The value of the thromboelastometry heparinase assay (HEPTEM) in cardiac surgery

Thrombosis and Haemostasis

Volumn 114, Issue 5, 2015, Pages 1058-1063

  Meesters, Michael Isaäc ^a   Lancé, Marcus Daniel ^b   van der Steeg, Robin ^a   Boer, Christa ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Heparin; Heparin lyase; Protamine; Thrombelastography

Indexed keywords

HEMOGLOBIN; HEPARIN; HEPARIN LYASE; PROTAMINE;

AGED; ARTICLE; BLOOD CLOTTING TIME; CARDIOPULMONARY BYPASS; CORONARY ARTERY BYPASS GRAFT; FEMALE; HEART SURGERY; HEMOSTASIS; HUMAN; MAJOR CLINICAL STUDY; MALE; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROTHROMBIN TIME; RETROSPECTIVE STUDY; THROMBOELASTOGRAPHY; BLOOD; BLOOD CLOTTING; CORONARY ARTERY DISEASE; METABOLISM; MIDDLE AGED; PROCEDURES; REPRODUCIBILITY;

AGED; BLOOD COAGULATION; CARDIOPULMONARY BYPASS; CORONARY ARTERY DISEASE; FEMALE; HEPARIN; HEPARIN LYASE; HUMANS; MALE; MIDDLE AGED; PROTAMINES; REPRODUCIBILITY OF RESULTS; RETROSPECTIVE STUDIES; THROMBELASTOGRAPHY;

EID: 84946554864     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH15-01-0066     Document Type: Article

References (23)

1. Mittermayr M, Margreiter J, Velik-Salchner C, et al. Effects of protamine and heparin can be detected and easily differentiated by modified thrombelastography (Rotem): an in vitro study. Br J Anaesth 2005; 95: 310–316.
2. Hanke AA, Herold U, Dirkmann D, et al. Thromboelastometry Based Early Goal-Directed Coagulation Management Reduces Blood Transfusion Requirements, Adverse Events, and Costs in Acute Type A Aortic Dissection: A Pilot Study. Transfus Med Hemother 2012; 39: 121–128.
3. Karlsson M, Ternstrom L, Hyllner M, et al. Prophylactic Fibrinogen Infusion in Cardiac Surgery Patients: Effects on Biomarkers of Coagulation, Fibrinolysis, and Platelet Function. Clin Appl Thromb Hemost 2011; 17: 396–404.
4. Brenner T, Schmidt K, Delang M, et al. Viscoelastic and aggregometric point-ofcare testing in patients with septic shock – cross-links between inflammation and haemostasis. Acta Anaesthesiol Scand 2012; 56: 1277–1290.
5. Carr J, Silverman N. The heparin-protamine interaction. A review. J Cardiovasc Surg 1999; 40: 659–666.
6. Ni Ainle F, Preston RJS, Jenkins PV, et al. Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation. Blood 2009; 114: 1658–1665.
7. Cobel-Geard R, Hassouna H. Interaction of protamine sulfate with thrombin. Am J Hematol 1983; 14: 227–233.
8. Chu AJ, Wang ZG, Raicu M, et al. Protamine inhibits tissue factor-initiated extrinsic coagulation. Br J Haematol 2001; 115: 392–399.
9. Mochizuki T, Olson PJ, Szlam F, et al. Protamine reversal of heparin affects platelet aggregation and activated clotting time after cardiopulmonary bypass. Anesth Analg 1998; 87: 781–785.
10. Nielsen VG. Protamine Enhances Fibrinolysis by Decreasing Clot Strength: Role of Tissue Factor-Initiated Thrombin Generation. Ann Thorac Surg 2006; 81: 1720–1727.
11. Bolliger D, Szlam F, Azran M, et al. The anticoagulant effect of protamine sulfate is attenuated in the presence of platelets or elevated factor VIII concentrations. Anesth Analg 2010; 111: 601–608.
12. Khan NU, Wayne CK, Barker J, et al. The effects of protamine overdose on coagulation parameters as measured by the thrombelastograph. Eur J Anaesthesiol 2010; 27: 624–627.
13. Gertler R, Wiesner G, Tassani-Prell P, et al. Are the Point-of-Care Diagnostics MULTIPLATE and ROTEM Valid in the Setting of High Concentrations of Heparin and Its Reversal With Protamine? J Cardiothorac Vasc Anesth 2011; 25: 981–986.
14. Mittermayr M, Velik-Salchner C, Stalzer B, et al. Detection of protamine and heparin after termination of cardiopulmonary bypass by thrombelastometry (ROTEM): results of a pilot study. Anesth Analg 2009; 108: 743–750.
15. Vonk ABA, Meesters MI, van Dijk WB, et al. Ten-year patterns in blood product utilization during cardiothoracic surgery with cardiopulmonary bypass in a tertiary hospital. Transfusion 2014; 54: 2608–2616.
16. Lang T, Bauters A, Braun SL, et al. Multi-centre investigation on reference ranges for ROTEM thromboelastometry. Blood Coagul Fibrinolysis 2005; 16: 301–310.
17. Nagler M, ten Cate H, Kathriner S, et al. Consistency of thromboelastometry analysis under scrutiny: results of a systematic evaluation within and between analysers. Thromb Haemost 2014; 111: 1161–1166.
18. Theusinger OM, Nürnberg J, Asmis LM, et al. Rotation thromboelastometry (ROTEM) stability and reproducibility over time. Eur J Cardiothorac Surg 2010; 37: 677–683.
19. Weber CF, Görlinger K, Meininger D, et al. Point-of-care testing: a prospective, randomized clinical trial of efficacy in coagulopathic cardiac surgery patients. Anesthesiology 2012; 117: 531–547.
20. Ichikawa J, Kodaka M, Nishiyama K, et al. Reappearance of circulating heparin in whole blood heparin concentration-based management does not correlate with postoperative bleeding after cardiac surgery. J Cardiothorac Vasc Anesth 2014; 28: 1015–1019.
21. Gronchi F, Perret A, Ferrari E, et al. Validation of rotational thromboelastometry during cardiopulmonary bypass. Eur J Anaesthesiol 2014; 31: 68–75.
22. Vonk AB, Veerhoek D, van den Brom CE, et al. Individualized heparin and protamine management improves rotational thromboelastometric parameters and postoperative hemostasis in valve surgery. J Cardiothorac Vasc Anesth 2014; 28: 235–241.
23. Newsletter ROTEM®, TEM International, October 2012, page 3.