STUDY; DNA DETERMINATION; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENETIC ASSOCIATION; GENOTYPE; HAPLOTYPE; HUMAN; INTERVIEW; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; POSITIVE AND NEGATIVE SYNDROME SCALE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SCHIZOPHRENIA; STRUCTURED CLINICAL INTERVIEW FOR DSM DISORDERS;

EID: 84946557236     PISSN: 17383684     EISSN: 19763026     Source Type: Journal    
DOI: 10.4306/pi.2015.12.4.551     Document Type: Article

References (30)

1. Leszczyńska-Rodziewicz A, Czerski PM, Kapelski P, Godlewski S, Dmitrzak-Weglarz M, Rybakowski J, et al. A polymorphism of the norepinephrine transporter gene in bipolar disorder and schizophrenia: lack of association. Neuropsychobiology 2002;45:182-185.
2. Wang YM, Xu F, Gainetdinov RR, Caron MG. Genetic approaches to studying norepinephrine function: knockout of the mouse norepinephrine transporter gene. Biol Psychiatry 1999;46:1124-1130.
3. Xu F, Gainetdinov RR, Wetsel WC, Jones SR, Bohn LM, Miller GW, et al. Mice lacking the norepinephrine transporter are supersensitive to psychostimulants. Nat Neurosci 2000;3:465-471.
4. Uhl GR, Johnson PS. Neurotransmitter transporters: three important gene families for neuronal function. J Exp Biol 1994;196:229-236.
5. King SC, Tiller AA, Chang AS, Lam DM. Differential regulation of the imipramine-sensitive serotonin transporter by cAMP in human JAr choriocarcinoma cells, rat PC12 pheochromocytoma cells, and C33-14-B1 transgenic mouse fibroblast cells. Biochem Biophys Res Commun 1992;183:487-491.
6. Figlewicz DP, Szot P, Israel PA, Payne C, Dorsa DM. Insulin reduces norepinephrine transporter mRNA in vivo in rat locus coeruleus. Brain Res 1993;602:161-164.
7. Brüss M, Kunz J, Lingen B, BÖnisch H. Chromosomal mapping of the human gene for the tricyclic antidepressant-sensitive noradrenaline transporter. Hum Genet 1993;91:278-280.
8. Porzgen P, Bonisch H, Bruss M. Molecular cloning and organization of the coding region of the human norepinephrine transporter gene. Biochem Biophys Res Commun 1995;215:1145-1150.
9. PÖrzgen P, BÖnisch H, Hammermann R, Brüss M. The human noradrenaline transporter gene contains multiple polyadenylation sites and two alternatively spliced C-terminal exons. Biochimet Biophys Acta 1998;1398:365-370.
10. Giros B, Wang YM, Suter S, McLeskey SB, Pifl C, Caron MG. Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters. J Biol Chem 1994;269:15985-15988.
11. Vandenbergh DJ, Persico AM, Uhl GR. A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs. Brain Res Mol Brain Res 1992;15:161-166.
12. Lesch KP, Wolozin BL, Estler HC, Murphy DL, Riederer P. Isolation of a cDNA encoding the human brain serotonin transporter. J Neural Transm Gen Sect 1993;91:67-72.
13. Ramamoorthy S, Bauman AL, Moore KR, Han H, Yang-Feng T, Chang AS, et al. Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. Proc Natl Acad Sci U S A 1993;90:2542-2546.
14. Kim CH, Kim HS, Cubells JF, Kim KS. A previously undescribed intron and extensive 5' upstream sequence, but not Phox2a-mediated transactivation, are necessary for high level cell type-specific expression of the human norepinephrine transporter gene. J Biol Chem 1999;274:6507-6518.
15. Inoue K, Itoh K, Yoshida K, Shimizu T, Suzuki T. Positive association between T-182C polymorphism in the norepinephrine transporter gene and susceptibility to major depressive disorder in a japanese population. Neuropsychobiology 2004;50:301-304.
16. Haenisch B, Linsel K, Brüss M, Gilsbach R, Propping P, Nothen MM, et al. Association of major depression with rare functional variants in norepinephrine transporter and serotonin1A receptor genes. Am J Med Genet B Neuropsychiatr Genet 2009;150B:1013-1016.
17. Lee YJ, Hohoff C, Domschke K, Sand P, Kuhlenbaumer G, Schirmacher A, et al. Norepinephrine transporter (NET) promoter and 5'-UTR polymorphisms: association analysis in panic disorder. Neurosci Lett 2005;377:40-43.
18. Zill P, Engel R, Baghai TC, Juckel G, Frodl T, Muller-Siecheneder F, et al. Identification of a naturally occurring polymorphism in the promoter region of the norepinephrine transporter and analysis in major depression. Neuropsychopharmacology 2002;26:489-493.
19. Stöber G, Nöthen MM, Pörzgen P, Brüss M, BÖnisch H, Knapp M, et al. Systematic search for variation in the human norepinephrine transporter gene: identification of five naturally occurring missense mutations and study of association with major psychiatric disorders. Am J Med Genet 1996;67:523-532.
20. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 4th Edition. Washington, DC: American Psychiatric Association; 1994.
21. First MB, Spitzer RL, Gibbon M, Williams JBW. Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition (SCID-I/P). New York: Biometrics Research; 2002.
22. Beck AT, Ward CH, Mendelson M, Mock J, Erbaugh J. An inventory for measuring depression. Arch Gen Psychiatry 1961;4:561-571.
23. Spielberger CD, Gorsuch RL, Lushene PR, Vagg PR, Jacobs AG. Manual for the State-Trait Anxiety Inventory (Form Y). Palo Alto: Consulting Psychologists Press, Inc; 1983.
24. Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophr Bull 1987;13:261-276.
25. Addington D, Addington J, Atkinson M. A psychometric comparison of the Calgary Depression Scale for Schizophrenia and the Hamilton Depression Rating Scale. Schizophr Res 1996;19:205-212.
26. Kim YK, Won SD, Lee KM, Choi HS, Jang HS, Lee BH, et al. A study on the reliability and validity of the Korean version of the Calgary Depression Scale for Schizophrenia (K-CDSS). J Korean Neuropsychiatr Assoc 2005;44:446-455.
27. Suzuki A, Matsumoto Y, Ishii G, Oshino S, Goto K, Otani K. No association between the -3081A/T polymorphism in the norepinephrine transporter gene promoter and personality traits in healthy subjects. Neurosci Lett 2007;425:192-194.
28. Cordeiro Q, Vallada H. Lack of association between a polymorphism of the norepinephrine transporter gene and schizophrenia in a Brazilian sample. Rev Bras Psiquiatr 2004;26:278.
29. Siuta MA, Robertson SD, Kocalis H, Saunders C, Gresch PJ, Khatri V, et al. Dysregulation of the norepinephrine transporter sustains cortical hypodopaminergia and schizophrenia-like behaviors in neuronal rictor null mice. PLoS Biol 2010;8:e1000393.
30. Poyurovsky M, Faragian S, Fuchs C, Pashinian A. Effect of the selective norepinephrine reuptake inhibitor reboxetine on cognitive dysfunction in schizophrenia patients: an add-on, double-blind placebo-controlled study. Isr J Psychiatry Relat Sci 2009;46:213-220.